Research Topics
| T C WrightSummaryAffiliation: Columbia University Country: USA Publications
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Detail Information
Publications
Screen-and-treat approaches for cervical cancer prevention in low-resource settings: a randomized controlled trialLynette Denny
Department of Obstetrics and Gynaecology, University of Cape Town, Cape Town, South Africa
JAMA 294:2173-81. 2005..Trial Registration http://clinicaltrials.gov Identifier: NCT00233727...- Human papillomavirus (HPV) detection among human immunodeficiency virus-infected pregnant Thai women: implications for future HPV immunizationLiesbeth J M Bollen
Thailand MOPH US CDC Collaboration, Nonthaburi, Rajavithi Hospital, Bangkok, Thailand, and Columbia University, New York, New York, USA
Sex Transm Dis 33:259-64. 2006..Prophylactic vaccines targeting HPV types 16 and 18 are being evaluated for efficacy among young women... 
Age considerations when vaccinating against HPVThomas C Wright
Columbia University, New York, New York 10032, USA
Gynecol Oncol 109:S40-7. 2008..This review discusses the various considerations that should be addressed when making recommendations of who should be vaccinated against HPV...- Alternative approaches to cervical cancer screening for developing countriesThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Building, 630 W 168th Street, New York, NY 10032, USA
Best Pract Res Clin Obstet Gynaecol 26:197-208. 2012.... 
Reduced acquisition and reactivation of human papillomavirus infections among older women treated with cryotherapy: results from a randomized trial in South AfricaSylvia Taylor
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
BMC Med 8:40. 2010..We investigated whether cervical cryotherapy reduces newly detected hrHPV infections among HIV-positive and HIV-negative women who were hrHPV negative when treated...- 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
J Low Genit Tract Dis 11:223-39. 2007..To provide updated consensus guidelines for the management of women with cervical intraepithelial neoplasia (CIN) or adenocarcinoma in situ (AIS)... - Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screeningThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404 P and S Building, 630 West 168th Street, New York, NY 10032, USA
Obstet Gynecol 103:304-9. 2004..If test results of either are abnormal, colposcopy should then be performed. This guidance should assist clinicians in utilizing HPV DNA testing in an effective manner, while minimizing unnecessary evaluations and treatments... - 2006 consensus guidelines for the management of women with abnormal cervical screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
J Low Genit Tract Dis 11:201-22. 2007..To provide revised evidence-based consensus guidelines for managing women with abnormal cervical cancer screening test results... - Chapter 14: HPV vaccine introduction in industrialized countriesThomas C Wright
Department of Pathology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
Vaccine 24:S3/122-31. 2006..Human papillomavirus (HPV) vaccination provides unique challenges in all of these areas because of the many gaps in our knowledge... - Chapter 30: HPV vaccines and screening in the prevention of cervical cancer; conclusions from a 2006 workshop of international expertsThomas C Wright
Department of Pathology, Columbia University, 630 W 168th Street, NY 10032, USA
Vaccine 24:S3/251-61. 2006..In this summary, we summarize the opinions of this expert group on how these advances can be introduced to provide the maximum benefit to women and to reduce the global burden of cervical cancer... - Cervical cancer screening in the 21st century: is it time to retire the PAP smear?Thomas C Wright
Department of Pathology, Columbia University, New York, NY 10032, USA
Clin Obstet Gynecol 50:313-23. 2007..Therefore, in the future it is likely that we will use HPV testing alone to screen, and reserve cervical cytology as a way to determine which HPV-positive women require additional follow-up or colposcopy... - 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:340-5. 2007..Moreover, management recommendations for women with biopsy-confirmed adenocarcinoma in situ are now included... - 2006 consensus guidelines for the management of women with abnormal cervical cancer screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:346-55. 2007..The 2004 Interim Guidance for HPV testing as an adjunct to cervical cytology for screening in women 30 years of age and older was formally adopted with only very minor modifications... - Use of visual screening methods for cervical cancer screeningThomas C Wright
