Laurent Yvan-Charvet

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow
    Mollie Ranalletta
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 26:2308-15. 2006
  2. ncbi request reprint [Raising HDL-cholesterol: the future drug therapy for atherosclerosis?]
    David Masson
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, Etats Unis
    Med Sci (Paris) 24:341-3. 2008
  3. ncbi request reprint SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 49:107-14. 2008
  4. pmc Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Circulation 118:1837-47. 2008
  5. ncbi request reprint In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis
    Laurent Yvan-Charvet
    INSERM, U671, Centre Biomédical des Cordeliers, 75270 Paris Cedex 06, France
    Arterioscler Thromb Vasc Biol 27:1340-5. 2007
  6. ncbi request reprint Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168 St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 27:1132-8. 2007
  7. pmc Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 30:139-43. 2010
  8. pmc ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, 630 W 168th St, Columbia University, New York, NY 10032, USA
    Circ Res 106:1861-9. 2010
  9. pmc Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 30:1430-8. 2010
  10. pmc ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Science 328:1689-93. 2010

Detail Information

Publications33

  1. ncbi request reprint Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow
    Mollie Ranalletta
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 26:2308-15. 2006
    ..Recent studies indicate that the ATP-binding cassette transporter ABCG1 can promote cholesterol efflux from macrophages to high-density lipoprotein. This study was designed to assess the in vivo role of macrophage ABCG1 in atherosclerosis...
  2. ncbi request reprint [Raising HDL-cholesterol: the future drug therapy for atherosclerosis?]
    David Masson
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, Etats Unis
    Med Sci (Paris) 24:341-3. 2008
  3. ncbi request reprint SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 49:107-14. 2008
    ..Previous findings of increased atherosclerosis in mice transplanted with SR-BI(-/-) bone marrow probably cannot be explained by a defect in macrophage cholesterol efflux...
  4. pmc Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Circulation 118:1837-47. 2008
    ..This study was undertaken to elucidate the mechanisms and consequences of enhanced inflammatory gene expression in ABC transporter-deficient macrophages...
  5. ncbi request reprint In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis
    Laurent Yvan-Charvet
    INSERM, U671, Centre Biomédical des Cordeliers, 75270 Paris Cedex 06, France
    Arterioscler Thromb Vasc Biol 27:1340-5. 2007
    ..This study examines the role of insulin and angiotensin II in high-density lipoprotein (HDL) metabolism by focusing on the regulation and function of scavenger receptor type-BI (SR-BI) in adipose tissue...
  6. ncbi request reprint Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168 St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 27:1132-8. 2007
    ..This study examines the effects of pharmacological inhibition of cholesteryl ester transfer protein (CETP) on the ability of high-density lipoprotein particles (HDL) to promote net cholesterol efflux from human THP-1 macrophage foam cells...
  7. pmc Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 30:139-43. 2010
    ..The underlying mechanisms may involve modulation of sterol levels and lipid organization in cell membranes...
  8. pmc ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, 630 W 168th St, Columbia University, New York, NY 10032, USA
    Circ Res 106:1861-9. 2010
    ..The ATP-binding cassette transporters ABCA1 and ABCG1 have a major role in promoting cholesterol efflux from macrophages to apolipoprotein A-1 and HDL and are upregulated during the phagocytosis of apoptotic cells (efferocytosis)...
  9. pmc Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 30:1430-8. 2010
    ....
  10. pmc ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Science 328:1689-93. 2010
    ..The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis...
  11. pmc Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 117:3900-8. 2007
    ..These results suggest that the combined effects of ABCA1 and ABCG1 in mediating macrophage sterol efflux are central to the antiatherogenic properties of HDL...
  12. pmc ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet
    Naoki Terasaka
    Division of Molecular Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 118:3701-13. 2008
    ..Our data suggest that ABCG1 and HDL maintain EC function in HCD-fed mice by promoting efflux of cholesterol and 7-oxysterols and preserving active eNOS dimer levels...
  13. pmc High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1
    Naoki Terasaka
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:15093-8. 2007
    ..These findings indicate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and related oxysterols from macrophages onto HDL and in protecting these cells from oxysterol-induced cytotoxicity...
  14. pmc Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice
    Marit Westerterp
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 112:1456-65. 2013
    ..Although it is widely assumed that this is attributable to the ability of high-density lipoprotein to promote cholesterol efflux from macrophage foam cells, direct experimental support for this hypothesis is lacking...
  15. pmc Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways
    Marit Westerterp
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY 10032, USA
    Cell Stem Cell 11:195-206. 2012
    ..Our data identify a role of cholesterol efflux pathways in the control of HSPC mobilization. This may translate into therapeutic strategies for atherosclerosis and hematologic malignancies...
  16. doi request reprint Cholesterol efflux: a novel regulator of myelopoiesis and atherogenesis
    Alan R Tall
    Department of Medicine, Columbia University, 630W 168th St, College of Physicians and Surgeons 8 401, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 32:2547-52. 2012
