Research Topics
Genomes and GenesSpecies | G M SullivanSummaryAffiliation: Columbia University Country: USA Publications
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Publications
PET Imaging of CRF1 with [11C]R121920 and [11C]DMP696: is the target of sufficient density?Gregory M Sullivan
Division of Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
Nucl Med Biol 34:353-61. 2007..The aim of this study was to investigate the in vivo binding characteristics of [11C]R121920 and [11C]DMP696 in the nonhuman primate for application in positron emission tomography (PET) studies of CRF1...
Low cerebrospinal fluid transthyretin levels in depression: correlations with suicidal ideation and low serotonin functionGregory M Sullivan
Division of Neuroscience, Department of Psychiatry, Columbia University, NY 10032, USA
Biol Psychiatry 60:500-6. 2006..Transthyretin (TTR) is a thyroid hormone binding protein synthesized by choroid plexus and secreted into cerebrospinal fluid (CSF). We sought to replicate and extend our previous findings of lower CSF TTR in depression...- Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorderGregory M Sullivan
Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Int J Neuropsychopharmacol 9:547-56. 2006..This difference in pathophysiology is potentially related to the greater morbidity and poorer treatment response of this group... - Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxietyGregory M Sullivan
Division of Neuroscience, Department of Psychiatry, New York 10032, USA
Biol Psychiatry 58:947-54. 2005..We investigated the relationship of anxiety expressed in major depressive disorder (MDD) to regional 5-HT1A binding... - Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulusG M Sullivan
Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 41, New York, NY 10032, USA
Neuroscience 128:7-14. 2004..The results are also not consistent with the hypothesis that BNST is only involved in unconditioned aspects of fear and anxiety... - Pharmacotherapy in post-traumatic stress disorder: evidence from randomized controlled trialsGregory M Sullivan
Columbia University College of Physicians and Surgeons, Department of Psychiatry, New York, NY 10032, USA
Curr Opin Investig Drugs 10:35-45. 2009..Where appropriate, RCT methodological problems that limit the conclusions drawn are discussed. In addition, recommendations for research to fill critical gaps in the knowledge of PTSD treatment are offered... - Effects of hyperventilation on heart rate and QT variability in panic disorder pre- and post-treatmentGregory M Sullivan
Department of Psychiatry, Columbia College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
Psychiatry Res 125:29-39. 2004..Yet these results must be interpreted cautiously; they are preliminary, exploratory and observed in a very small sample without a healthy comparison group... - Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depressionGregory M Sullivan
Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 41, New York, NY 10032, USA
Biol Psychiatry 66:223-30. 2009.... - Neuroanatomical hypothesis of panic disorder, revisedJ M Gorman
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, USA
Am J Psychiatry 157:493-505. 2000..Here they revise that hypothesis to consider developments in the preclinical understanding of the neurobiology of fear and avoidance... - Respiratory variability in panic disorderJ M Martinez
Department of Psychiatry, Columbia University, New York, New York 10032, USA
Depress Anxiety 14:232-7. 2001..Our data suggest that increased respiratory variability may be an important trait feature for some panic disorder patients and may make them more vulnerable to CO(2)-induced panic... - Treatment of depressed bipolar patients with alcohol use disorders: plenty of room for improvementEnrique Baca-Garcia
Molecular Imaging and Neuropathology Division, NYS Psychiatric Institute and Columbia University, New York 10032, USA
J Affect Disord 115:262-8. 2009..We hypothesize that the adequacy of antidepressant treatment and the compliance with treatment for those with AUD are lower than for those without AUD... - Elevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormalityJeffrey M Miller
Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, New York, NY 10033, USA
Neuropsychopharmacology 34:2275-84. 2009.... - Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptorsJ S Dileep Kumar
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
Bioorg Med Chem 14:4029-34. 2006..PET studies in baboon show that [11C]6 penetrates the BBB and accumulates in brain. No detectable specific binding was observed, likely due to the rapid metabolism or low density of CRF1 receptors in primate brain... - Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerationsRamin V Parsey
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Biol Psychiatry 68:170-8. 2010..Discrepancies can be related to differences in study population or methodology. We sought to replicate our findings in a novel cohort and determine whether choice of reference region and outcome measure could explain discrepancies... - Biodistribution and radiation dosimetry of 11C-WAY100,635 in humansRamin V Parsey
Division of Brain Imaging, Department of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
J Nucl Med 46:614-9. 2005..Dose estimates for current human studies are based on data from rat dosimetry studies. We report the biodistribution and dosimetry of the PET serotonin 1A antagonist 11C-WAY100,635 in humans... - Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?Juan J Carballo
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, United States
J Affect Disord 109:57-63. 2008..Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects... - Association between familial suicidal behavior and frequency of attempts among depressed suicide attemptersD Lizardi
School of Social Work, Columbia University, New York, NY 10027, USA
Acta Psychiatr Scand 119:406-10. 2009..The current study aimed to examine whether a family history of suicidal acts predicts severity of suicide attempts... - Finding a home for post-traumatic stress disorder in biological psychiatry. Is it a disorder of anxiety, mood, stress, or memory?Gregory M Sullivan
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, Unit 3, New York, NY 10032, USA
Psychiatr Clin North Am 25:463-8, ix. 2002.... 
Hot flashes and panic attacks: a comparison of symptomatology, neurobiology, treatment, and a role for cognitionLaura J Hanisch
Department of Psychiatry, University of Pennsylvania, USA
Psychol Bull 134:247-69. 2008..This model yields readily testable hypotheses and may provide a template for exploring the role of cognition in the frequency and severity of hot flashes and, in turn, a basis for the development of nonpharmacological treatments...- Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdalaGregory M Sullivan
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Biol Psychiatry 53:863-70. 2003..Doxapram is a respiratory stimulant that reliably evokes panic attacks in patients with panic disorder. We examined doxapram in four rodent models of anxiety and sought to identify brain regions involved in its behavioral effects... - The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptineNesha S Burghardt
W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
Biol Psychiatry 55:1171-8. 2004..The findings also indicate that auditory fear conditioning can be a useful tool in understanding differences in the effects of short-term and long-term antidepressant treatment with serotonergic medications... - Comorbid anxiety in bipolar disorder: does it have an independent effect on suicidality?Atsuo Nakagawa
Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan
Bipolar Disord 10:530-8. 2008..This study examined the impact of comorbid Cluster B personality disorder and anxiety disorder on suicidality in bipolar disorder...
Research Grants
- BRAIN PATHOPHYSIOLOGY IN ANXIETY DISORDERSGREGORY SULLIVAN; Fiscal Year: 2007..Through such work, he seeks to contribute to the understanding of the pathophysiology of PD in order to suggest improved therapeutics for this devastating and underrecognized brain disorder. ..