Alin Vonica

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis
    Alin Vonica
    Laboratory of Vertebrate Embryology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Dev Biol 350:13-23. 2011
  2. ncbi Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor
    Esther Bell
    The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, NY 10021, USA
    Development 130:1381-9. 2003
  3. pmc The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity
    Alin Vonica
    The Laboratory of Vertebrate Embryology, The Rockefeller University, P O Box 32, 1230 York Avenue, New York, NY 10021, USA
    Dev Biol 312:90-102. 2007
  4. ncbi The left-right axis is regulated by the interplay of Coco, Xnr1 and derrière in Xenopus embryos
    Alin Vonica
    The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, NY 10021, USA
    Dev Biol 303:281-94. 2007
  5. pmc FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development
    Mario N Chamorro
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Varmus Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    EMBO J 24:73-84. 2005
  6. ncbi An obligatory caravanserai stop on the silk road to neural induction: inhibition of BMP/GDF signaling
    Alin Vonica
    Laboratory of Molecular Embryology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Semin Cell Dev Biol 17:117-32. 2006
  7. ncbi Scaling of BMP gradients in Xenopus embryos
    Paul Francois
    Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 461:E1; discussion E2. 2009
  8. pmc Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4
    Aryeh Warmflash
    Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:E1947-56. 2012
  9. pmc The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
    Hua Gao
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 150:764-79. 2012
  10. pmc APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
    Yutaka Shimomura
    Department of Dermatology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC15 204a, New York, New York 10032, USA
    Nature 464:1043-7. 2010

Collaborators

Detail Information

Publications12

  1. pmc APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis
    Alin Vonica
    Laboratory of Vertebrate Embryology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Dev Biol 350:13-23. 2011
    ..This demonstrates for the first time that a putative RNA/DNA editing enzyme regulates TGFβ signaling and plays a major role in development...
  2. ncbi Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor
    Esther Bell
    The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, NY 10021, USA
    Development 130:1381-9. 2003
    ..Because of this embryological activity, we have renamed this clone Coco, after the Spanish word meaning head...
  3. pmc The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity
    Alin Vonica
    The Laboratory of Vertebrate Embryology, The Rockefeller University, P O Box 32, 1230 York Avenue, New York, NY 10021, USA
    Dev Biol 312:90-102. 2007
    ..We conclude that the maternal Wnt pathway generates the Nieuwkoop center in vitro and the organizer in vivo by activating a common set of genes, without the need of an intermediary signaling step...
  4. ncbi The left-right axis is regulated by the interplay of Coco, Xnr1 and derrière in Xenopus embryos
    Alin Vonica
    The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, NY 10021, USA
    Dev Biol 303:281-94. 2007
    ..We conclude that derrière, Xnr1, and Coco define a posttranscriptionally regulated signaling center, which is a necessary link in the signaling chain leading to an increased TGF-beta signal on the left side of the embryo...
  5. pmc FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development
    Mario N Chamorro
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Varmus Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    EMBO J 24:73-84. 2005
    ....
  6. ncbi An obligatory caravanserai stop on the silk road to neural induction: inhibition of BMP/GDF signaling
    Alin Vonica
    Laboratory of Molecular Embryology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Semin Cell Dev Biol 17:117-32. 2006
    ..We conclude that synergy between accumulated knowledge and technical progress will maintain Xenopus at the forefront of research in neural development...
  7. ncbi Scaling of BMP gradients in Xenopus embryos
    Paul Francois
    Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 461:E1; discussion E2. 2009
    ..We believe that the evidence for scaling in Xenopus is misinterpreted, and that their model for embryonic patterning disagrees with prior data. The experiments they present supporting their model admit alternative interpretations...
  8. pmc Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4
    Aryeh Warmflash
    Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:E1947-56. 2012
    ..Thus, R-Smads relay graded information about ligand levels that is integrated with intrinsic temporal control reflected in Smad4 into the active signaling complex...
  9. pmc The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
    Hua Gao
    Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 150:764-79. 2012
    ..These findings reveal that metastasis-initiating cells need to overcome organ-specific antimetastatic signals in order to undergo reactivation...
  10. pmc APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
    Yutaka Shimomura
    Department of Dermatology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, VC15 204a, New York, New York 10032, USA
    Nature 464:1043-7. 2010
    ..As APCDD1 is expressed in a broad repertoire of cell types, our findings indicate that APCDD1 may regulate a diversity of biological processes controlled by Wnt signalling...
  11. ncbi Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein
    Ignacio Munoz-Sanjuan
    The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, NY, USA
    Development 129:5529-40. 2002
    ....
  12. ncbi Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo
    Alin Vonica
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Biol 250:112-27. 2002
    ..Since Brachyury is considered to have a major role in mesoderm formation, it is possible that Wnts might play a role in mesoderm specification, in addition to patterning...