Nikolaos Tezapsidis

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Obesity-related leptin regulates Alzheimer's Abeta
    Darius C Fewlass
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    FASEB J 18:1870-8. 2004
  2. ncbi request reprint Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutation
    Jane M Johnston
    Department of Pharmacology and Physiology, Medical Sciences Building, University of Medicine, Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103 2714, USA
    Neurosci Lett 395:159-64. 2006
  3. ncbi request reprint Microtubular interactions of presenilin direct kinesis of Abeta peptide and its precursors
    Nikolaos Tezapsidis
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, P and S 15 408, 630 W 168th St, New York, NY 10032, USA
    FASEB J 17:1322-4. 2003
  4. pmc Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells
    Steven J Greco
    Neurotez Inc, Bridgewater, NJ, USA
    Biochem Biophys Res Commun 376:536-41. 2008

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Obesity-related leptin regulates Alzheimer's Abeta
    Darius C Fewlass
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    FASEB J 18:1870-8. 2004
    ..Thus, leptin can modulate bidirectional Abeta kinesis, reducing its levels extracellularly. Most strikingly, chronic administration of leptin to AD-transgenic animals reduced the brain Abeta load, underlying its therapeutic potential...
  2. ncbi request reprint Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutation
    Jane M Johnston
    Department of Pharmacology and Physiology, Medical Sciences Building, University of Medicine, Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103 2714, USA
    Neurosci Lett 395:159-64. 2006
    ..This indicates that PS1 mutation may introduce aberrations in the intracellular Ca2+ mobilization in astrocytes contributing to the accelerated pathogenesis in FAD...
  3. ncbi request reprint Microtubular interactions of presenilin direct kinesis of Abeta peptide and its precursors
    Nikolaos Tezapsidis
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Pathology, College of Physicians and Surgeons, Columbia University, P and S 15 408, 630 W 168th St, New York, NY 10032, USA
    FASEB J 17:1322-4. 2003
    ..However, this approach may be hampered by a low efficiency, because it may also block Abeta clearance from the interstitial space of the CNS...
  4. pmc Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells
    Steven J Greco
    Neurotez Inc, Bridgewater, NJ, USA
    Biochem Biophys Res Commun 376:536-41. 2008
    ..Thus, leptin, which ameliorates both amyloid beta and tau-related pathological pathways, holds promise as a novel therapeutic for Alzheimer's disease...