Rafael Yuste

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Morphological changes in dendritic spines associated with long-term synaptic plasticity
    R Yuste
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Annu Rev Neurosci 24:1071-89. 2001
  2. ncbi request reprint Fluorescence microscopy today
    Rafael Yuste
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Methods 2:902-4. 2005
  3. ncbi request reprint The cortex as a central pattern generator
    Rafael Yuste
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, Box 2435, New York 10027, USA
    Nat Rev Neurosci 6:477-83. 2005
  4. ncbi request reprint Dendritic spines and linear networks
    Rafael Yuste
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, NY, USA
    J Physiol Paris 98:479-86. 2004
  5. ncbi request reprint Genesis of dendritic spines: insights from ultrastructural and imaging studies
    Rafael Yuste
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Rev Neurosci 5:24-34. 2004
  6. ncbi request reprint On the function of dendritic spines
    R Yuste
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuroscientist 7:387-95. 2001
  7. ncbi request reprint Calcium microdomains in aspiny dendrites
    Jesse H Goldberg
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 40:807-21. 2003
  8. ncbi request reprint Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex
    Daniella Dumitriu
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Cereb Cortex 17:81-91. 2007
  9. ncbi request reprint Synfire chains and cortical songs: temporal modules of cortical activity
    Yuji Ikegaya
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 304:559-64. 2004
  10. ncbi request reprint Imaging the motility of dendritic protrusions and axon terminals: roles in axon sampling and synaptic competition
    Sila Konur
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Mol Cell Neurosci 27:427-40. 2004

Research Grants

  1. SPINE MOTILITY AND VISUAL PLASTICITY
    Rafael Yuste; Fiscal Year: 2004
  2. IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX
    Rafael Yuste; Fiscal Year: 2004
  3. SPINE MOTILITY AND VISUAL PLASTICITY
    Rafael Yuste; Fiscal Year: 2005
  4. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2006
  5. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2007
  6. NEURAL CIRCUITS & PLASTICITY GORDON RESEARCH CONFERENCE
    Rafael Yuste; Fiscal Year: 2007
  7. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2009
  8. IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX
    Rafael Yuste; Fiscal Year: 2003
  9. SPINE MOTILITY AND VISUAL PLASTICITY
    Rafael Yuste; Fiscal Year: 2003
  10. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 1999

Detail Information

Publications87

  1. ncbi request reprint Morphological changes in dendritic spines associated with long-term synaptic plasticity
    R Yuste
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Annu Rev Neurosci 24:1071-89. 2001
    ..Still, they highlight once more how form and function go hand in hand in the central nervous system...
  2. ncbi request reprint Fluorescence microscopy today
    Rafael Yuste
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Methods 2:902-4. 2005
    ..Further advances in fluorophore design, molecular biological tools and nonlinear and hyper-resolution microscopies are poised to profoundly transform many fields of biological research...
  3. ncbi request reprint The cortex as a central pattern generator
    Rafael Yuste
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, Box 2435, New York 10027, USA
    Nat Rev Neurosci 6:477-83. 2005
    ....
  4. ncbi request reprint Dendritic spines and linear networks
    Rafael Yuste
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, NY, USA
    J Physiol Paris 98:479-86. 2004
    ..Linear integration could also help the neocortex decode the sensory world and may have additional computational advantages. In this view, spines would be the anatomical signature of linear networks...
  5. ncbi request reprint Genesis of dendritic spines: insights from ultrastructural and imaging studies
    Rafael Yuste
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Rev Neurosci 5:24-34. 2004
  6. ncbi request reprint On the function of dendritic spines
    R Yuste
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuroscientist 7:387-95. 2001
    ..Spines therefore would play a crucial circuit role, remarkably analogous to synaptic matrix elements of associative neural networks. This model highlights the economical, yet elegant, design of CNS circuits...
  7. ncbi request reprint Calcium microdomains in aspiny dendrites
    Jesse H Goldberg
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 40:807-21. 2003
    ..Because aspiny dendrites throughout the CNS express CP-AMPA receptors, we propose that CP-AMPA receptors mediate a spine-free mechanism of input-specific calcium compartmentalization...
