KIM LEWIS MCBRIDE

Summary

Affiliation: Columbus Children's Research Institute
Country: USA

Publications

  1. pmc Epidemiology of noncomplex left ventricular outflow tract obstruction malformations (aortic valve stenosis, coarctation of the aorta, hypoplastic left heart syndrome) in Texas, 1999-2001
    Kim L McBride
    Department of Molecular and Human Genetics, Columbus Children s Research Institute, Ohio State University, 43205, USA
    Birth Defects Res A Clin Mol Teratol 73:555-61. 2005
  2. ncbi request reprint Heritability of plasma amino acid levels in different nutritional states
    Kim L McBride
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Mol Genet Metab 90:217-20. 2007
  3. ncbi request reprint Genetic testing in autism: how much is enough?
    Gail E Herman
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, Ohio 43205, USA
    Genet Med 9:268-74. 2007
  4. pmc Linkage analysis of left ventricular outflow tract malformations (aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome)
    Kim L McBride
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Eur J Hum Genet 17:811-9. 2009
  5. pmc Echocardiographic evaluation of asymptomatic parental and sibling cardiovascular anomalies associated with congenital left ventricular outflow tract lesions
    Mark B Lewin
    Division of Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatrics 114:691-6. 2004
  6. pmc NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling
    Kim L McBride
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
    Hum Mol Genet 17:2886-93. 2008
  7. ncbi request reprint Renal anomalies in family members of infants with bilateral renal agenesis/adysplasia
    Andrew L Schwaderer
    Division of Nephrology, Department of Pediatrics, Columbus Children s Hospital, The Ohio State University College of Medicine, 700 Children s Drive, Columbus, OH 43205, USA
    Pediatr Nephrol 22:52-6. 2007
  8. pmc Inheritance analysis of congenital left ventricular outflow tract obstruction malformations: Segregation, multiplex relative risk, and heritability
    Kim L McBride
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Am J Med Genet A 134:180-6. 2005
  9. pmc Significant contributions of the extraembryonic membranes and maternal genotype to the placental pathology in heterozygous Nsdhl deficient female embryos
    David Cunningham
    Department of Pediatrics, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, OH 43205, USA
    Hum Mol Genet 19:364-73. 2010
  10. doi request reprint Parental knowledge and attitudes toward hypertrophic cardiomyopathy genetic testing
    Sara M Fitzgerald-Butt
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
    Pediatr Cardiol 31:195-202. 2010

Research Grants

Collaborators

  • J A Towbin
  • Gail E Herman
  • Paul Schliekelman
  • Cynthia A Gerhardt
  • Angela Lin
  • Andrew Schwaderer
  • Thomas W Prior
  • K Vannatta
  • Brad H Rovin
  • David Cunningham
  • Sara M Fitzgerald-Butt
  • Elizabeth A Varga
  • Yan Yang
  • Mark B Lewin
  • John W Belmont
  • Seema R Lalani
  • Lindsey Byrne
  • Tiffany Talabere
  • Matthew Kennedy
  • Natalie Bir
  • Timothy M Hoffman
  • Matthew Pastore
  • Lee A Hebert
  • Karla N Jones
  • Gloria C Higgins
  • Maddie Hebert
  • Yaoling Shu
  • Haikady N Nagaraja
  • Erwin K Chung
  • Bi Zhou
  • Carol A Blanchong
  • Robert M Rennebohm
  • Robert A S Roubey
  • C Yung Yu
  • Stephanie L Savelli
  • Yee Ling Wu
  • Robert R Rice
  • Kevin V Hackshaw
  • Betty P Tsao
  • Jennifer M Grossman
  • Daniel J Birmingham
  • Kathryn Kitzmiller
  • Wilbur Lam
  • Andres Menesses
  • Ricardo Pignatelli
  • Ana Combes
  • Louis I Bezold
  • Susan Fernbach
  • Norman Kaplan
  • Carlos Bacino
  • David W Stockton
  • Margaret A Hefner
  • John M Graham
  • Sandra L Davenport
  • Susan D Fernbach
  • Nancy L Glass
  • Laura M Molinari
  • William J Craigen

