Research Topics
Genomes and Genes | D E ComingsSummaryCountry: USA Publications
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Publications
Polygenic inheritance and micro/minisatellitesD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
Mol Psychiatry 3:21-31. 1998....- Association of the serotonin transporter gene with serum cholesterol levels and heart diseaseD E Comings
Department of Medical Genetics, City of Hope National Medical Center, Duarte, California, 91910, USA
Mol Genet Metab 67:248-53. 1999..Replication of these findings in independent, epidemiologically based studies is required... - Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genesD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
Clin Genet 57:178-96. 2000..For ODD different genotypes of the same genes were often used. These results support the value of the simultaneous examination of multiple candidate genes... - Association of the neutral endopeptidase (MME) gene with anxietyD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
Psychiatr Genet 10:91-4. 2000..0125. These results support a role of genetic variants of enkephalin metabolism in anxiety... - The additive effect of neurotransmitter genes in pathological gamblingD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
Clin Genet 60:107-16. 2001..Multi-gene profiles in specific individuals may be of assistance in choosing the appropriate treatment... - Reward deficiency syndrome: genetic aspects of behavioral disordersD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
Prog Brain Res 126:325-41. 2000..Techniques such as the Multivariate Analysis of Associations, which simultaneously examine the contribution of multiple genes, hold promise for understanding the genetic make up of polygenic disorders... - Association of the androgen receptor gene (AR) with ADHD and conduct disorderD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
Neuroreport 10:1589-92. 1999..004) with the lowest scores in those with the longer alleles at both polymorphisms. These results suggest that genetic variation at the human AR gene plays a role in human externalizing disorders... - A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) geneD E Comings
Department of Medical Genetics, City of Hope Medical Center, 1500 East Duarte Road, Duarte, CA 91010 0269, USA
Am J Med Genet B Neuropsychiatr Genet 118:110-4. 2003.... - The LEP gene and age of menarche: maternal age as a potential cause of hidden stratification in association studiesD E Comings
Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91910, USA
Mol Genet Metab 73:204-10. 2001..If maternal age effects prove to be generalized, failure to take them into consideration could provide a source of hidden stratification that could significantly alter the replication of association studies... - Cholecystokinin (CCK) gene as a possible risk factor for smoking: a replication in two independent samplesD E Comings
Department of Medical Genetics, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
Mol Genet Metab 73:349-53. 2001..A major detriment to smoking cessation, especially in women, is the fear of gaining weight. These observations suggested that genetic variants in the CCK gene might be a possible risk factor for smoking... - Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjectsD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
Psychiatr Genet 10:39-42. 2000..The ADRA2A gene accounted for 1.8-8.3% of the variance of these scores... - Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer diseaseM B Mann
Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
Am J Med Genet 105:312-6. 2001..007), but not in late-onset AD (LOAD). These data suggest that genetic variation in the promoter of the PNMT gene is associated with increased susceptibility to the sporadic form of EOAD... - Association between the gamma-aminobutyric acid A3 receptor gene and multiple sclerosisR Gade-Andavolu
Department of Medical Genetics, City of Hope Medical Center, Duarte, Calif 91910, USA
Arch Neurol 55:513-6. 1998..Since gamma-aminobutyric acid also modulates the release of prolactin, we examined the possible association between alleles of the GABRA3 (gamma-aminobutyric acid A3 receptor) gene and MS... - Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeatD E Comings
Department of Medical Genetics, Beckman Research Institute, City of Hope Medical Center, Duarte, California 91010, USA
Genomics 29:390-6. 1995..The 3' end of intron 5 showed an extensive CCCT pentanucleotide repeat that was markedly polymorphic. These polymorphisms allow the TDO2 gene to be examined for a possible role in psychiatric disorders... - Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disordersD E Comings
Department of Medical Genetics, City of Hope National Medical Center, Duarte, CA 91010, USA
Pharmacogenetics 6:307-18. 1996..We hope to encourage additional research into the potential role the TDO2 gene in these and other psychiatric disorders... - Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disordersD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010, USA
Ann N Y Acad Sci 931:50-83. 2001..The implications of the polygenic model for the understanding, diagnosis and treatment of ADHD and TS, as well as other psychiatric disorders, are reviewed... - The DRD4 gene and the spiritual transcendence scale of the character temperament indexD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
Psychiatr Genet 10:185-9. 2000..91). These results suggest the DRD4 gene may play a role in the personality trait of spiritual acceptance. This may be a function of the high concentration of the dopamine D4 receptor in the cortical areas, especially the frontal cortex... - Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorderD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
Clin Genet 58:31-40. 2000.... - Cannabinoid receptor gene (CNR1): association with i.v. drug useD E Comings
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
Mol Psychiatry 2:161-8. 1997..Independent studies should be designed to further confirm the hypothesis that cannabinoid receptors may contribute to the susceptibility to drug abuse... - Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disordersD E Comings
Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91010
Genomics 9:301-8. 1991..The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism... - Serotonin transporter gene polymorphisms in alcohol dependenceM D Thompson
Department of Pharmacology, University of Toronto, M5S 2S1, Toronto, Ontario, Canada
Alcohol 22:61-7. 2000..The data presented suggests a trend toward increased frequency of the S promoter allele in alcohol-dependent, alcoholic-TS and TS patients... - Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholismG A Madrid
School of Public Health, Loma Linda University, 11201 Benton St, Loma Linda, CA 92357, USA
Alcohol 23:117-22. 2001....