RICHARD BERT VALLEE

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones
    Richard B Vallee
    Department of Pathology and Cell Biology, Program in Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Trends Cell Biol 19:347-55. 2009
  2. pmc LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
    Jin Wu Tsai
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 170:935-45. 2005
  3. pmc Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function
    Chin Yin Tai
    University of Massachusetts Medical School, Department of Cell Biology, Worcester, MA 01605, USA
    J Cell Biol 156:959-68. 2002
  4. pmc Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment
    Dileep Varma
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Biol 182:1045-54. 2008
  5. pmc A role for cytoplasmic dynein and LIS1 in directed cell movement
    Denis L Dujardin
    College of Physicians and Surgeons, Department of Pathology, Columbia University, P and S 15 409, 630 W 168th St, New York, NY 10032, USA
    J Cell Biol 163:1205-11. 2003
  6. pmc Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function
    Dileep Varma
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Biol 172:655-62. 2006
  7. pmc NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
    Stephanie A Stehman
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Biol 178:583-94. 2007
  8. pmc A cytoplasmic dynein tail mutation impairs motor processivity
    Kassandra M Ori-McKenney
    Department of Pathology and Cell Biology, Columbia University New York, NY 10032, USA
    Nat Cell Biol 12:1228-34. 2010
  9. pmc High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport
    Julie Y Yi
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10027, USA
    J Cell Biol 195:193-201. 2011
  10. pmc Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells
    Jin Wu Tsai
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Nat Neurosci 13:1463-71. 2010

Research Grants

  1. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2000
  2. Mechanism of Action of the Lissencephaly Gene LIS-1
    RICHARD BERT VALLEE; Fiscal Year: 2011
  3. Molecular Genetics of Cytoplasmic Dyein
    Richard Vallee; Fiscal Year: 2009
  4. Molecular Genetics of Cytoplasmic Dyein
    RICHARD BERT VALLEE; Fiscal Year: 2010
  5. Mechanism of Action of the Lissencephaly Gene LIS-1
    RICHARD BERT VALLEE; Fiscal Year: 2010
  6. Molecular Genetics of Cytoplasmic Dyein
    Richard Vallee; Fiscal Year: 2009
  7. Mechanism of Action of the Lissencephaly Gene LIS-1
    Richard Vallee; Fiscal Year: 2009
  8. Molecular Genetics of Cytoplasmic Dyein
    Richard Vallee; Fiscal Year: 2007
  9. Mechanism of Action of the Lissencephaly Gene LIS-1
    Richard Vallee; Fiscal Year: 2007
  10. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2004

