DEBRA WOLGEMUTH

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Distinct roles for the mammalian A-type cyclins during oogenesis
    Jenny Liao Persson
    Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA
    Reproduction 130:411-22. 2005
  2. pmc Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1
    Sunil K Panigrahi
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e47862. 2012
  3. pmc The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids
    Binyamin D Berkovits
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Nucleic Acids Res 40:7162-75. 2012
  4. pmc Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis
    Laetitia Martinerie
    Departments of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS Genet 10:e1004165. 2014
  5. pmc Role of cyclins in controlling progression of mammalian spermatogenesis
    Debra J Wolgemuth
    Departments of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Int J Dev Biol 57:159-68. 2013
  6. pmc Retinoid signaling during spermatogenesis as revealed by genetic and metabolic manipulations of retinoic acid receptor alpha
    D J Wolgemuth
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Soc Reprod Fertil Suppl 63:11-23. 2007
  7. ncbi Regulation of the mitotic and meiotic cell cycles in the male germ line
    Debra J Wolgemuth
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Recent Prog Horm Res 57:75-101. 2002
  8. ncbi A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice
    D Liu
    The Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 224:388-400. 2000
  9. ncbi The A-type cyclins and the meiotic cell cycle in mammalian male germ cells
    Debra J Wolgemuth
    Department of Genetics and Development, Institute of Human Nutrition, Center for Reproductive Sciences, and The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Int J Androl 27:192-9. 2004
  10. pmc Function of cyclins in regulating the mitotic and meiotic cell cycles in male germ cells
    Debra J Wolgemuth
    Departments of Genetics and Development and Obstetrics and Gynecology, The Institute of Human Nutrition, The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    Cell Cycle 7:3509-13. 2008

Research Grants

  1. Role of Cyclin A's in Mammalian Meiosis
    Debra J Wolgemuth; Fiscal Year: 2010
  2. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2004
  3. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2006
  4. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2007
  5. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2009
  6. Function of the Bromodomain Protein Brdt in Spermatogenesis
    DEBRA WOLGEMUTH; Fiscal Year: 2009
  7. Function of the Bromodomain Protein Brdt in Spermatogenesis
    Debra J Wolgemuth; Fiscal Year: 2010
  8. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2005
  9. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2005
  10. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2004

Collaborators

Detail Information

Publications80

  1. ncbi Distinct roles for the mammalian A-type cyclins during oogenesis
    Jenny Liao Persson
    Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA
    Reproduction 130:411-22. 2005
    ..These results suggest that in the female germ line, cyclin A2 but not cyclin A1 has distinct roles in both mitosis and meiosis...
  2. pmc Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1
    Sunil K Panigrahi
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e47862. 2012
    ....
  3. pmc The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids
    Binyamin D Berkovits
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Nucleic Acids Res 40:7162-75. 2012
    ..These modulations alter 3'-UTR processing in round spermatids; importantly, the BD1 is essential for these functions...
  4. pmc Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis
    Laetitia Martinerie
    Departments of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS Genet 10:e1004165. 2014
    ..These results highlight a new role for E-type cyclins as important regulators of male meiosis. ..
  5. pmc Role of cyclins in controlling progression of mammalian spermatogenesis
    Debra J Wolgemuth
    Departments of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Int J Dev Biol 57:159-68. 2013
    ..While the focus is on mammalian spermatogenesis, we note contrasts with similar functions in the female germ line when relevant and also draw upon observations in other model systems to provide further insight...
  6. pmc Retinoid signaling during spermatogenesis as revealed by genetic and metabolic manipulations of retinoic acid receptor alpha
    D J Wolgemuth
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Soc Reprod Fertil Suppl 63:11-23. 2007
    ..We also review how dietary, pharmacologic and genetic strategies, alone or in combination, can be used to gain further insight into retinoid function in mammalian spermatogenesis...