    ....
  17. ncbi request reprint ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain
    Nan Wang
    Department of Medicine, Columbia University, PS 8 401, 630 W 168th St, New York, NY 10032, USA
    FASEB J 22:1073-82. 2008
    ....
  18. pmc ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice
    Andrew J Murphy
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 121:4138-49. 2011
    ..Although endogenous apoA-I was ineffective, pharmacologic approaches to increasing cholesterol efflux suppressed stem cell proliferative responses...
  19. pmc Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis
    Andrew J Murphy
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, New York, USA
    Nat Med 19:586-94. 2013
    ..HDL infusions may offer a new approach to reducing atherothrombotic events associated with increased platelet production...
  20. ncbi request reprint Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells
    Dongying Cui
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Leukoc Biol 82:1040-50. 2007
    ..These findings have implications for macrophage physiology in both AC clearance and atherosclerotic plaque progression...
  21. doi request reprint Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue
    Laurent Yvan-Charvet
    Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie, Centre Biomédical des Cordeliers, Paris, France
    Endocrinology 150:1421-8. 2009
    ..Furthermore, despite a reduction of adipose mass in KOVEX, AT2 deficiency caused increased renin production, further worsening the hypertension caused by AGT overexpression...
  22. ncbi request reprint Prevention of adipose tissue depletion during food deprivation in angiotensin type 2 receptor-deficient mice
    Laurent Yvan-Charvet
    Institut National de la Sante et de la Recherche Medicale, Unité 671, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Endocrinology 147:5078-86. 2006
    ..These data reveal an important physiological role of AT2R in metabolic adaptations to fasting...
  23. pmc Anti-atherogenic mechanisms of high density lipoprotein: effects on myeloid cells
    Andrew J Murphy
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Biochim Biophys Acta 1821:513-21. 2012
    ..This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  24. pmc Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation
    Chao Ling Kuo
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA
    Arterioscler Thromb Vasc Biol 31:2483-92. 2011
    ..Common genetic variants in a 58-kb region of chromosome 9p21, near the CDKN2A/CDKN2B tumor suppressor locus, are strongly associated with coronary artery disease. However, the underlying mechanism of action remains unknown...
  25. doi request reprint HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis
    Alan R Tall
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 7:365-75. 2008
    ..A variety of approaches to increasing HDL may eventually be successful in treating atherosclerosis...
  26. doi request reprint ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase
    Naoki Terasaka
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168 St, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 30:2219-25. 2010
    ..To investigate whether cholesterol efflux to high-density lipoprotein (HDL) via ATP-binding cassette transporter G1 (ABCG1) modulates the interaction of caveolin (Cav) 1 and endothelial NO synthase (eNOS)...
  27. doi request reprint Role of adipose tissue renin-angiotensin system in metabolic and inflammatory diseases associated with obesity
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York, USA
    Kidney Int 79:162-8. 2011
    ....
  28. doi request reprint ATP-Binding Cassette Transporters, Atherosclerosis, and Inflammation
    Marit Westerterp
    From the Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY M W, A E B, L Y C, A J M, N W, A R T Departments of Medical Biochemistry M W and Vascular Medicine A E B, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands and Haematopoiesis and Leukocyte Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Australia A J M
    Circ Res 114:157-70. 2014
    ....
  29. doi request reprint Mild renal dysfunction and metabolites tied to low HDL cholesterol are associated with monocytosis and atherosclerosis
    Anjali Ganda
    Division of Nephrology, College of Physicians and Surgeons, Columbia University, PH4 124, 622 W 168th St, New York, NY 10032, USA
    Circulation 127:988-96. 2013
    ..We hypothesized that individuals with mild renal dysfunction at increased cardiovascular risk would have reduced high-density lipoprotein levels, high blood monocyte counts, and accelerated atherosclerosis...
  30. ncbi request reprint Gender-related response of lipid metabolism to dietary fatty acids in the hamster
    Anne Morise
    Laboratoire d Endocrinologie de la Nutrition, Universite Paris Sud, 91405 Orsay Cedex, France
    Br J Nutr 95:709-20. 2006
    ..012). In conclusion, in our model, the response of either TG or CH to dietary fatty acids is modulated differently by gender. The possible relevance of these interactions to dietary practice should be taken into account in man...
  31. ncbi request reprint Insulin and angiotensin II induce the translocation of scavenger receptor class B, type I from intracellular sites to the plasma membrane of adipocytes
    Anne Laure Tondu
    INSERM U671, Universite Pierre et Marie Curie, Institut Biomedical des Cordeliers, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 280:33536-40. 2005
    ..This suggests that SR-BI might participate in the storage of lipids in the adipose tissue...
  32. ncbi request reprint Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance
    Laurent Yvan-Charvet
    Unit 465, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Diabetes 54:991-9. 2005
    ..These data support the idea that AT2R-dependent Ang II signaling increases adipose cell mass and glucose intolerance and thus could participate to the deleterious effects of a high-fat diet...
  33. ncbi request reprint The failure of torcetrapib: was it the molecule or the mechanism?
    Alan R Tall
    Arterioscler Thromb Vasc Biol 27:257-60. 2007