Research Topics
| I Bernard WeinsteinSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Cancer. Addiction to oncogenes--the Achilles heal of cancerI Bernard Weinstein
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
Science 297:63-4. 2002
The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damageHaiyang Li
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
J Cell Biol 183:253-65. 2008..Our findings suggest that the tumor suppressor function of HINT1 is caused by, at least in part, its normal role in enhancing cellular responses to DNA damage by regulating the functions of both gamma-H2AX and ATM...- Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapyI Bernard Weinstein
College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Nat Clin Pract Oncol 3:448-57. 2006..e. the 'Achilles' heel,' in specific cancers. Finally, we discuss the use of molecular targeted agents in combination with other anticancer agents as a strategy to optimize therapy and prevent disease recurrence... - Sulindac sulfide and exisulind inhibit expression of the estrogen and progesterone receptors in human breast cancer cellsJin T E Lim
Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Clin Cancer Res 12:3478-84. 2006..Thus, these and related compounds may provide a novel approach to the prevention and treatment of human breast cancers, especially those that are ER positive... - Polyphenolic constituents of Actaea racemosaPaiboon Nuntanakorn
Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, Bronx, New York 10468, USA
J Nat Prod 69:314-8. 2006..Compounds 1 and 2 also exhibited a small stimulating effect on the growth of MCF-7 breast cancer cell proliferation 1.24-fold (14 microM) and 1.14-fold (10 microM), respectively, compared to untreated cells... - The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerizationDanhua Xiao
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, 701 West 168th Street, Room 1509, New York, NY 10032, USA
Mol Cancer Ther 5:60-7. 2006.... - EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cellsMasahito Shimizu
Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
J Exp Ther Oncol 5:69-78. 2005..These findings extend our previous evidence that EGCG may be useful in the chemoprevention and/or treatment of colorectal cancer... - Effects of a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on growth, apoptosis, gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell linesHong-Ying Ruan
Department of Otorhinolaryngology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
Head Neck 28:158-65. 2006..CONCLUSIONS: These results suggest that DHMEQ may be effective when used alone or in combination with other agents in the treatment of HNSCC... - Antioxidant and cytotoxic isoprenylated coumarins from Mammea americanaHui Yang
Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, Bronx, NY 10468, USA
Planta Med 71:852-60. 2005..In the SW-480 cell line, the three new coumarins, 1 - 3, also exhibited dose-dependent increases in sub-diploid cells by flow cytometry, indicating that they induce apoptosis... - Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cellsDanhua Xiao
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
Mol Cancer Ther 4:1388-98. 2005..These findings may be useful in the identification, synthesis, and development of organosulfur compounds that have anticancer activity... - (-)-Epigallocatechin gallate and polyphenon E inhibit growth and activation of the epidermal growth factor receptor and human epidermal growth factor receptor-2 signaling pathways in human colon cancer cellsMasahito Shimizu
Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New York, New York 10032-2704, USA
Clin Cancer Res 11:2735-46. 2005..Poly E contains about 60% EGCG, yet pure EGCG and Poly E had similar potencies (expressed as microg/ml). Poly E may be preferable because it is easier to prepare and this mixture of catechins may exert synergistic effects... - Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cellsJin T E Lim
Department of Environmental Health Sciences, The Joseph L Mailman School of Public Health, Columbia University, New York, NY 10027, USA
Proc Natl Acad Sci U S A 102:5156-61. 2005..These findings suggest that CDK6 may play an important role in the development and/or progression of a subset of human prostate cancers by stimulating the activity of the AR... - Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cellsMasahito Shimizu
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Clin Cancer Res 10:6710-21. 2004..Our results suggest that the combination of acyclic retinoid plus OSI-461 might be an effective regimen for the chemoprevention and chemotherapy of human hepatoma and possibly other malignancies... - Antisense targeting protein kinase C alpha and beta1 inhibits gastric carcinogenesisXiao-Hua Jiang
Department of Gastroenterology, Rui-Jin Hospital, Shanghai, P.R. China
Cancer Res 64:5787-94. 2004..These data provide evidence that targeting PKCalpha and PKCbeta1 by antisense method is a promising therapy for gastric cancer... - Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularizationMasayoshi Yasui
Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
Clin Cancer Res 12:4720-9. 2006..CONCLUSIONS: Our results suggest that cyclin D1 may play a role in the maintenance of VEGF expression and that AS CyD1 could be potentially useful for targeting both cancer cells and their microenvironment of tumor vessels... - Actein and a fraction of black cohosh potentiate antiproliferative effects of chemotherapy agents on human breast cancer cellsLinda Saxe Einbond
Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
Planta Med 72:1200-6. 2006.... - The history of Cancer Research: introducing an AACR Centennial seriesI Bernard Weinstein
Columbia University Medical Center, New York, New York 10032, USA
Cancer Res 68:6861-2. 2008 
Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1Bo Cen
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Cancer Res 68:5355-62. 2008..They also provide a rationale for further developing activators of PKG for the prevention and treatment of cancer...- (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cellsSeiji Adachi
Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, HHSC 1509, 701 West 168th Street, New York, NY 10032 2704, USA
Carcinogenesis 29:1986-93. 2008..This sequestrating of inactivated EGFRs into endosomes may explain, at least in part, the ability of EGCG to inhibit activation of the EGFR and thereby exert anticancer effects... - Oncogene addictionI Bernard Weinstein
Herbert Irving Comprehensive Cancer Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032 2704, USA
Cancer Res 68:3077-80; discussion 3080. 2008..e., the "Achilles heel") in specific cancers. Combination therapy may also be required to prevent the escape of cancers from a given state of oncogene addiction... - TREK-1 is a novel molecular target in prostate cancerIryna Voloshyna
Department of Pharmacology, Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
Cancer Res 68:1197-203. 2008..Taken together, these data suggest that TREK-1 expression is associated with abnormal cell proliferation and may be a novel marker for and a molecular target in prostate cancer... - Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase GJae Won Soh
Biomedical Research Center for Signal Transduction Networks, Department of Chemistry, Inha University, Incheon, Korea
Mol Carcinog 47:519-25. 2008.... - The growth inhibitory effect of actein on human breast cancer cells is associated with activation of stress response pathwaysLinda Saxe Einbond
Department of Rehabilitation Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Int J Cancer 121:2073-83. 2007..Since actein activated transcription factors that enhance apoptosis, and repressed cell cycle genes, it may be useful in the prevention and therapy of breast cancer... - Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells--phosphorylated RXR alpha is a critical target for colon cancer managementKenji Yamazaki
Department of Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
Gut 56:1557-63. 2007..In this study the effects of p-RXR alpha on the ability of RXR alpha and PPAR gamma ligands to inhibit growth in colon cancer cells was examined... - Gene expression analysis of the mechanisms whereby black cohosh inhibits human breast cancer cell growthLinda Saxe Einbond
Department of Rehabilitation Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Anticancer Res 27:697-712. 2007..Our aim is to identify alterations in gene expression induced by treatment with a methanolic extract (MeOH) of black cohosh... - Dip1 inhibits growth and gene transcription in MCF-7 breast cancer cellsTao Su
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
J Exp Ther Oncol 6:117-27. 2007..Although the precise mechanism by which Dip1 inhibits gene transcription and the growth of MCF-7 cells remain to be determined, the present results suggest that Dip1 is a candidate tumor suppressor gene... - Signal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinomaMuneyuki Masuda
Department of Otorhinolaryngology, Kyushu Koseinenkin Hospital, 2 1 1, Kishinoura, Nishiku, Kitakyushu 806 8501, Japan
Oral Oncol 43:785-90. 2007..01). These results strongly indicate that Stat3 directly up-regulates VEGF transcription and thereby promotes angiogenesis in HNSCC. Inhibition of Stat3 activity may provide a new anti-angiogenic therapy in HNSCC... - Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cellsHaiyang Li
Herbert Irving Comprehensive Cancer Center, Department of Medicine, Columbia University, New York, New York 10032, USA
Cancer Res 66:11399-408. 2006..Thus, PKCbeta1 and beta2 may play important positive roles in the growth of at least a subset of human breast cancers. Therefore, inhibitors of these isoforms may be useful in breast cancer chemoprevention or therapy... - Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cellsAtsuko Deguchi
Herbert Irving Comprehensive Cancer Center, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032-2704, USA
Cancer Res 64:3966-73. 2004.... - Acyclic retinoid activates retinoic acid receptor beta and induces transcriptional activation of p21(CIP1) in HepG2 human hepatoma cellsMasumi Suzui
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Mol Cancer Ther 3:309-16. 2004..These findings suggest that the growth inhibitory effects of ACR are mediated at least in part through RARbeta and that both RARbeta and p21(CIP1) play critical roles in the molecular mechanisms of growth inhibition induced by ACR... - Effects of acyclic retinoid on growth, cell cycle control, epidermal growth factor receptor signaling, and gene expression in human squamous cell carcinoma cellsMasahito Shimizu
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032-2704, USA