  8. ncbi request reprint Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex
    Daniella Dumitriu
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Cereb Cortex 17:81-91. 2007
    ..This suggests that different interneuron types could channel different temporal patterns of activity. Our results also confirm the importance of the axonal morphology to classify interneurons...
  9. ncbi request reprint Synfire chains and cortical songs: temporal modules of cortical activity
    Yuji Ikegaya
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 304:559-64. 2004
    ..Sequences of active neurons have distinct spatial structures and are repeated in the same order over tens of seconds, revealing modular temporal dynamics. Higher order sequences are replayed with compressed timing...
  10. ncbi request reprint Imaging the motility of dendritic protrusions and axon terminals: roles in axon sampling and synaptic competition
    Sila Konur
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Mol Cell Neurosci 27:427-40. 2004
    ..Spine "morphing" could therefore be the morphological signature for synaptic input competition in central synapses...
  11. pmc Global dendritic calcium spikes in mouse layer 5 low threshold spiking interneurones: implications for control of pyramidal cell bursting
    Jesse H Goldberg
    Department of Biological Sciences, Columbia University, New York, NY 1002, USA
    J Physiol 558:465-78. 2004
    ....
  12. pmc Ca2+ imaging of mouse neocortical interneurone dendrites: contribution of Ca2+-permeable AMPA and NMDA receptors to subthreshold Ca2+dynamics
    Jesse H Goldberg
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    J Physiol 551:67-78. 2003
    ..These data highlight different strategies in dendritic signal processing by distinct classes of interneurones...
  13. ncbi request reprint Two-photon photostimulation and imaging of neural circuits
    Volodymyr Nikolenko
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, Box 2435, New York, New York 10027, USA
    Nat Methods 4:943-50. 2007
    ..We combined this approach with two-photon calcium imaging in an all-optical method to image and manipulate circuit activity...
  14. ncbi request reprint A visual thalamocortical slice
    Jason N MacLean
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, New York 10027, USA
    Nat Methods 3:129-34. 2006
    ..Finally, we compared cortical activity after LGN stimulation with spontaneous cortical activity and found significant overlap of the spatiotemporal dynamics generated by both types of events...
  15. pmc The spine neck filters membrane potentials
    Roberto Araya
    Howard Hughes Medical Institute and Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 103:17961-6. 2006
    ..We conclude that the spine neck plays an electrical role in the transmission of membrane potentials, isolating synapses electrically...
  16. ncbi request reprint Morphological and physiological characterization of layer VI corticofugal neurons of mouse primary visual cortex
    Joshua C Brumberg
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurophysiol 89:2854-67. 2003
    ..Our results show that cortico-thalamic neurons represent a specific functional and morphological class of layer VI neurons...
  17. pmc UP states protect ongoing cortical activity from thalamic inputs
    Brendon O Watson
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY, USA
    PLoS ONE 3:e3971. 2008
    ..Our results demonstrate that cortical dynamics during UP states are insensitive to thalamic inputs...
  18. pmc Axo-dendritic overlap and laminar projection can explain interneuron connectivity to pyramidal cells
    Adam M Packer
    HHMI, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Cereb Cortex 23:2790-802. 2013
    ..Thus, the spatial profile of the connectivity maps and even the postsynaptic position of interneuron contacts could result from the mere overlap of axonal and dendritic arborizations and their laminar projections patterns. ..
  19. pmc State-dependent function of neocortical chandelier cells
    Alan R Woodruff
    Department Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York 10027, USA
    J Neurosci 31:17872-86. 2011
    ..Thus, neocortical chandelier cells, even from within a homogeneous population, appear to play a dual role in the circuit, helping to activate quiescent pyramidal neurons, while at the same time inhibiting active ones...
  20. pmc Sodium channels amplify spine potentials
    Roberto Araya
    Howard Hughes Medical Institute, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 104:12347-52. 2007
    ..Spine sodium channels could boost synaptic potentials and facilitate action potential backpropagation...
