YAAKOV contact STERN

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Cognitive reserve in ageing and Alzheimer's disease
    Yaakov Stern
    Cognitive Neuroscience Division, Department of Neurology and Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Lancet Neurol 11:1006-12. 2012
  2. pmc Training cognitive control in older adults with the space fortress game: the role of training instructions and basic motor ability
    Helena M Blumen
    Cognitive Neuroscience Division, Taub Institute, Columbia University New York, NY, USA
    Front Aging Neurosci 2:145. 2010
  3. pmc Cognitive declines precede and predict functional declines in aging and Alzheimer's disease
    Laura B Zahodne
    Cognitive Neuroscience Division, Department of Neurology and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 8:e73645. 2013
  4. pmc Space Fortress game training and executive control in older adults: a pilot intervention
    Yaakov Stern
    Taub Institute, Columbia University, Cognitive Neuroscience Division, New York, NY 10032, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 18:653-77. 2011
  5. pmc Task difficulty modulates young-old differences in network expression
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute for the Study of Alzheimer s Disease and the Aging Brain, Columbia University College ofPhysicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Brain Res 1435:130-45. 2012
  6. pmc A common neural network for cognitive reserve in verbal and object working memory in young but not old
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute, NY, USA
    Cereb Cortex 18:959-67. 2008
  7. pmc Cognitive reserve
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
    Neuropsychologia 47:2015-28. 2009
  8. ncbi request reprint The concept of cognitive reserve: a catalyst for research
    Yaakov Stern
    Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Clin Exp Neuropsychol 25:589-93. 2003
  9. ncbi request reprint Exploring the neural basis of cognitive reserve
    Yaakov Stern
    Department of Neurology, Taub Institute for Research in Alzheimer s Disease and the Aging Brain and College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Clin Exp Neuropsychol 25:691-701. 2003
  10. ncbi request reprint Cognitive reserve and Alzheimer disease
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute, New York, NY 10032, USA
    Alzheimer Dis Assoc Disord 20:112-7. 2006

Research Grants

Detail Information

Publications94

  1. pmc Cognitive reserve in ageing and Alzheimer's disease
    Yaakov Stern
    Cognitive Neuroscience Division, Department of Neurology and Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Lancet Neurol 11:1006-12. 2012
    ..Greater understanding of the concept of cognitive reserve could lead to interventions to slow cognitive ageing or reduce the risk of dementia...
  2. pmc Training cognitive control in older adults with the space fortress game: the role of training instructions and basic motor ability
    Helena M Blumen
    Cognitive Neuroscience Division, Taub Institute, Columbia University New York, NY, USA
    Front Aging Neurosci 2:145. 2010
    ..g., EC instructions) - and the confluence between such basic abilities and higher-level cognitive control abilities should be further examined...
  3. pmc Cognitive declines precede and predict functional declines in aging and Alzheimer's disease
    Laura B Zahodne
    Cognitive Neuroscience Division, Department of Neurology and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 8:e73645. 2013
    ..To investigate the temporal ordering of cognitive and functional declines separately in older adults with or without Alzheimer's disease (AD)...
  4. pmc Space Fortress game training and executive control in older adults: a pilot intervention
    Yaakov Stern
    Taub Institute, Columbia University, Cognitive Neuroscience Division, New York, NY 10032, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 18:653-77. 2011
    ..Future SF interventions need to carefully consider increasing the duration and or the intensity of the intervention by providing at-home game training, reducing the motor demands of the game, and selecting appropriate outcome measures...
  5. pmc Task difficulty modulates young-old differences in network expression
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute for the Study of Alzheimer s Disease and the Aging Brain, Columbia University College ofPhysicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Brain Res 1435:130-45. 2012
    ..These findings suggest that neuroimaging studies comparing task-related activation across groups with different cognitive abilities must be interpreted in light of the relative difficulty of the task for each group...
  6. pmc A common neural network for cognitive reserve in verbal and object working memory in young but not old
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute, NY, USA
    Cereb Cortex 18:959-67. 2008
    ..This spatial pattern could represent a general neural instantiation of CR that is affected by the aging process...