  7. ncbi Regulation of the mitotic and meiotic cell cycles in the male germ line
    Debra J Wolgemuth
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Recent Prog Horm Res 57:75-101. 2002
    ..Finally, the role of the novel A-type cyclin, cyclin A1, during male meiosis is discussed in depth...
  8. ncbi A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice
    D Liu
    The Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 224:388-400. 2000
    ..In particular, it may be directly involved in the initial amplification of MPF through the activating phosphorylation on Cdc25 phosphatases...
  9. ncbi The A-type cyclins and the meiotic cell cycle in mammalian male germ cells
    Debra J Wolgemuth
    Department of Genetics and Development, Institute of Human Nutrition, Center for Reproductive Sciences, and The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Int J Androl 27:192-9. 2004
    ..We have now determined that human cyclin A1 is expressed in similar stages of spermatogenesis and are exploring its role in human male infertility and whether it may be a novel target for new approaches for male contraception...
  10. pmc Function of cyclins in regulating the mitotic and meiotic cell cycles in male germ cells
    Debra J Wolgemuth
    Departments of Genetics and Development and Obstetrics and Gynecology, The Institute of Human Nutrition, The Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    Cell Cycle 7:3509-13. 2008
    ....
  11. pmc Regulating mitosis and meiosis in the male germ line: critical functions for cyclins
    Debra J Wolgemuth
    Department of Genetics and Development, Columbia University Medical Center, 1150 St Nicholas Avenue, Room 608, New York, NY 10032, USA
    Philos Trans R Soc Lond B Biol Sci 365:1653-62. 2010
    ....
  12. pmc Function of the A-type cyclins during gametogenesis and early embryogenesis
    Debra J Wolgemuth
    Department of Genetics and Development, Columbia University Medical Center, Russ Berrie 608, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Results Probl Cell Differ 53:391-413. 2011
    ..In contrast, cyclin A2-deficiency is marked by early embryonic lethality; thus, understanding the function of cyclin A2 in the adult germ line awaits conditional mutagenesis or other approaches to knock down its expression...
  13. ncbi Insights into regulation of the mammalian cell cycle from studies on spermatogenesis using genetic approaches in animal models
    D J Wolgemuth
    Department of Genetics and Development, The Center for Reproductive Sciences, The Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cytogenet Genome Res 103:256-66. 2003
    ..Elucidating the key control points and proteins may also enhance our understanding of the etiology of infertility and provide new directions for contraception...
  14. ncbi Cyclin A1 is required for meiosis in the male mouse
    D Liu
    Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Genet 20:377-80. 1998
    ..Cyclin A1 is therefore essential for spermatocyte passage into the first meiotic division in male mice, a function that cannot be complemented by the concurrently expressed B-type cyclins...
  15. ncbi The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes
    K Rhee
    Department of Genetics and Development, The Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 124:2167-77. 1997
    ..Our results further provide evidence that in vivo, mouse Nek2 is involved in events of meiosis, including but not limited to chromosomal condensation...
  16. pmc Role of retinoid signaling in the regulation of spermatogenesis
    S S W Chung
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cytogenet Genome Res 105:189-202. 2004
    ..The possible cellular mechanisms that may be affected by the lack of retinoid signaling are discussed, in particular, cell cycle regulation and cell-cell interaction, both of which are critical for normal spermatogenesis...
  17. ncbi Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle
    J Don
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell Growth Differ 3:495-505. 1992
    ..These results suggest a role for meg1 during germ cell differentiation, possibly during meiotic prophase...
  18. pmc Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1
    C Liao
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:6853-8. 2001
    ..The data further support an important role of cyclin A1 in hematopoiesis and the etiology of myeloid leukemia...
  19. ncbi The developmentally restricted pattern of expression in the male germ line of a murine cyclin A, cyclin A2, suggests roles in both mitotic and meiotic cell cycles
    S E Ravnik
    Department of Genetics and Development, College of Physicians, New York, New York 10032, USA
    Dev Biol 173:69-78. 1996
    ....