Detail Information

Publications15

  1. pmc Epidemiology of noncomplex left ventricular outflow tract obstruction malformations (aortic valve stenosis, coarctation of the aorta, hypoplastic left heart syndrome) in Texas, 1999-2001
    Kim L McBride
    Department of Molecular and Human Genetics, Columbus Children s Research Institute, Ohio State University, 43205, USA
    Birth Defects Res A Clin Mol Teratol 73:555-61. 2005
    ..The Texas Birth Defects Registry, an active surveillance program, enables study in a large, diverse population including Hispanics...
  2. ncbi request reprint Heritability of plasma amino acid levels in different nutritional states
    Kim L McBride
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Mol Genet Metab 90:217-20. 2007
    ....
  3. ncbi request reprint Genetic testing in autism: how much is enough?
    Gail E Herman
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, Ohio 43205, USA
    Genet Med 9:268-74. 2007
    ..To evaluate the yield of genetic testing in children with autism spectrum disorders...
  4. pmc Linkage analysis of left ventricular outflow tract malformations (aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome)
    Kim L McBride
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Eur J Hum Genet 17:811-9. 2009
    ..Overlapping linkage peaks provide evidence for a common genetic etiology...
  5. pmc Echocardiographic evaluation of asymptomatic parental and sibling cardiovascular anomalies associated with congenital left ventricular outflow tract lesions
    Mark B Lewin
    Division of Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatrics 114:691-6. 2004
    ..This study sought to define the incidence of cardiac anomalies in first-degree relatives of children with congenital aortic valve stenosis (AVS), coarctation of the aorta (CoA), and hypoplastic left heart syndrome (HLHS)...
  6. pmc NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling
    Kim L McBride
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
    Hum Mol Genet 17:2886-93. 2008
    ..These results also establish for the first time that AVS, COA and HLHS can share a common pathogenetic mechanism at the molecular level, explaining observations of these defects co-occurring within families...
  7. ncbi request reprint Renal anomalies in family members of infants with bilateral renal agenesis/adysplasia
    Andrew L Schwaderer
    Division of Nephrology, Department of Pediatrics, Columbus Children s Hospital, The Ohio State University College of Medicine, 700 Children s Drive, Columbus, OH 43205, USA
    Pediatr Nephrol 22:52-6. 2007
    ..The increased prevalence of a range of renal anomalies within affected families raises the possibility that isolated renal malformations result from unidentified gene-environment interactions...
  8. pmc Inheritance analysis of congenital left ventricular outflow tract obstruction malformations: Segregation, multiplex relative risk, and heritability
    Kim L McBride
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Am J Med Genet A 134:180-6. 2005
    ..This data can also provide families with important information for screening asymptomatic relatives for potentially harmful cardiac defects...
  9. pmc Significant contributions of the extraembryonic membranes and maternal genotype to the placental pathology in heterozygous Nsdhl deficient female embryos
    David Cunningham
    Department of Pediatrics, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, OH 43205, USA
    Hum Mol Genet 19:364-73. 2010
    ..283 mm(2); P = 0.024). These data demonstrate significant effects of the mother and fetal membranes on pregnancy outcome, with possible implications for cholesterol homeostasis during human pregnancy...
  10. doi request reprint Parental knowledge and attitudes toward hypertrophic cardiomyopathy genetic testing
    Sara M Fitzgerald-Butt
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH, USA
    Pediatr Cardiol 31:195-202. 2010
    ..This study provides healthcare providers with a framework to understand caregivers' knowledge and views of genetic testing, which can be used to improve clinical care for pediatric HCM patients...
  11. ncbi request reprint Toward a genetic etiology of CHARGE syndrome: I. A systematic scan for submicroscopic deletions
    Seema R Lalani
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Genet A 118:260-6. 2003
    ..This screen sets upper limits on the length of a CHARGE-related microdeletion, should that be the genetic mechanism underlying the phenotype...
  12. doi request reprint The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly
    Elizabeth A Varga
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Genet Med 11:111-7. 2009
    ..To define the prevalence of PTEN mutations in a clinical cohort of pediatric subjects with autism spectrum disorders (ASDs), developmental delay/mental retardation (DD/MR), and/or macrocephaly and to assess genotype-phenotype correlations...
  13. pmc Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European America
    Yan Yang
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Am J Hum Genet 80:1037-54. 2007
    ..This work demonstrates how gene CNV and its related polymorphisms are associated with the susceptibility to a human complex disease...
  14. ncbi request reprint A family-based association study of congenital left-sided heart malformations and 5,10 methylenetetrahydrofolate reductase
    Kim L McBride
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Birth Defects Res A Clin Mol Teratol 70:825-30. 2004
    ..Two previous small case-control studies suggested methylenetetrahydrofolate reductase (MTHFR) polymorphisms may be associated with this group of malformations...
  15. doi request reprint Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly
    Kim L McBride
    Center for Molecular and Human Genetics, Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Autism Res 3:137-41. 2010
    ..We recommend testing for mutations in PTEN for individuals with ASD or MR/DD and macrocephaly. If mutations are found, other family members should be offered testing and the adults offered cancer screening if they have a PTEN mutation...

Research Grants1

  1. Genetics of Congenital Left-sided Heart Defects
    Kim McBride; Fiscal Year: 2007
    ..The proposed studies will launch the applicant on an independent research career, providing a base on which to advance genetic analyses of CCVM with the aim to reduce their occurrence and provide new treatment opportunities. ..