Yuxin Yin

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
    Yuxin Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nature 422:527-31. 2003
  2. pmc Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21
    Yuxin Yin
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:8864-9. 2004
  3. doi request reprint PTEN: a new guardian of the genome
    Y Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Oncogene 27:5443-53. 2008
  4. ncbi request reprint p53 kingdom, a new prospect for its control mechanism and apoptotic defense
    Yuxin Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Cell Cycle 2:279-80. 2003
  5. doi request reprint DUSP1 is controlled by p53 during the cellular response to oxidative stress
    Yu Xin Liu
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cancer Res 6:624-33. 2008
  6. ncbi request reprint Dual specificity phosphatase 1/CL100 is a direct transcriptional target of E2F-1 in the apoptotic response to oxidative stress
    Jianli Wang
    Department of Radiation Oncology, Center for Radiological Research, College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 67:6737-44. 2007
  7. ncbi request reprint TAp73 is a downstream target of p53 in controlling the cellular defense against stress
    Jianli Wang
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:29152-62. 2007
  8. ncbi request reprint A molecular link between E2F-1 and the MAPK cascade
    Jianli Wang
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:18521-31. 2007
  9. ncbi request reprint A novel function for human Rad9 protein as a transcriptional activator of gene expression
    Howard B Lieberman
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, New York 10032, USA
    Cell Cycle 3:1008-10. 2004
  10. ncbi request reprint Essential role for nuclear PTEN in maintaining chromosomal integrity
    Wen Hong Shen
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cell 128:157-70. 2007

Collaborators

  • Howard B Lieberman
  • Charis Eng
  • Adam J Ratner
  • Richard Baer
  • M Prakash Hande
  • Eric Hall
  • Jianli Wang
  • Wen Hong Shen
  • Yu Xin Liu
  • Y Jenny Jin
  • Zhuo Sun
  • Jorge L Aguilar
  • Jingjing Wu
  • Paul W Brandt-Rauf
  • Xi Kang
  • Chuanxin Huang
  • Kristy L Lamb
  • Jinxue He
  • TingTing Gu
  • Ritwij Kulkarni
  • Alexander Kikuchi
  • Sandeep Soman
  • Tara M Randis
  • Jianfen Guo
  • Pier Paolo Pandolfi
  • Hong Wu
  • Adayabalam S Balajee
  • Yan J Jin
  • M Prakash Hande
  • Alan C Wong
  • David P Yin
  • Victor B Zhurkin
  • Tom K Hei
  • Changhong Qiao
  • Keith W Kelley
  • Robert H McCusker
  • Robert Dantzer
  • Gregory G Freund
  • Suzanne R Broussard

Detail Information

Publications15

  1. ncbi request reprint PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
    Yuxin Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nature 422:527-31. 2003
    ..Identification of a palindromic motif as a p53-binding site may reveal a novel mechanism whereby p53 regulates its target genes...
  2. pmc Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21
    Yuxin Yin
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:8864-9. 2004
    ..Furthermore, hRAD9 might regulate other cellular processes as well by modulating transcription of multiple down-stream target genes...
  3. doi request reprint PTEN: a new guardian of the genome
    Y Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Oncogene 27:5443-53. 2008
    ..Thus, we propose that PTEN is a new guardian of the genome. In this review, we will discuss new discoveries on the role of PTEN in tumor suppression and explore mechanisms by which PTEN maintains genomic stability...
  4. ncbi request reprint p53 kingdom, a new prospect for its control mechanism and apoptotic defense
    Yuxin Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Cell Cycle 2:279-80. 2003
  5. doi request reprint DUSP1 is controlled by p53 during the cellular response to oxidative stress
    Yu Xin Liu
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cancer Res 6:624-33. 2008
    ..Our results reveal a mechanism whereby p53 selectively regulates target genes and suggest a way in which subgroups of those target genes might be controlled independently...
  6. ncbi request reprint Dual specificity phosphatase 1/CL100 is a direct transcriptional target of E2F-1 in the apoptotic response to oxidative stress
    Jianli Wang
    Department of Radiation Oncology, Center for Radiological Research, College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 67:6737-44. 2007
    ..Interestingly, E2F-1 is acetylated following oxidative stress. Our findings show that E2F-1 is a transcriptional activator of DUSP1 and that DUSP1 is a link between E2F-1 and MAP kinases...
  7. ncbi request reprint TAp73 is a downstream target of p53 in controlling the cellular defense against stress
    Jianli Wang
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:29152-62. 2007
    ..Our data reveal a new pathway for cellular protection against oxidative damage and provide evidence that TAp73 is a stress-response gene and a downstream effector in the p53 pathway...
  8. ncbi request reprint A molecular link between E2F-1 and the MAPK cascade
    Jianli Wang
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:18521-31. 2007
    ..Characterization of MKP-2 as a cell death mediator may lead to the development of new strategies for cancer treatment...
  9. ncbi request reprint A novel function for human Rad9 protein as a transcriptional activator of gene expression
    Howard B Lieberman
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, New York 10032, USA
    Cell Cycle 3:1008-10. 2004
    ..In this review, the newly defined ability of Rad9 to transactivate p21 and other downstream target genes is discussed in terms of the activities already associated with this protein...
  10. ncbi request reprint Essential role for nuclear PTEN in maintaining chromosomal integrity
    Wen Hong Shen
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cell 128:157-70. 2007
    ..We propose that PTEN acts as a guardian of genome integrity...
  11. pmc Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane pores
    Jorge L Aguilar
    Department of Pediatrics, Columbia University, New York, New York, United States of America
    PLoS ONE 4:e8076. 2009
    ..Epithelial regulation of MAPK signaling in response to membrane disruption involves distinct pathways and may require different strategies for therapeutic interventions...
  12. pmc PTEN C-terminal deletion causes genomic instability and tumor development
    Zhuo Sun
    Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PRC Department of Radiation Oncology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cell Rep 6:844-54. 2014
    ..Our data highlight the essential role of the PTEN C terminus in the maintenance of genomic stability and suppression of tumorigenesis. ..
  13. ncbi request reprint A novel mechanism for p53 to regulate its target gene ECK in signaling apoptosis
    Y Jenny Jin
    Department of Radiation Oncology College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Mol Cancer Res 4:769-78. 2006
    ..Our findings show that p53 is a transcriptional regulator of ECK in mediating apoptosis. The discovery of the novel p53-binding motif in the promoter may lead to the identification of a new class of p53 target genes...
  14. ncbi request reprint Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis
    Wen Hong Shen
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 66:6033-9. 2006
    ..These data suggest that p53 regulates distinct genes via different binding mechanisms and that MKP2 is an essential target of p53 in signaling apoptosis...
  15. ncbi request reprint Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis
    Wen Hong Shen
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 279:7438-46. 2004
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