D E Comings

Summary

Country: USA

Publications

  1. ncbi Polygenic inheritance and micro/minisatellites
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Mol Psychiatry 3:21-31. 1998
  2. ncbi Association of the serotonin transporter gene with serum cholesterol levels and heart disease
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, California, 91910, USA
    Mol Genet Metab 67:248-53. 1999
  3. ncbi Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 57:178-96. 2000
  4. ncbi Association of the neutral endopeptidase (MME) gene with anxiety
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Psychiatr Genet 10:91-4. 2000
  5. ncbi The additive effect of neurotransmitter genes in pathological gambling
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 60:107-16. 2001
  6. ncbi Reward deficiency syndrome: genetic aspects of behavioral disorders
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Prog Brain Res 126:325-41. 2000
  7. ncbi Association of the androgen receptor gene (AR) with ADHD and conduct disorder
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Neuroreport 10:1589-92. 1999
  8. ncbi A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, 1500 East Duarte Road, Duarte, CA 91010 0269, USA
    Am J Med Genet B Neuropsychiatr Genet 118:110-4. 2003
  9. ncbi The LEP gene and age of menarche: maternal age as a potential cause of hidden stratification in association studies
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91910, USA
    Mol Genet Metab 73:204-10. 2001
  10. ncbi Cholecystokinin (CCK) gene as a possible risk factor for smoking: a replication in two independent samples
    D E Comings
    Department of Medical Genetics, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    Mol Genet Metab 73:349-53. 2001

Collaborators

Detail Information

Publications22

  1. ncbi Polygenic inheritance and micro/minisatellites
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Mol Psychiatry 3:21-31. 1998
    ....
  2. ncbi Association of the serotonin transporter gene with serum cholesterol levels and heart disease
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, California, 91910, USA
    Mol Genet Metab 67:248-53. 1999
    ..Replication of these findings in independent, epidemiologically based studies is required...
  3. ncbi Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 57:178-96. 2000
    ..For ODD different genotypes of the same genes were often used. These results support the value of the simultaneous examination of multiple candidate genes...
  4. ncbi Association of the neutral endopeptidase (MME) gene with anxiety
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Psychiatr Genet 10:91-4. 2000
    ..0125. These results support a role of genetic variants of enkephalin metabolism in anxiety...
  5. ncbi The additive effect of neurotransmitter genes in pathological gambling
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 60:107-16. 2001
    ..Multi-gene profiles in specific individuals may be of assistance in choosing the appropriate treatment...
  6. ncbi Reward deficiency syndrome: genetic aspects of behavioral disorders
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Prog Brain Res 126:325-41. 2000
    ..Techniques such as the Multivariate Analysis of Associations, which simultaneously examine the contribution of multiple genes, hold promise for understanding the genetic make up of polygenic disorders...
  7. ncbi Association of the androgen receptor gene (AR) with ADHD and conduct disorder
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Neuroreport 10:1589-92. 1999
    ..004) with the lowest scores in those with the longer alleles at both polymorphisms. These results suggest that genetic variation at the human AR gene plays a role in human externalizing disorders...
  8. ncbi A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, 1500 East Duarte Road, Duarte, CA 91010 0269, USA
    Am J Med Genet B Neuropsychiatr Genet 118:110-4. 2003
    ....
  9. ncbi The LEP gene and age of menarche: maternal age as a potential cause of hidden stratification in association studies
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91910, USA
    Mol Genet Metab 73:204-10. 2001
    ..If maternal age effects prove to be generalized, failure to take them into consideration could provide a source of hidden stratification that could significantly alter the replication of association studies...
  10. ncbi Cholecystokinin (CCK) gene as a possible risk factor for smoking: a replication in two independent samples
    D E Comings
    Department of Medical Genetics, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    Mol Genet Metab 73:349-53. 2001
    ..A major detriment to smoking cessation, especially in women, is the fear of gaining weight. These observations suggested that genetic variants in the CCK gene might be a possible risk factor for smoking...
  11. ncbi Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
    Psychiatr Genet 10:39-42. 2000
    ..The ADRA2A gene accounted for 1.8-8.3% of the variance of these scores...
  12. ncbi Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease
    M B Mann
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
    Am J Med Genet 105:312-6. 2001
    ..007), but not in late-onset AD (LOAD). These data suggest that genetic variation in the promoter of the PNMT gene is associated with increased susceptibility to the sporadic form of EOAD...
  13. ncbi Association between the gamma-aminobutyric acid A3 receptor gene and multiple sclerosis
    R Gade-Andavolu
    Department of Medical Genetics, City of Hope Medical Center, Duarte, Calif 91910, USA
    Arch Neurol 55:513-6. 1998
    ..Since gamma-aminobutyric acid also modulates the release of prolactin, we examined the possible association between alleles of the GABRA3 (gamma-aminobutyric acid A3 receptor) gene and MS...
  14. ncbi Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat
    D E Comings
    Department of Medical Genetics, Beckman Research Institute, City of Hope Medical Center, Duarte, California 91010, USA
    Genomics 29:390-6. 1995
    ..The 3' end of intron 5 showed an extensive CCCT pentanucleotide repeat that was markedly polymorphic. These polymorphisms allow the TDO2 gene to be examined for a possible role in psychiatric disorders...
  15. ncbi Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Pharmacogenetics 6:307-18. 1996
    ..We hope to encourage additional research into the potential role the TDO2 gene in these and other psychiatric disorders...
  16. ncbi Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010, USA
    Ann N Y Acad Sci 931:50-83. 2001
    ..The implications of the polygenic model for the understanding, diagnosis and treatment of ADHD and TS, as well as other psychiatric disorders, are reviewed...
  17. ncbi The DRD4 gene and the spiritual transcendence scale of the character temperament index
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
    Psychiatr Genet 10:185-9. 2000
    ..91). These results suggest the DRD4 gene may play a role in the personality trait of spiritual acceptance. This may be a function of the high concentration of the dopamine D4 receptor in the cortical areas, especially the frontal cortex...
  18. ncbi Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 58:31-40. 2000
    ....
  19. ncbi Cannabinoid receptor gene (CNR1): association with i.v. drug use
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Mol Psychiatry 2:161-8. 1997
    ..Independent studies should be designed to further confirm the hypothesis that cannabinoid receptors may contribute to the susceptibility to drug abuse...
  20. ncbi Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91010
    Genomics 9:301-8. 1991
    ..The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism...
  21. ncbi Serotonin transporter gene polymorphisms in alcohol dependence
    M D Thompson
    Department of Pharmacology, University of Toronto, M5S 2S1, Toronto, Ontario, Canada
    Alcohol 22:61-7. 2000
    ..The data presented suggests a trend toward increased frequency of the S promoter allele in alcohol-dependent, alcoholic-TS and TS patients...
  22. ncbi Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholism
    G A Madrid
    School of Public Health, Loma Linda University, 11201 Benton St, Loma Linda, CA 92357, USA
    Alcohol 23:117-22. 2001
    ....