Clin Cancer Res 10:1130-40. 2004..A hypothetical model explaining these two phases is presented. The diverse effects that we obtained with ACR suggest that this agent might be useful in the chemoprevention and/or therapy of human SCCs... - Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumorsKonstantin Christov
Department of Surgical Oncology, University of Illinois, Chicago, IL, USA
Breast Cancer Res Treat 77:253-64. 2003.... - Overexpression of cyclin D1 contributes to malignancy by up-regulation of fibroblast growth factor receptor 1 via the pRB/E2F pathwayEtsu Tashiro
Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan
Cancer Res 63:424-31. 2003.... - Vasodilator-stimulated phosphoprotein (VASP) phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein kinase GAtsuko Deguchi
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
Mol Cancer Ther 1:803-9. 2002..These results suggest that VASP phosphorylation can provide a useful endogenous cellular biomarker for anticancer agents that cause cGMP-mediated apoptosis... - CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cellsJung-Taek Yoon
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Cancer Ther 1:393-404. 2002..Therefore, CP248 is a novel MT-active agent that may be useful in the treatment of glioblastoma, and possibly other types of cancer, because of its dual effects on protein kinase G and MTs... - Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transductionMuneyuki Masuda
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, HHSC-1509, 701 W. 168th Street, New York, NY 10032, USA
J Exp Ther Oncol 2:350-9. 2002..Therefore, EGCG may be useful in treating HNSCC and breast carcinoma because it can exert both antiproliferative and antiangiogenic activities... - Inhibition of histone acetyltransferase function of p300 by PKCdeltaL W Yuan
Department of Physiology and Biophysics, School of Medicine, Boston University, 715 Albany St, MA 02118, USA
Biochim Biophys Acta 1592:205-11. 2002..These findings identify a new signal transduction pathway by which PKCdelta may inhibit cell growth and promote cellular differentiation... - Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-beta(1)-dependent pathwayXiao-Hua Jiang
Department of Gastroenterology, Rui-Jin Hospital, Shanghai, PR China
Oncogene 21:6113-22. 2002..We also suggest that PKCbeta(1) act as survival mediator in gastric cancer, and its down-regulation by COX-2 inhibitor SC-236 may provide new target for future treatment of gastric cancer... - Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-deltaKristen Page
Department of Pediatrics and the Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois, USA
Am J Respir Cell Mol Biol 27:204-13. 2002..These data suggest that PKCdelta attenuates cyclin D1 promoter activity via the regulation of three distinct cis-acting regulatory elements... - Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1Masumi Suzui
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Cancer Res 62:3997-4006. 2002..These novel effects of ACR provide further evidence that ACR may be a valuable agent in the chemoprevention and therapy of hepatoma and possibly other human malignancies... - Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinomaMuneyuki Masuda
Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, HHSC 1509, New York, New York 10032, USA
Cancer Res 62:3351-5. 2002..Furthermore, agents that target Stat3 may be useful in the treatment of HNSCC... - Overexpression of cyclin DI contributes to malignant properties of esophageal tumor cells by increasing VEGF production and decreasing Fas expressionMasafum Shintani
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
Anticancer Res 22:639-47. 2002.... - The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracilMuneyuki Masuda
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Kyushu University, Fukuoka 812 0052, Japan
Jpn J Cancer Res 93:329-39. 2002..Therefore, the addition to FAR therapy of agents that inhibit activation of the Stat3 pathway may enhance the clinical response of patients with HNSCC to FAR therapy... - Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell linesAndrew K Joe
Herbert Irving Comprehensive Cancer Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Clin Cancer Res 8:893-903. 2002..CONCLUSIONS: These studies provide support for the use of resveratrol in chemoprevention and cancer therapy trials. Cyclin D1, cyclin B1, beta-catenin, and apoptotic index could be useful biomarkers to evaluate treatment efficacy... - Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C deltaKristen Page
Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
J Immunol 170:5681-9. 2003..Finally, PKC delta-CAT induced transcription from the GM-CSF, RANTES, and ICAM-1 promoters. Together these data suggest that PKC delta plays a key role in the regulation of airway epithelial cell NF-kappa B-dependent gene expression... - Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genesJae Won Soh
Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 278:34709-16. 2003..These results provide evidence that the activation of PKC-alpha or PKC-epsilon in mouse fibroblasts can play an important role in enhancing cell cycle progression and cell proliferation... - Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cellsLinda Saxe Einbond
