Research Topics
Genomes and Genes | David L SulzerSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Publications
Regulation of quantal size by presynaptic mechanismsD Sulzer
Department of Neurology, Columbia University, New York, USA
Rev Neurosci 11:159-212. 2000..We include detailed information on performing nonparametric resampling statistical analysis, the Kolmogorov-Smirnov test for two populations, and random walk simulations using spreadsheet programs...- Dopamine transport currents are promoted from curiosity to physiologyDavid Sulzer
Departments of Neurology and Psychiatry, Columbia University, Department of Neuroscience, New York State Psychiatric Institute, Black 305, 650W 168th Street, New York, NY 10032, USA
Trends Neurosci 26:173-6. 2003..This response extends the range of states regulated by neurotransmitter feedback, and could contribute importantly to understanding amphetamine action... 
How addictive drugs disrupt presynaptic dopamine neurotransmissionDavid Sulzer
Departments of Psychiatry, Neurology, and Pharmacology, Columbia University Medical Center, Black 308, 650 W 168 St, New York, NY 10032, USA
Neuron 69:628-49. 2011....
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and diseaseDavid Sulzer
Department of Neurology, Columbia University, New York, NY 10036, USA
J Neurochem 106:24-36. 2008....- Parkinson's disease: return of an old prime suspectDavid Sulzer
Department of Neurology, Columbia University Medical School, New York State Psychiatric Institute, New York, NY 10032, USA
Neuron 55:8-10. 2007..This shift protects SN neurons in chemical models of Parkinson's disease (PD), suggesting that elevated intracellular Ca2+ participates in SN cell loss and that dihydropyridines may provide therapy in PD... - Mechanisms of neurotransmitter release by amphetamines: a reviewDavid Sulzer
Department of Psychiatry, Neurology and Pharmacology, New York State Psychiatric Institute, Columbia University, 650 W 168th Street, Black Building Room 309, New York, NY 10032, USA
Prog Neurobiol 75:406-33. 2005.... - Clues to how alpha-synuclein damages neurons in Parkinson's diseaseDavid Sulzer
Department of Neurology, Columbia University Medical School, New York State Psychiatric Institute, New York, New York 10032, USA
Mov Disord 25:S27-31. 2010..Additional causes of PD may interfere at other points with normal handling and degradation of alpha-syn, providing a variety of entry points to a converging neurodegenerative path underlying the disease... - Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesiclesD Sulzer
Department of Neurology, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 97:11869-74. 2000..However, NM in organelles associated with secretory pathways may interfere with signaling, as it delays stimulated neurite outgrowth in PC12 cells... - Dale's principle and glutamate corelease from ventral midbrain dopamine neuronsD Sulzer
Department of Psychiatry, Columbia University, New York, New York, USA
Amino Acids 19:45-52. 2000..However, the relationship between dopamine and glutamate release from dopamine neuron synapses in the intact brain--and the mechanisms involved--has yet to be resolved... - Multiple hit hypotheses for dopamine neuron loss in Parkinson's diseaseDavid Sulzer
Department of Neurology, Black 309, 650 West, 168th Street, Columbia University, New York State Psychiatric Institute, New York City, NY 10032, USA
Trends Neurosci 30:244-50. 2007..We discuss the properties of substantia nigra dopamine neurons that might make them particular targets of such multiple hits... - Presynaptic regulation of dopamine transmission in schizophreniaGholson J Lyon
Department of Psychiatry, Columbia University, New York City, NY 10032, USA
Schizophr Bull 37:108-17. 2011..New laboratory approaches are elucidating mechanisms that control the level of presynaptic DA stores, thus contributing to fundamental understanding of the basic pathophysiologic mechanism in schizophrenia... - Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosisKristin E Larsen
Department of Neurology, Columbia University School of Medicine, New York, New York 10032, USA
J Neurosci 26:11915-22. 2006..We conclude that alpha-syn overexpression inhibits a vesicle "priming" step, after secretory vesicle trafficking to "docking" sites but before calcium-dependent vesicle membrane fusion... - Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neuronsEugene V Mosharov
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
Neuron 62:218-29. 2009..Thus, an interaction between Ca2+, DA(cyt), and alpha-synuclein may underlie the susceptibility of SN neurons in PD, suggesting multiple therapeutic targets... - Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesisKristin E Larsen
Department of Neurology, Columbia University, and New York Psychiatric Institute, New York, New York 10032, USA
J Neurosci 22:8951-60. 2002.... - Dopamine neurons release transmitter via a flickering fusion poreRoland G W Staal
Department of Neurology, Black 305, 650 West 168th St, Columbia University, New York, New York 10032, USA
Nat Neurosci 7:341-6. 2004..This mode of exocytosis is a potential mechanism whereby neurons can rapidly reuse vesicles without undergoing the comparatively slow process of recycling... - Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminalsNiko G Gubernator
Department of Chemistry, Columbia University, New York, NY 10027, USA