  7. pmc Cognitive reserve
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
    Neuropsychologia 47:2015-28. 2009
    ..It then focuses on methodologic issues that are important when attempting to elucidate the neural underpinnings of cognitive reserve using imaging studies, and reviews some of our group's work in order to demonstrate these issues...
  8. ncbi request reprint The concept of cognitive reserve: a catalyst for research
    Yaakov Stern
    Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Clin Exp Neuropsychol 25:589-93. 2003
  9. ncbi request reprint Exploring the neural basis of cognitive reserve
    Yaakov Stern
    Department of Neurology, Taub Institute for Research in Alzheimer s Disease and the Aging Brain and College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Clin Exp Neuropsychol 25:691-701. 2003
    ..This differential processing may help explain individual differences in capacity, and may underlie reserve against age-related or other pathologic changes...
  10. ncbi request reprint Cognitive reserve and Alzheimer disease
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute, New York, NY 10032, USA
    Alzheimer Dis Assoc Disord 20:112-7. 2006
    ..There is also the possibility that directly enhancing CR may help forestall the diagnosis of AD...
  11. ncbi request reprint What is cognitive reserve? Theory and research application of the reserve concept
    Yaakov Stern
    G H Sergievsky Center, The Taub Institute, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Int Neuropsychol Soc 8:448-60. 2002
    ..Epidemiologic and imaging data that help to develop and support the concept of reserve are presented...
  12. ncbi request reprint Factors associated with incident human immunodeficiency virus-dementia
    Y Stern
    Department of Neurology and Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 58:473-9. 2001
    ..Antecedents to human immunodeficiency virus-dementia (HIV-D) are poorly understood...
  13. ncbi request reprint Rate of memory decline in AD is related to education and occupation: cognitive reserve?
    Y Stern
    Department of Neurology, The Gertrude H Sergievsky Center, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neurology 53:1942-7. 1999
    ..To determine whether the rate of decline in performance on a memory test is more rapid in AD patients with higher versus lower educational and occupational attainment...
  14. ncbi request reprint Different brain networks mediate task performance in normal aging and AD: defining compensation
    Y Stern
    Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Neurology 55:1291-7. 2000
    ..To determine whether the pathologic mechanisms of AD alter the brain networks subserving performance of a verbal recognition task...
  15. pmc Brain networks associated with cognitive reserve in healthy young and old adults
    Yaakov Stern
    Cognitive Neuroscience Division, Taub Institute, College of Physicians and Surgeons, Columbia University, New York, USA
    Cereb Cortex 15:394-402. 2005
    ..Thus, for the old subjects this topography may represent an altered, compensatory network that is used to maintain function in the face of age-related physiological changes...
  16. ncbi request reprint Prospective comparative study of the evolution of probable Alzheimer's disease and Parkinson's disease dementia
    Y Stern
    Gertrude H Sergievsky Center, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032
    J Int Neuropsychol Soc 4:279-84. 1998
    ..We conclude that while pAD and PD dementia are similar in many respects, differences in their evolution support previous observation of unique features in the 2 dementias and suggest different underlying pathologies...
  17. ncbi request reprint An investigation of clinical correlates of Lewy bodies in autopsy-proven Alzheimer disease
    Y Stern
    Department of Neurology and Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 58:460-5. 2001
    ....
  18. ncbi request reprint The neuropsychological profiles of mild Alzheimer's disease and questionable dementia as compared to age-related cognitive decline
    Elise Caccappolo Van Vliet
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Int Neuropsychol Soc 9:720-32. 2003
    ..Areas of lower functioning in QD subjects as compared to elderly controls included category fluency and visuospatial ability...
  19. ncbi request reprint Mortality in patients with dementia after ischemic stroke
    David W Desmond
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Neurology 59:537-43. 2002
    ..The authors investigated dementia as a predictor of long-term survival among patients with ischemic stroke...
