D E Comings

Summary

Country: USA

Publications

  1. ncbi request reprint Association of CCR5 delta32 deletion with early death in multiple sclerosis
    Radhika Gade-Andavolu
    Genetic Research Institute of the Desert, Eisenhower Medical Center, Rancho Mirage, California 92270, USA
    Genet Med 6:126-31. 2004
  2. pmc Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary
    Kenneth Blum
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Theor Biol Med Model 5:24. 2008
  3. ncbi request reprint Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010, USA
    Ann N Y Acad Sci 931:50-83. 2001
  4. ncbi request reprint Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women
    David E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
    Am J Med Genet 114:527-9. 2002
  5. ncbi request reprint Parent-daughter transmission of the androgen receptor gene as an explanation of the effect of father absence on age of menarche
    David E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Child Dev 73:1046-51. 2002
  6. ncbi request reprint A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, 1500 East Duarte Road, Duarte, CA 91010 0269, USA
    Am J Med Genet B Neuropsychiatr Genet 118:110-4. 2003
  7. ncbi request reprint A multigene test for the risk of sporadic breast carcinoma
    David E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010, USA
    Cancer 97:2160-70. 2003
  8. ncbi request reprint Maternal age at the birth of the first child as an epistatic factor in polygenic disorders
    David E Comings
    Carlsbad Science Foundation, Monrovia, California, USA
    Am J Med Genet B Neuropsychiatr Genet 141:1-6. 2006
  9. pmc Neurogenetic interactions and aberrant behavioral co-morbidity of attention deficit hyperactivity disorder (ADHD): dispelling myths
    David E Comings
    Carlsbad Science Foundation, Emeritus Professor City of Hope Medical Center, Duarte, California, USA
    Theor Biol Med Model 2:50. 2005
  10. ncbi request reprint Reward deficiency syndrome: genetic aspects of behavioral disorders
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Prog Brain Res 126:325-41. 2000