  20. ncbi The distinct and developmentally regulated patterns of expression of members of the mouse Cdc25 gene family suggest differential functions during gametogenesis
    S Wu
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Dev Biol 170:195-206. 1995
    ....
  21. ncbi Specific expression of soluble adenylyl cyclase in male germ cells
    M L Sinclair
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York, USA
    Mol Reprod Dev 56:6-11. 2000
    ....
  22. ncbi Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis
    Q Zhang
    Center for Reproductive Sciences, and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Endocrinology 140:2790-800. 1999
    ..These observations suggest unique roles for cyclin D3 in the control of cell division and differentiation in the germ line and the differential regulation of mitotic and meiotic cell cycles during male and female gametogenesis...
  23. ncbi Developmentally regulated expression during gametogenesis of the murine gene meg1 suggests a role in meiosis
    J Don
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Mol Reprod Dev 38:16-23. 1994
    ..These results suggest that meg1 is indeed a meiosis-associated gene in both male and female germ cells through the pachytene stage of meiosis I and appears to exhibit sex-specific differences in its expression thereafter...
  24. ncbi Identification of a mouse B-type cyclin which exhibits developmentally regulated expression in the germ line
    D L Chapman
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York
    Mol Reprod Dev 33:259-69. 1992
    ..This pattern of cycB1 expression further suggests that cycB1 may have different functions in the two cell types, only one of which correlates with progression of the cell cycle...
  25. ncbi Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation
    K Rhee
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Dev Dyn 204:406-20. 1995
    ..These results suggest that Cdk family kinases may exhibit various functions in germinal and somatic cells during gametogenesis, not only in the cell cycle but also in other regulatory processes, including differentiation...
  26. ncbi Isolation of the murine cyclin B2 cDNA and characterization of the lineage and temporal specificity of expression of the B1 and B2 cyclins during oogenesis, spermatogenesis and early embryogenesis
    D L Chapman
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Development 118:229-40. 1993
    ..These results demonstrate that there are lineage- and developmental-specific differences in the pattern of the B cyclins in mammalian germ cells, in contrast to the co-expression of B cyclins in the early conceptus...
  27. ncbi The mouse transcription factor Stat4 is expressed in haploid male germ cells and is present in the perinuclear theca of spermatozoa
    G Herrada
    Department of Genetics and Development, The Center for Reproductive Sciences, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Cell Sci 110:1543-53. 1997
    ....
  28. ncbi Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development
    D J Wolgemuth
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Nature 337:464-7. 1989
    ..This overexpression correlated with changes in the normal developmental program of the gut, resulting in an inherited abnormal phenotype known as megacolon...
  29. ncbi Characterization of D1Pas1, a mouse autosomal homologue of the human AZFa region DBY, as a nuclear protein in spermatogenic cells
    D R Session
    Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Fertil Steril 76:804-11. 2001
    ..To gain insight into the function of D1Pas1 in spermatogenesis...
  30. pmc Zfp-37, a new murine zinc finger encoding gene, is expressed in a developmentally regulated pattern in the male germ line
    P S Burke
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Nucleic Acids Res 20:2827-34. 1992
    ..The pattern of expression of Zfp-37 and the presence of the zinc finger domain suggest that Zfp-37 may have a role in regulating spermiogenesis...
  31. ncbi The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation
    V Besset
    Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell Growth Differ 10:173-81. 1999
    ..These results suggest that Pctaire1 kinase might have an important role in differentiated cells such as postmitotic neurons and spermatogenic cells...
  32. ncbi Cell lineage specificity of expression of the murine transforming growth factor beta 3 and transforming growth factor beta 1 genes
    F Watrin
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Cell Growth Differ 2:77-83. 1991
    ..This result demonstrates a new pattern of TGF beta 1 gene expression, consistent with cell lineage-specific transcriptional regulation during spermatogenesis...
