G Struhl

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Spineless-aristapedia: a homeotic gene that does not control the development of specific compartments in Drosophila
    G Struhl
    Genetics 102:737-49. 1982
  2. ncbi request reprint Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
    G Struhl
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell 6:625-36. 2000
  3. ncbi request reprint Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen
    G Struhl
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Development 124:2155-65. 1997
  4. pmc Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
    G Struhl
    Department of Genetics and Development, and Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:229-34. 2001
  5. ncbi request reprint Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen
    G Struhl
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Development 124:2143-54. 1997
  6. ncbi request reprint Nuclear access and action of notch in vivo
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 93:649-60. 1998
  7. ncbi request reprint Dual roles for patched in sequestering and transducing Hedgehog
    Y Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 87:553-63. 1996
  8. ncbi request reprint Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos
    S Greenwood
    Howard Hughes Medical Institute, and Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 124:4879-86. 1997
  9. ncbi request reprint Protein kinase A and hedgehog signaling in Drosophila limb development
    J Jiang
    Howard Hughes Medical Institute, Department of Genetics and Development Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 80:563-72. 1995
  10. ncbi request reprint Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
    C M Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 126:5441-52. 1999

Collaborators

Detail Information

Publications57

  1. pmc Spineless-aristapedia: a homeotic gene that does not control the development of specific compartments in Drosophila
    G Struhl
    Genetics 102:737-49. 1982
    ....
  2. ncbi request reprint Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
    G Struhl
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell 6:625-36. 2000
    ..Hence, Notch, beta-APP, and perhaps other proteins may be targeted for Presenilin-mediated transmembrane cleavage by upstream processing events that sever the extracellular domain from the rest of the protein...
  3. ncbi request reprint Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen
    G Struhl
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Development 124:2155-65. 1997
    ..We conclude that, in the abdomen, cell type and cell polarity reflect distinct outputs of Hh signalling and propose that these outputs are controlled by separable gradient and signal relay mechanisms...
  4. pmc Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
    G Struhl
    Department of Genetics and Development, and Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:229-34. 2001
    ....
  5. ncbi request reprint Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen
    G Struhl
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Development 124:2143-54. 1997
    ..Many of these results are unexpected and lead us to reassess the role of gradients and compartments in patterning insect segments...
  6. ncbi request reprint Nuclear access and action of notch in vivo
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 93:649-60. 1998
    ....
  7. ncbi request reprint Dual roles for patched in sequestering and transducing Hedgehog
    Y Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 87:553-63. 1996
    ..Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement...
  8. ncbi request reprint Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos
    S Greenwood
    Howard Hughes Medical Institute, and Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 124:4879-86. 1997
    ....
  9. ncbi request reprint Protein kinase A and hedgehog signaling in Drosophila limb development
    J Jiang
    Howard Hughes Medical Institute, Department of Genetics and Development Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 80:563-72. 1995
    ..We propose that the basal activity of PKA imposes a block on the transcription of dpp and wg and that hh exerts its organizing influence by alleviating this block...
  10. ncbi request reprint Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila
    C M Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 126:5441-52. 1999
    ..These results extend prior evidence of a ligand-receptor relationship between Wnt and Frizzled proteins and suggest that Fz and Fz2 are the primary receptors for Wg in Drosophila...
  11. ncbi request reprint Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway
    S Greenwood
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 126:5795-808. 1999
    ....
  12. ncbi request reprint Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    J Jiang
    Howard Hughes Medical Institute, Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 391:493-6. 1998
    ....
  13. ncbi request reprint Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor
    A Tomlinson
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell 7:487-95. 2001
    ....
  14. ncbi request reprint Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye
    A Tomlinson
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 126:5725-38. 1999
    ..As a consequence of this reciprocal cell fate decision, the R4 cell moves asymmetrically relative to the R3 cell, initiating the appropriate chiral pattern of the remaining cells of the ommatidium...
  15. ncbi request reprint RNA recognition and translational regulation by a homeodomain protein
    J Dubnau
    Howard Hughes Medical Research Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 379:694-9. 1996
    ..RNA binding by bcd seems to involve direct interactions between the bcd homeodomain and discrete target sequences within the 3' untranslated region of the cad messenger RNA and to block the initiation of cad translation...
  16. ncbi request reprint Organizing activity of wingless protein in Drosophila
    G Struhl
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 72:527-40. 1993
    ..We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc...