  21. ncbi request reprint Internal dynamics determine the cortical response to thalamic stimulation
    Jason N MacLean
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Neuron 48:811-23. 2005
    ..Our data demonstrate that precise spatiotemporal activity patterns can be triggered by thalamic inputs and indicate that the thalamus serves to release intrinsic cortical dynamics...
  22. ncbi request reprint Activity-regulated dynamic behavior of early dendritic protrusions: evidence for different types of dendritic filopodia
    Carlos Portera-Cailliau
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 23:7129-42. 2003
    ....
  23. pmc Ca2+ imaging of mouse neocortical interneurone dendrites: Ia-type K+ channels control action potential backpropagation
    Jesse H Goldberg
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    J Physiol 551:49-65. 2003
    ..We propose that interneurones have a perisomatic and a distal dendritic functional compartment, with different integrative functions...
  24. pmc Dense and overlapping innervation of pyramidal neurons by chandelier cells
    Melis Inan
    Department Psychiatry, Weill Cornell Medical College, New York, New York 10065, USA
    J Neurosci 33:1907-14. 2013
    ..We conclude that ChCs innervate neighboring pyramidal neurons in a dense and overlapping manner, a connectivity pattern that could enable ChCs to exert a widespread influence on their local circuits...
  25. pmc Imaging membrane potential in dendritic spines
    Mutsuo Nuriya
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 103:786-90. 2006
    ..Our optical measurements of membrane potential from spines demonstrate directly that backpropagating action potentials invade the spines...
  26. pmc Dense inhibitory connectivity in neocortex
    Elodie Fino
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 69:1188-203. 2011
    ..We conclude that local inhibitory connectivity is promiscuous, does not form subnetworks, and can approach the theoretical limit of a completely connected synaptic matrix...
  27. ncbi request reprint Space matters: local and global dendritic Ca2+ compartmentalization in cortical interneurons
    Jesse H Goldberg
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Trends Neurosci 28:158-67. 2005
    ..In addition, interneuron dendrites generate diverse Ca(2+) signals that reflect this circuit function and probably also implement subclass-specific plasticity and homeostasis...
  28. ncbi request reprint Role of dendritic spines in action potential backpropagation: a numerical simulation study
    David Tsay
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurophysiol 88:2834-45. 2002
    ..Finally, we show that changes in spine morphology significantly influence backpropagation efficacy. These results suggest that, by clustering sodium channels, spines may serve to control backpropagation...
  29. ncbi request reprint Attractor dynamics of network UP states in the neocortex
    Rosa Cossart
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 423:283-8. 2003
    ..Because of their stereotyped spatiotemporal dynamics, we conclude that network UP states are circuit attractors--emergent features of feedback neural networks that could implement memory states or solutions to computational problems...
  30. ncbi request reprint Quantitative morphologic classification of layer 5 neurons from mouse primary visual cortex
    Areti Tsiola
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Comp Neurol 461:415-28. 2003
    ..Cluster analysis of neuronal morphologies provides an objective method to quantitatively define different neuronal phenotypes and may serve as a basis for describing neocortical circuits...
  31. ncbi request reprint Reverse optical probing (ROPING) of neocortical circuits
    Gloster Aaron
    HHMI, Department Biological Sciences, Columbia University, New York, USA
    Synapse 60:437-40. 2006
    ..This technique can quickly reveal monosynaptically connected neurons...
  32. ncbi request reprint Feedforward inhibition contributes to the control of epileptiform propagation speed
    Andrew J Trevelyan
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York 10027, USA
    J Neurosci 27:3383-7. 2007
    ..Thus, a single mechanism could account for the wide range of propagation velocities of epileptiform events observed in vitro and in vivo...
  33. ncbi request reprint On the electrical function of dendritic spines
    David Tsay
    Department of Biological Sciences, Columbia University, 1002 Fairchild, New York, NY 10032, USA
    Trends Neurosci 27:77-83. 2004
    ..Although direct experimental investigations of the electrical properties of spines have not yet taken place, spines could play a significant electrical role, greatly influencing dendritic integration and the function of neural circuits...