  33. ncbi Differential expression of the proto-oncogenes c-abl and c-mos in developing mouse germ cells
    Y Iwaoki
    Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Exp Cell Res 206:212-9. 1993
    ..Quantitative evaluation suggested that c-abl mRNA levels in oocytes are at least an order of magnitude lower than those of c-mos transcripts...
  34. ncbi The identification and characterization of expression of Pftaire-1, a novel Cdk family member, suggest its function in the mouse testis and nervous system
    V Besset
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Reprod Dev 50:18-29. 1998
    ....
  35. ncbi Conservation and divergence of patterns of expression and lineage-specific transcripts in orthologues and paralogues of the mouse Hox-1.4 gene
    F Watrin
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Dev Biol 156:136-45. 1993
    ..4, Hox-1.3 and Hox-1.5, are expressed in the germ line but at lower levels. Further, both Hox-1.3 and Hox-1.4 produced unique, germ line-specific transcripts as compared to other adult tissues and the Day 12.5 embryo...
  36. ncbi N-cadherin protein distribution in normal embryos and in embryos carrying mutations in the homeobox gene Hoxa-4
    A I Packer
    Department of Genetics, The Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Dev Biol 41:459-68. 1997
    ....
  37. ncbi Distinct patterns of expression of the D-type cyclins during testicular development in the mouse
    S E Ravnik
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Genet 16:171-8. 1995
    ..Also surprising was the observation that cyclin D3 expression was highest in the non-dividing, haploid, round spermatids. The possible roles of these cyclins in the events of spermatogenesis are discussed...
  38. ncbi Zfp-51, a murine zinc finger encoding gene mapping to the t-complex region of chromosome 17, encodes 19 contiguous zinc fingers and is ubiquitously expressed
    P S Burke
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Mamm Genome 5:387-9. 1994
  39. pmc Oral administration of a retinoic Acid receptor antagonist reversibly inhibits spermatogenesis in mice
    Sanny S W Chung
    Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA
    Endocrinology 152:2492-502. 2011
    ..Our results suggest that testes are exquisitely sensitive to disruption of retinoid signaling and that RAR antagonists may represent new lead molecules in developing nonsteroidal male contraceptives...
  40. pmc Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line
    Z F Zakeri
    Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Mol Cell Biol 8:2925-32. 1988
    ..These observations suggest that specific HSP70 gene family members play distinct roles in the differentiation of the germ cell lineage in mammals...
  41. ncbi Identification and characterization of the developmentally regulated pattern of expression in the testis of a mouse gene exhibiting similarity to the family of phosphodiesterases
    V Vambutas
    Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Biochim Biophys Acta 1217:203-6. 1994
    ..Analysis of RNA from testes at different stages of development suggested that the p4-6 gene is most abundantly expressed in germ cells that have completed the meiotic divisions...
  42. ncbi Sequence and expression of a cDNA encoding the mouse homologue of the rat ribosomal protein L28
    P S Burke
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    Gene 142:315-6. 1994
    ..Northern blot hybridization analysis detected a single transcript in embryo, placenta and adult tissues...
  43. ncbi The segment-specific pattern of A-raf expression in the mouse epididymis is regulated by testicular factors
    M A Winer
    Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Endocrinology 136:2561-72. 1995
    ....
  44. ncbi Differential expression of the c-abl proto-oncogene and the homeo box-containing gene Hox 1.4 during mouse spermatogenesis
    R N Duggal
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Ann N Y Acad Sci 513:112-27. 1987
    ..4 is expressed in the germ cells as soon as they have entered meiosis. Future studies will focus on examining the protein products of these genes and their function in testicular cells...
  45. ncbi Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling
    Q Zhang
    Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Dev Biol 183:222-33. 1997
    ..These observations provide new insight into the possible function of this novel Cdk during both differentiation and apoptotic cell death...