  20. ncbi request reprint Predicting age-related dual-task effects with individual differences on neuropsychological tests
    Roee Holtzer
    Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neuropsychology 19:18-27. 2005
    ..The authors conclude that compromised central executive may underlie age-related decline in dual-task performance...
  21. ncbi request reprint Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community
    Jennifer J Manly
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 62:1739-46. 2005
    ....
  22. ncbi request reprint Incidence of dementia after ischemic stroke: results of a longitudinal study
    David W Desmond
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Stroke 33:2254-60. 2002
    ..We conducted the present study to investigate the incidence and clinical predictors of dementia after ischemic stroke...
  23. ncbi request reprint H215O PET study of impairment of nonverbal recognition with normal aging
    Karen E Anderson
    Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Neuropsychiatry Clin Neurosci 17:192-200. 2005
    ..Elderly subjects did not show the relationship between parahippocampal flow and SLS, which was observed in younger subjects. These differences suggest that age-related functional brain changes partly explain performance deficits...
  24. pmc Patient dependence and longitudinal changes in costs of care in Alzheimer's disease
    Carolyn W Zhu
    Geriatric Research, Education, and Clinical Center GRECC, James J Peters VA Medical Center, Bronx, NY, NY 10468, USA
    Dement Geriatr Cogn Disord 26:416-23. 2008
    ..To examine the incremental effect of patients' dependence on others, on cost of medical and nonmedical care, and on informal caregiving hours over time...
  25. ncbi request reprint Relation of cognitive reserve and task performance to expression of regional covariance networks in an event-related fMRI study of nonverbal memory
    Christian Habeck
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuroimage 20:1723-33. 2003
    ..e., there were reserve-related physiological differences that presumably would persist were there no subject differences in task performance. This suggests that this network may represent a neural correlate of CR...
  26. ncbi request reprint APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals
    Benjamin Tycko
    Department of Pathology, Division of Neuropathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Arch Neurol 61:1434-9. 2004
    ..Polymorphisms in regulatory sequences of APOE have also been related to AD, but the effects are inconsistent across studies...
  27. ncbi request reprint Sources of errors on visuoperceptual tasks: role of education, literacy, and search strategy
    Desiree A Byrd
    G H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Brain Cogn 58:251-7. 2005
    ....
  28. ncbi request reprint Incidence and predictors of seizures in patients with Alzheimer's disease
    Joan C Amatniek
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Epilepsia 47:867-72. 2006
    ..Limited information is available on the incidence of seizures, and no reports exist of seizure predictors in AD patients...
  29. pmc Do neuropsychological tests have the same meaning in Spanish speakers as they do in English speakers?
    Karen L Siedlecki
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neuropsychology 24:402-11. 2010
    ..The purpose of this study was to examine whether neuropsychological tests translated into Spanish measure the same cognitive constructs as the original English versions...
  30. pmc Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, New York, NY 10032, USA
    Neuroimage 19:1215-27. 2003
    ..Brain regions where systematic relationships between CR and brain activation differ as a function of aging are loci where compensation for aging has occurred. They may mediate differential ability to cope with brain changes in aging...
  31. pmc Frequency and course of mild cognitive impairment in a multiethnic community
    Jennifer J Manly
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY, USA
    Ann Neurol 63:494-506. 2008
    ....
  32. ncbi request reprint Identification and differential vulnerability of a neural network in sleep deprivation
    Sandra Bell-McGinty
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, 630 West 168th Street, PH 18, New York, USA
    Cereb Cortex 14:496-502. 2004
    ..A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation...
  33. pmc Verbal fluency predicts mortality in Alzheimer disease
    Stephanie Cosentino
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, NY, USA
    Cogn Behav Neurol 19:123-9. 2006
    ..To assess the predictive value of neuropsychologic profiles, at diagnosis, for mortality in incident Alzheimer disease (AD)...
  34. pmc Performance degradation and altered cerebral activation during dual performance: evidence for a bottom-up attentional system
    Yunglin Gazes
    Cognitive Neuroscience Division, Taub Institute, Columbia University, New York, NY 10032, USA
    Behav Brain Res 210:229-39. 2010
    ..Furthermore, the ventral attention system, rather than the dorsal attention system, was found to mediate task coordination between tracking and visual detection...
