Research Topics
Genomes and GenesSpecies | Deliang TangSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Effects of prenatal exposure to coal-burning pollutants on children's development in ChinaDeliang Tang
Mailman School of Public Health, Columbia University, Department of Environmental Health Sciences, Columbia University, New York, NY 10032 USA
Environ Health Perspect 116:674-9. 2008..Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs), lead, and mercury are released by combustion of coal and other fossil fuels...- Grilled meat consumption and PhIP-DNA adducts in prostate carcinogenesisDeliang Tang
Environmental Health Science, Columbia University Mailman School of Public Health, 630 W 168th Street, P and S 19 407, New York, NY, USA
Cancer Epidemiol Biomarkers Prev 16:803-8. 2007..Our results suggest that dietary interventions targeted at lower consumption of grilled red meats may reduce prostate cancer risk via the PhIP prostate carcinogenic pathway... - PAH-DNA adducts in cord blood and fetal and child development in a Chinese cohortDeliang Tang
Department of Environmental Health Sciences, and Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA, and Chongqing Children Hospital, China
Environ Health Perspect 114:1297-300. 2006..001), and 30 months of age (p<0.001). The findings suggest that exposure to elevated levels of PAHs, with the Tongliang power plant being a significant source, is associated with reduced fetal and child growth in this population... - Effect of gene-environment Interactions on mental development in African American, Dominican, and Caucasian mothers and newbornsShuang Wang
Department of Biostatistics, Columbia University, New York, NY 10032, USA
Ann Hum Genet 74:46-56. 2010..The strongest and most consistent effect observed was between PAH and haplotype ACCGGC of the CYP1B1 gene... - Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newbornsShuang Wang
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 17:405-13. 2008..However, with our limited sample size, the current findings are suggestive only, warranting further study... - Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center cohortFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 115:1497-502. 2007.... - Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city childrenFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 114:1287-92. 2006..The results require confirmation but suggest that environmental PAHs at levels recently encountered in New York City air may adversely affect children's cognitive development at 3 years of age, with implications for school performance... - Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damageFrederica P Perera
Mailman School of Public Health of Columbia University, Department of Environmental Health Sciences, New York, New York 10032, USA
Environ Health Perspect 112:1133-6. 2004..The findings have implications for risk assessment, given the need to protect children as a sensitive subset of the population... 
Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control studyDeliang Tang
Department of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York City, NY 10032, USA
Breast Cancer Res Treat 78:217-22. 2003..Contrary to our hypothesis PAH-DNA adduct levels in breast tissue were not associated with SULT1A1 genotype. Our findings are consistent with a prior report that the Arg/His polymorphism in SULT1A1 is associated with breast cancer risk...- Relation between cord blood mercury levels and early child development in a World Trade Center cohortSally Ann Lederman
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 116:1085-91. 2008..This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development... - Benefits of reducing prenatal exposure to coal-burning pollutants to children's neurodevelopment in ChinaFrederica Perera
Department of Environmental Health Sciences, Columbia University, New York, New York, USA
Environ Health Perspect 116:1396-400. 2008..PAHs are reproductive and developmental toxicants, mutagens, and carcinogens... - Relation between prenatal lipid-soluble micronutrient status, environmental pollutant exposure, and birth outcomesElizabeth T Masters
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Am J Clin Nutr 86:1139-45. 2007..Significant effects of environmental pollutants on birth outcomes have been observed in our study population, and nutritional status may be an additional factor influencing fetal development and effects of environmental toxins... - Urinary naphthol metabolites and chromosomal aberrations in 5-year-old childrenManuela A Orjuela
Department of Pediatrics, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 21:1191-202. 2012..Although prenatal (maternal) PAH exposure predicts chromosomal aberrations in cord blood, few studies have examined chromosomal aberrations in school-age children and none has examined their association with metabolites of specific PAHs... - Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 yearsFrederica P Perera