  34. ncbi request reprint Systematic regulation of spine sizes and densities in pyramidal neurons
    Sila Konur
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurobiol 56:95-112. 2003
    ..Individual neurons also appear to regulate their apical and basal spine densities and morphologies in concert. Our data provide evidence for a homeostatic control of excitatory synaptic strength...
  35. pmc Dense, unspecific connectivity of neocortical parvalbumin-positive interneurons: a canonical microcircuit for inhibition?
    Adam M Packer
    HHMI, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 31:13260-71. 2011
    ..We conclude that the microcircuit architecture for PV+ interneurons, and probably neocortical inhibition in general, is an unspecific, densely homogenous matrix covering all nearby pyramidal cells...
  36. pmc Imaging voltage in neurons
    Darcy S Peterka
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Neuron 69:9-21. 2011
    ....
  37. doi request reprint Second-harmonic generation imaging of membrane potential with photon counting
    Jiang Jiang
    HHMI, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Microsc Microanal 14:526-31. 2008
    ..Trial-to-trial variability is also reduced by 50%. Finally, we show that, using photon counting, the kinetics of fast events such as action potentials can be recorded more accurately...
  38. pmc Second harmonic generation in neurons: electro-optic mechanism of membrane potential sensitivity
    Jiang Jiang
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY, USA
    Biophys J 93:L26-8. 2007
    ..We conclude that FM 4-64 senses membrane potential through an electro-optic mechanism, without significant chromophore membrane reorientation, redistribution, or spectral shift...
  39. pmc Dendritic spines and distributed circuits
    Rafael Yuste
    HHMI, Department Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 71:772-81. 2011
    ..Spines would endow these circuits with nonsaturating, linear integration and input-specific learning rules, which would enable them to function as neural networks, with emergent encoding and processing of information...
  40. ncbi request reprint Large-scale imaging of cortical network activity with calcium indicators
    Yuji Ikegaya
    Department of Biological Sciences, Columbia University, 1002 Fairchild Center, M C 2435 New York, NY 10027, USA
    Neurosci Res 52:132-8. 2005
    ..Here we describe the detailed methods of bulk loading of AM dyes we developed and have been improving for imaging with a spinning disk confocal microscope...
  41. pmc Dendritic spines linearize the summation of excitatory potentials
    Roberto Araya
    Howard Hughes Medical Institute and Departments of Biological Sciences and Chemistry, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 103:18799-804. 2006
    ..Linear integration could be an essential feature of cortical and other spine-laden circuits...
  42. doi request reprint The logic of inhibitory connectivity in the neocortex
    Elodie Fino
    HHMI, Department of Biological Sciences, Columbia University, New York, NY, USA
    Neuroscientist 19:228-37. 2013
    ..In a last section, the authors describe briefly the link between dense inhibitory networks and different interneuron functions described in the neocortex...
  43. pmc Two-photon optogenetics of dendritic spines and neural circuits
    Adam M Packer
    Howard Hughes Medical Institute HHMI, Columbia University, New York, New York, USA
    Nat Methods 9:1202-5. 2012
    ..Using a spatial light modulator, we split the laser beam onto several neurons and performed simultaneous optogenetic activation of selected neurons in three dimensions...
  44. ncbi request reprint Thalamocortical bursts trigger recurrent activity in neocortical networks: layer 4 as a frequency-dependent gate
    Michael Beierlein
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 22:9885-94. 2002
    ....
  45. pmc A portable laser photostimulation and imaging microscope
    Volodymyr Nikolenko
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, NY 10027, USA
    J Neural Eng 7:045001. 2010
    ..As a proof of principle, we generate complex excitation patterns on fluorescent samples and also perform functional imaging of neuronal activity in living brain slices...
  46. ncbi request reprint Modular propagation of epileptiform activity: evidence for an inhibitory veto in neocortex
    Andrew J Trevelyan
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 26:12447-55. 2006
    ..5-1 Hz) steps across the cortical network. We propose that the interneurons that supply the vetoing inhibition define these modular circuit territories...
