Melodie R Winawer

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Evidence for a shared genetic susceptibility to migraine and epilepsy
    Melodie R Winawer
    GH Sergievsky Center, Columbia University, New York, New York 10032, USA
    Epilepsia 54:288-95. 2013
  2. pmc Recruitment for genetic studies of epilepsy
    Sylwia Misiewicz
    GH Sergievsky Center, Columbia University, New York, NY, United States
    Epilepsy Res 101:122-8. 2012
  3. pmc Familial clustering of seizure types within the idiopathic generalized epilepsies
    M R Winawer
    G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neurology 65:523-8. 2005
  4. ncbi request reprint Genetic epidemiology of epilepsy or what do we tell families?
    Melodie R Winawer
    G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Epilepsia 46:24-30. 2005
  5. ncbi request reprint Phenotype definition in epilepsy
    Melodie R Winawer
    Department of Neurology and Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
    Epilepsy Behav 8:462-76. 2006
  6. pmc Use of chromosome substitution strains to identify seizure susceptibility loci in mice
    Melodie R Winawer
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Mamm Genome 18:23-31. 2007
  7. pmc Mapping a mouse limbic seizure susceptibility locus on chromosome 10
    Melodie R Winawer
    Department of Neurology, Columbia University, New York, New York 10032, USA
    Epilepsia 52:2076-83. 2011
  8. pmc Four new families with autosomal dominant partial epilepsy with auditory features: clinical description and linkage to chromosome 10q24
    Melodie R Winawer
    G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Epilepsia 43:60-7. 2002
  9. pmc Increased seizure severity and seizure-related death in mice lacking HCN1 channels
    Bina Santoro
    Department of Neuroscience, Columbia University, New York, New York, USA
    Epilepsia 51:1624-7. 2010

Research Grants

  1. PHENOTYPE DEFINITION IN THE GENETICS OF EPILEPSY
    Melodie Winawer; Fiscal Year: 2004
  2. A Multidisciplinary Approach to Epilepsy Genetics
    Melodie Winawer; Fiscal Year: 2007
  3. Genetics of Mouse Seizure Susceptibility
    Melodie Rose Winawer; Fiscal Year: 2010

Detail Information

Publications9

  1. pmc Evidence for a shared genetic susceptibility to migraine and epilepsy
    Melodie R Winawer
    GH Sergievsky Center, Columbia University, New York, New York 10032, USA
    Epilepsia 54:288-95. 2013
    ..We investigated the hypothesis of shared genetic effects on migraine and epilepsy in the Epilepsy Phenome/Genome Project (EPGP) cohort...
  2. pmc Recruitment for genetic studies of epilepsy
    Sylwia Misiewicz
    GH Sergievsky Center, Columbia University, New York, NY, United States
    Epilepsy Res 101:122-8. 2012
    ..Saliva DNA collection, monetary incentives and patient education can improve participation. This information can facilitate study design in epilepsy genetics...
  3. pmc Familial clustering of seizure types within the idiopathic generalized epilepsies
    M R Winawer
    G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neurology 65:523-8. 2005
    ..To examine the genetic relationships among epilepsies with different seizure types--myoclonic, absence, and generalized tonic-clonic--within the idiopathic generalized epilepsies (IGEs)...
  4. ncbi request reprint Genetic epidemiology of epilepsy or what do we tell families?
    Melodie R Winawer
    G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Epilepsia 46:24-30. 2005
    ..Although there have been many exciting advances in the last few decades-both molecular and epidemiologic-what we have learned has not appreciably changed what we tell families, and what we tell them can remain reassuring...
  5. ncbi request reprint Phenotype definition in epilepsy
    Melodie R Winawer
    Department of Neurology and Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
    Epilepsy Behav 8:462-76. 2006
    ..Finally, several molecular approaches to phenotype definition are discussed, in which the molecular defect, rather than the clinical phenotype, is used as a starting point...
  6. pmc Use of chromosome substitution strains to identify seizure susceptibility loci in mice
    Melodie R Winawer
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Mamm Genome 18:23-31. 2007
    ..CSS mapping suggests seizure susceptibility loci on mouse Chromosomes 10 and 18. This approach provides a framework for identifying potentially novel homologous candidate genes for human temporal lobe epilepsy...
  7. pmc Mapping a mouse limbic seizure susceptibility locus on chromosome 10
    Melodie R Winawer
    Department of Neurology, Columbia University, New York, New York 10032, USA
    Epilepsia 52:2076-83. 2011
    ..Herein we report further genetic mapping of pilocarpine quantitative trait loci (QTLs) on Ch10...
  8. pmc Four new families with autosomal dominant partial epilepsy with auditory features: clinical description and linkage to chromosome 10q24
    Melodie R Winawer
    G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Epilepsia 43:60-7. 2002
    ..We assessed clinical features and linkage evidence in four newly ascertained families with ADPEAF, to refine the clinical phenotype and confirm the genetic localization...
  9. pmc Increased seizure severity and seizure-related death in mice lacking HCN1 channels
    Bina Santoro
    Department of Neuroscience, Columbia University, New York, New York, USA
    Epilepsia 51:1624-7. 2010
    ..Therefore, down-regulation of HCN1 associated with human epilepsy and rodent models may be a contributing factor in seizure behavior...

Research Grants6

  1. PHENOTYPE DEFINITION IN THE GENETICS OF EPILEPSY
    Melodie Winawer; Fiscal Year: 2004
    ..Drs. R. Ottman, W.A. Hauser, S. Hodge, T. C. Gilliam and M. Morrell will provide guidance in these endeavors. ..
  2. A Multidisciplinary Approach to Epilepsy Genetics
    Melodie Winawer; Fiscal Year: 2007
    ..abstract_text> ..
  3. Genetics of Mouse Seizure Susceptibility
    Melodie Rose Winawer; Fiscal Year: 2010
    ..These genes can be examined in human populations as well as be investigated with functional experimental models. Discovery of susceptibility genes can provide insight into epilepsy pathophysiology and transform therapeutic strategies. ..