BENJAMIN contact TYCKO

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease
    Eleni S Athan
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Neurol 59:1793-9. 2002
  2. pmc Altered DNA methylation in leukocytes with trisomy 21
    Kristi Kerkel
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA
    PLoS Genet 6:e1001212. 2010
  3. pmc Epigenomic insights into common disease
    Kate Revill
    Cold Spring Harbor Laboratory, New York, NY 11794, USA
    Genome Med 3:71. 2011
  4. pmc Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation
    Catherine A Lynch
    Cancer and Ageing Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, United Kingdom
    Mol Cancer 1:2. 2002
  5. pmc TP73 allelic expression in human brain and allele frequencies in Alzheimer's disease
    Quanyi Li
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    BMC Med Genet 5:14. 2004
  6. pmc Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Med Genet 7:24. 2006
  7. pmc The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface
    Lorraine Clark
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Genet 3:11. 2002
  8. ncbi The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers
    Benjamin Tycko
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Curr Mol Med 7:479-89. 2007
  9. pmc Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS
    Benjamin Tycko
    Institute for Cancer Genetics and Taub Institute, Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Am J Hum Genet 86:109-12. 2010
  10. ncbi Imprinted genes in placental growth and obstetric disorders
    B Tycko
    Institute for Cancer Genetics, Department of Pathology, Columbia University, New York, NY 10032, USA
    Cytogenet Genome Res 113:271-8. 2006

Research Grants

  1. Epigenomics of Alzheimer's Disease
    BENJAMIN contact TYCKO; Fiscal Year: 2010
  2. Allele-specific Mapping in Alzheimer's Disease
    BENJAMIN contact TYCKO; Fiscal Year: 2010
  3. Epigenomics of Alzheimer's Disease
    Benjamin Tycko; Fiscal Year: 2009
  4. Genomic and Epigenomic Profiling by MSNP
    Benjamin Tycko; Fiscal Year: 2007
  5. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2007
  6. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2006
  7. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2005
  8. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2004
  9. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2003
  10. MONOALLELIC EXPRESSION OF HUMAN GENES
    Benjamin Tycko; Fiscal Year: 2002