  35. pmc The heritability of abstract reasoning in Caribbean Latinos with familial Alzheimer disease
    Beverly Johnson
    Taub Institute on Alzheimer s Disease and the Aging Brain, New York, NY, USA
    Dement Geriatr Cogn Disord 24:411-7. 2007
    ..To better understand the genetic influence on component phenotypes of AD, we estimated the heritability (h(2)) of abstract reasoning and examined its relation with apolipoprotein epsilon 4 (APOE-epsilon 4)...
  36. pmc Contribution of vascular risk factors to the progression in Alzheimer disease
    Elizabeth P Helzner
    Gertrude H Sergievsky Center, Columbia University Medical Center, NY, New York, USA
    Arch Neurol 66:343-8. 2009
    ....
  37. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  38. doi request reprint A prospective cohort study of neuropsychological test performance in ALS
    Paul H Gordon
    Department of Neurology, Columbia University, New York, NY, USA
    Amyotroph Lateral Scler 11:312-20. 2010
    ..The strongest neuropsychological predictors of cognitive status were measures of executive, episodic memory and language function. Cognitively impaired patients had shorter survival time...
  39. pmc Inducible nitric oxide synthase promoter polymorphism affords protection against cognitive dysfunction after carotid endarterectomy
    Gene T Yocum
    Department of Anesthesiology, Columbia University, New York, NY 10032, USA
    Stroke 40:1597-603. 2009
    ..We investigated whether the 4-repeat variant (iNOS(+)) affects the incidence of cognitive dysfunction after CEA...
  40. pmc Aging does not affect brain patterns of repetition effects associated with perceptual priming of novel objects
    Anja Soldan
    Columbia University Medical Center, New York, NY, USA
    J Cogn Neurosci 20:1762-76. 2008
    ....
  41. ncbi request reprint Depressive symptoms in Alzheimer's disease: natural course and temporal relation to function and cognitive status
    Roee Holtzer
    Cognitive Neuroscience Division, Taub Institute, G H Gertrude Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA
    J Am Geriatr Soc 53:2083-9. 2005
    ..To examine the natural course of depressive symptoms in patients with probable Alzheimer's disease (AD), specifically, the temporal relationship between depressive symptoms, function, and cognitive status...
  42. ncbi request reprint An observational study of cognitive impairment in amyotrophic lateral sclerosis
    Gregory A Rippon
    Department of Neurology, Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Eleanor and Lou Gehrig MDA ALS Research Center, New York, NY, USA
    Arch Neurol 63:345-52. 2006
    ..Clinical and pathologic features overlap in frontotemporal lobar dementia and ALS. Demographics, respiratory status, bulbar site of onset, and disease severity are potential risk factors for cognitive impairment in ALS...
  43. pmc Evidence for age-related changes to temporal attention and memory from the choice time production task
    Cynthia M Gooch
    Division of Cognitive Neuroscience, Taub Institute, Columbia University, New York, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16:285-310. 2009
    ..Results from each experiment separately show age-related changes to attention and memory in temporal processing using different measures and manipulations in the same task...
  44. pmc The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort
    Joseph H Lee
    Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 64:501-6. 2007
    ..To investigate the association between Alzheimer disease (AD) and variant alleles in SORL1 using a series of single nucleotide polymorphisms (SNPs) in an urban, multiethnic, community-based population...
  45. ncbi request reprint Ischemic stroke and depression
    David W Desmond
    Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Int Neuropsychol Soc 9:429-39. 2003
    ..SIGH-D item analyses suggested that a reliance on nonsomatic rather than somatic symptoms would result in the most accurate diagnoses of depression after ischemic stroke...
  46. pmc Food combination and Alzheimer disease risk: a protective diet
    Yian Gu
    The Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Arch Neurol 67:699-706. 2010
    ..Because foods are not consumed in isolation, dietary pattern (DP) analysis of food combination, taking into account the interactions among food components, may offer methodological advantages...
