I Bernard Weinstein

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy
    I Bernard Weinstein
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nat Clin Pract Oncol 3:448-57. 2006
  2. ncbi request reprint Cancer. Addiction to oncogenes--the Achilles heal of cancer
    I Bernard Weinstein
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Science 297:63-4. 2002
  3. ncbi request reprint Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Clin Cancer Res 10:6710-21. 2004
  4. ncbi request reprint Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032 2704, USA
    Clin Cancer Res 10:1130-40. 2004
  5. ncbi request reprint (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New York, New York 10032 2704, USA
    Clin Cancer Res 11:2735-46. 2005
  6. ncbi request reprint The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization
    Danhua Xiao
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, 701 West 168th Street, Room 1509, New York, NY 10032, USA
    Mol Cancer Ther 5:60-7. 2006
  7. ncbi request reprint Gene expression analysis of the mechanisms whereby black cohosh inhibits human breast cancer cell growth
    Linda Saxe Einbond
    Department of Rehabilitation Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Anticancer Res 27:697-712. 2007
  8. ncbi request reprint Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells
    Haiyang Li
    Herbert Irving Comprehensive Cancer Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cancer Res 66:11399-408. 2006
  9. ncbi request reprint Acyclic retinoid activates retinoic acid receptor beta and induces transcriptional activation of p21(CIP1) in HepG2 human hepatoma cells
    Masumi Suzui
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Mol Cancer Ther 3:309-16. 2004
  10. ncbi request reprint Sulindac sulfide and exisulind inhibit expression of the estrogen and progesterone receptors in human breast cancer cells
    Jin T E Lim
    Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Cancer Res 12:3478-84. 2006

Detail Information

Publications65

  1. ncbi request reprint Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy
    I Bernard Weinstein
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nat Clin Pract Oncol 3:448-57. 2006
    ..e. the 'Achilles' heel,' in specific cancers. Finally, we discuss the use of molecular targeted agents in combination with other anticancer agents as a strategy to optimize therapy and prevent disease recurrence...
  2. ncbi request reprint Cancer. Addiction to oncogenes--the Achilles heal of cancer
    I Bernard Weinstein
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Science 297:63-4. 2002
  3. ncbi request reprint Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Clin Cancer Res 10:6710-21. 2004
    ..Our results suggest that the combination of acyclic retinoid plus OSI-461 might be an effective regimen for the chemoprevention and chemotherapy of human hepatoma and possibly other malignancies...
  4. ncbi request reprint Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032 2704, USA
    Clin Cancer Res 10:1130-40. 2004
    ..A hypothetical model explaining these two phases is presented. The diverse effects that we obtained with ACR suggest that this agent might be useful in the chemoprevention and/or therapy of human SCCs...
  5. ncbi request reprint (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New York, New York 10032 2704, USA
    Clin Cancer Res 11:2735-46. 2005
    ..In this study we compared the cellular and molecular effects of EGCG with a well-standardized decaffeinated green tea catechin mixture Polyphenon E (Poly E) on human colon cancer cell lines...
  6. ncbi request reprint The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization
    Danhua Xiao
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, 701 West 168th Street, Room 1509, New York, NY 10032, USA
    Mol Cancer Ther 5:60-7. 2006
    ....
  7. ncbi request reprint Gene expression analysis of the mechanisms whereby black cohosh inhibits human breast cancer cell growth
    Linda Saxe Einbond
    Department of Rehabilitation Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Anticancer Res 27:697-712. 2007
    ..Our aim is to identify alterations in gene expression induced by treatment with a methanolic extract (MeOH) of black cohosh...
  8. ncbi request reprint Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells
    Haiyang Li
    Herbert Irving Comprehensive Cancer Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cancer Res 66:11399-408. 2006
    ..Thus, PKCbeta1 and beta2 may play important positive roles in the growth of at least a subset of human breast cancers. Therefore, inhibitors of these isoforms may be useful in breast cancer chemoprevention or therapy...
  9. ncbi request reprint Acyclic retinoid activates retinoic acid receptor beta and induces transcriptional activation of p21(CIP1) in HepG2 human hepatoma cells
    Masumi Suzui
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Mol Cancer Ther 3:309-16. 2004
    ..These findings suggest that the growth inhibitory effects of ACR are mediated at least in part through RARbeta and that both RARbeta and p21(CIP1) play critical roles in the molecular mechanisms of growth inhibition induced by ACR...