Detail Information

Publications49

  1. ncbi Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease
    Eleni S Athan
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Neurol 59:1793-9. 2002
    ..Missense mutations in the amyloid precursor protein (APP) gene cause early-onset Alzheimer disease (AD). However, little is known regarding the effects of polymorphisms in regulatory sequences of APP on AD susceptibility...
  2. pmc Altered DNA methylation in leukocytes with trisomy 21
    Kristi Kerkel
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA
    PLoS Genet 6:e1001212. 2010
    ..We conclude that altered gene-specific DNA methylation is a recurrent and functionally relevant downstream response to trisomy 21 in human cells...
  3. pmc Epigenomic insights into common disease
    Kate Revill
    Cold Spring Harbor Laboratory, New York, NY 11794, USA
    Genome Med 3:71. 2011
    ..A report on the Wellcome Trust Scientific Conference 'Epigenomics of Common Diseases', Hinxton, Cambridge, UK, September 13-16, 2011...
  4. pmc Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation
    Catherine A Lynch
    Cancer and Ageing Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, United Kingdom
    Mol Cancer 1:2. 2002
    ..Recent work has suggested that methylation of a gene may lead to deacetylation of its associated histones and that silenced genes can be reactivated by increasing histone acetylation levels...
  5. pmc TP73 allelic expression in human brain and allele frequencies in Alzheimer's disease
    Quanyi Li
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    BMC Med Genet 5:14. 2004
    ..TP73 mRNA is transcribed from three promoters, termed P1-P3, and there is evidence for an additional complexity in its regulation, namely, a variable allelic expression bias in some human tissues...
  6. pmc Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Med Genet 7:24. 2006
    ..Down syndrome (DS) is caused by trisomy 21 (+21), but the aberrations in gene expression resulting from this chromosomal aneuploidy are not yet completely understood...
  7. pmc The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface
    Lorraine Clark
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Genet 3:11. 2002
    ..Although other genes in this chromosomal region show conserved synteny with genes on human Chr11p15.5, there are no obvious human orthologues of Tnfrh1 or Tnfrh2...
  8. ncbi The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers
    Benjamin Tycko
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Curr Mol Med 7:479-89. 2007
    ..The identities of these genes will likely suggest new targeted therapies for urological malignancies...
  9. pmc Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS
    Benjamin Tycko
    Institute for Cancer Genetics and Taub Institute, Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA
    Am J Hum Genet 86:109-12. 2010
    ..But this paper and recent work from other laboratories(2,3) raises the possibility of a more immediate and practical application for ASM mapping, namely to help extract maximum information from genome-wide association studies...
  10. ncbi Imprinted genes in placental growth and obstetric disorders
    B Tycko
    Institute for Cancer Genetics, Department of Pathology, Columbia University, New York, NY 10032, USA
    Cytogenet Genome Res 113:271-8. 2006
    ..Here we review this area and describe recent data indicating altered expression of imprinted genes in the placental response to maternal vascular underperfusion associated with IUGR...
  11. pmc Allele-specific DNA methylation: beyond imprinting
    Benjamin Tycko
    Institute for Cancer Genetics and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Hum Mol Genet 19:R210-20. 2010
    ....
  12. ncbi Genetic and epigenetic mosaicism in cancer precursor tissues
    Benjamin Tycko
    Institute for Cancer Genetics and Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Ann N Y Acad Sci 983:43-54. 2003
    ..Here I review this evidence, focusing on loss of heterozygosity (LOH) and gain of DNA methylation...
  13. ncbi Physiological functions of imprinted genes
    Benjamin Tycko
    Institute for Cancer Genetics, Columbia University, New York, New York, USA
    J Cell Physiol 192:245-58. 2002
    ..otago.ac.nz/IGC) containing a comprehensive database of imprinted genes. Ultimately, these data will answer the long-debated question of whether there is a coherent biological rationale for imprinting...
  14. ncbi DNA methylation in genomic imprinting
    B Tycko
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mutat Res 386:131-40. 1997
    ....
  15. ncbi APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals
    Benjamin Tycko
    Department of Pathology, Division of Neuropathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Arch Neurol 61:1434-9. 2004
    ..Polymorphisms in regulatory sequences of APOE have also been related to AD, but the effects are inconsistent across studies...
  16. ncbi Biallelic expression of HRAS and MUCDHL in human and mouse
    Michael Goldberg
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Hum Genet 112:334-42. 2003
    ..5...
  17. ncbi Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease
    Joseph H Lee
    Gertrude H Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 63:1591-8. 2006
    ..To identify novel candidate regions for late-onset Alzheimer disease (LOAD) and to confirm linkage in previously identified chromosomal regions...
  18. ncbi Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics
    Lucia Olarte
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 63:1586-90. 2006
    ..The primary effect of the apolipoprotein E epsilon4 (APOE epsilon4) allele is on the age at onset of Alzheimer disease (AD)...
  19. ncbi Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors
    Eric Yuan
    Institute for Cancer Genetics, Division of Pathology, Columbia University Medical Center, New York, New York 10032, USA
    Mol Cancer Res 3:493-502. 2005
    ..The data further suggest a biological difference between sporadic Wilms' tumors with and without LOI...
  20. ncbi Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1
    Anjana Saxena
    Institute for Cancer Genetics, Department of Pathology, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    J Biol Chem 277:49935-44. 2002
    ..Thus, Ipl and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs...
  21. pmc Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, G H Sergievsky Center, New York, NY, USA
    Dement Geriatr Cogn Disord 25:476-82. 2008
    ..Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD...
  22. pmc Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (carriers of the epsilon4 allele)
    Nikolaos Scarmeas
    Departments of Neurology, College of Physicians and Surgeons of Columbia University Medical Center 622 West 168th St, PH 19th floor New York, NY 10032, USA
    Am J Geriatr Psychiatry 12:596-605. 2004
    ..The authors investigated APOE-mediated differential brain activation in a group of healthy elderly subjects...
  23. ncbi Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line
    John Jakob
    Institute for Cancer Genetics, Columbia University, Russ Berrie Pavilion, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Genes Chromosomes Cancer 42:372-83. 2005
    ..These data support the concept that two independent tumor-suppressor loci exist at chromosome segment 18q21.1, one at SMAD4 and the other potentially at an enhancer of DCC or an unrelated novel gene...
  24. pmc CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors
    Chi Ming Li
    Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Am J Pathol 165:1943-53. 2004
    ..Beta-Catenin stabilization can initiate tumorigenesis in other systems, and this mechanism is likely critical in tumor formation after loss of WT1...
  25. doi Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation
    Kristi Kerkel
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Genet 40:904-8. 2008