Collaborators

Detail Information

Publications40

  1. pmc Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones
    Richard B Vallee
    Department of Pathology and Cell Biology, Program in Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Trends Cell Biol 19:347-55. 2009
    ..The former cells exhibit unusual features of centrosome and nuclear movement, whereas growth cones offer an opportunity to evaluate motor protein function in a region of cytoplasm free of these organelles...
  2. pmc LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
    Jin Wu Tsai
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Biol 170:935-45. 2005
    ..Finally, axonal growth also ceased. These results identify multiple distinct and novel roles for LIS1 in nucleokinesis and process dynamics and suggest that nuclear position controls neural progenitor cell division...
  3. pmc Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function
    Chin Yin Tai
    University of Massachusetts Medical School, Department of Cell Biology, Worcester, MA 01605, USA
    J Cell Biol 156:959-68. 2002
    ..Together, our data suggest a novel role for LIS1 in mediating CLIP-170-dynein interactions and in coordinating dynein cargo-binding and motor activities...
  4. pmc Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment
    Dileep Varma
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Biol 182:1045-54. 2008
    ..These results identify a novel function for the dynein motor in stable microtubule attachment and maintenance of kinetochore orientation during metaphase chromosome alignment...
  5. pmc A role for cytoplasmic dynein and LIS1 in directed cell movement
    Denis L Dujardin
    College of Physicians and Surgeons, Department of Pathology, Columbia University, P and S 15 409, 630 W 168th St, New York, NY 10032, USA
    J Cell Biol 163:1205-11. 2003
    ..Together, these results implicate a leading edge cortical pool of dynein in both early and persistent steps in directed cell movement...
  6. pmc Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function
    Dileep Varma
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Biol 172:655-62. 2006
    ..We also find ZW10 enriched at the leading edge of migrating fibroblasts, suggesting that ZW10 serves as a general regulator of dynein function throughout the cell cycle...
  7. pmc NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
    Stephanie A Stehman
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Biol 178:583-94. 2007
    ..Together, these results identify a common function for NudE and NudEL in mitotic progression and identify an alternative mechanism for dynein recruitment to and regulation at kinetochores...
  8. pmc A cytoplasmic dynein tail mutation impairs motor processivity
    Kassandra M Ori-McKenney
    Department of Pathology and Cell Biology, Columbia University New York, NY 10032, USA
    Nat Cell Biol 12:1228-34. 2010
    ..These results suggest a potential role for the dynein tail in motor function, and provide direct evidence for a link between single-motor processivity and disease...
  9. pmc High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport
    Julie Y Yi
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10027, USA
    J Cell Biol 195:193-201. 2011
    ..Our data also reveal a specific but cell type-restricted role for LIS1 in large vesicular transport and provide the first quantitative support for a general role for LIS1 in high-load dynein functions...
  10. pmc Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells
    Jin Wu Tsai
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Nat Neurosci 13:1463-71. 2010
    ..These observations provide direct evidence that kinesins are involved in nuclear migration and neurogenesis and suggest that a cell cycle-dependent switch between distinct microtubule motors drives interkinetic nuclear migration...
  11. doi request reprint Multiple modes of cytoplasmic dynein regulation
    Richard B Vallee
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    Nat Cell Biol 14:224-30. 2012
    ..Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions...
  12. pmc Neuronal migration defects in the Loa dynein mutant mouse
    Kassandra M Ori-McKenney
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Neural Dev 6:26. 2011
    ....
  13. ncbi request reprint How dynein helps the cell find its center: a servomechanical model
    Richard B Vallee
    Department of Pathology and Anatomy, Columbia University College of Physicians and Surgeons, P and S 15 409, 630 W 168th St, New York, NY 10032, USA
    Trends Cell Biol 15:288-94. 2005
    ..Recent evidence indicates that the cell has the remarkable ability to calculate is geometric center, and, with the help of dynein, to position the centrosome at this central site. Here, we outline models to account for this behavior...
  14. ncbi request reprint Q & A. Richard Vallee
    Richard Vallee
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Curr Biol 17:R903-5. 2007
  15. ncbi request reprint Dynein: An ancient motor protein involved in multiple modes of transport
    Richard B Vallee
    Departments of Pathology and Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, New York, New York 10032, USA
    J Neurobiol 58:189-200. 2004
    ..The current status of the complex dynein cargo-binding mechanism is evaluated. Finally, recent genetic evidence supporting a role in axonal transport and revealing a role in neurodegenerative conditions is reviewed...
  16. ncbi request reprint Autoinhibitory and other autoregulatory elements within the dynein motor domain
    Richard B Vallee
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, P and S 15 410, 630 W 168th St, New York, NY 10032, USA
    J Struct Biol 156:175-81. 2006
    ..This article reviews recent efforts to probe the mechanism by which the dyneins produce force, and work from the authors' lab regarding long-range conformational regulation of dynein enzymatic activity...
  17. ncbi request reprint The cellular roles of the lissencephaly gene LIS1, and what they tell us about brain development
    Richard B Vallee
    Department of Pathology and Cell Biology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032 USA
    Genes Dev 20:1384-93. 2006
  18. pmc ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?
    Richard B Vallee
    Deptartment of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    Cell Cycle 5:2447-51. 2006
    ..Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here...
  19. ncbi request reprint Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue
    Jin Wu Tsai
    Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, 630 W 168th Street, New York, New York 10032, USA
    Nat Neurosci 10:970-9. 2007
    ..Thus, dynein pulls on the microtubule network from the swelling. The nucleus is transported along the trailing microtubules by dynein assisted by myosin II...
