Marc Tatar

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Gen Comp Endocrinol 142:347-56. 2005
  2. ncbi request reprint Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    Dae Sung Hwangbo
    Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nature 429:562-6. 2004
  3. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008
  4. pmc Juvenile hormone regulation of Drosophila aging
    Rochele Yamamoto
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA
    BMC Biol 11:85. 2013
  5. pmc Drosophila lifespan control by dietary restriction independent of insulin-like signaling
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 7:199-206. 2008
  6. pmc Drosophila germ-line modulation of insulin signaling and lifespan
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 105:6368-73. 2008
  7. pmc Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Aging Cell 11:978-85. 2012
  8. pmc Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin
    Alan O Bergland
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
    PLoS Genet 8:e1002631. 2012
  9. ncbi request reprint The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
    Aging Cell 1:75-80. 2002
  10. ncbi request reprint Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Mutations in insulin signaling pathway alter juvenile hormone synthesis in Drosophila melanogaster
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Gen Comp Endocrinol 142:347-56. 2005
    ....
  2. ncbi request reprint Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    Dae Sung Hwangbo
    Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nature 429:562-6. 2004
    ..These findings suggest that autonomous and non-autonomous roles of insulin signalling combine to control ageing...
  3. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008
    ..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge...
  4. pmc Juvenile hormone regulation of Drosophila aging
    Rochele Yamamoto
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA
    BMC Biol 11:85. 2013
    ..With this system we test potential explanations for how juvenile hormone modulates aging...
  5. pmc Drosophila lifespan control by dietary restriction independent of insulin-like signaling
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 7:199-206. 2008
    ....
  6. pmc Drosophila germ-line modulation of insulin signaling and lifespan
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 105:6368-73. 2008
    ..These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved...
  7. pmc Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Aging Cell 11:978-85. 2012
    ..dilp6 thus appears to bridge dFOXO, adipose tissue and brain endocrine function to regulate Drosophila longevity...
  8. pmc Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin
    Alan O Bergland
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
    PLoS Genet 8:e1002631. 2012
    ..Taken together these data suggest that natural variation in Drip expression in the corazonin producing neurons contributes to standing variation in fitness by altering the concentration of two neurohormones...
  9. ncbi request reprint The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
    Aging Cell 1:75-80. 2002
    ..Remarkably, in similarly sized cohorts of male and female ch1/ch1 and of male ch1/+ mortality deceleration is absent. Mortality deceleration is a phenotype of chico...
  10. ncbi request reprint Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
  11. pmc Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America
    PLoS Genet 9:e1003941. 2013
    ..Reduced insulin secretion from the brain may subsequently reinforce longevity assurance through decreased systemic insulin/IGF signaling. ..
  12. pmc Counting calories in Drosophila diet restriction
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Exp Gerontol 42:247-51. 2007
    ..Since caloric intake correlates with yeast concentration and thus with the intake of every metabolite in this dietary component, it is premature to conclude for Drosophila that calories do not explain extension of life span...
  13. ncbi request reprint Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Box G W, Brown University, Providence, RI 02912, USA
    Aging Cell 2:327-33. 2003
    ..Although nutritional conditions of the larvae can affect the subsequent body size and fecundity of adults, these are not sufficient to slow aging...
  14. ncbi request reprint High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO
    Boris Gershman
    Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Physiol Genomics 29:24-34. 2007
    ....
  15. pmc Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan
    Rochele Yamamoto
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 10:729-32. 2011
    ....
  16. pmc Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models?
    Marc Tatar
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Gerontol A Biol Sci Med Sci 64:161-3. 2009
    ..It was the consensus of the working session that making healthspan an operational metric would be an innovation needed for the genetic power of model systems to address this aspect of human aging...
  17. ncbi request reprint Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants
    Meng Ping Tu
    Brown University, Providence, Rhode Island 02912, USA
    Aging Cell 1:158-60. 2002
  18. pmc Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity
    Alina Garbuzov
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA
    Fly (Austin) 4:306-11. 2010
    ..We conclude that 20-HE facilitates the initial expression of innate immunity while it simultaneously induces negative regulation via microRNA control of antimicrobial peptide translation...
  19. ncbi request reprint The neuroendocrine regulation of Drosophila aging
    Marc Tatar
    Division of Biology and Medicine, Brown University, Box G W, Providence, Rhode Island 02192, USA
    Exp Gerontol 39:1745-50. 2004
    ....
  20. pmc A role for Drosophila dFoxO and dFoxO 5'UTR internal ribosomal entry sites during fasting
    Eugenia Villa-Cuesta
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e11521. 2010
    ..IRES mediated translation of dFoxO and dInR may be essential to ensure function and sensitivity of the insulin signaling pathway during fasting...
