BENJAMIN contact TYCKO
Affiliation: Columbia University
Tycko B. DNA methylation in genomic imprinting. Mutat Res. 1997;386:131-40 pubmed
Tycko B. Imprinted genes in placental growth and obstetric disorders. Cytogenet Genome Res. 2006;113:271-8 pubmed
..Here we review this area and describe recent data indicating altered expression of imprinted genes in the placental response to maternal vascular underperfusion associated with IUGR. ..
Mendioroz M, Do C, Jiang X, Liu C, Darbary H, Lang C, et al
. Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models. Genome Biol. 2015;16:263 pubmed publisher
..These data point to novel biological mechanisms in DS and have general implications for trans effects of chromosomal duplications and aneuploidies on epigenetic patterning. ..
Tycko B. Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS. Am J Hum Genet. 2010;86:109-12 pubmed publisher
..But this paper and recent work from other laboratories(2,3) raises the possibility of a more immediate and practical application for ASM mapping, namely to help extract maximum information from genome-wide association studies. ..
Shen J, Lefave C, Sirosh I, Siegel A, Tycko B, Santella R. Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas. BMC Med Genomics. 2015;8:28 pubmed publisher
..These results suggest that integrative analyses of epigenomic and genomic data provide an efficient way to filter functional biomarkers for future epidemiological studies in human cancers. ..
Do C, Lang C, Lin J, Darbary H, Krupska I, Gaba A, et al
. Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation. Am J Hum Genet. 2016;98:934-955 pubmed publisher