Yu Sun

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K
    Yu Sun
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 104:455-65. 2009
  2. ncbi Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Cancer Prev Res (Phila) 4:1052-60. 2011
  3. ncbi Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system
    Yu Sun
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794 8173, USA
    Breast Cancer Res 14:R20. 2012
  4. ncbi Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds
    Liqun Huang
    Department of Medicine, Division of Cancer Prevention, Stony Brook University, Stony Brook, New York 11794, USA
    Cancer Res 71:7617-27. 2011
  5. ncbi Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    Gastroenterology 139:1320-32. 2010
  6. ncbi Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts
    Caihua Zhu
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    Stem Cells 30:2065-75. 2012
  7. ncbi Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models
    Gang Xie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794 8173, USA
    J Pharmacol Exp Ther 337:876-86. 2011
  8. ncbi Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents
    Yu Sun
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York, USA
    J Pharmacol Exp Ther 338:775-83. 2011
  9. ncbi Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice
    Carrie L Welch
    Columbia University, Department of Medicine, P and S 8 401, 630 W 168th St, New York, NY 10032, USA
    Circulation 116:2444-52. 2007
  10. ncbi Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes
    Mingming Hao
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 279:14171-8. 2004

Collaborators

Detail Information

Publications15

  1. ncbi Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K
    Yu Sun
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 104:455-65. 2009
    ....
  2. ncbi Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Cancer Prev Res (Phila) 4:1052-60. 2011
    ..P-S/DFMO has an intricate mechanism of action extending beyond polyamines and including the thioredoxin system, an emerging regulator of chemoprevention. P-S/DFMO merits further evaluation...
  3. ncbi Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system
    Yu Sun
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794 8173, USA
    Breast Cancer Res 14:R20. 2012
    ..We investigated its efficacy and mechanism of action in the treatment of breast cancer in preclinical models...
  4. ncbi Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds
    Liqun Huang
    Department of Medicine, Division of Cancer Prevention, Stony Brook University, Stony Brook, New York 11794, USA
    Cancer Res 71:7617-27. 2011
    ..Taken together, our findings show the strong anticancer efficacy and promising safety of phospho-NSAIDs in preclinical models of breast, colon, and pancreatic cancer, suggesting further evaluation as anticancer agents...
  5. ncbi Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice
    Gerardo G MacKenzie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    Gastroenterology 139:1320-32. 2010
    ..However, chronic administration of NSAIDs is associated with significant side effects, mainly of the gastrointestinal tract. Given these limitations, we synthesized phospho-sulindac (P-S; OXT-328), a novel sulindac derivative...
  6. ncbi Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts
    Caihua Zhu
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794 8173, USA
    Stem Cells 30:2065-75. 2012
    ..These results indicate that PS has a strong inhibitory effect against breast cancer, acting, at least in part, by targeting CSCs through a signaling mechanism involving Wnt signaling...
  7. ncbi Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models
    Gang Xie
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794 8173, USA
    J Pharmacol Exp Ther 337:876-86. 2011
    ..These results provide a pharmacological basis to explain, at least in part, the anticancer efficacy and safety of this promising compound and indicate that PI merits further evaluation as an anticancer agent...
  8. ncbi Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents
    Yu Sun
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York, USA
    J Pharmacol Exp Ther 338:775-83. 2011
    ....
  9. ncbi Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice
    Carrie L Welch
    Columbia University, Department of Medicine, P and S 8 401, 630 W 168th St, New York, NY 10032, USA
    Circulation 116:2444-52. 2007
    ..However, other species are highly resistant to plaque complications, and the specific processes predisposing to plaque destabilization and thrombosis are poorly understood...
  10. ncbi Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes
    Mingming Hao
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 279:14171-8. 2004
    ....
  11. ncbi Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet
    Suzhao Li
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 105:1072-82. 2009
    ..Defective clearance of apoptotic cells by macrophages (efferocytosis) is thought to lead to increased necrotic core formation and inflammation in atherosclerotic lesions...
  12. ncbi Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion
    Yu Sun
    Division of Molecular Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Biol Chem 278:27688-94. 2003
    ..LXR and ABCA1-induced changes in membrane lipid organization had favorable effects on processing of APP, suggesting a new approach to the treatment of Alzheimer's disease...
  13. ncbi Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles
    Rongrong Zhu
    Division of Cancer Prevention Department of Medicine, Stony Brook University, Stony Brook, New York, USA
    Pharm Res 29:3090-101. 2012
    ..To evaluate the antitumor efficacy of solid lipid nanoparticle-encapsulated phospho-sulindac (SLN-PS) in human lung cancer...
  14. ncbi Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect
    Liqun Huang
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Carcinogenesis 31:1982-90. 2010
    ..Our results suggest that OXT-922 possesses promising anticancer properties and deserves further evaluation...
  15. ncbi Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure
    Yu Sun
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:5813-20. 2003
    ..ABCA1-mediated cholesterol and phospholipid efflux may be uncoupled in pathological states associated with high SCD activity, as in hyperinsulinemic obese mice, or in animals treated with LXR activators...