    ..This recurrent phenomenon of sequence-dependent ASM has practical implications for mapping and interpreting associations of noncoding SNPs and haplotypes with human phenotypes...
  26. ncbi Immunohistochemistry for the imprinted gene product IPL/PHLDA2 for facilitating the differential diagnosis of complete hydatidiform mole
    Harshwardhan M Thaker
    Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    J Reprod Med 49:630-6. 2004
    ..To determine if immunohistochemistry for PHLDA2 (also known as IPL and TSSC3), the product of a paternally imprinted, maternally expressed gene, can be used as a tool in the differential diagnosis of molar gestations...
  27. ncbi The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts
    Lorraine N Clark
    Department of Pathology, Columbia University, New York, NY, USA
    Neurosci Lett 347:17-20. 2003
    ..7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P=0.2)...
  28. ncbi Onset of dementia is associated with age at menopause in women with Down's syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Ann Neurol 54:433-8. 2003
    ..Our findings support the hypothesis that reductions in estrogens after menopause contribute to the cascade of pathological processes leading to AD...
  29. ncbi Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE
    Stavra N Romas
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 59:87-91. 2002
    ....
  30. ncbi Chromosome arm 16q in Wilms tumors: unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene
    Albert Yeh
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Genes Chromosomes Cancer 35:156-63. 2002
    ..These data argue against the CTCF gene as a target of Chr16 LOH in WTs, but leave open the possibility that post-transcriptional loss of CTCF protein may account for some instances of LOI...
  31. ncbi Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys
    Michael Goldberg
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Am J Physiol Renal Physiol 283:F454-63. 2002
    ..These results suggest that although human mu-protocadherin may mediate a homotypic adhesive interaction, it may have additional functions in terminally differentiated epithelia...
  32. pmc Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?
    Tamas A Gonda
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, United States
    Semin Cell Dev Biol 21:2-10. 2010
    ....
  33. pmc Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University, New York, New York, USA
    Am J Pathol 160:2181-90. 2002
    ..The WT-signature set also contained the Wnt receptor FZD7, the tumor antigen PRAME, the imprinted gene NNAT and the metastasis-associated transcription factor E1AF...
  34. pmc Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease
    Joseph H Lee
    The Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Neurogenetics 9:51-60. 2008
    ..The novel loci at 5q15, 17q25.1, 13q33, and 17p13 and the previously reported loci at 7q36.3, 12q13, 14q23, and 14q32 need further investigation...
  35. pmc Placental overgrowth in mice lacking the imprinted gene Ipl
    Dale Frank
    Institute for Cancer Genetics, Department of Pathology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:7490-5. 2002
    ..The data further indicate that Ipl can act, at least in part, independently of insulin-like growth factor-2 signaling. Thus, genomic imprinting regulates multiple pathways to control placental size...
  36. ncbi A single nucleotide polymorphism chip-based method for combined genetic and epigenetic profiling: validation in decitabine therapy and tumor/normal comparisons
    Eric Yuan
    Institute for Cancer Genetics, Columbia University Medical Center, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cancer Res 66:3443-51. 2006
    ..MSNP simultaneously detects aberrations in DNA copy number and loss of heterozygosity, making it a generally useful approach for combined genetic and epigenetic profiling in tissue samples from cancer patients...
  37. pmc Global hypomethylation of genomic DNA in cancer-associated myofibroblasts
    Le Jiang
    Institute for Cancer Genetics and Department of Medicine, Columbia University, New York, New York 10032, USA
    Cancer Res 68:9900-8. 2008
    ....
  38. ncbi Preservation of cognitive and functional ability as markers of longevity
    Nicole Schupf
    G H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease, Department of Epidemiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurobiol Aging 25:1231-40. 2004
    ..The results of the present study identify phenotypes associated with preserved cognitive and functional abilities which may serve as markers for longevity...
  39. ncbi Placental growth retardation due to loss of imprinting of Phlda2
    Martha Salas
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Mech Dev 121:1199-210. 2004
    ..Consistent with this conclusion, we observed significant placental stunting in BAC-transgenic mice that over-expressed Phlda2 and one flanking gene, Slc22a1l, but did not over-express Cdkn1c...
  40. ncbi Thirtyfold multiplex genotyping of the p53 gene using solid phase capturable dideoxynucleotides and mass spectrometry
    Sobin Kim
    Columbia Genome Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Genomics 83:924-31. 2004
    ..This is the highest level of multiplex genotyping reported thus far using MS, indicating that the approach might be applicable to screening a repertoire of genotypes in candidate genes as potential disease markers...
  41. pmc Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices
    Yurong Xin
    Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, New York, United States of America
    PLoS ONE 5:e11357. 2010
    ..Large-scale whole genome DNA methylation profiling of the normal human brain offers tremendous potential in understanding the role of DNA methylation in brain development and function...
  42. ncbi Faithful tissue-specific expression of the human chromosome 21-linked COL6A1 gene in BAC-transgenic mice
    Luzhou Xing
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, New York 10032, USA
    Mamm Genome 18:113-22. 2007
    ..The lack of a strong cardiac or skin phenotype in the COL6A1 BAC-transgenic mice suggests that the increased expression of this gene does not, by itself, account for these phenotypes in Down syndrome...
  43. pmc Regulation of supply and demand for maternal nutrients in mammals by imprinted genes
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    J Physiol 547:35-44. 2003
    ..These data and hypotheses are important, as deregulation of supply and demand affects fetal growth and has long term consequences for health in mammals both in the neonatal period and, as a result of fetal programming, in adulthood...
  44. ncbi The history of cancer epigenetics
    Andrew P Feinberg
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Rev Cancer 4:143-53. 2004
  45. ncbi Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 390:93-7. 2005
    ..These results suggest that the apolipoprotein E epsilon4 allele has an independent and strong relation to early mortality...
  46. ncbi Genomic imprinting: piece of cake
    Benjamin Tycko
    Nature 417:913-4. 2002
  47. pmc A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16
    Marianne K H Kim
    Division of Hematology Oncology, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    Neoplasia 10:69-78. 2008
    ..These data suggest that IFI16 and WT1, in certain cellular context including sporadic Wilms tumors, may support cell survival...
  48. doi Successful aging in a 70-year-old man with down syndrome: a case study
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Intellect Dev Disabil 46:215-28. 2008
    ..The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome...
  49. pmc Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome
    Warren B Zigman
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    Neurosci Lett 416:279-84. 2007
    ..402, p=.095, 95% CI: .138, 1.173). If the protective effects of statins can be further validated, these findings suggest that their use may delay or prevent AD onset in vulnerable populations...