Science 324:1441-4. 2009..A frequency-dependent heterogeneity of presynaptic terminals was revealed that was dependent in part on D2 dopamine receptors, indicating a mechanism for frequency-dependent coding of presynaptic selection... - D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neuronsViviana Davila
Department of Neurology, Columbia University, New York, NY 10032, USA
J Neurosci 23:5693-7. 2003..Thus, it appears that D3 activation of GIRK currents in SN neurons does not occur or is exceedingly rare... - Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cellsEugene V Mosharov
Department of Neurology, Columbia University, New York, New York 10032, USA
J Neurosci 23:5835-45. 2003..These derivatives reside in the cytosol for hours after treatment and may be an underlying cause of drug-related cytotoxicity... - Neurodegeneration and neuroprotection in Parkinson diseaseStanley Fahn
Department of Neurology, Columbia University, New York, New York 10032, USA
NeuroRx 1:139-54. 2004..We then outline potential approaches to neuroprotection for PD that are derived from current notions on disease pathogenesis... - Glutamate controls growth rate and branching of dopaminergic axonsYvonne Schmitz
Departments of Neurology, Columbia University School of Medicine, New York State Psychiatric Institute, New York, 10032, USA
J Neurosci 29:11973-81. 2009..Understanding the mechanisms of dopaminergic axonal arborization is essential to the development of treatments that aim to restore dopaminergic innervation in Parkinson's disease... - Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in miceMarta Paterlini
Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
Nat Neurosci 8:1586-94. 2005..This interaction modulates a number of schizophrenia-related phenotypes, providing a framework for understanding the high disease risk associated with this locus, the expression of the phenotype, or both... - Analysis of exocytotic events recorded by amperometryEugene V Mosharov
Department of Neurology, Black Building 305, 650 W 168th Street, Columbia University, New York, New York 10032, USA
Nat Methods 2:651-8. 2005..The purpose of this review is to provide practical guidelines for performing amperometric recordings of exocytotic activity and interpreting the results based on shape characteristics of individual release events... - Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTPWilliam Dauer
Department of Neurology, Columbia University, New York, NY 10027, USA
Proc Natl Acad Sci U S A 99:14524-9. 2002.... - Presynaptic regulation of dopaminergic neurotransmissionYvonne Schmitz
Department of Neurology, Columbia Univeristy, New York, NY 10032, USA
J Neurochem 87:273-89. 2003..Moreover, recordings with carbon-fiber electrodes from cultured neurons have provided analysis of catecholamine release and its plasticity at the quantal level... - Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapsesNao Chuhma
Department of Psychiatry, Columbia University, New York, New York 10032, USA
J Neurosci 24:972-81. 2004..So dopamine neurons make glutamatergic synaptic connections to accumbens neurons. We propose that dopamine neuron glutamatergic transmission may be the initial component of the incentive salience signal... - Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targetsNikolai Kholodilov
Department of Neurology, Psychiatry, Pharmacology, and Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Neurosci 24:3136-46. 2004..GDNF in VTA targets, however, is sufficient to regulate the adult number of DA neurons... - Altered dopamine release and uptake kinetics in mice lacking D2 receptorsYvonne Schmitz
Department of Neurology, Columbia University, New York, New York 10032, USA
J Neurosci 22:8002-9. 2002..These results from D2-null mutant mice support the suggestion that D2 autoreceptors and dopamine transporters interact to regulate the amplitude and timing of dopamine signals... - Secretory vesicle rebound hyperacidification and increased quantal size resulting from prolonged methamphetamine exposureDmitriy Markov
Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
J Neurochem 107:1709-21. 2008..Thus, under some conditions of prolonged exposure, AMPHs and other weak bases can enhance, rather than deplete, the vesicular release of catecholamines via a compensatory response resulting in vesicle acidification... - Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptorsHui Zhang
Department of Neurology, Columbia University, New York, New York 10032, USA
J Neurosci 23:10585-92. 2003..Thus, under conditions in which glutamate escapes the confines of its synapse, it can elicit the presynaptic suppression of dopaminergic neurotransmission... - A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in miceKristin E Larsen
Columbia University, Department of Neurology, New York, NY 10032, and Cecil B. Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
Brain Res 1120:1-12. 2006..These results indicate that TTC can serve as a non-viral vehicle to substantially improve the delivery of functionally active growth factors to motor neurons in the mammalian CNS... - Cargo recognition failure is responsible for inefficient autophagy in Huntington's diseaseMarta Martinez-Vicente
Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York, USA
Nat Neurosci 13:567-76. 2010..We propose that inefficient engulfment of cytosolic components by autophagosomes is responsible for their slower turnover, functional decay and accumulation inside HD cells... - Development of pH-responsive fluorescent false neurotransmittersMinhee Lee
Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027, USA
