Research Topics
Genomes and Genes | RICHARD BERT VALLEESummaryAffiliation: Columbia University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth conesRichard B Vallee
Department of Pathology and Cell Biology, Program in Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Trends Cell Biol 19:347-55. 2009..The former cells exhibit unusual features of centrosome and nuclear movement, whereas growth cones offer an opportunity to evaluate motor protein function in a region of cytoplasm free of these organelles...
Multiple modes of cytoplasmic dynein regulationRichard B Vallee
Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
Nat Cell Biol 14:224-30. 2012..Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions...- Neuronal migration defects in the Loa dynein mutant mouseKassandra M Ori-McKenney
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
Neural Dev 6:26. 2011.... 
Q & A. Richard ValleeRichard Vallee
Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Curr Biol 17:R903-5. 2007- ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?Richard B Vallee
Deptartment of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
Cell Cycle 5:2447-51. 2006..Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here... - The cellular roles of the lissencephaly gene LIS1, and what they tell us about brain developmentRichard B Vallee
Department of Pathology and Cell Biology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032 USA
Genes Dev 20:1384-93. 2006 - Autoinhibitory and other autoregulatory elements within the dynein motor domainRichard B Vallee
Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, P and S 15 410, 630 W 168th St, New York, NY 10032, USA
J Struct Biol 156:175-81. 2006..This article reviews recent efforts to probe the mechanism by which the dyneins produce force, and work from the authors' lab regarding long-range conformational regulation of dynein enzymatic activity... - How dynein helps the cell find its center: a servomechanical modelRichard B Vallee
Department of Pathology and Anatomy, Columbia University College of Physicians and Surgeons, P and S 15 409, 630 W 168th St, New York, NY 10032, USA
Trends Cell Biol 15:288-94. 2005..Recent evidence indicates that the cell has the remarkable ability to calculate is geometric center, and, with the help of dynein, to position the centrosome at this central site. Here, we outline models to account for this behavior... - Dynein: An ancient motor protein involved in multiple modes of transportRichard B Vallee
Departments of Pathology and Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, New York, New York 10032, USA
J Neurobiol 58:189-200. 2004..The current status of the complex dynein cargo-binding mechanism is evaluated. Finally, recent genetic evidence supporting a role in axonal transport and revealing a role in neurodegenerative conditions is reviewed... - Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignmentDileep Varma
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
J Cell Biol 182:1045-54. 2008..These results identify a novel function for the dynein motor in stable microtubule attachment and maintenance of kinetochore orientation during metaphase chromosome alignment... - Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissueJin Wu Tsai
Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, 630 W 168th Street, New York, New York 10032, USA
Nat Neurosci 10:970-9. 2007..Thus, dynein pulls on the microtubule network from the swelling. The nucleus is transported along the trailing microtubules by dynein assisted by myosin II... - Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein functionDileep Varma
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
J Cell Biol 172:655-62. 2006..We also find ZW10 enriched at the leading edge of migrating fibroblasts, suggesting that ZW10 serves as a general regulator of dynein function throughout the cell cycle... - NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochoresStephanie A Stehman
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
J Cell Biol 178:583-94. 2007..Together, these results identify a common function for NudE and NudEL in mitotic progression and identify an alternative mechanism for dynein recruitment to and regulation at kinetochores... - A role for cytoplasmic dynein and LIS1 in directed cell movementDenis L Dujardin
College of Physicians and Surgeons, Department of Pathology, Columbia University, P and S 15 409, 630 W 168th St, New York, NY 10032, USA
J Cell Biol 163:1205-11. 2003..Together, these results implicate a leading edge cortical pool of dynein in both early and persistent steps in directed cell movement... - Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domainsPeter Höök
Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
J Biol Chem 280:33045-54. 2005.... - The dynein family at a glancePeter Höök
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
J Cell Sci 119:4369-71. 2006 - LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stagesJin Wu Tsai
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Cell Biol 170:935-45. 2005..Finally, axonal growth also ceased. These results identify multiple distinct and novel roles for LIS1 in nucleokinesis and process dynamics and suggest that nuclear position controls neural progenitor cell division... - Asymmetric centrosome inheritance maintains neural progenitors in the neocortexXiaoqun Wang
Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue, New York, New York 10065, USA
Nature 461:947-55. 2009..These results indicate that preferential inheritance of the centrosome with the mature older mother centriole is required for maintaining radial glia progenitors in the developing mammalian neocortex... - Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowthPeter W Grabham
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Neurosci 27:5823-34. 2007..These data may explain, in part, the role of these proteins in brain developmental disease and support an important role in diverse aspects of neuronal differentiation and nervous system development... - LIS1 and NudE induce a persistent dynein force-producing stateRichard J McKenney
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