  47. ncbi request reprint Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory study
    Gilberto Levy
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mov Disord 17:250-7. 2002
    ..The association of smoking with incident dementia in PD deserves further study...
  48. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  49. pmc Construct validity of cognitive reserve in a multiethnic cohort: The Northern Manhattan Study
    Karen L Siedlecki
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Int Neuropsychol Soc 15:558-69. 2009
    ....
  50. ncbi request reprint Longitudinal assessment of patient dependence in Alzheimer disease
    Adam M Brickman
    Department of Neurology, Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 59:1304-8. 2002
    ..Validity and reliability of this scale have been demonstrated, but the progression throughout long periods in patients with Alzheimer disease (AD) has not previously been examined...
  51. ncbi request reprint Psychopathological features in Alzheimer's disease: course and relationship with cognitive status
    Roee Holtzer
    Sergievsky Center, New York, New York 10032, USA
    J Am Geriatr Soc 51:953-60. 2003
    ..To examine the course, clinical correlates, and relationship between cognitive status and psychopathological features in patients with probable Alzheimer's disease (AD) followed over a 5-year period...
  52. ncbi request reprint Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease
    Joseph H Lee
    Gertrude H Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 63:1591-8. 2006
    ..To identify novel candidate regions for late-onset Alzheimer disease (LOAD) and to confirm linkage in previously identified chromosomal regions...
  53. ncbi request reprint Memory and executive function impairment predict dementia in Parkinson's disease
    Gilberto Levy
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Mov Disord 17:1221-6. 2002
    ..Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD...
  54. ncbi request reprint Leisure activity and cognitive decline in incident Alzheimer disease
    Elizabeth P Helzner
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 64:1749-54. 2007
    ..High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD)...
  55. pmc Age effects on load-dependent brain activations in working memory for novel material
    Roee Holtzer
    Ferkauf Graduate School of Psychology, Yeshiva University, NY, USA
    Brain Res 1249:148-61. 2009
    ..Delineating how these theories work in concert can increase knowledge of age-related effects on working memory...
  56. ncbi request reprint Effects of hormone replacement therapy and aging on cognition: evidence for executive dysfunction
    Domonick J Wegesin
    G H Sergievsky Center, Columbia University New York, New York, 10032, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:301-28. 2007
    ..Overall, findings support the hypothesis that estrogen use may temper age-related cognitive decline by helping to maintain functions subserved by the frontal lobes...
  57. pmc Mediterranean diet, Alzheimer disease, and vascular mediation
    Nikolaos Scarmeas
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 63:1709-17. 2006
    ..To examine the association between the Mediterranean diet (MeDi) and Alzheimer disease (AD) in a different AD population and to investigate possible mediation by vascular pathways. Design, Setting, Patients, and..
  58. pmc Separating function from structure in perfusion imaging of the aging brain
    Iris Asllani
    Program for Imaging and Cognitive Sciences in the Department of Radiology, Columbia University, New York, New York, USA
    Hum Brain Mapp 30:2927-35. 2009
    ....
  59. pmc Mediterranean diet and mild cognitive impairment
    Nikolaos Scarmeas
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 66:216-25. 2009
    ..Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored...
  60. pmc Comparison of patient and caregiver reports of patient activity participation and its relationship to mental health in patients with Alzheimer's disease
    Karen L Siedlecki
    Cognitive Neuroscience Division, Taub Institute, Columbia University, New York, NY 10032, USA
    J Gerontol B Psychol Sci Soc Sci 64:687-95. 2009
    ..Predictors of patient-rated activity participation did not differ as a function of age or cognition...
  61. ncbi request reprint Onset of dementia is associated with age at menopause in women with Down's syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Ann Neurol 54:433-8. 2003
    ..Our findings support the hypothesis that reductions in estrogens after menopause contribute to the cascade of pathological processes leading to AD...
  62. pmc Examining the multifactorial nature of cognitive aging with covariance analysis of positron emission tomography data
    Karen L Siedlecki
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Int Neuropsychol Soc 15:973-81. 2009
    ..The findings from this study are consistent with the multifactorial nature of cognitive aging...