J Am Chem Soc 132:8828-30. 2010..Mini202 is sufficiently bright, photostable, and suitable for two-photon microscopy. This probe will enable fundamental neuroscience and neuroendocrine research as well as drug screening efforts... - Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagyMarta Martinez-Vicente
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, New York, New York 10461, USA
J Clin Invest 118:777-88. 2008..As blockage of CMA increases cellular vulnerability to stressors, we propose that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons... - Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathwaysGuomei Tang
Department of Pathology, Center for Neurobiology and Behavior, Center for Parkinson s Disease and Other Movement Disorders, Columbia University, New York, NY 10032, USA
Hum Mol Genet 17:1540-55. 2008..Our study suggests that AxD mutant GFAP accumulation stimulates autophagy, in a manner regulated by p38 MAPK and mTOR signaling pathways. Autophagy, in turn, serves as a mechanism to reduce GFAP levels... - AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine releaseJacob Bendor
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA
EMBO J 29:2813-26. 2010..These results also suggest a novel therapeutic target for the treatment of dopaminergic dysfunction... - Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministrationNigel S Bamford
Department of Neurology, University of Washington, Seattle, WA 98105, USA
Neuron 58:89-103. 2008..These mechanisms might provide a synaptic basis that underlies addiction and habit learning and their long-term maintenance... - Antidepressants and the monoamine masqueradeDavid Sulzer
Department of Neurology, Columbia University, New York State Psychiatric Institute, New York, New York 10032, USA
Neuron 46:1-2. 2005..The results suggest that release of serotonin by dopamine neurons may contribute to the effects of multiple major classes of antidepressants... - Alpha-synuclein overexpression increases cytosolic catecholamine concentrationEugene V Mosharov
Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA
J Neurosci 26:9304-11. 2006.... - Methamphetamine inhibits antigen processing, presentation, and phagocytosisZsolt Talloczy
Department of Neurology, Columbia University, New York, New York, United States of America
PLoS Pathog 4:e28. 2008..Meth exerts previously unreported direct immunosuppressive effects that contribute to increased risk of infection and exacerbate AIDS pathology... - PKC theta activity maintains normal quantal size in chromaffin cellsRoland G W Staal
Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA
J Neurochem 105:1635-41. 2008..These findings demonstrate neurosecretory regulation by a novel PKC isoform, PKC theta, and should contribute to defining mechanisms of activity-dependent regulation of neurosecretion... - The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamateRobert T Fremeau
Department of Neurology, University of California School of Medicine, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 99:14488-93. 2002..The dendritic expression of VGLUT3 by particular neurons also indicates the potential for retrograde synaptic signaling. The distribution and subcellular location of VGLUT3 thus suggest novel modes of signaling by glutamate... - Transgenic superoxide dismutase overproducer: murineSerge Przedborski
Departments of Neurology and Pathology, Columbia University, New York, New York 10032, USA
Methods Enzymol 349:180-90. 2002 - Frequency-dependent modulation of dopamine release by nicotineHui Zhang
Department of Neurology, Columbia University, 650 W 168th Street, New York, New York 10032, USA
Nat Neurosci 7:581-2. 2004..Nicotine may thus enhance the contrast of dopamine signals associated with behavioral cues... - Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoaminesHaiyan Li
Graduate Programs in Neuroscience and Cell Biology, Department of Neurology and Physiology, UCSF School of Medicine, 600 16th Street, San Francisco, California 94143, USA
Neuron 48:619-33. 2005..VMAT2 thus defines a population of secretory vesicles that mediate the activity-dependent somatodendritic release of multiple retrograde signals involved in synaptic function, growth, and plasticity...
Research Grants
- Presynaptic mechanisms in dopamine neurotransmissionDavid Sulzer; Fiscal Year: 2009..3) Define how focal DA input selects particular corticostriatal terminals. Hypothesis: Enhanced signal/background of DA input regulated by the mechanisms above selects nearby sets of corticostriatal inputs. ..
- Presynaptic mechanisms in dopamine neurotransmissionDavid Sulzer; Fiscal Year: 2007..3) Define how focal DA input selects particular corticostriatal terminals. Hypothesis: Enhanced signal/background of DA input regulated by the mechanisms above selects nearby sets of corticostriatal inputs. ..
- Basic Neuroscience Training Grant at Columbia UniversityDavid Sulzer; Fiscal Year: 2007....
- Presynaptic mechanisms in dopamine neurotransmissionDavid Sulzer; Fiscal Year: 2006..This model could provide the initial stage of synaptic rewiring by drugs of abuse. ..
- 2005 Gordon Conference on CatecholaminesDavid Sulzer; Fiscal Year: 2005..abstract_text> ..
- AMPHETAMINE AND D2 REGULATION OF DOPAMINE QUANTAL SIZEDavid Sulzer; Fiscal Year: 2001..abstract_text> ..
- Presynaptic mechanisms in dopamine neurotransmissionDavid Sulzer; Fiscal Year: 2010..3) Define how focal DA input selects particular corticostriatal terminals. Hypothesis: Enhanced signal/background of DA input regulated by the mechanisms above selects nearby sets of corticostriatal inputs. ..