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Association of CCR5 delta32 deletion with early death in multiple sclerosis
    Radhika Gade-Andavolu
    Genetic Research Institute of the Desert, Eisenhower Medical Center, Rancho Mirage, California 92270, USA
    Genet Med 6:126-31. 2004
    ..Because trafficking of inflammatory T cells into the central nervous system (CNS) is a key player in the pathogenesis of multiple sclerosis (MS), we investigated the possible association of CCR5 delta32 deletion in this disorder...
  2. pmc Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary
    Kenneth Blum
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Theor Biol Med Model 5:24. 2008
    ..In essence, D2 receptor stimulation signals negative feedback mechanisms in the mesolimbic system to induce mRNA expression causing proliferation of D2 receptors...
  3. ncbi request reprint Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010, USA
    Ann N Y Acad Sci 931:50-83. 2001
    ..The implications of the polygenic model for the understanding, diagnosis and treatment of ADHD and TS, as well as other psychiatric disorders, are reviewed...
  4. ncbi request reprint Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women
    David E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
    Am J Med Genet 114:527-9. 2002
    ..030, F = 13.37, P =.0003. By contrast, in men r(2) =.00001, F = 0.002, P =.96. These results are consistent with a gender-specific role of the CHRM2 gene in depression in women...
  5. ncbi request reprint Parent-daughter transmission of the androgen receptor gene as an explanation of the effect of father absence on age of menarche
    David E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Child Dev 73:1046-51. 2002
    ....
  6. ncbi request reprint A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, 1500 East Duarte Road, Duarte, CA 91010 0269, USA
    Am J Med Genet B Neuropsychiatr Genet 118:110-4. 2003
    ....
  7. ncbi request reprint A multigene test for the risk of sporadic breast carcinoma
    David E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010, USA
    Cancer 97:2160-70. 2003
    ..These were the leptin gene (LEP), the leptin receptor gene (LEPR), the catechol-0-methyltransferase gene (COMT), the dopamine D(2) receptor gene (DRD2), the estrogen 1 receptor gene (ESR1), and the androgen receptor gene (AR)...
  8. ncbi request reprint Maternal age at the birth of the first child as an epistatic factor in polygenic disorders
    David E Comings
    Carlsbad Science Foundation, Monrovia, California, USA
    Am J Med Genet B Neuropsychiatr Genet 141:1-6. 2006
    ..The epistatic effects of maternal age 1st were stronger than maternal age. This type of epistatic factor may be generalizable to many other gene-trait interactions...
  9. pmc Neurogenetic interactions and aberrant behavioral co-morbidity of attention deficit hyperactivity disorder (ADHD): dispelling myths
    David E Comings
    Carlsbad Science Foundation, Emeritus Professor City of Hope Medical Center, Duarte, California, USA
    Theor Biol Med Model 2:50. 2005
    ..Since most misconceptions contain elements of truth, where does the reality lie?..
  10. ncbi request reprint Reward deficiency syndrome: genetic aspects of behavioral disorders
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Prog Brain Res 126:325-41. 2000
    ..Techniques such as the Multivariate Analysis of Associations, which simultaneously examine the contribution of multiple genes, hold promise for understanding the genetic make up of polygenic disorders...
  11. ncbi request reprint Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 57:178-96. 2000
    ..For ODD different genotypes of the same genes were often used. These results support the value of the simultaneous examination of multiple candidate genes...
  12. ncbi request reprint The additive effect of neurotransmitter genes in pathological gambling
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 60:107-16. 2001
    ..Multi-gene profiles in specific individuals may be of assistance in choosing the appropriate treatment...
  13. ncbi request reprint The LEP gene and age of menarche: maternal age as a potential cause of hidden stratification in association studies
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91910, USA
    Mol Genet Metab 73:204-10. 2001
    ..If maternal age effects prove to be generalized, failure to take them into consideration could provide a source of hidden stratification that could significantly alter the replication of association studies...
  14. ncbi request reprint Association of the neutral endopeptidase (MME) gene with anxiety
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Psychiatr Genet 10:91-4. 2000
    ..0125. These results support a role of genetic variants of enkephalin metabolism in anxiety...
  15. ncbi request reprint Cannabinoid receptor gene (CNR1): association with i.v. drug use
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Mol Psychiatry 2:161-8. 1997
    ..Independent studies should be designed to further confirm the hypothesis that cannabinoid receptors may contribute to the susceptibility to drug abuse...
  16. ncbi request reprint Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
    Psychiatr Genet 10:39-42. 2000
    ..The ADRA2A gene accounted for 1.8-8.3% of the variance of these scores...
  17. ncbi request reprint Association of the androgen receptor gene (AR) with ADHD and conduct disorder
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Neuroreport 10:1589-92. 1999
    ..004) with the lowest scores in those with the longer alleles at both polymorphisms. These results suggest that genetic variation at the human AR gene plays a role in human externalizing disorders...
  18. ncbi request reprint Cholecystokinin (CCK) gene as a possible risk factor for smoking: a replication in two independent samples
    D E Comings
    Department of Medical Genetics, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    Mol Genet Metab 73:349-53. 2001