Department of Pathology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Obstet Gynecol Clin North Am 29:701-34. 2002..In the near future we should be able to determine whether these approaches should be incorporated into routine clinical care... - HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancerT C Wright
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
JAMA 283:81-6. 2000..In many other regions of the world, there is only limited access to cervical cancer screening... - 2001 Consensus Guidelines for the management of women with cervical cytological abnormalitiesThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Bldg, 630 W 168th St, New York, NY 10032, USA
JAMA 287:2120-9. 2002..To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors... - Human immunodeficiency virus 1 expression in the female genital tract in association with cervical inflammation and ulcerationT C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Am J Obstet Gynecol 184:279-85. 2001.... - 2001 consensus guidelines for the management of women with cervical intraepithelial neoplasiaThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, USA
Am J Obstet Gynecol 189:295-304. 2003.... - Estradiol-induced hyperplasia in endometrial biopsies from women on hormone replacement therapyThomas C Wright
Department of Pathology, Columbia University Presbiterian Medical Center, New York, New York 10032, USA
Am J Surg Pathol 26:1269-75. 2002 - Molecular variants of human papillomavirus type 16 and risk for cervical neoplasia in South AfricaJ J Tu
Department of Pathology, Weill Medical College of Cornell University, New York, New York, USA
Int J Gynecol Cancer 16:736-42. 2006..In this setting where African HPV 16 variants were common, no increased risk for cervical neoplasia was found among women with these variants compared with other HPV 16 variants... - Prevalence of visible disruption of cervical epithelium and cervical ectopy in African women using Depo-ProveraL Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Contraception 59:363-7. 1999.... - HPV DNA testing for cervical cancer screening. FIGO 6th Annual Report on the Results of Treatment in Gynecological CancerThomas C Wright
Department of Pathology, Columbia University, New York, USA. tcw1columbia.edu
Int J Gynaecol Obstet 95:S239-46. 2006 - Anal intraepithelial neoplasia in heterosexual and homosexual HIV-positive men with access to antiretroviral therapyT J Wilkin
Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, New York 10011, USA
J Infect Dis 190:1685-91. 2004.... - Is viral status needed before vaccination?Thomas C Wright
Department of Pathology, Columbia University, Room 16 404, P and S Building, 630 West 168th Street, New York, NY, United States
Vaccine 26:A12-5. 2008..The increase in cost and the other barriers afforded by a prior to vaccination test requirement would result in a lower coverage, the key indicator of a successful vaccination program... - Direct comparison of liquid-based and conventional cytology in a South African screening trialSylvia Taylor
Department of Pathology, Columbia University, New York, NY 10032, USA
Int J Cancer 118:957-62. 2006..Because of the higher unit cost of LBC, low resource settings should carefully consider the potential benefits and drawbacks of LBC before adopting this new technology... - Adding a test for human papillomavirus DNA to cervical-cancer screeningThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, USA
N Engl J Med 348:489-90. 2003 - Efficacy of human papillomavirus-based screen-and-treat for cervical cancer prevention among HIV-infected womenLouise Kuhn
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
AIDS 24:2553-61. 2010..Here, we evaluate the efficacy among HIV-infected women of a simpler, screen-and-treat strategy in which all women with a positive screening test are treated with cryotherapy... - Prevalence of underlying adenocarcinoma in women with atypical endometrial hyperplasiaJamie Shutter
Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA
Int J Gynecol Pathol 24:313-8. 2005..025). In conclusion, there is a high prevalence of underlying endometrial adenocarcinoma among women undergoing hysterectomy for any of atypical endometrial proliferation... - Differential subtraction chain, a method for identifying differences in genomic DNA and mRNAJ H Luo
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
Nucleic Acids Res 27:e24. 1999..Overall, DSC represents a fast, efficient and sensitive method for identifying differences in genomic DNA and mRNA and can be easily applied in a variety of biological systems... - Impact of utilizing p16INK4A immunohistochemistry on estimated performance of three cervical cancer screening testsQi Zhang