  20. ncbi request reprint The dynein family at a glance
    Peter Höök
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Sci 119:4369-71. 2006
  21. ncbi request reprint Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains
    Peter Höök
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:33045-54. 2005
    ....
  22. pmc Dynein recruitment to nuclear pores activates apical nuclear migration and mitotic entry in brain progenitor cells
    Daniel Jun Kit Hu
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Cell 154:1300-13. 2013
    ..These results reveal that cell-cycle control of apical nuclear migration occurs by motor protein recruitment and identify a role for nucleus- and centrosome-associated forces in mitotic entry. PAPERCLIP: ..
  23. pmc Asymmetric centrosome inheritance maintains neural progenitors in the neocortex
    Xiaoqun Wang
    Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue, New York, New York 10065, USA
    Nature 461:947-55. 2009
    ..These results indicate that preferential inheritance of the centrosome with the mature older mother centriole is required for maintaining radial glia progenitors in the developing mammalian neocortex...
  24. ncbi request reprint Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth
    Peter W Grabham
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 27:5823-34. 2007
    ..These data may explain, in part, the role of these proteins in brain developmental disease and support an important role in diverse aspects of neuronal differentiation and nervous system development...
  25. pmc LIS1 and NudE induce a persistent dynein force-producing state
    Richard J McKenney
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Cell 141:304-14. 2010
    ..These results likely explain the requirement for LIS1 and NudE in the transport of nuclei, centrosomes, chromosomes, and the microtubule cytoskeleton as well as the particular sensitivity of migrating neurons to reduced LIS1 expression...
  26. pmc Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit
    K Helen Bremner
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Cell Host Microbe 6:523-35. 2009
    ..These results identify hexon as a direct receptor for cytoplasmic dynein and demonstrate that hexon recruits dynein for transport to the nucleus by a mechanism distinct from that for physiological dynein cargo...
  27. ncbi request reprint Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells
    Atsushi Mikami
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Cell Sci 115:4801-8. 2002
    ..These data support a specific role for dynein 2 in the generation and maintenance of cilia...
  28. pmc Modes and mishaps of neuronal migration in the mammalian brain
    Christine Metin
    Institut du Fer a Moulin, Inserm Unité Mixte de Recherche S 839, 75005 Paris, France, Department of Pathology, Columbia University, New York, New York 10032, USA
    J Neurosci 28:11746-52. 2008
    ..We will also discuss how these and other events essential for normal migration of neurons can be disrupted by genetic and environmental factors that contribute to neurological disease in humans...
  29. doi request reprint The dynein stalk contains an antiparallel coiled coil with region-specific stability
    Peter Höök
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    Biochemistry 48:2710-3. 2009
    ....
  30. pmc Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration
    Jan Schmoranzer
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Curr Biol 19:1065-74. 2009
    ..However, centrosomes are maintained at the cell center during orientation in fibroblasts, suggesting that factors working at sites other than the leading edge may also be involved...
  31. pmc Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes
    Dileep Varma
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:3493-8. 2010
    ..Although the described traps offer a method for rapid inhibition of dynein function, the design principle can be extended to other molecular complexes for in vivo studies...
  32. pmc Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex
    John C Williams
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 104:10028-33. 2007
    ..These data suggest that, in the dynein complex, the LCs do not bind cargo, in apparent disagreement with a role for LCs in dynein cargo binding interactions...
  33. ncbi request reprint Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors
    Guangyu Zhu
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Med Chem 49:2063-76. 2006
    ..The inhibitory effect of purealin was concentration dependent and uncompetitive, supporting the hypothesis that it does not compete with the binding of ATP...
  34. ncbi request reprint Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation
    Satoshi O Suzuki
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, 812 8582 Fukuoka, Japan
    Acta Neuropathol 113:591-9. 2007
    ..These findings are compatible with the idea that LIS1 and its interacting proteins play a role in glioma migration and proliferation analogous to their role during brain development...
  35. pmc Cytoplasmic dynein nomenclature
    K Kevin Pfister
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 171:411-3. 2005
    ..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms...
  36. pmc Crystal structure of the GTPase domain of rat dynamin 1
    Thomas F Reubold
    Abteilung Biophysik, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 102:13093-8. 2005
    ..Our results support a model in which switch I residue Arg-59 gates GTP binding in an assembly-dependent manner and the GTPase effector domain functions as an assembly-dependent GTPase activating protein in the fashion of RGS-type GAPs...
  37. ncbi request reprint Differential regulation of dynein-driven melanosome movement
    Amy R Reilein
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 309:652-8. 2003
    ..Our data indicate that melanosome-associated dynein is regulated independently of bulk cytoplasmic dynein and involves a subfraction of dynein with a distinct subunit composition...
  38. ncbi request reprint Molecular motors: A magnificent machine
    Richard B Vallee
    Nature 421:701-2. 2003
  39. pmc A requirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organization
    Brian T Helfand
    Northwestern University School of Medicine, Department of Cell and Molecular Biology, Chicago, IL 60611, USA
    J Cell Biol 157:795-806. 2002
    ..Furthermore, these motors are to a large extent responsible for the long recognized relationships between vimentin IFs and MTs...
  40. ncbi request reprint Dynein at the cortex
    Denis L Dujardin
    University of Massachusetts Medical School, Biotech 4, Suite 312, 377 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Opin Cell Biol 14:44-9. 2002
    ..The possibility that a cortically bound form of dynein might represent its most ancient evolutionary state is discussed...