    ..A major detriment to smoking cessation, especially in women, is the fear of gaining weight. These observations suggested that genetic variants in the CCK gene might be a possible risk factor for smoking...
  19. ncbi request reprint Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Pharmacogenetics 6:307-18. 1996
    ..We hope to encourage additional research into the potential role the TDO2 gene in these and other psychiatric disorders...
  20. ncbi request reprint Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease
    M B Mann
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
    Am J Med Genet 105:312-6. 2001
    ..007), but not in late-onset AD (LOAD). These data suggest that genetic variation in the promoter of the PNMT gene is associated with increased susceptibility to the sporadic form of EOAD...
  21. ncbi request reprint Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 58:31-40. 2000
    ....
  22. ncbi request reprint Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat
    D E Comings
    Department of Medical Genetics, Beckman Research Institute, City of Hope Medical Center, Duarte, California 91010, USA
    Genomics 29:390-6. 1995
    ..The 3' end of intron 5 showed an extensive CCCT pentanucleotide repeat that was markedly polymorphic. These polymorphisms allow the TDO2 gene to be examined for a possible role in psychiatric disorders...
  23. ncbi request reprint The DRD4 gene and the spiritual transcendence scale of the character temperament index
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA
    Psychiatr Genet 10:185-9. 2000
    ..91). These results suggest the DRD4 gene may play a role in the personality trait of spiritual acceptance. This may be a function of the high concentration of the dopamine D4 receptor in the cortical areas, especially the frontal cortex...
  24. ncbi request reprint Association between the gamma-aminobutyric acid A3 receptor gene and multiple sclerosis
    R Gade-Andavolu
    Department of Medical Genetics, City of Hope Medical Center, Duarte, Calif 91910, USA
    Arch Neurol 55:513-6. 1998
    ..Since gamma-aminobutyric acid also modulates the release of prolactin, we examined the possible association between alleles of the GABRA3 (gamma-aminobutyric acid A3 receptor) gene and MS...
  25. ncbi request reprint Polygenic inheritance and micro/minisatellites
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Mol Psychiatry 3:21-31. 1998
    ....
  26. ncbi request reprint Association of the serotonin transporter gene with serum cholesterol levels and heart disease
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, California, 91910, USA
    Mol Genet Metab 67:248-53. 1999
    ..Replication of these findings in independent, epidemiologically based studies is required...
  27. ncbi request reprint Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders
    D E Comings
    Department of Medical Genetics, City of Hope National Medical Center, Duarte, California 91010
    Genomics 9:301-8. 1991
    ..The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism...
  28. ncbi request reprint Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis
    Michael B Mann
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA, USA
    J Neuroimmunol 124:101-5. 2002
    ..The data suggest that these promoter polymorphisms of the PNMT gene, both independently and cumulatively, show association with MS...
  29. ncbi request reprint Association between the low molecular weight cytosolic acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome
    Nunzio Bottini
    The Burnham Institute, La Jolla, CA, USA
    Neurosci Lett 330:198-200. 2002
    ..0005), but this difference was restricted to cases with comorbid attention-deficit hyperactivity disorder (P<0.0001) and conduct disorder (P<0.0002), while having little relevance to TS itself...
  30. ncbi request reprint Are dopaminergic genes involved in a predisposition to pathological aggression? Hypothesizing the importance of "super normal controls" in psychiatricgenetic research of complex behavioral disorders
    Thomas J H Chen
    Chang Jung Christian University, Taiwan, ROC
    Med Hypotheses 65:703-7. 2005
    ....
  31. ncbi request reprint RANTES: a genetic risk marker for multiple sclerosis
    Radhika Gade-Andavolu
    Genetic Research Institute of the Desert, Eisenhower Medical Center, Probst 308, 39000 Bob Hope Dr, Rancho Mirage, CA 92270, USA
    Mult Scler 10:536-9. 2004
    ..Considering its potential role in MS, we screened two functional polymorphisms in the proximal promoter region of the RANTES in MS patients versus controls...
  32. ncbi request reprint Phenylethanolamine N-methyltransferase G-148A genetic variant and weight loss in obese women
    Warren R Peters
    Loma Linda University, Center for Health Promotion, Loma Linda, California 92350, USA
    Obes Res 11:415-9. 2003
    ..To understand the impact of the phenylethanolamine N-methyltransferase (PNMT) G-148A gene and nutritional variables on weight loss in obese women...
  33. ncbi request reprint Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism
    Diane Olin
    California State Polytechnic University, Pomona, CA, USA
    Neurosci Lett 381:275-8. 2005
    ..In a logistic regression analysis including APOE, age, sex and BDNF, BDNF was significant at p<.0001. We concluded that BDNF gene variants are significant risk factors for late onset AD...
  34. ncbi request reprint Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity
    Miles D Thompson
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 129:69-75. 2004
    ..Further work is warranted to study the variability of the orexin/hypocretin system in a variety of disorders characterized by EDS...
  35. ncbi request reprint Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women
    Nunzio Bottini
    The Burnham Institute, La Jolla, CA, USA
    Mol Genet Metab 77:226-9. 2002
    ..The confirmation of ACP1 as a modifier gene of the metabolic complications could open the door to the prevention of the lethal complications of obesity...
  36. ncbi request reprint The real problem in association studies
    David E Comings
    Am J Med Genet B Neuropsychiatr Genet 116:102. 2003