Cell 141:304-14. 2010..These results likely explain the requirement for LIS1 and NudE in the transport of nuclei, centrosomes, chromosomes, and the microtubule cytoskeleton as well as the particular sensitivity of migrating neurons to reduced LIS1 expression... - Modes and mishaps of neuronal migration in the mammalian brainChristine Metin
Institut du Fer a Moulin, Inserm Unité Mixte de Recherche S 839, 75005 Paris, France, Department of Pathology, Columbia University, New York, New York 10032, USA
J Neurosci 28:11746-52. 2008..We will also discuss how these and other events essential for normal migration of neurons can be disrupted by genetic and environmental factors that contribute to neurological disease in humans... - The dynein stalk contains an antiparallel coiled coil with region-specific stabilityPeter Höök
Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
Biochemistry 48:2710-3. 2009.... - Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunitK Helen Bremner
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
Cell Host Microbe 6:523-35. 2009..These results identify hexon as a direct receptor for cytoplasmic dynein and demonstrate that hexon recruits dynein for transport to the nucleus by a mechanism distinct from that for physiological dynein cargo... - Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cellsAtsushi Mikami
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Cell Sci 115:4801-8. 2002..These data support a specific role for dynein 2 in the generation and maintenance of cilia... - Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migrationJan Schmoranzer
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
Curr Biol 19:1065-74. 2009..However, centrosomes are maintained at the cell center during orientation in fibroblasts, suggesting that factors working at sites other than the leading edge may also be involved... - Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processesDileep Varma
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 107:3493-8. 2010..Although the described traps offer a method for rapid inhibition of dynein function, the design principle can be extended to other molecular complexes for in vivo studies... - Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferationSatoshi O Suzuki
Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, 812 8582 Fukuoka, Japan
Acta Neuropathol 113:591-9. 2007..These findings are compatible with the idea that LIS1 and its interacting proteins play a role in glioma migration and proliferation analogous to their role during brain development... - Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore functionChin Yin Tai
University of Massachusetts Medical School, Department of Cell Biology, Worcester, MA 01605, USA
J Cell Biol 156:959-68. 2002..Together, our data suggest a novel role for LIS1 in mediating CLIP-170-dynein interactions and in coordinating dynein cargo-binding and motor activities... - Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitorsGuangyu Zhu
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Med Chem 49:2063-76. 2006..The inhibitory effect of purealin was concentration dependent and uncompetitive, supporting the hypothesis that it does not compete with the binding of ATP... - Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complexJohn C Williams
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 104:10028-33. 2007..These data suggest that, in the dynein complex, the LCs do not bind cargo, in apparent disagreement with a role for LCs in dynein cargo binding interactions... - A requirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organizationBrian T Helfand
Northwestern University School of Medicine, Department of Cell and Molecular Biology, Chicago, IL 60611, USA
J Cell Biol 157:795-806. 2002..Furthermore, these motors are to a large extent responsible for the long recognized relationships between vimentin IFs and MTs... - Cytoplasmic dynein nomenclatureK Kevin Pfister
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Cell Biol 171:411-3. 2005..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms... - Crystal structure of the GTPase domain of rat dynamin 1Thomas F Reubold
Abteilung Biophysik, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 102:13093-8. 2005..Our results support a model in which switch I residue Arg-59 gates GTP binding in an assembly-dependent manner and the GTPase effector domain functions as an assembly-dependent GTPase activating protein in the fashion of RGS-type GAPs... - Molecular motors: A magnificent machineRichard B Vallee
Nature 421:701-2. 2003 - Differential regulation of dynein-driven melanosome movementAmy R Reilein
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Biochem Biophys Res Commun 309:652-8. 2003..Our data indicate that melanosome-associated dynein is regulated independently of bulk cytoplasmic dynein and involves a subfraction of dynein with a distinct subunit composition... - Dynein at the cortexDenis L Dujardin
University of Massachusetts Medical School, Biotech 4, Suite 312, 377 Plantation Street, Worcester, Massachusetts 01605, USA
Curr Opin Cell Biol 14:44-9. 2002..The possibility that a cortically bound form of dynein might represent its most ancient evolutionary state is discussed...
Research Grants
- Mechanism of Action of the Lissencephaly Gene LIS-1RICHARD BERT VALLEE; Fiscal Year: 2011..These studies are of considerable relevance to understanding normal and abnormal brain development, cell migration, cell division, the causes of mental retardation, and stem cell behavior. ..
- Molecular Genetics of Cytoplasmic DyeinRichard Vallee; Fiscal Year: 2009..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
- Molecular Genetics of Cytoplasmic DyeinRICHARD BERT VALLEE; Fiscal Year: 2010..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
- Molecular Genetics of Cytoplasmic DyeinRichard Vallee; Fiscal Year: 2009..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
- Mechanism of Action of the Lissencephaly Gene LIS-1Richard Vallee; Fiscal Year: 2007..These studies are of considerable relevance to understanding normal and abnormal brain development, cell migration, cell division, the causes of mental retardation, and stem cell behavior. ..
- MECHANISM OF ACTION OF THE LISSENCEPHALY GENES LIS-1Richard Vallee; Fiscal Year: 2004....