  17. ncbi request reprint In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
    Y Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Development 125:4943-8. 1998
    ....
  18. ncbi request reprint A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube
    J Briscoe
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Institute, Columbia University, 701 West 168th Street, 10032, New York, NY, USA
    Mol Cell 7:1279-91. 2001
    ..mPtc1(Deltaloop2) expression also caused the abnormal spread of Shh to more dorsal cells, indicating that Shh in the neural tube, like Hh in Drosophila, induces a feedback mechanism that limits its range of action...
  19. ncbi request reprint Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 74:331-45. 1993
    ..Our results also suggest that equivalent truncated forms of lin-12/Notch family members in vertebrates, including known oncogenes, are similarly active...
  20. ncbi request reprint Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade
    E Ronchi
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Cell 74:347-55. 1993
    ..We propose that phosphorylation resulting from the activity of the tor signal transduction cascade down-regulates transcriptional activation by the bcd morphogen...
  21. ncbi request reprint Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development
    J Jiang
    Howard Hughes Medical Institute Department of Genetics and Development Columbia University College of Physicians and Surgeons New York, New York 10032, USA
    Cell 86:401-9. 1996
    ....
  22. ncbi request reprint The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila
    J Casanova
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Nature 362:152-5. 1993
    ..Ligand trapping by receptor may also localize spatial signals in other patterning systems, including specification of the dorsal-ventral axis in Drosophila and of vulval cell fates in Caenorhabditis elegans...
  23. ncbi request reprint Presenilin is required for activity and nuclear access of Notch in Drosophila
    G Struhl
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 398:522-5. 1999
    ..Furthermore, we provide evidence that presenilin is required for the proteolytic release of the intracellular domain from the membrane following activation of Notch by ligand...
  24. ncbi request reprint Differing strategies for organizing anterior and posterior body pattern in Drosophila embryos
    G Struhl
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Nature 338:741-4. 1989
    ..Within this hunchback-free domain the pattern of abdominal segments must be specified by other morphogens, possibly by shorter range gradients of the products of zygotic gap genes Kruppel, knirps and tailless...
  25. ncbi request reprint Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila
    J Casanova
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genes Dev 3:2025-38. 1989
    ....
  26. ncbi request reprint RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos
    R P Wharton
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Cell 67:955-67. 1991
    ..Based on these and other results, we argue that nos acts as a morphogen, controlling hb expression (and hence abdominal pattern) as a function of its concentration-dependent interaction with the NREs...
  27. ncbi request reprint The gradient morphogen bicoid is a concentration-dependent transcriptional activator
    G Struhl
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 57:1259-73. 1989
    ..They also suggest that the bcd gradient has the instructive capacity to activate other subordinate control genes by the same mechanism, each in a distinct spatial domain according to its affinity for bcd protein...
  28. ncbi request reprint Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila
    H M Chung
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Nat Cell Biol 3:1129-32. 2001
    ....
  29. ncbi request reprint Structure of the Drosophila BicaudalD protein and its role in localizing the the posterior determinant nanos
    R P Wharton
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 59:881-92. 1989
    ..Taken together, these results suggest that BicD encodes a cytoskeleton-like protein involved in transporting or anchoring the nanos morphogen within the oocyte cytoplasm...
  30. ncbi request reprint cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos
    P M Macdonald
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, N Y 10032
    Nature 336:595-8. 1988
    ....
  31. ncbi request reprint Control of Drosophila body pattern by the hunchback morphogen gradient
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 69:237-249. 1992
    ..Thus, hb protein functions as a classical morphogen, triggering several distinct responses as a function of its graded distribution...
  32. ncbi request reprint Decoding positional information: regulation of the pair-rule gene hairy
    K R Howard
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Development 110:1223-31. 1990
    ....
  33. ncbi request reprint Direct and long-range action of a wingless morphogen gradient
    M Zecca
    Zoologisches Institut der Universitat Zurich, Switzerland
    Cell 87:833-44. 1996
    ..We interpret these findings as evidence that Wg can act directly and at long range as a gradient morphogen during normal development...
  34. ncbi request reprint Polycomb group proteins and heritable silencing of Drosophila Hox genes
    D Beuchle
    Max Planck Institut fur Entwicklungsbiologie, Spemannstr 35 III, 72076 Tubingen, Germany
    Development 128:993-1004. 2001
    ..Some PcG proteins may be required to define and propagate this mark; others may function to repress the transcription of Hox genes that bear the mark...
  35. ncbi request reprint Bristle patterns and compartment boundaries in the tarsi of Drosophila
    P A Lawrence
    J Embryol Exp Morphol 51:195-208. 1979
    ..These results support the selector gene model of development (Garcia-Bellido, 1975) and emphasize that collaboration between polyclones is important in pattern formation...
  36. ncbi request reprint hedgehog and engrailed: pattern formation and polarity in the Drosophila abdomen
    P A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 126:2431-9. 1999