  10. ncbi request reprint Sulindac sulfide and exisulind inhibit expression of the estrogen and progesterone receptors in human breast cancer cells
    Jin T E Lim
    Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Cancer Res 12:3478-84. 2006
    ..Thus, these and related compounds may provide a novel approach to the prevention and treatment of human breast cancers, especially those that are ER positive...
  11. ncbi request reprint Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells
    Jin T E Lim
    Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10021, USA
    Clin Cancer Res 9:4972-82. 2003
    ..Thus, these compounds may provide a novel approach to the prevention and treatment of human prostate cancer...
  12. ncbi request reprint Epigallocatechin-3-gallate inhibits activation of HER-2/neu and downstream signaling pathways in human head and neck and breast carcinoma cells
    Muneyuki Masuda
    Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Cancer Res 9:3486-91. 2003
    ....
  13. ncbi request reprint EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    J Exp Ther Oncol 5:69-78. 2005
    ..These findings extend our previous evidence that EGCG may be useful in the chemoprevention and/or treatment of colorectal cancer...
  14. ncbi request reprint The growth inhibitory effect of actein on human breast cancer cells is associated with activation of stress response pathways
    Linda Saxe Einbond
    Department of Rehabilitation Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Cancer 121:2073-83. 2007
    ..Since actein activated transcription factors that enhance apoptosis, and repressed cell cycle genes, it may be useful in the prevention and therapy of breast cancer...
  15. ncbi request reprint Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells
    Andrew K Joe
    Herbert Irving Comprehensive Cancer Center, 701 West 168th Street, HHSC 1509, New York, NY 10032, USA
    J Exp Ther Oncol 3:83-94. 2003
    ..These studies provide support for the use of exisulind in BE chemoprevention trials, and of exisulind or CP248 in the therapy of patients with esophageal carcinoma...
  16. ncbi request reprint Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation
    Danhua Xiao
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 63:6825-37. 2003
    ....
  17. ncbi request reprint Actein and a fraction of black cohosh potentiate antiproliferative effects of chemotherapy agents on human breast cancer cells
    Linda Saxe Einbond
    Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    Planta Med 72:1200-6. 2006
    ....
  18. ncbi request reprint Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells
    Danhua Xiao
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Mol Cancer Ther 4:1388-98. 2005
    ..These findings may be useful in the identification, synthesis, and development of organosulfur compounds that have anticancer activity...
  19. pmc The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage
    Haiyang Li
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    J Cell Biol 183:253-65. 2008
    ..Our findings suggest that the tumor suppressor function of HINT1 is caused by, at least in part, its normal role in enhancing cellular responses to DNA damage by regulating the functions of both gamma-H2AX and ATM...
  20. doi request reprint Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1
    Bo Cen
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 68:5355-62. 2008
    ..They also provide a rationale for further developing activators of PKG for the prevention and treatment of cancer...
  21. ncbi request reprint Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells
    Lin Wang
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032 2704, USA
    Cancer Res 67:4700-8. 2007
    ..These results suggest that HINT1 inhibits AP-1 activity by binding to a POSH-JNK2 complex, thus inhibiting the phosphorylation of c-Jun. This effect could contribute to the tumor suppressor activity of HINT1...
  22. ncbi request reprint Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells
    Atsuko Deguchi
    Herbert Irving Comprehensive Cancer Center, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032 2704, USA
    Cancer Res 64:3966-73. 2004
    ....
  23. doi request reprint Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src
    Bo Cen
    Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 284:5265-76. 2009
    ....
  24. ncbi request reprint Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase G
    Atsuko Deguchi
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Mol Cancer Ther 1:803-9. 2002
    ..These results suggest that VASP phosphorylation can provide a useful endogenous cellular biomarker for anticancer agents that cause cGMP-mediated apoptosis...
  25. ncbi request reprint Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction
    Muneyuki Masuda
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, HHSC 1509, 701 W 168th Street, New York, NY 10032, USA
    J Exp Ther Oncol 2:350-9. 2002
    ..Therefore, EGCG may be useful in treating HNSCC and breast carcinoma because it can exert both antiproliferative and antiangiogenic activities...
  26. ncbi request reprint Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes
    Jae Won Soh
    Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:34709-16. 2003
    ..These results provide evidence that the activation of PKC-alpha or PKC-epsilon in mouse fibroblasts can play an important role in enhancing cell cycle progression and cell proliferation...