  47. ncbi request reprint Developmental regulation of spine and filopodial motility in primary visual cortex: reduced effects of activity and sensory deprivation
    Sila Konur
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, New York 10027, USA
    J Neurobiol 59:236-46. 2004
    ....
  48. ncbi request reprint Second harmonic imaging of membrane potential of neurons with retinal
    Boaz A Nemet
    Columbia University, Department of Biological Sciences, 1212 Amsterdam Avenue, New York, New York 10027, USA
    J Biomed Opt 9:873-81. 2004
    ..SHRIMP could have wide applicability in neuroscience and, by modifying rhodopsin, could in principle be subject for developing genetically engineered voltage sensors...
  49. pmc Decorrelating action of inhibition in neocortical networks
    Tanya Sippy
    HHMI, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 33:9813-30. 2013
    ..We conclude that inhibitory interneurons do not have synchronous activity during UP states, and that their function may be to decorrelate rather than to synchronize the firing of neurons within the local network...
  50. ncbi request reprint Gap junctions in developing neocortex: a review
    Rafael J Montoro
    Deparment of Biological Sciences, Columbia University, New York, NY 10027, USA
    Brain Res Brain Res Rev 47:216-26. 2004
    ..The function of this gap junctional coupling is still mysterious, though it may be involved in controlling neurogenesis, differentiation or the formation of columnar microcircuits...
  51. ncbi request reprint A problem with Hebb and local spikes
    Jesse Goldberg
    Dept of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, Box 2435, New York, NY 10027, USA
    Trends Neurosci 25:433-5. 2002
    ..We propose that the inverted Hebbian plasticity of synapses involved in local spikes, and/or local dendritic homeostatic plasticity, could prevent an unbalanced distribution of synaptic weights on the dendritic tree...
  52. pmc SLM Microscopy: Scanless Two-Photon Imaging and Photostimulation with Spatial Light Modulators
    Volodymyr Nikolenko
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University New York, NY, USA
    Front Neural Circuits 2:5. 2008
    ..Moreover, the use of SLMs expands the flexibility of laser microscopy, as it can substitute traditional simple fixed lenses with any calculated lens function...
  53. ncbi request reprint Electrical compartmentalization in dendritic spines
    Rafael Yuste
    Departments of Biological Sciences and Neuroscience, Howard Hughes Medical Institute, and Kavli Institute for Brain Science, Columbia University, New York, NY 10027, USA
    Annu Rev Neurosci 36:429-49. 2013
    ....
  54. pmc Astrocytic regulation of cortical UP states
    Kira E Poskanzer
    Howard Hughes Medical Institute and Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 108:18453-8. 2011
    ..These results demonstrate that astroglia can play a causal role in regulating the synchronized activation of neuronal ensembles...
  55. ncbi request reprint Calcium dynamics of spines depend on their dendritic location
    Knut Holthoff
    Department Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 33:425-37. 2002
    ..Thus, the spine location apparently determines its calcium dynamics and synaptic plasticity. Our results highlight the precision in design of neocortical neurons...
  56. ncbi request reprint Regulation of dendritic length and branching by semaphorin 3A
    Vivian Fenstermaker
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurobiol 58:403-12. 2004
    ..We conclude that Sema3A is necessary for the elaboration of second and third order dendritic branches in pyramidal neurons...
  57. ncbi request reprint Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: evidence for two forms of spine motility
    Ayumu Tashiro
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Mol Cell Neurosci 26:429-40. 2004
    ..We propose that these two different types of spine motility serve different functions in synaptogenesis and synapse maturation...
  58. ncbi request reprint Calcium oscillations in neocortical astrocytes under epileptiform conditions
    Ayumu Tashiro
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, Box 2435, New York, New York 10027, USA
    J Neurobiol 50:45-55. 2002
    ..Astrocytic calcium oscillations could mediate reactive astrogliosis, contribute to the pathogenesis of chronic epileptic syndromes, and be used as a diagnostic test for epileptic tissue...