Department of Pathology, Columbia University, New York, NY, USA
Int J Cancer 120:351-6. 2007..In contrast, the sensitivity of other tests, such as VIA, may be overestimated with an imperfect gold standard... - Effective cervical neoplasia detection with a novel optical detection system: a randomized trialRonald D Alvarez
University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 104:281-9. 2007..To assess whether the use of a novel optical detection system (ODS) as an adjunct to colposcopy increases the detection of biopsy-confirmed CIN 2,3... - Cost-effectiveness of human papillomavirus DNA testing for cervical cancer screening in women aged 30 years or moreSue J Goldie
Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts 02115 5924, USA
Obstet Gynecol 103:619-31. 2004..To evaluate the cost-effectiveness of human papillomavirus (HPV) DNA testing as a primary screening test in combination with cervical cytology in women aged 30 years or more... - Direct visual inspection for cervical cancer screening: an analysis of factors influencing test performanceLynette Denny
Department of Obstetrics and Gynecology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Cancer 94:1699-707. 2002..CONCLUSIONS: This study confirmed the utility of DVI as a primary screening test. Evaluation of the clinical effectiveness of screening with this low-cost and simple test in low-resource settings is necessary... - Cervical cancer prevention for all the world's women: new approaches offer opportunities and promiseThomas C Wright
Diagn Cytopathol 35:845-8. 2007 - Cost-effectiveness of alternative triage strategies for atypical squamous cells of undetermined significanceJane J Kim
Department of Health Policy and Management, Harvard Center for Risk Analysis, 718 Huntington Ave, Second Floor, Boston, MA 02115, USA
JAMA 287:2382-90. 2002..CONCLUSION: Reflex HPV DNA testing provides the same or greater life expectancy benefits and is more cost-effective than other management strategies for women diagnosed as having ASC-US... - HIV-1 infection and risk of vulvovaginal and perianal condylomata acuminata and intraepithelial neoplasia: a prospective cohort studyLois J Conley
Division of HIV/AIDS Prevention, Surveillance, and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA
Lancet 359:108-13. 2002.... - Visualization techniques (colposcopy, direct visual inspection, and spectroscopic and other visual methods). Summary of task force 7Thomas C Wright
MediSpectra Inc, Lexington, Massachusetts, USA
Acta Cytol 46:793-800. 2002..The novel high-technology visual screening methods that utilize electrooptical sensors to identify cervical abnormalities are still in the developmental phases but offer considerable potential... - A comprehensive natural history model of HPV infection and cervical cancer to estimate the clinical impact of a prophylactic HPV-16/18 vaccineSue J Goldie
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 106:896-904. 2003..These include a better understanding of the heterogeneity of vaccine response, the effect of type-specific vaccination on other HPV types and the degree to which vaccination effect persists over time... - Cervical cancer control, priorities and new directionsJoseph Monsonego
EUROGIN, Paris, France
Int J Cancer 108:329-33. 2004..We report the conclusions of the Experts' Meeting at the EUROGIN 2003 conference... - Dynamics of human papillomavirus infection between biopsy and excision of cervical intraepithelial neoplasia: results from the ZYC101a protocolChristopher P Crum
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusettsm USA
J Infect Dis 189:1348-54. 2004..Little is known about the dynamics of human papillomavirus (HPV) during the follow-up of cervical intraepithelial neoplasia (CIN) 2/3 after biopsy... - Projected clinical benefits and cost-effectiveness of a human papillomavirus 16/18 vaccineSue J Goldie
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115 5924, USA
J Natl Cancer Inst 96:604-15. 2004..We explored the clinical benefits and cost-effectiveness of introducing an HPV16/18 vaccine in a population with an organized cervical cancer screening program... - Cost-effectiveness of human papillomavirus DNA testing in the United Kingdom, The Netherlands, France, and ItalyJane J Kim
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, USA
J Natl Cancer Inst 97:888-95. 2005..CONCLUSIONS: HPV DNA testing has the potential to improve health benefits at a reasonable cost compared with current screening policies in four European countries... - Managing abnormal cytology results in pregnancyStewart L Massad
Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, PO Box 19640, Springfield, IL 62794, USA
J Low Genit Tract Dis 9:146-8. 2005 - Can cervicography be improved? An evaluation with arbitrated cervicography interpretationsDiana L Schneider
Division of Immigration Health Services, US Public Health Service, Washington, DC 20536, USA
Am J Obstet Gynecol 187:15-23. 2002..The purpose of this study was to estimate the optimal performance of cervicography. We compared an arbitrated cervigram classification with an arbitrated referent diagnosis of cervical neoplasia... - Acceptability of self-collection of specimens for HPV DNA testing in an urban populationR Anhang
Harvard University, Boston, Massachusetts, USA
J Womens Health (Larchmt) 14:721-8. 2005.... - The 2001 Bethesda System terminologyBarbara S Apgar
Department of Family Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Am Fam Physician 68:1992-8. 2003..The presence of normal or abnormal endometrial cells is to be reported in women who are at least 40 years of age. Educational notes and comments on ancillary testing may be added as appropriate... - Cost-effectiveness of cervical-cancer screening in five developing countriesSue J Goldie
Department of Health Policy and Management, Harvard School of Public Health, Boston, USA
N Engl J Med 353:2158-68. 2005..Cervical-cancer screening strategies that involve the use of conventional cytology and require multiple visits have been impractical in developing countries... - Cervical cancer prevention - a paradigm shift?Lynnette Denny
University of Cape Town, Groote Schuur Hospital, H 45, Old Main Building, Observatory 7925, South Africa
Gynecol Oncol 99:S12. 2005 - Concomitant Essure tubal sterilization and Thermachoice endometrial ablation: feasibility and safetyRafael F Valle
Northwestern University Medical School, Chicago, Illinois 60611, USA
Fertil Steril 86:152-8. 2006..Somerville, NJ) and transcervical sterilization by intratubal insert (Essure Permanent Birth Control System; Conceptus, San Carlos, CA)... - News media coverage of human papillomavirusRebecca Anhang
Harvard Center for Risk Analysis, Harvard School of Public Health, 718 Huntington Avenue, Suite 2, Boston, MA 02115-5924, USA
Cancer 100:308-14. 2004.... - Women's desired information about human papillomavirusRebecca Anhang
Harvard Center for Risk Analysis, Harvard School of Public Health, 718 Huntington Avenue, Suite 2, Boston, MA 02115-5924, USA
Cancer 100:315-20. 2004.... - Chapter 29: Knowledge gaps and priorities for research on prevention of HPV infection and cervical cancerEduardo L Franco
Division of Cancer Epidemiology, Departments of Oncology and Epidemiology and Biostatistics, McGill University, 546 Pine Avenue West, Montreal, Quebec, Canada
Vaccine 24:S3/242-9. 2006..The field of HPV and cervical cancer prevention has never been so multi-disciplinary. A new era has begun and the challenges are many... - The carcinogenicity of human papillomavirus types reflects viral evolutionMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MA, USA
Virology 337:76-84. 2005..These results present several clear clues and research directions in our ongoing efforts to understand HPV carcinogenesis... - The menstrual cycle does not affect human immunodeficiency virus type 1 levels in vaginal secretionsJulie M Villanueva
Department of Medicine, Emory University School of Medicine, Grady Infectious Disease Program, Atlanta, GA 30333, USA
J Infect Dis 185:170-7. 2002..VVLs were not correlated with plasma estradiol or progesterone levels (P>.05). These results suggest that hormonal changes during the menstrual cycle do not have a significant effect on HIV-1 RNA levels in vaginal secretions... - Increased detection of high-grade cervical intraepithelial neoplasia utilizing an optical detection system as an adjunct to colposcopyRonald D Alvarez
University of Alabama at Birmingham, Birmingham, Alabama, USA
Gynecol Oncol 106:23-8. 2007..To evaluate the impact of using a novel optical detection system (ODS) as an adjunct to colposcopy... - Alliance for cervical cancer prevention: setting the record straightJacqueline Sherris
Am J Public Health 97:200-1; author reply 201-202. 2007 - Nested case-control study of cervical mucosal lesions, ectopy, and incident HIV infection among women in Cape Town, South AfricaLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, South Africa
Sex Transm Dis 33:683-7. 2006..Protection of the mucosa of the cervix may provide an important approach for new HIV prevention technologies...