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 120:921-6. 2012.... - Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growthFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 113:1062-7. 2005..04). The findings suggest that exposure to elevated levels of PAHs, indicated by PAH-DNA adducts in cord blood, may have contributed to reduced fetal growth in women exposed to the WTC event... - Racial differences in clinical and pathological associations with PhIP-DNA adducts in prostateDeliang Tang
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA
Int J Cancer 121:1319-24. 2007..In conclusion, while PhIP-DNA adduct levels in prostate cells do not vary significantly by race, our results suggest that PhIP exposure may have stronger effects on prostate tumor differentiation in African-American men... - DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and ChinaFrederica Perera
Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, Columbia Center for Children s Environmental Health, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 14:709-14. 2005..The data support preventive policies to limit PAH exposure to pregnant women and children... - Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohortRobin M Whyatt
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Pediatrics 124:e1213-20. 2009..Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City... - Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health studyFrederica P Perera
Department of Environmental Health Sciences, Columbia Center for Children's Environmental Health, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 15:1417-9. 2006 - Modulation of the effect of prenatal PAH exposure on PAH-DNA adducts in cord blood by plasma antioxidantsElizabeth A Kelvin
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 18:2262-8. 2009..05; P = 0.165; among those with high carotenoids: beta = 0.06; P = 0.111). These results suggest a protective effect of micronutrients on the DNA damage and potential cancer risk associated with prenatal PAH exposure... - The interaction between alcohol consumption and GSTM1 genotype on polycyclic aromatic hydrocarbon-DNA adduct levels in breast tissueAndrew Rundle
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Cancer Epidemiol Biomarkers Prev 12:911-4. 2003..This apparent difference in PAH metabolism in response to alcohol may be an important clue as to how alcohol influences breast cancer risk... 
Modeling exposure to air pollution from the WTC disaster based on reports of perceived air pollutionSally Ann Lederman
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 100 Haven Avenue, 25F, New York, NY 10032, USA
Risk Anal 28:287-301. 2008..MAP developed from reports of PAP may be useful to identify high-risk areas and predict health outcomes when there are multiple sources of pollution and a "distance from source" analysis is impossible...- Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city childrenVirginia A Rauh
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Ave, B 109, New York, NY 10032, USA
Pediatrics 118:e1845-59. 2006..The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children... - Prenatal PAH exposure is associated with chromosome-specific aberrations in cord bloodManuela A Orjuela
Departments of Pediatrics Oncology, Environmental Health Sciences, Biostatistics and Genetics, Columbia University, New York, NY, United States
Mutat Res 703:108-14. 2010..The observed chromosome-specific effects of prenatal airborne PAHs raise concern about potential cancer risk... - Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokersLaverne A Mooney
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, Columbia University, New York, NY, USA
Cancer Epidemiol Biomarkers Prev 14:237-42. 2005..Although the results of this trial showthe potential chemopreventive role of antioxidants, thebest way for smokers to reduce their cancer risk remains smoking cessation... - Prenatal exposure to PBDEs and neurodevelopmentJulie B Herbstman
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, Columbia Center for Children s Environmental Health, New York, New York 10032, USA
Environ Health Perspect 118:712-9. 2010..Animal studies suggest that prenatal PBDE exposure may result in adverse neurodevelopmental effects... - Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancerDeliang Tang
Department of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Breast Cancer Res Treat 75:159-66. 2002..68 OD v.s. 0.40 OD, p = 0.01). The trend of increasing PAH-DNA adduct levels with either the Asn/Asn or Gln/Gln genotype was greater in tumor tissue than the trend in BBD control tissue... - Fluorescence in situ hybridization is necessary to detect an association between chromosome aberrations and polycyclic aromatic hydrocarbon exposure in utero and reveals nonrandom chromosome involvementKirsti A Bocskay
