STEPHEN STURLEY

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. request reprint
    Sturley S. Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast. Biochim Biophys Acta. 2000;1529:155-63 pubmed
    ..In addition to definition of the sterol biosynthetic pathway, almost to completion, the remarkable conservation of other components of sterol homeostasis are described in this review. ..
  2. request reprint
    Sturley S, Patterson M, Balch W, Liscum L. The pathophysiology and mechanisms of NP-C disease. Biochim Biophys Acta. 2004;1685:83-7 pubmed
  3. Sturley S, Hussain M. Lipid droplet formation on opposing sides of the endoplasmic reticulum. J Lipid Res. 2012;53:1800-10 pubmed publisher
    ..This default pathway directs droplets into the cytoplasm where they accumulate in many lipid disorders...
  4. Gulati S, Balderes D, Kim C, Guo Z, Wilcox L, Area Gomez E, et al. ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification. FASEB J. 2015;29:4682-94 pubmed publisher
  5. Munkacsi A, Hammond N, Schneider R, Senanayake D, Higaki K, Lagutin K, et al. Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat. J Biol Chem. 2017;292:4395-4410 pubmed publisher
    ..These results suggest that HDAC inhibitors have utility to treat visceral NP-C disease. However, it is clear that improved blood-brain barrier penetration will be required to alleviate the neurological symptoms of human NP-C disease. ..