  46. ncbi Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation
    J R Mertz
    Department of Cell Biology and Anatomical Sciences, City University of New York Medical School, New York, New York 10031, USA
    J Biol Chem 272:11744-9. 1997
    ..We propose that this cDNA encodes a previously unknown stereospecific enzyme, 9-cis-retinol dehydrogenase, which probably plays a role in 9-cis-retinoic acid formation...
  47. ncbi Distinct transcripts are recognized by sense and antisense riboprobes for a member of the murine HSP70 gene family, HSP70.2, in various reproductive tissues
    A K Murashov
    Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Reprod Dev 43:17-24. 1996
    ..Furthermore, we have made the surprising observation of antisense transcription of the hsp70.2 gene in several mouse tissues, revealing another level of complexity in the regulation and function of heat shock proteins...
  48. ncbi Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element
    A I Packer
    Department of Genetics and Development, The Center for Reproductive Sciences and the Columbia Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 125:1991-8. 1998
    ..These data add to the evidence that Hox gene expression is regulated, in part, by endogenous retinoids and autoregulatory loops...
  49. ncbi Developmental and cell lineage specificity of raf family gene expression in mouse testis
    A G Wadewitz
    Center for Reproductive Sciences, Columbia Univeristy College of Physicians and Surgeons, New York, New York 10032
    Oncogene 8:1055-62. 1993
    ..These studies indicate that each raf gene exhibits a characteristic, limited pattern of expression and suggests that the different forms may play a unique regulatory role in androgen production and/or spermatogenesis...
  50. ncbi Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/ reductase able to catalyze cis-retinol oxidation
    M V Gamble
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    J Lipid Res 40:2279-92. 1999
    ..Taken together, these data extend our understanding of the properties of cRDH and provide additional support for our hypothesis that cRDH may play an important role in 9-cis-retinoic acid formation...
  51. ncbi Murine Myak, a member of a family of yeast YAK1-related genes, is highly expressed in hormonally modulated epithelia in the reproductive system and in the embryonic central nervous system
    E Shang
    The Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Reprod Dev 55:372-8. 2000
    ..Myak is also highly expressed in the aqueduct of the adult brain and in the brain and spinal cord of day 12.5 embryos...
  52. ncbi Multiple levels of regulation exist for expression of the Hoxa-4 (Hox-1.4) gene in the mouse testis
    C M Viviano
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Cell Mol Biol Res 39:483-95. 1993
    ..Only a proportion of the Hoxa-4 mRNA in germ cells was found to be associated with polysomes, suggesting that translational regulation may also operate as a means of control of Hoxa-4 expression in this adult lineage...
  53. ncbi Structural abnormalities associated with congenital megacolon in transgenic mice that overexpress the Hoxa-4 gene
    V M Tennyson
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Dev Dyn 198:28-53. 1993
    ..In both animals, the data are consistent with the hypothesis that the defects arise as a result of a defective interaction between the precursors of enteric neurons and smooth muscle...
  54. ncbi Fetal development of the enteric nervous system of transgenic mice that overexpress the Hoxa-4 gene
    V M Tennyson
    Department of Anatomy, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Dev Dyn 211:269-91. 1998
    ....
  55. pmc The conserved transcriptome in human and rodent male gametogenesis
    Frederic Chalmel
    Biozentrum and Swiss Institute of Bioinformatics, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 104:8346-51. 2007
    ..Expression profiling data further identified numerous conserved genes of biological and clinical interest previously unassociated with the mammalian male germ line...
  56. ncbi Cyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure
    Richard K Cheng
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 100:1741-8. 2007
    ..The ability of cultured transgenic cardiomyocytes to undergo cytokinesis provides mechanistic support for the regenerative capacity of cyclin A2...
  57. pmc Cyclin A1-deficient mice lack histone H3 serine 10 phosphorylation and exhibit altered aurora B dynamics in late prophase of male meiosis
    Helen D Nickerson
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 306:725-35. 2007
    ..These data suggest a critical and concentration-dependent function for cyclin A1 in the pericentromeric region in late diplotene of meiosis, perhaps in assembly or function of the passenger protein complex...