  27. pmc (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells
    Seiji Adachi
    Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, HHSC 1509, 701 West 168th Street, New York, NY 10032 2704, USA
    Carcinogenesis 29:1986-93. 2008
    ..This sequestrating of inactivated EGFRs into endosomes may explain, at least in part, the ability of EGCG to inhibit activation of the EGFR and thereby exert anticancer effects...
  28. ncbi request reprint Role of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment
    Jae Won Soh
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, N Y, USA
    Prog Exp Tumor Res 37:261-85. 2003
  29. pmc Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis
    Tao Su
    Herbert Irving Comprehensive Cancer Center and Integrated Program in Cellular, Molecular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:7824-9. 2003
    ..Taken together, these findings suggest that, like FHIT, PKCI may normally play a tumor-suppressor role. The possible role of PKCI as a tumor suppressor in humans remains to be determined...
  30. ncbi request reprint Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells
    Jae Won Soh
    Herbert Irving Comprehensive Cancer Center and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Exp Ther Oncol 3:115-26. 2003
    ..Therefore, inhibitors of PKC-alpha may potentiate the activity of cytotoxic agents in the therapy of breast cancer...
  31. ncbi request reprint Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells
    Atsuko Deguchi
    Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Res 65:8442-7. 2005
    ..Taken together, these results provide evidence that the cGMP/PKG pathway can play an important role in the induction of 15-LOX-1 expression by nonsteroidal antiinflammatory drugs and related agents...
  32. pmc Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells
    Jin T E Lim
    Department of Environmental Health Sciences, The Joseph L Mailman School of Public Health, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 102:5156-61. 2005
    ..These findings suggest that CDK6 may play an important role in the development and/or progression of a subset of human prostate cancers by stimulating the activity of the AR...
  33. ncbi request reprint Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1
    Masumi Suzui
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 62:3997-4006. 2002
    ..These novel effects of ACR provide further evidence that ACR may be a valuable agent in the chemoprevention and therapy of hepatoma and possibly other human malignancies...
  34. ncbi request reprint EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells
    Masahito Shimizu
    Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Biochem Biophys Res Commun 334:947-53. 2005
    ..These findings expand the roles of EGCG as an inhibitor of critical RTKs involved in cell proliferation, providing further evidence that EGCG and related compounds may be useful in the chemoprevention or treatment of colorectal cancer...
  35. ncbi request reprint Dip1 inhibits growth and gene transcription in MCF-7 breast cancer cells
    Tao Su
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    J Exp Ther Oncol 6:117-27. 2007
    ..Although the precise mechanism by which Dip1 inhibits gene transcription and the growth of MCF-7 cells remain to be determined, the present results suggest that Dip1 is a candidate tumor suppressor gene...
  36. doi request reprint TREK-1 is a novel molecular target in prostate cancer
    Iryna Voloshyna
    Department of Pharmacology, Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
    Cancer Res 68:1197-203. 2008
    ..Taken together, these data suggest that TREK-1 expression is associated with abnormal cell proliferation and may be a novel marker for and a molecular target in prostate cancer...
  37. ncbi request reprint Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    Muneyuki Masuda
    Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, HHSC 1509, New York, New York 10032, USA
    Cancer Res 62:3351-5. 2002
    ..Furthermore, agents that target Stat3 may be useful in the treatment of HNSCC...
  38. ncbi request reprint Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells
    Linda Saxe Einbond
    Herbert Irvign Comperhensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Breast Cancer Res Treat 83:221-31. 2004
    ..Further studies are in progress to identify the mechanisms by which actein and related compounds present in black cohosh inhibit growth of human breast cancer cells...
  39. ncbi request reprint CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells
    Jung Taek Yoon
    Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cancer Ther 1:393-404. 2002
    ..Therefore, CP248 is a novel MT-active agent that may be useful in the treatment of glioblastoma, and possibly other types of cancer, because of its dual effects on protein kinase G and MTs...
  40. doi request reprint Oncogene addiction
    I Bernard Weinstein
    Herbert Irving Comprehensive Cancer Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032 2704, USA
    Cancer Res 68:3077-80; discussion 3080. 2008
    ..e., the "Achilles heel") in specific cancers. Combination therapy may also be required to prevent the escape of cancers from a given state of oncogene addiction...