Research Grants18

  1. Epigenomics of Alzheimer's Disease
    BENJAMIN contact TYCKO; Fiscal Year: 2010
    ....
  2. Allele-specific Mapping in Alzheimer's Disease
    BENJAMIN contact TYCKO; Fiscal Year: 2010
    ..By this strategy we expect to be able to more confidently identify genes that affect susceptibility to AD. ..
  3. Epigenomics of Alzheimer's Disease
    Benjamin Tycko; Fiscal Year: 2009
    ....
  4. Genomic and Epigenomic Profiling by MSNP
    Benjamin Tycko; Fiscal Year: 2007
    ..Data from MSNP are expected to shed light on cancer pathogenesis and produce new and robust markers for cancer diagnosis and detection. ..
  5. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2007
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  6. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2006
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  7. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2005
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  8. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2004
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  9. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2003
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  10. MONOALLELIC EXPRESSION OF HUMAN GENES
    Benjamin Tycko; Fiscal Year: 2002
    ..Finally, they will test the hypothesis that the untranslated H19 RNA acts in trans to inhibit the translation of growth-promoting mRNAs. ..
  11. MONOALLELIC EXPRESSION OF HUMAN GENES
    Benjamin Tycko; Fiscal Year: 2000
    ..Finally, they will test the hypothesis that the untranslated H19 RNA acts in trans to inhibit the translation of growth-promoting mRNAs. ..
  12. MONOALLELIC EXPRESSION OF HUMAN GENES
    Benjamin Tycko; Fiscal Year: 1999
    ..Finally, they will test the hypothesis that the untranslated H19 RNA acts in trans to inhibit the translation of growth-promoting mRNAs. ..
  13. MONOALLELIC EXPRESSION OF HUMAN GENES
    Benjamin Tycko; Fiscal Year: 2001
    ..Finally, they will test the hypothesis that the untranslated H19 RNA acts in trans to inhibit the translation of growth-promoting mRNAs. ..