  59. pmc Evidence of an inhibitory restraint of seizure activity in humans
    Catherine A Schevon
    Department of Neurology, Columbia University, New York, New York 10025, USA
    Nat Commun 3:1060. 2012
    ..These findings have important implications for how we localize seizure activity and map its spread...
  60. pmc Designing optimal stimuli to control neuronal spike timing
    Yashar Ahmadian
    Department of Statistics and Center for Theoretical Neuroscience, Columbia University, New York, NY 10032, USA
    J Neurophysiol 106:1038-53. 2011
    ..We also tested the intracellular current injection method on pyramidal cells in mouse cortical slices, quantifying the dependence of spiking reliability and timing precision on constraints imposed on the applied currents...
  61. ncbi request reprint Bidirectional regulation of hippocampal mossy fiber filopodial motility by kainate receptors: a two-step model of synaptogenesis
    Ayumu Tashiro
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 38:773-84. 2003
    ..A two-step model of synaptogenesis can also explain the opposite effects of neuronal activity on the motility of dendritic protrusions...
  62. ncbi request reprint Origin and classification of neocortical interneurons
    Rafael Yuste
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027
    Neuron 48:524-7. 2005
    ..An effort to standardize the nomenclature of interneurons is underway. Because different interneuron subtypes have different ontogenic origin, they could be classified based on their developmental specification by transcription factors...
  63. ncbi request reprint Multiphoton stimulation of neurons
    Hajime Hirase
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurobiol 51:237-47. 2002
    ..The combination of multiphoton stimulation and optical probing could enable systematic analysis of circuits...
  64. pmc Quantitative classification of somatostatin-positive neocortical interneurons identifies three interneuron subtypes
    Laura M McGarry
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University New York, NY, USA
    Front Neural Circuits 4:12. 2010
    ..These different morphological and electrophysiological characteristics could make each of these three interneuron subtypes particularly suited for a different function within the cortical circuit...
  65. pmc Two-photon imaging with diffractive optical elements
    Brendon O Watson
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University New York, NY, USA
    Front Neural Circuits 3:6. 2009
    ..DOE scanning can easily improve the detection of time-varying signals in two-photon and other non-linear microscopic techniques...
  66. pmc Of mice and men, and chandeliers
    Alan Woodruff
    The Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York, United States of America
    PLoS Biol 6:e243. 2008
    ....
  67. ncbi request reprint A two-photon and second-harmonic microscope
    Volodymyr Nikolenko
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Methods 30:3-15. 2003
    ..We can also perform simultaneous optical imaging and optical stimulation experiments and combine them with second harmonic generation measurements...
  68. pmc RuBi-Glutamate: Two-Photon and Visible-Light Photoactivation of Neurons and Dendritic spines
    Elodie Fino
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University New York, NY, USA
    Front Neural Circuits 3:2. 2009
    ..RuBi-Glutamate therefore enables the photoactivation of neuronal dendrites and circuits with visible or two-photon light sources, achieving single cell, or even single spine, precision...
  69. pmc Photorelease of GABA with Visible Light Using an Inorganic Caging Group
    Emiliano M Rial Verde
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University New York, NY, USA
    Front Neural Circuits 2:2. 2008
    ..Finally, we illustrate two potential applications of RuBi-GABA uncaging: GABA receptor mapping, and optical silencing of neuronal firing...
  70. pmc Depolarizing effect of neocortical chandelier neurons
    Alan Woodruff
    Howard Hughes Medical Institute, Department Biological Sciences, Columbia University New York, NY, USA
    Front Neural Circuits 3:15. 2009
    ..Our results support the idea that chandelier cells depolarize pyramidal neurons and could potentially have an excitatory effect on the network at rest...
  71. pmc The enigmatic function of chandelier cells
    Alan R Woodruff
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University New York, NY, USA
    Front Neurosci 4:201. 2010
    ..Here we review these recent developments and their implications. We focus in particular on whether chandelier cells may provide a depolarizing, excitatory effect on pyramidal neuron output, in addition to a powerful inhibition...