  41. ncbi request reprint Mast cells provide a "HINT" to the function of an exotic nucleotide
    I Bernard Weinstein
    College of Physicians and Surgeons, Columbia University, 701 West 168th Street, HHSC 1509, New York, NY 10032, USA
    Immunity 20:119-20. 2004
    ..This naturally occurring compound consists of two adenosines linked by four phosphate residues, and has been proposed as an intracellular and extracellular signaling molecule...
  42. ncbi request reprint Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines
    Andrew K Joe
    Herbert Irving Comprehensive Cancer Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Clin Cancer Res 8:893-903. 2002
    ..We examined the effects of the phytochemical resveratrol in six human cancer cell lines (MCF7, SW480, HCE7, Seg-1, Bic-1, and HL60)...
  43. doi request reprint The history of Cancer Research: introducing an AACR Centennial series
    I Bernard Weinstein
    Columbia University Medical Center, New York, New York 10032, USA
    Cancer Res 68:6861-2. 2008
  44. ncbi request reprint Cyclin D1 expression in the intestinal mucosa and tumors of Apc1638N mice
    Hiroharu Shinozaki
    Strang Cancer Prevention Center, New York, NY 10021, USA
    Anticancer Res 23:2217-26. 2003
    ..These altered patterns of expression of cyclin D1 may provide useful biomarkers of abnormal cell development for studies of tumorigenesis and the effects of chemopreventive agents...
  45. ncbi request reprint Overexpression of cyclin DI contributes to malignant properties of esophageal tumor cells by increasing VEGF production and decreasing Fas expression
    Masafum Shintani
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
    Anticancer Res 22:639-47. 2002
    ....
  46. ncbi request reprint New bioactive polyphenols from Theobroma grandiflorum ("cupuaƧu")
    Hui Yang
    Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, USA
    J Nat Prod 66:1501-4. 2003
    ..While 1 was less active as an antioxidant than 2, the known compounds were more potent in the DPPH assay (IC(50) range 39.7-89.7 microM)...
  47. ncbi request reprint Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-beta(1)-dependent pathway
    Xiao hua Jiang
    Department of Gastroenterology, Rui Jin Hospital, Shanghai, PR China
    Oncogene 21:6113-22. 2002
    ..We also suggest that PKCbeta(1) act as survival mediator in gastric cancer, and its down-regulation by COX-2 inhibitor SC-236 may provide new target for future treatment of gastric cancer...
  48. doi request reprint Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G
    Jae Won Soh
    Biomedical Research Center for Signal Transduction Networks, Department of Chemistry, Inha University, Incheon, Korea
    Mol Carcinog 47:519-25. 2008
    ....
  49. ncbi request reprint Bioactive novel polyphenols from the fruit of Manilkara zapota (Sapodilla)
    Jun Ma
    Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, USA
    J Nat Prod 66:983-6. 2003
    ..Compound 2 showed high antioxidant activity (IC(50) = 23.5 microM) in the DPPH free-radical assay and displayed cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC(50) values of 154 and 134 microM, respectively...
  50. ncbi request reprint Nonsteroidal anti-inflammatory drug use associated with reduced incidence of adenocarcinomas of the esophagus and gastric cardia that overexpress cyclin D1: a population-based study
    Marilie D Gammon
    University of North Carolina, School of Public Health, Department of Epidemiology, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 13:34-9. 2004
    ..These data suggest that the reduction in risk associated with NSAID use may be restricted to those esophageal and gastric cardia adenocarcinomas that overexpress cyclin D1...
  51. ncbi request reprint The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil
    Muneyuki Masuda
    Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Kyushu University, Fukuoka 812 0052, Japan
    Jpn J Cancer Res 93:329-39. 2002
    ..Therefore, the addition to FAR therapy of agents that inhibit activation of the Stat3 pathway may enhance the clinical response of patients with HNSCC to FAR therapy...
  52. ncbi request reprint Antioxidant and cytotoxic isoprenylated coumarins from Mammea americana
    Hui Yang
    Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, Bronx, NY 10468, USA
    Planta Med 71:852-60. 2005
    ..In the SW-480 cell line, the three new coumarins, 1 - 3, also exhibited dose-dependent increases in sub-diploid cells by flow cytometry, indicating that they induce apoptosis...