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
Environ Mol Mutagen 48:114-23. 2007..Together, these results suggest that PAHs may be targeting specific chromosomes and highlight the importance of using the more sensitive detection methods to assess risk in populations with low levels of exposure... - Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a]pyrene-DNA adducts, and genomic DNA methylation in cord bloodJulie B Herbstman
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York 10032, USA
Environ Health Perspect 120:733-8. 2012..Objective: We explored whether prenatal exposure to PAHs is associated with genomic DNA methylation in cord blood and whether methylation levels are associated with the presence of detectable PAH-DNA adducts... - Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohortMatthew S Perzanowski
Columbia Center for Children s Environmental Health CCCEH, New York, NY 10032, USA
Thorax 65:118-23. 2010.... - Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city childrenFrederica P Perera
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 119:1176-81. 2011..Prenatal PAH exposure measured by personal monitoring has been linked to cognitive deficits in childhood in a prospective study conducted by the Columbia Center for Children's Environmental Health... - Methods for detecting interactions between imprinted genes and environmental exposures using birth cohort designs with mother-offspring pairsShuang Wang
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Hum Hered 71:196-208. 2011.... - Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbonsKirsti A Bocskay
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, B-109, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 14:506-11. 2005..If confirmed, this finding may open new avenues for prevention... - Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort StudyFrederica P Perera
Division of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York City, NY 10032, USA
Carcinogenesis 23:1641-6. 2002..The findings underscore the complex and important role of biological susceptibility as a determinant of risk from carcinogens found in tobacco smoke and other environmental compounds... - Molecular evidence of an interaction between prenatal environmental exposures and birth outcomes in a multiethnic populationFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Avenue B 109, New York, NY 10032, USA
Environ Health Perspect 112:626-30. 2004..This study provides evidence that combined exposure to environmental pollutants at levels currently encountered in New York City adversely affects fetal development... - Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthmaFrederica Perera
The Columbia Center for Children s Environmental Health, Columbia University Mailman School of Public Health, New York, New York, United States of America
PLoS ONE 4:e4488. 2009..The results support the emerging theory of early origins of later life disease development... - Current needs and future directions of occupational safety and heath in a globalized worldFrederica P Perera
Mailman School of Public Health, Columbia University, New York, NY, United States
Neurotoxicology 33:805-9. 2012.... - Neighborhood socioeconomic status modifies the association between individual smoking status and PAH-DNA adduct levels in prostate tissueAndrew Rundle
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Environ Mol Mutagen 53:384-91. 2012..001). Neighborhood SES modifies the association between individual smoking status and PAH-DNA adduct levels in prostate tissue... - Association between the ras p21 oncoprotein in blood samples and breast cancerAndrew Rundle
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Cancer Lett 185:71-8. 2002..Ras p21 may be useful in the early detection of breast tumors and in post-surgical follow-up of patients, giving patients and physicians new tools for managing breast cancer... - Prenatal insecticide exposures and birth weight and length among an urban minority cohortRobin M Whyatt
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 112:1125-32. 2004..Findings support recent regulatory action to phase out residential uses of the insecticides... - Lack of association between physical activity in smokers and plasma glutathione peroxidase levelsAndrew Rundle
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Cancer Epidemiol Biomarkers Prev 17:1004-6. 2008 - A prospective study of socioeconomic status, prostate cancer screening and incidence among men at high risk for prostate cancerAndrew Rundle
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, NY 10032, USA