    ..Finally, we find that when engrailed is removed from P cells (of, say, segment A5) they transform not into A cells of the same segment, but into A cells of the same parasegment (segment A6)...
  37. ncbi request reprint The hedgehog morphogen and gradients of cell affinity in the abdomen of Drosophila
    P A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 126:2441-9. 1999
    ..Within the P compartment we found some evidence for a U-shaped gradient of affinity, but this cannot be due to Hedgehog which does not act in the P compartment...
  38. ncbi request reprint Morphogens, compartments, and pattern: lessons from drosophila?
    P A Lawrence
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 85:951-61. 1996
  39. ncbi request reprint Homeotic transformations of the abdominal segments of Drosophila caused by breaking or deleting a central portion of the bithorax complex
    G Morata
    J Embryol Exp Morphol 78:319-41. 1983
    ..We discuss these results in the light of current views of the organization and function of the complex...
  40. ncbi request reprint Different requirements for homeotic genes in the soma and germ line of Drosophila
    P A Lawrence
    Cell 35:27-34. 1983
    ..These results suggest that selector genes are inactive in the germ line where they may be regulated by a different mechanism than in the soma...
  41. pmc Genes controlling segmental specification in the Drosophila thorax
    G Struhl
    Proc Natl Acad Sci U S A 79:7380-4. 1982
    ..Result iii suggests that a product of the Ubx+ gene also plays an early, regulatory role in ensuring the correct spatial expression of the Scr+ gene during subsequent development...
  42. ncbi request reprint Early role of the esc+ gene product in the determination of segments in Drosophila
    G Struhl
    Cell 31:285-92. 1982
    ..These results support the hypothesis that the esc+ gene product has a discrete early function in the initiation of segmental determination...
  43. pmc Further studies of the engrailed phenotype in Drosophila
    P A Lawrence
    EMBO J 1:827-33. 1982
    ..These results support the hypothesis that the engrailed+ gene is required exclusively in cells of posterior compartments to specify their characteristic cell affinities and pattern...
  44. ncbi request reprint Similarities between trunk and spätzle, putative extracellular ligands specifying body pattern in Drosophila
    J Casanova
    Centre d Investigació i Desenvolupament CSIC, Barcelona, Spain
    Genes Dev 9:2539-44. 1995
    ..We propose that trk encodes an extracellular ligand involved in specifying terminal body pattern and suggest by analogy with spz that a cleaved form of trk constitutes the ligand for the tor receptor...
  45. ncbi request reprint Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
    M Zecca
    Zoologisches Institut, Universitat Zurich, Switzerland
    Development 121:2265-78. 1995
    ..Finally, we report evidence suggesting that dpp may exert its organizing influence by acting as a gradient morphogen in contrast to hh which appears to act principally as a short range inducer of dpp...
  46. ncbi request reprint An oncogenic form of human raf can specify terminal body pattern in Drosophila
    J Casanova
    Centre d Investigació i Desenvolupament CSIC, Barcelona, Spain
    Mech Dev 48:59-64. 1994
    ....
  47. ncbi request reprint Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    Nature 368:208-14. 1994
    ....
  48. ncbi request reprint Direct and long-range action of a DPP morphogen gradient
    D Nellen
    Zoologisches Institut, Universitat Zurich, Switerland
    Cell 85:357-68. 1996
    ..We propose that DPP acts as a gradient morphogen during wing development...
  49. pmc Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila
    G Struhl
    EMBO J 4:3259-64. 1985
    ....
  50. ncbi request reprint A molecular gradient in early Drosophila embryos and its role in specifying the body pattern
    P M Macdonald
    Nature 324:537-45. 1986
    ..Mutations in the cad gene that reduce or eliminate the gradient cause abnormal zygotic expression of at least one segmentation gene (fushi tarazu) and alter the global body pattern...
  51. ncbi request reprint Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genes
    P A Lawrence
    Nature 328:440-2. 1987
    ..These boundary lines, rather than the narrowing zonal stripes, would delimit the anterior boundaries of engrailed and other homoeotic genes and thereby subdivide the embryo into parasegments...
  52. ncbi request reprint Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box
    P M Macdonald
    Cell 47:721-34. 1986
    ..Together, these 14 stripes are required for the activation of coincident stripes of engrailed transcripts, leading to the subdivision of the embryo into compartmental and segmental units...
  53. ncbi request reprint Regulation of the Ultrabithorax gene of Drosophila by other bithorax complex genes
    G Struhl
    Cell 43:507-19. 1985
    ..Using mutations in the abd-A, Abd-B, and esc (extra sex combs) genes we show that these distinct patterns result in large part from regulation of Ubx gene expression by the abd-A and Abd-B gene functions...
  54. ncbi request reprint Role of the esc+ gene product in ensuring the selective expression of segment-specific homeotic genes in Drosophila
    G Struhl
    J Embryol Exp Morphol 76:297-331. 1983
    ..On the basis of these results, I propose a tentative outline of the roles and realms of action of all of these genes...
  55. ncbi request reprint A homoeotic mutation transforming leg to antenna in Drosophila
    G Struhl
    Nature 292:635-8. 1981
  56. ncbi request reprint A gene product required for correct initiation of segmental determination in Drosophila
    G Struhl
    Nature 293:36-41. 1981
    ..The resulting combinations of active and inactive genes established at this time then maintain the specific pathways of development followed subsequently by the different segments...
  57. ncbi request reprint Are cross-regulatory interactions between homoeotic genes functionally significant?
    A González-Reyes
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Madrid, Spain
    Nature 344:78-80. 1990
    ..Hence our results challenge the view that these, and possibly other cross-regulatory interactions have a role in determining segmental identity...