  72. pmc A neural circuit for angular velocity computation
    Samuel B Snider
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University New York, NY, USA
    Front Neural Circuits 4:123. 2010
    ..Our analysis reveals the maximum information available to the fly given its physical architecture and the mathematics governing the rotation-induced forces at the haltere's end knob...
  73. pmc Single-shock LTD by local dendritic spikes in pyramidal neurons of mouse visual cortex
    Knut Holthoff
    Physiologisches Institut, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    J Physiol 560:27-36. 2004
    ..This depression does not require somatic spiking and is input specific. Moreover, a single synaptic stimulus can evoke a dendritic spike and a brief local dendritic calcium transient, and is sufficient for the full induction of LTD...
  74. ncbi request reprint Protein kinase A regulates calcium permeability of NMDA receptors
    V Arvydas Skeberdis
    Rose F Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Neurosci 9:501-10. 2006
    ..Our data link PKA-dependent synaptic plasticity to Ca2+ signaling in spines and thus provide a new mechanism whereby PKA regulates the induction of LTP...
  75. ncbi request reprint Cortical area and species differences in dendritic spine morphology
    Ruth Benavides-Piccione
    Instituto Cajal, Madrid, Spain
    J Neurocytol 31:337-46. 2002
    ..Our data suggests that the average synaptic input is modulated according to cortical area and differs among species. We discuss the implications of these findings for common algorithms of cortical processing...
  76. ncbi request reprint Calcium imaging of cortical networks dynamics
    Rosa Cossart
    INMED, INSERM U29, Parc Scientifique de Luminy, BP 13, 13273 Marseille, Cedex 9, France
    Cell Calcium 37:451-7. 2005
    ....
  77. ncbi request reprint Dendritic size of pyramidal neurons differs among mouse cortical regions
    Ruth Benavides-Piccione
    Instituto Cajal, Madrid, Spain
    Cereb Cortex 16:990-1001. 2006
    ..Our data suggest that each cortical region is built with specific neuronal components...
  78. ncbi request reprint BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
    Fernando Aguado
    Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
    Development 130:1267-80. 2003
    ..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
  79. ncbi request reprint Stimulating neurons with light
    Edward M Callaway
    The Salk Institute for Biological Studies, Systems Neurobiology Laboratories, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Neurobiol 12:587-92. 2002
    ..Different methods that have been developed in the last several decades have been used to probe neuronal sensitivity, mimic synaptic input, and elucidate patterns of neural connectivity...
  80. ncbi request reprint Spine motility. Phenomenology, mechanisms, and function
    Tobias Bonhoeffer
    Max Planck Institut fur Neurobiologie, Martinsried, Munich, Germany
    Neuron 35:1019-27. 2002
    ..This idea revisits concepts originally formulated by Cajal, who proposed over a hundred years ago that spines might help to increase and modify synaptic connections...
  81. pmc High speed two-photon imaging of calcium dynamics in dendritic spines: consequences for spine calcium kinetics and buffer capacity
    L Niels Cornelisse
    Department of Experimental Neurophysiology, Centre for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 2:e1073. 2007
    ..Simulations at zero calcium-dye conditions show that calmodulin is more efficiently activated in spines, which indicates that spine morphology and buffering conditions in neocortical spines favor synaptic plasticity...
  82. ncbi request reprint Analysis of multineuronal activation patterns from calcium-imaging experiments in brain slices
    Robert C Froemke
    Department of Molecular and Cell Biology, University of Calkifornia Berkeley, 94720, USA
    Trends Cardiovasc Med 12:247-52. 2002
    ....
  83. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
    ..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project...
  84. ncbi request reprint The source of afterdischarge activity in neocortical tonic-clonic epilepsy
    Andrew J Trevelyan
    School of Neurology, Neurobiology and Psychiatry, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Neurosci 27:13513-9. 2007
    ..Our data suggest a complex view of seizures in which the ictal event and its constituent discharges originate from distinct locations...
  85. doi request reprint Role of Rho GTPases in the morphogenesis and motility of dendritic spines
    Ayumu Tashiro
    Centre for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway
    Methods Enzymol 439:285-302. 2008
    ....