  58. ncbi Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle
    Yong Ha Kim
    School of Biological Sciences, Seoul National University, Seoul, 151 742, Korea
    Biochem Biophys Res Commun 290:730-6. 2002
    ..Additionally, the nuclear localization of Nek2 was increased during S phase. Such dynamic behavior of Nek2 suggests that Nek2 may be a mitotic regulator that is involved in diverse cell cycle events...
  59. ncbi The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation
    Enyuan Shang
    The Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA
    Development 134:3507-15. 2007
    ..This is the first demonstration that deletion of just one of the two bromodomains in members of the BET sub-family of bromodomain-containing proteins has profound effects on in vivo differentiation...
  60. ncbi Effects of acute alcohol intoxication in the second trimester of pregnancy on development of the murine fetal lung
    Xiangyuan Wang
    Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am J Obstet Gynecol 197:269.e1-4. 2007
    ..We further hypothesized that these effects would be apparent morphologically and by altered Hoxb5 expression...
  61. pmc Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality
    Kevin M Hopkins
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 24:7235-48. 2004
    ..These investigations establish Mrad9 as a key mammalian genetic element of pathways that regulate the cellular response to DNA damage, maintenance of genomic integrity, and proper embryonic development...
  62. ncbi Induction of apoptosis involving multiple pathways is a primary response to cyclin A1-deficiency in male meiosis
    Glicella Salazar
    Department of Genetics and Development, Institute of Human Nutrition, Center for Reproductive Sciences, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY10032, USA
    Dev Dyn 234:114-23. 2005
    ..This finding suggested that p53 may be involved in the process by which the arrested germ cells are removed from the seminiferous tubules but that other pathways function as well to ensure removal of the arrested spermatocytes...
  63. pmc Male sterility in mice lacking retinoic acid receptor alpha involves specific abnormalities in spermiogenesis
    Sanny S W Chung
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Differentiation 73:188-98. 2005
    ..Further, the resulting apoptosis in elongating spermatids appears to involve pathways other than that mediated by activated caspase-3...
  64. ncbi Tcp10 promoter-directed expression of the Nek2 gene in mouse meiotic spermatocytes
    Kunsoo Rhee
    Department of Genetics and Development, Center for Reproductive Sciences, The Irving Comprehensive Cancer Center, New York, NY 10032, USA
    Mol Cells 13:85-90. 2002
    ..These results revealed that even only slightly elevated production of the Nek2 protein disturbed the normal development of male germ cells, possibly in meiosis...
  65. ncbi Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin
    Thomas B Nguyen
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 277:41960-9. 2002
    ..The mouse cDNA has allowed us to further localize cyclin B3 mRNA to leptotene and zygotene spermatocytes. The expression pattern of mammalian cyclin B3 suggests that it may be important for events occurring in early meiotic prophase I...
  66. ncbi Apoptosis in male germ cells in response to cyclin A1-deficiency and cell cycle arrest
    Glicella Salazar
    Department of Genetics and Development, Institute of Human Nutrition, Center for Reproductive Sciences, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Biochem Pharmacol 66:1571-9. 2003
    ..The mechanisms by which the cells sense the cell cycle arrest and the regulation of the decision to undergo cell death are under investigation...
  67. ncbi Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors
    Ching Liao
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Int J Cancer 108:654-64. 2004
    ..The abundant ectopic expression of cyclin A1 in non-seminomatous GCTs and its absence in CIS and seminomas is likely linked to the tumor transformation and progression and may be relevant to clinical prognosis...
  68. ncbi NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi
    Jae Cheal Yoo
    School of Biological Sciences, Seoul National University, Seoul, 151 742, Korea
    Exp Cell Res 292:393-402. 2004
    ..These results propose a possible involvement of Nek2 in biological processes of the Golgi body, perhaps in relation to the inheritance of Golgi during mitosis or to cell cycle stage-specific regulation of exocytosis...