Cancer Causes Control 24:297-303. 2013..However, the extent to which screening explains this association has not been well quantified... - Children's environmental health research--highlights from the Columbia Center for Children's Environmental HealthFrederica Perera
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Ann N Y Acad Sci 1076:15-28. 2006..This article summarizes the recent findings from the Center's projects in the context of current research in children's environmental health... - Air pollution threatens the health of children in ChinaAlexander Millman
Columbia University, 100 Haven Ave, 25F, Tower 3, New York, NY 10032, USA
Pediatrics 122:620-8. 2008..DATA SOURCES/DATA EXTRACTION: To fill this gap, we reviewed relevant published environmental studies, biomedical and molecular/epidemiologic research, and economic and policy analyses... - Molecular epidemiologic studies of polycyclic aromatic hydrocarbon-DNA adducts and breast cancerAndrew Rundle
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Mol Mutagen 39:201-7. 2002..14%). We hypothesize that the higher prevalence results from a referral bias and discuss how this may influence our results... - Elevated polycyclic aromatic hydrocarbon-DNA adducts in benign prostate and risk of prostate cancer in African AmericansDeliang Tang
Department of Environmental Health Sciences, Columbia University, New York, NY, USA
Carcinogenesis 34:113-20. 2013.... - DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysisFabrizio Veglia
Life Sciences and Epidemiology Unit, ISI Foundation, Torino 10133, Italy
Carcinogenesis 29:932-6. 2008..The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years... - Polycyclic aromatic hydrocarbon--DNA adducts in prostate and biochemical recurrence after prostatectomyBenjamin A Rybicki
Departments of Biostatistics and Research Epidemiology and Surgical Pathology, Henry Ford Health System, Detroit, Michigan 48202, USA
Clin Cancer Res 14:750-7. 2008..DNA adduct levels may be influenced by metabolic activity, DNA repair capabilities, and genomic integrity, all of which play a role in cancer progression... - SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressivenessChristine Neslund-Dudas
Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI 48202, USA
Prostate 67:1654-63. 2007..Two polymorphisms, a valine (V) for leucine (L) substitution at the 89 codon of the SRD5A2 gene and a (TG)n,(TA)n,(CA)n repeat polymorphism within the third intron of the HSD3B2 gene were evaluated with regard to prostate cancer risk... - Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by raceNora L Nock
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
Cancer Epidemiol Biomarkers Prev 16:1236-45. 2007..2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05). We present evidence, for the first time in human prostate that the association between smoking and PAH-DNA adducts differs by race and is modified by common genetic variants... - Polycyclic aromatic hydrocarbon-DNA adducts in prostate cancerBenjamin A Rybicki
Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan, USA
Cancer Res 64:8854-9. 2004..Our results show that PAH-DNA adducts are present in the prostate but vary with regard to cellular histology. In prostate tumor cells, decreased cellular differentiation and increased tumor proliferation may reduce PAH-DNA adduct levels... - Exposure to PM2.5 and PAHs from the Tong Liang, China epidemiological studyJudith C Chow
Division of Atmospheric Sciences, Desert Research Institute, 2215 Raggio Parkway, Reno, NV, 89512, USA and Aerosol and Environmental Division, Institute of Earth Environment, Chinese Academy of Science, Xian, China corrected
J Environ Sci Health A Tox Hazard Subst Environ Eng 41:517-42. 2006..5 to 3.5 times during the coal-fired power plant operational period. However, further investigation is needed to determine the relative contribution from residential and utility coal combustion and vehicular activities... - Polycyclic aromatic hydrocarbon-DNA adduct formation in prostate carcinogenesisBenjamin A Rybicki
Department of Biostatistics and Research Epidemiology, Henry Ford Health System, 1 Ford Place 3E, Detroit, MI 48202, USA
Cancer Lett 239:157-67. 2006..We have demonstrated the presence of PAH-DNA adducts in prostate cancer cases, but further validation of this biomarker as a carcinogenic agent in human prostate is needed... - DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese populationSenqing Chen
Laboratory of Genetics, Jiangsu Institute for Cancer Research, Nanjing 210009, People s Republic of China
Carcinogenesis 23:1321-5. 2002..Our results suggested that the genotypes of XRCC1 194Trp/Trp and XPD 751 Lys allele might be the risk genotypes for lung cancer in Chinese population...
Research Grants
- CYCLIN D1 AS BIOMARKER OF BREAST CANCER RISKDeliang Tang; Fiscal Year: 2001..Once validated, this biomarker could be useful in the early detection, management and follow up of breast cancer. ..