Ira Tabas

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. Zhou A, Wang X, Lin C, Han J, Yong J, Nadolski M, et al. C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. Circ Res. 2015;116:1736-43 pubmed publisher
    ..The mechanisms involve newly discovered roles of CHOP in the transcriptional and post-translational regulation of KLF4. ..
  2. Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. Proc Natl Acad Sci U S A. 2014;111:14530-5 pubmed publisher
    ..Knowledge of this mechanism may provide new strategies for promoting inflammation resolution in chronic inflammatory diseases. ..
  3. Zheng Z, Nayak L, Wang W, Yurdagul A, Wang X, Cai B, et al. An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. Blood. 2018;: pubmed publisher
    ..The inverse correlation between DACH1 and ATF6/PLAT is conserved in human liver. These findings reveal a regulated pathway in hepatocytes that contributes to basal circulating levels of tPA and to fibrinolysis after vascular injury. ..
  4. Proto J, Doran A, Gusarova G, Yurdagul A, Sozen E, Subramanian M, et al. Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity. 2018;49:666-677.e6 pubmed publisher
    ..These findings suggest an expanded role of Treg cells in inflammation resolution and provide a mechanistic basis for Treg-cell-enhancement strategies for non-resolving inflammatory diseases. ..
  5. Subramanian M, Thorp E, Tabas I. Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling. Circ Res. 2015;116:e13-24 pubmed publisher
    ..This action of GM-CSF is mediated by its interleukin-23-inducing activity rather than its role as a growth factor. ..
  6. Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol. 2011;13:184-90 pubmed publisher
    ..The molecular mechanisms linking ER stress to apoptosis are the topic of this review, with emphases on relevance to pathophysiology and integration and complementation among the various apoptotic pathways induced by ER stress. ..
  7. Tabas I, Glass C. Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science. 2013;339:166-72 pubmed publisher
    ..However, new advances in understanding inflammatory signaling and its links to resolution pathways, together with new drug development, offer promise in this area of translational biomedical research. ..
  8. Tabas I, García Cardeña G, Owens G. Recent insights into the cellular biology of atherosclerosis. J Cell Biol. 2015;209:13-22 pubmed publisher
    ..These advances illustrate how in-depth mechanistic knowledge of the cellular pathobiology of atherosclerosis can lead to new ideas for therapy. ..
  9. Tabas I. 2016 Russell Ross Memorial Lecture in Vascular Biology: Molecular-Cellular Mechanisms in the Progression of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2017;37:183-189 pubmed publisher
    ..Work in this area has the potential to potentiate the cardiovascular benefits of apoB-lipoprotein-lowering therapy. ..

More Information

Publications13

  1. Ozcan L, Ghorpade D, Zheng Z, de Souza J, Chen K, Bessler M, et al. Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance. Cell Rep. 2016;15:2214-2225 pubmed publisher
    ..Thus, DACH1-mediated corepression in hepatocytes emerges as an important link between obesity and insulin resistance. ..
  2. Wang X, Zheng Z, Caviglia J, Corey K, Herfel T, Cai B, et al. Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis. Cell Metab. 2016;24:848-862 pubmed publisher
    ..In summary, TAZ represents a previously unrecognized factor that contributes to the critical process of steatosis-to-NASH progression. ..
  3. Wang Y, Subramanian M, Yurdagul A, Barbosa Lorenzi V, Cai B, de Juan Sanz J, et al. Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Cell. 2017;171:331-345.e22 pubmed publisher
    ..Thus, mitochondrial fission in response to AC uptake is a critical process that enables macrophages to clear multiple ACs and to avoid the pathologic consequences of defective efferocytosis in vivo. ..
  4. Tabas I, Lichtman A. Monocyte-Macrophages and T Cells in Atherosclerosis. Immunity. 2017;47:621-634 pubmed publisher
    ..Herein, we review select topics that shed light on these processes and suggest new treatment strategies. ..