Laurent Yvan Charvet
Affiliation: Columbia University
Yvan Charvet L, Matsuura F, Wang N, Bamberger M, Nguyen T, Rinninger F, et al
. Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL. Arterioscler Thromb Vasc Biol. 2007;27:1132-8 pubmed
Yvan Charvet L, Bobard A, Bossard P, Massiera F, Rousset X, Ailhaud G, et al
. In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis. Arterioscler Thromb Vasc Biol. 2007;27:1340-5 pubmed
..This study examines the role of insulin and angiotensin II in high-density lipoprotein (HDL) metabolism by focusing on the regulation and function of scavenger receptor type-BI (SR-BI) in adipose tissue...
Yvan Charvet L, Pagler T, Wang N, Senokuchi T, Brundert M, Li H, et al
. SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL. J Lipid Res. 2008;49:107-14 pubmed
..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
Yvan Charvet L, Welch C, Pagler T, Ranalletta M, Lamkanfi M, Han S, et al
. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation. 2008;118:1837-47 pubmed publisher
..This study was undertaken to elucidate the mechanisms and consequences of enhanced inflammatory gene expression in ABC transporter-deficient macrophages...
Yvan Charvet L, Kling J, Pagler T, Li H, Hubbard B, Fisher T, et al
. Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. Arterioscler Thromb Vasc Biol. 2010;30:1430-8 pubmed publisher
Yvan Charvet L, Pagler T, Gautier E, Avagyan S, Siry R, Han S, et al
. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science. 2010;328:1689-93 pubmed publisher
..The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis. ..
Yvan Charvet L, Ranalletta M, Wang N, Han S, Terasaka N, Li R, et al
. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest. 2007;117:3900-8 pubmed
..These results suggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central to the antiatherogenic properties of HDL...
Yvan Charvet L, Wang N, Tall A. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arterioscler Thromb Vasc Biol. 2010;30:139-43 pubmed publisher
..The underlying mechanisms may involve modulation of sterol levels and lipid organization in cell membranes...
Yvan Charvet L, Pagler T, Seimon T, Thorp E, Welch C, Witztum J, et al
. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res. 2010;106:1861-9 pubmed publisher
..The ATP-binding cassette transporters ABCA1 and ABCG1 have a major role in promoting cholesterol efflux from macrophages to apolipoprotein A-1 and HDL and are upregulated during the phagocytosis of apoptotic cells (efferocytosis)...