  53. ncbi request reprint Overexpression of phosphatidylinositol synthase enhances growth and G1 progression in NIH3T3 cells
    Atsuko Deguchi
    Herbert Irving Comprehensive Cancer Center, Columbia University, 701 W 168th St, HHSC 1509, New York, NY 10032, USA
    Jpn J Cancer Res 93:157-66. 2002
    ..Moreover, PIS overexpression potentiated the colony formation of NIH3T3 cells in soft agar. These results suggest that PIS accelerates G1 progression and stimulates growth by increasing cellular levels of cyclins D1 and E...
  54. ncbi request reprint Effects of a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on growth, apoptosis, gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell lines
    Hong Ying Ruan
    Department of Otorhinolaryngology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Head Neck 28:158-65. 2006
    ..Recent studies provide evidence that the constitutive activation of nuclear factor-kappa B, NF-kappaB plays a critical role in enhancing the growth of several types of malignancies, including head and neck squamous cell carcinoma (HNSCC)...
  55. ncbi request reprint Overexpression of cyclin D1 contributes to malignancy by up-regulation of fibroblast growth factor receptor 1 via the pRB/E2F pathway
    Etsu Tashiro
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223 8522, Japan
    Cancer Res 63:424-31. 2003
    ....
  56. ncbi request reprint Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors
    Konstantin Christov
    Department of Surgical Oncology, University of Illinois, Chicago, IL, USA
    Breast Cancer Res Treat 77:253-64. 2003
    ....
  57. ncbi request reprint Polyphenolic constituents of Actaea racemosa
    Paiboon Nuntanakorn
    Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, Bronx, New York 10468, USA
    J Nat Prod 69:314-8. 2006
    ..Compounds 1 and 2 also exhibited a small stimulating effect on the growth of MCF-7 breast cancer cell proliferation 1.24-fold (14 microM) and 1.14-fold (10 microM), respectively, compared to untreated cells...
  58. ncbi request reprint Inhibition of histone acetyltransferase function of p300 by PKCdelta
    L W Yuan
    Department of Physiology and Biophysics, School of Medicine, Boston University, 715 Albany St, MA 02118, USA
    Biochim Biophys Acta 1592:205-11. 2002
    ..These findings identify a new signal transduction pathway by which PKCdelta may inhibit cell growth and promote cellular differentiation...
  59. ncbi request reprint Antisense targeting protein kinase C alpha and beta1 inhibits gastric carcinogenesis
    Xiao hua Jiang
    Department of Gastroenterology, Rui Jin Hospital, Shanghai, P R China
    Cancer Res 64:5787-94. 2004
    ..These data provide evidence that targeting PKCalpha and PKCbeta1 by antisense method is a promising therapy for gastric cancer...
  60. ncbi request reprint Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization
    Masayoshi Yasui
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Clin Cancer Res 12:4720-9. 2006
    ..Our aim was to determine the effects of cyclin D1 inhibition on tumor-associated neovascularization and endothelial cell growth...
  61. ncbi request reprint Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta
    Kristen Page
    Department of Pediatrics and the Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 27:204-13. 2002
    ..These data suggest that PKCdelta attenuates cyclin D1 promoter activity via the regulation of three distinct cis-acting regulatory elements...
  62. ncbi request reprint Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta
    Kristen Page
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:5681-9. 2003
    ..Finally, PKC delta-CAT induced transcription from the GM-CSF, RANTES, and ICAM-1 promoters. Together these data suggest that PKC delta plays a key role in the regulation of airway epithelial cell NF-kappa B-dependent gene expression...
  63. ncbi request reprint Signal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinoma
    Muneyuki Masuda
    Department of Otorhinolaryngology, Kyushu Koseinenkin Hospital, 2 1 1, Kishinoura, Nishiku, Kitakyushu 806 8501, Japan
    Oral Oncol 43:785-90. 2007
    ..01). These results strongly indicate that Stat3 directly up-regulates VEGF transcription and thereby promotes angiogenesis in HNSCC. Inhibition of Stat3 activity may provide a new anti-angiogenic therapy in HNSCC...
  64. pmc Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer management
    Kenji Yamazaki
    Department of Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Gut 56:1557-63. 2007
    ..In this study the effects of p-RXR alpha on the ability of RXR alpha and PPAR gamma ligands to inhibit growth in colon cancer cells was examined...
  65. ncbi request reprint The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells
    Seiji Adachi
    Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New Yourk, NY 10032 2704, USA
    Cancer Res 67:6493-501. 2007
    ..These effects may also explain the ability of EGCG to inhibit activation of other membrane-associated RTKs, and they may play a critical role in the anticancer effects of this and related compounds...