  69. ncbi Developmental stage-specific expression of Rbm suggests its involvement in early phases of spermatogenesis
    Jungmin Lee
    School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Hum Reprod 10:259-64. 2004
    ..These observations suggest that Rbm functions in early but not later stages of male germ cell development...
  70. ncbi Making the commitment to meiosis
    Debra J Wolgemuth
    Nat Genet 38:1362-3. 2006
  71. pmc Retinoic acid receptor alpha is required for synchronization of spermatogenic cycles and its absence results in progressive breakdown of the spermatogenic process
    Sanny S W Chung
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Dev Dyn 230:754-66. 2004
    ..Retinoid signaling through RAR alpha, thus, appears to be critical for establishment of synchronous progression of spermatogenesis and the subsequent establishment of correct cellular associations...
  72. ncbi Essential role of Plzf in maintenance of spermatogonial stem cells
    Jose A Costoya
    Cancer Biology and Genetics Program, Department of Pathology Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Genet 36:653-9. 2004
    ..These results identify Plzf as a spermatogonia-specific transcription factor in the testis that is required to regulate self-renewal and maintenance of the stem cell pool...
  73. ncbi Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium
    Hina W Chaudhry
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 279:35858-66. 2004
    ..These results reveal a previously unrecognized critical role for cyclin A2 in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium...
  74. ncbi Distinct regions of the mouse cyclin A1 gene, Ccna1, confer male germ-cell specific expression and enhancer function
    Karen M Lele
    The Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA
    Biol Reprod 71:1340-7. 2004
    ..3 kb upstream of the putative Ccna1 transcriptional start can direct expression of lacZ to spermatocytes, while sequences located between -4.8 kb and -1.3 kb of the putative transcriptional start site may enhance expression of lacZ...
  75. pmc Primary spermatocyte-specific Cre recombinase activity in transgenic mice
    Sanny S W Chung
    Department of Genetics and Development, Columbia University Medical Center, 630 W 168th Street, New York, NY 10032, USA
    Transgenic Res 13:289-94. 2004
    ..Robust expression of X-gal was detected in early to mid-late spermatocytes at stages V-VIII. We conclude that this transgenic line is a powerful tool for deleting genes of interest specifically during male meiosis...
  76. ncbi Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein
    Thomas E Crowley
    Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Endocrinol 16:1727-37. 2002
    ..Localization of Fsrg1 on euchromatin, the transcribed portion of the chromosomes, is consistent with its hypothesized function as a transcription regulator...
  77. ncbi Identification of unique, differentiation stage-specific patterns of expression of the bromodomain-containing genes Brd2, Brd3, Brd4, and Brdt in the mouse testis
    Enyuan Shang
    The Institute of Human Nutrition, Columbia University Medical Center, New York, NY 10032, USA
    Gene Expr Patterns 4:513-9. 2004
    ..Rather, their expression is tightly regulated in the male germ cell lineage, suggesting that they likely have specific roles in different developmental stages and/or cell types...
  78. ncbi Bromodomain containing 2 (Brd2) is expressed in distinct patterns during ovarian folliculogenesis independent of FSH or GDF9 action
    Rhonda K Trousdale
    Departments of Genetics and Development and Obstetrics and Gynecology, The Center for Reproductive Sciences, The Institute of Human Nutrition, Columbia University Medical Center, New York, New York 10032, USA
    Mol Reprod Dev 68:261-8. 2004
    ..The distinct patterns of Brd2 localization within the adult ovary supports a role for Brd2 in mitotic and possibly meiotic cell cycle regulation...
  79. ncbi Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia
    ThomasE Crowley
    Department of Obstetrics and Gynecology, Columbia University Medical Center, 630 W 168th St, New York, NY 10032, USA
    Brain Res Dev Brain Res 149:93-101. 2004
    ..Our findings are also consistent with the cell cycle progression/transcription coactivator function suggested by the association of Brd2 with E2F-1 and E2F-2...