  21. pmc Reproductive aging in invertebrate genetic models
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Ann N Y Acad Sci 1204:149-55. 2010
    ..elegans and D. melanogaster appears to be regulated by signaling that depends on the presence of germline stem cells in the adult gonad. These invertebrate models provide powerful tools to dissect conserved causes of reproductive aging...
  22. pmc Quantitative trait loci affecting phenotypic plasticity and the allometric relationship of ovariole number and thorax length in Drosophila melanogaster
    Alan O Bergland
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Genetics 180:567-82. 2008
    ..The results are discussed in the context of multivariate trait evolution...
  23. ncbi request reprint A smell to die for
    Marc Tatar
    Department Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Dev Cell 12:322-4. 2007
    ..How dietary restriction extends life span may involve anticipatory neurons. The odor of dietary yeast is sufficient to speed Drosophila aging while mutants of an odorant-binding protein extend life span...
  24. ncbi request reprint Unearthing Loci that influence life span
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Sci Aging Knowledge Environ 2003:PE5. 2003
    ..In this Perspective, I discuss the implications of this result in the context of gene regulation and mechanisms of aging...
  25. ncbi request reprint Restriction of amino acids extends lifespan in Drosophila melanogaster
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Mech Ageing Dev 127:643-6. 2006
    ..Dietary restriction through dilution of yeast may extend longevity because this limits the intake of amino acids...
  26. ncbi request reprint Comment on "Long-lived Drosophila with overexpressed dFOXO in adult fat body"
    Marc Tatar
    Brown University, Division of Biology and Medicine, Box G W, Providence, RI 02912, USA
    Science 307:675; author reply 675. 2005
  27. pmc Resveratrol inhibits protein translation in hepatic cells
    Eugenia Villa-Cuesta
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 6:e29513. 2011
    ..We conclude that resveratrol is an inhibitor of global protein synthesis, and that this effect is mediated through modulation of mTOR-dependent and independent signaling...
  28. doi request reprint Metabolism by remote control
    Marc Tatar
    Brown University, Providence, RI 02912, USA
    Cell Metab 10:164-6. 2009
    ..In this issue of Cell Metabolism, GĂ©minard et al. (2009) describe how secretion of insulin-like peptides is remotely controlled by the fat body (an adipose, liver-like tissue) in response to dietary amino acids...
  29. ncbi request reprint SIR2 calls upon the ER
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Cell Metab 2:281-2. 2005
    ..Paradoxically, these stress genes are repressed by SIR2, suggesting that resveratrol increases life span by inhibiting this SIR2 action...
  30. ncbi request reprint Regulation of aging by germline stem cells
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Sci Aging Knowledge Environ 2002:pe2. 2002
    ..The author compares the new results to previous findings in the fruit fly and discusses possible mechanisms behind the inverse relationship between reproduction and life-span extension...
  31. ncbi request reprint Resource allocation to reproduction and soma in Drosophila: a stable isotope analysis of carbon from dietary sugar
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    J Insect Physiol 52:763-70. 2006
    ..Because carbon from larval sucrose appears to be fairly "replaceable", larval sucrose cannot be a limiting substrate in resource allocation between reproduction and lifespan...
  32. ncbi request reprint Drosophila diet restriction in practice: do flies consume fewer nutrients?
    Kyung Jin Min
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Mech Ageing Dev 127:93-6. 2006
    ..To understand the importance of specific nutrients relative to calories as mediators of Drosophila aging, we must directly measure food intake and control for the feeding stimulation of nutrients...
  33. pmc The plate half-full: status of research on the mechanisms of dietary restriction in Drosophila melanogaster
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Exp Gerontol 46:363-8. 2011
    ..Strong analyses of genes required for DR should be a priority in future research with Drosophila and this may be made most robust by considering the effect of mutants in the context of the geometric framework...
  34. ncbi request reprint Diet restriction in Drosophila melanogaster. Design and analysis
    Marc Tatar
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Interdiscip Top Gerontol 35:115-36. 2007
    ..Finally, it remains unknown whether or not DR functions through insulin-related signaling...
  35. ncbi request reprint Aging of the innate immune response in Drosophila melanogaster
    Melissa Zerofsky
    Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
    Aging Cell 4:103-8. 2005
    ..Consequently, maximum reproduction will occur when the immune response is tightly controlled in young females, even if this increases infection risk at later ages...
  36. pmc Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation
    Nicola Neretti
    Institute for Brain and Neural Systems, Brown University, Providence RI, USA
    BMC Bioinformatics 8:S16. 2007
    ....
  37. pmc Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster
    Rachel Whitaker
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence RI, 02912, USA
    Aging (Albany NY) 6:355-68. 2014
    ....
  38. ncbi request reprint The endocrine regulation of aging by insulin-like signals
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 299:1346-51. 2003
    ....
  39. ncbi request reprint Aging. Dietary advice on Q
    Marc Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 295:54-5. 2002