Herbert Irvign Comperhensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Breast Cancer Res Treat 83:221-31. 2004..Further studies are in progress to identify the mechanisms by which actein and related compounds present in black cohosh inhibit growth of human breast cancer cells... - Nonsteroidal anti-inflammatory drug use associated with reduced incidence of adenocarcinomas of the esophagus and gastric cardia that overexpress cyclin D1: a population-based studyMarilie D Gammon
University of North Carolina, School of Public Health, Department of Epidemiology, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 13:34-9. 2004..These data suggest that the reduction in risk associated with NSAID use may be restricted to those esophageal and gastric cardia adenocarcinomas that overexpress cyclin D1... - Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cellsJae Won Soh
Herbert Irving Comprehensive Cancer Center and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Exp Ther Oncol 3:115-26. 2003..Therefore, inhibitors of PKC-alpha may potentiate the activity of cytotoxic agents in the therapy of breast cancer... - New bioactive polyphenols from Theobroma grandiflorum ("cupuaçu")Hui Yang
Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, USA
J Nat Prod 66:1501-4. 2003..While 1 was less active as an antioxidant than 2, the known compounds were more potent in the DPPH assay (IC(50) range 39.7-89.7 microM)... - Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activationDanhua Xiao
Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Cancer Res 63:6825-37. 2003.... - Overexpression of phosphatidylinositol synthase enhances growth and G1 progression in NIH3T3 cellsAtsuko Deguchi
Herbert Irving Comprehensive Cancer Center, Columbia University, 701 W 168th St, HHSC 1509, New York, NY 10032, USA
Jpn J Cancer Res 93:157-66. 2002..Moreover, PIS overexpression potentiated the colony formation of NIH3T3 cells in soft agar. These results suggest that PIS accelerates G1 progression and stimulates growth by increasing cellular levels of cyclins D1 and E... - Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cellsJin T E Lim
Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10021, USA
Clin Cancer Res 9:4972-82. 2003..Thus, these compounds may provide a novel approach to the prevention and treatment of human prostate cancer... - Epigallocatechin-3-gallate inhibits activation of HER-2/neu and downstream signaling pathways in human head and neck and breast carcinoma cellsMuneyuki Masuda
Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Clin Cancer Res 9:3486-91. 2003.... - Bioactive novel polyphenols from the fruit of Manilkara zapota (Sapodilla)Jun Ma
Department of Biological Sciences, Lehman College and The Graduate Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, USA
J Nat Prod 66:983-6. 2003..Compound 2 showed high antioxidant activity (IC(50) = 23.5 microM) in the DPPH free-radical assay and displayed cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC(50) values of 154 and 134 microM, respectively... - Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cellsAndrew K Joe
Herbert Irving Comprehensive Cancer Center, 701 West 168th Street, HHSC 1509, New York, NY 10032, USA
J Exp Ther Oncol 3:83-94. 2003..These studies provide support for the use of exisulind in BE chemoprevention trials, and of exisulind or CP248 in the therapy of patients with esophageal carcinoma... - Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesisTao Su
Herbert Irving Comprehensive Cancer Center and Integrated Program in Cellular, Molecular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:7824-9. 2003..Taken together, these findings suggest that, like FHIT, PKCI may normally play a tumor-suppressor role. The possible role of PKCI as a tumor suppressor in humans remains to be determined... - Role of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatmentJae-Won Soh
Department of Medicine, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, N.Y, USA
Prog Exp Tumor Res 37:261-85. 2003 - Hint1 inhibits growth and activator protein-1 activity in human colon cancer cellsLin Wang
Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032 2704, USA
Cancer Res 67:4700-8. 2007..These results suggest that HINT1 inhibits AP-1 activity by binding to a POSH-JNK2 complex, thus inhibiting the phosphorylation of c-Jun. This effect could contribute to the tumor suppressor activity of HINT1... - Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cellsAtsuko Deguchi
Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
Cancer Res 65:8442-7. 2005..Taken together, these results provide evidence that the cGMP/PKG pathway can play an important role in the induction of 15-LOX-1 expression by nonsteroidal antiinflammatory drugs and related agents... - EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cellsMasahito Shimizu
Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
Biochem Biophys Res Commun 334:947-53. 2005..These findings expand the roles of EGCG as an inhibitor of critical RTKs involved in cell proliferation, providing further evidence that EGCG and related compounds may be useful in the chemoprevention or treatment of colorectal cancer... - The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cellsSeiji Adachi
Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New Yourk, NY 10032 2704, USA
Cancer Res 67:6493-501. 2007..These effects may also explain the ability of EGCG to inhibit activation of other membrane-associated RTKs, and they may play a critical role in the anticancer effects of this and related compounds...