  86. ncbi request reprint Neocortical circuits: evolutionary aspects and specificity versus non-specificity of synaptic connections. Remarks, main conclusions and general comments and discussion
    Javier DeFelipe
    Instituto Cajal CSIC, Madrid, Spain
    J Neurocytol 31:387-416. 2002

Research Grants24

  1. SPINE MOTILITY AND VISUAL PLASTICITY
    Rafael Yuste; Fiscal Year: 2004
    ..abstract_text> ..
  2. IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX
    Rafael Yuste; Fiscal Year: 2004
    ..Also, our results will be particularly useful in identifying the cellular and circuit mechanism responsible for the lower seizure threshold of developing and juvenile neocortex and the transition from interictal to ictal events. ..
  3. SPINE MOTILITY AND VISUAL PLASTICITY
    Rafael Yuste; Fiscal Year: 2005
    ..abstract_text> ..
  4. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2006
    ..In addition, they will help understand the central pathophysiological consequences of amblyopia and strabismus and improve analysis of visual evoked potentials and early diagnosis of visual pathologies. ..
  5. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2007
    ..In addition, they will help understand the central pathophysiological consequences of amblyopia and strabismus and improve analysis of visual evoked potentials and early diagnosis of visual pathologies. ..
  6. NEURAL CIRCUITS & PLASTICITY GORDON RESEARCH CONFERENCE
    Rafael Yuste; Fiscal Year: 2007
    ..Finally, 50% of the invited speakers are women and we are also requesting support to fund the attendance of underrepresented groups. ..
  7. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2009
    ..Besides its potential importance for our understanding of how the cortex works, our results could help design strategies to better control, diagnose and repair cortical function. ..
  8. IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX
    Rafael Yuste; Fiscal Year: 2003
    ..Also, our results will be particularly useful in identifying the cellular and circuit mechanism responsible for the lower seizure threshold of developing and juvenile neocortex and the transition from interictal to ictal events. ..
  9. SPINE MOTILITY AND VISUAL PLASTICITY
    Rafael Yuste; Fiscal Year: 2003
    ..abstract_text> ..
  10. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 1999
    ....
  11. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2000
    ....
  12. IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX
    Rafael Yuste; Fiscal Year: 2000
    ..Also, our results will be particularly useful in identifying the cellular and circuit mechanism responsible for the lower seizure threshold of developing and juvenile neocortex and the transition from interictal to ictal events. ..
  13. SPINE MOTILITY AND VISUAL PLASTICITY
    Rafael Yuste; Fiscal Year: 2001
    ..abstract_text> ..
  14. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2001
    ....
  15. IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX
    Rafael Yuste; Fiscal Year: 2000
    ..Also, our results will be particularly useful in identifying the cellular and circuit mechanism responsible for the lower seizure threshold of developing and juvenile neocortex and the transition from interictal to ictal events. ..
  16. IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX
    Rafael Yuste; Fiscal Year: 2001
    ..Also, our results will be particularly useful in identifying the cellular and circuit mechanism responsible for the lower seizure threshold of developing and juvenile neocortex and the transition from interictal to ictal events. ..
  17. SPINE MOTILITY AND VISUAL PLASTICITY
    Rafael Yuste; Fiscal Year: 2002
    ..abstract_text> ..
  18. IMAGING EPILEPTIFORM EVENTS IN JUVENILE NEOCORTEX
    Rafael Yuste; Fiscal Year: 2002
    ..Also, our results will be particularly useful in identifying the cellular and circuit mechanism responsible for the lower seizure threshold of developing and juvenile neocortex and the transition from interictal to ictal events. ..
  19. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2003
    ..In addition, they will help understand the central pathophysiological consequences of amblyopia and strabismus and improve analysis of visual evoked potentials and early diagnosis of visual pathologies. ..
  20. IMAGING FUNCTIONAL CONNECTIVITY IN VISUAL CORTEX
    Rafael Yuste; Fiscal Year: 2010
    ..Besides its potential importance for our understanding of how the cortex works, our results could help design strategies to better control, diagnose and repair cortical function. ..