  80. ncbi Regulation of the cyclin A1 protein is associated with its differential subcellular localization in hematopoietic and leukemic cells
    Jenny Ekberg
    Division of Pathology, Department of Laboratory Medicine, Lund University, University Hospital, Malmo S 20502, Sweden
    Oncogene 23:9082-9. 2004
    ..Our results indicate that the altered intracellular distribution of cyclin A1 in leukemic cells correlates with the status of the leukemic phenotype...

Research Grants24

  1. Role of Cyclin A's in Mammalian Meiosis
    Debra J Wolgemuth; Fiscal Year: 2010
    ..They will further enhance our understanding of the control of meiosis as it relates to male infertility and possible new targets for contraception. ..
  2. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2004
    ..Given the clear role of cyclin A in male meiotic progression, our; studies will also further our understanding of the genetic control of mammalian meiosis. ..
  3. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2006
    ..abstract_text> ..
  4. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2007
    ..They will further enhance our understanding of the control of meiosis as it relates to male infertility and possible new targets for contraception. ..
  5. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2009
    ..They will further enhance our understanding of the control of meiosis as it relates to male infertility and possible new targets for contraception. ..
  6. Function of the Bromodomain Protein Brdt in Spermatogenesis
    DEBRA WOLGEMUTH; Fiscal Year: 2009
    ..Our studies will provide important insight into the potential mis- function of human BRDT in cases of unexplained (or idiopathic) infertility in men and may provide a new and novel target for male contraception. ..
  7. Function of the Bromodomain Protein Brdt in Spermatogenesis
    Debra J Wolgemuth; Fiscal Year: 2010
    ..Our studies will provide important insight into the potential mis-function of human BRDT in cases of unexplained (or idiopathic) infertility in men and may provide a new and novel target for male contraception. ..
  8. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2005
    ..Given the clear role of cyclin A in male meiotic progression, our; studies will also further our understanding of the genetic control of mammalian meiosis. ..
  9. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2005
    ..abstract_text> ..
  10. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2004
    ..Given the clear role of cyclin A in male meiotic progression, our; studies will also further our understanding of the genetic control of mammalian meiosis. ..
  11. CYCLIN AS AND MAMMALIAN MEIOSIS
    DEBRA WOLGEMUTH; Fiscal Year: 1999
    ..These studies will provide insight as to the in vivo functions of the cyclin A~s and their interacting proteins in mammalian cells in general and in germ cells in particular. ..
  12. CYCLIN AS AND MAMMALIAN MEIOSIS
    DEBRA WOLGEMUTH; Fiscal Year: 2000
    ..These studies will provide insight as to the in vivo functions of the cyclin A~s and their interacting proteins in mammalian cells in general and in germ cells in particular. ..
  13. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2001
    ..Given the clear role of cyclin A in male meiotic progression, our; studies will also further our understanding of the genetic control of mammalian meiosis. ..
  14. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2002
    ..Given the clear role of cyclin A in male meiotic progression, our; studies will also further our understanding of the genetic control of mammalian meiosis. ..
  15. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2003
    ..Given the clear role of cyclin A in male meiotic progression, our; studies will also further our understanding of the genetic control of mammalian meiosis. ..
  16. Role of Cyclin A's in Mammalian Meiosis
    DEBRA WOLGEMUTH; Fiscal Year: 2002
    ..Given the clear role of cyclin A in male meiotic progression, our; studies will also further our understanding of the genetic control of mammalian meiosis. ..
  17. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2003
    ..abstract_text> ..
  18. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2004
    ..abstract_text> ..
  19. Function of the Bromodomain Protein Brdt in Spermatogenesis
    Debra J Wolgemuth; Fiscal Year: 2010
    ..Our studies will provide important insight into the potential mis- function of human BRDT in cases of unexplained (or idiopathic) infertility in men and may provide a new and novel target for male contraception. ..