Research Grants17

  1. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2000
    ....
  2. Mechanism of Action of the Lissencephaly Gene LIS-1
    RICHARD BERT VALLEE; Fiscal Year: 2011
    ..These studies are of considerable relevance to understanding normal and abnormal brain development, cell migration, cell division, the causes of mental retardation, and stem cell behavior. ..
  3. Molecular Genetics of Cytoplasmic Dyein
    Richard Vallee; Fiscal Year: 2009
    ..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
  4. Molecular Genetics of Cytoplasmic Dyein
    RICHARD BERT VALLEE; Fiscal Year: 2010
    ..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
  5. Mechanism of Action of the Lissencephaly Gene LIS-1
    RICHARD BERT VALLEE; Fiscal Year: 2010
    ..These studies are of considerable relevance to understanding normal and abnormal brain development, cell migration, cell division, the causes of mental retardation, and stem cell behavior. ..
  6. Molecular Genetics of Cytoplasmic Dyein
    Richard Vallee; Fiscal Year: 2009
    ..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
  7. Mechanism of Action of the Lissencephaly Gene LIS-1
    Richard Vallee; Fiscal Year: 2009
    ..These studies are of considerable relevance to understanding normal and abnormal brain development, cell migration, cell division, the causes of mental retardation, and stem cell behavior. ..
  8. Molecular Genetics of Cytoplasmic Dyein
    Richard Vallee; Fiscal Year: 2007
    ..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
  9. Mechanism of Action of the Lissencephaly Gene LIS-1
    Richard Vallee; Fiscal Year: 2007
    ..These studies are of considerable relevance to understanding normal and abnormal brain development, cell migration, cell division, the causes of mental retardation, and stem cell behavior. ..
  10. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2004
    ....
  11. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2003
    ....
  12. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2001
    ....
  13. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2002
    ....
  14. MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1
    Richard Vallee; Fiscal Year: 2001
    ....
  15. Mechanism of Action of the Lissencephaly Gene LIS-1
    RICHARD BERT VALLEE; Fiscal Year: 2010
    ..These studies are of considerable relevance to understanding normal and abnormal brain development, cell migration, cell division, the causes of mental retardation, and stem cell behavior. ..