  63. ncbi request reprint Inter- and intraindividual variability in recognition memory: effects of aging and estrogen use
    Domonick J Wegesin
    Division of Cognitive Neuroscience, Gertrude H Sergievsky Center and Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Neuropsychology 18:646-57. 2004
    ..Overall, age-related increases in variability differed with the type of variability measured, and estrogen use, but not est + prog use, appeared to reduce age-related increases in at least 1 form of variability...
  64. ncbi request reprint Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment
    D P Devanand
    Department of Biological Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Neurol 62:975-80. 2005
    ..In cognitively impaired patients without dementia, the utility of apolipoprotein E (APOE) genotyping is unclear...
  65. ncbi request reprint The effects of aging on time reproduction in delayed free-recall
    Brian C Rakitin
    Division of Cognitive Neuroscience, Taub Institute, Columbia University, New York, NY 10032, United States
    Brain Cogn 58:17-34. 2005
    ....
  66. pmc Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Arch Neurol 60:359-65. 2003
    ..This has been interpreted as suggesting that cognitive reserve allows these patients to cope better with the pathologic changes in AD...
  67. ncbi request reprint Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE
    Stavra N Romas
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 59:87-91. 2002
    ....
  68. ncbi request reprint Structural MRI covariance patterns associated with normal aging and neuropsychological functioning
    Adam M Brickman
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 20032, USA
    Neurobiol Aging 28:284-95. 2007
    ..The results suggest that identifiable networks of grey and white matter regions systematically decline with age and that pattern expression is linked to age-related cognitive decline...
  69. pmc Imaging studies and APOE genotype in persons at risk for Alzheimer's disease
    Nikolaos Scarmeas
    Columbia University Medical Center, 622 West 168th Street, PH 19th Floor, New York, NY 10032, USA
    Curr Psychiatry Rep 8:11-7. 2006
    ..APOE-related findings in imaging studies of nondemented subjects may be the result of incipient AD pathologic changes or of genetic heterogeneity in brain structure and function...
  70. ncbi request reprint Older adults' reports of formal care hours and administrative records
    Steven M Albert
    Gertrude H Sergievsky Center, PH 19, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Gerontologist 44:186-92. 2004
    ..We examined these issues in a New York City sample by assessing older adults' reports of weekly home care hours and Medicaid billing records...
  71. ncbi request reprint Distinct spatial patterns of brain activity associated with memory storage and search
    Eric Zarahn
    The Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Columbia University, New York, NY 10032, USA
    Neuroimage 33:794-804. 2006
    ..These patterns were significantly different, suggesting that memory search and working memory maintenance are mediated by distinct neural mechanisms...
  72. pmc Plasma ß-amyloid and cognitive decline
    Stephanie A Cosentino
    The Gertrude H Sergievsky Center, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 67:1485-90. 2010
    ..To determine if plasma β-amyloid (Aβ) levels (1) can be linked to specific cognitive changes that constitute conversion to Alzheimer disease (AD) and (2) correspond to cognitive change independent of dementia...
  73. ncbi request reprint Age-related changes in source memory retrieval: an ERP replication and extension
    Domonick J Wegesin
    Division of Cognitive Neuroscience, G H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
    Brain Res Cogn Brain Res 13:323-38. 2002
    ..These results are consistent with the frontal lobe deficit hypothesis of aging and provide some evidence that old and young may use distinct cortical networks during source memory retrieval...
  74. pmc Cognitive reserve in aging
    A M Tucker
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, USA
    Curr Alzheimer Res 8:354-60. 2011
    ..Thus, even late-stage interventions hold promise to boost cognitive reserve and thus reduce the prevalence of Alzheimer's disease and other age-related problems...
  75. pmc A controlled prospective study of neuropsychological dysfunction following carotid endarterectomy
    Eric J Heyer
    Department of Anesthesiology, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 59:217-22. 2002
    ....
  76. ncbi request reprint A new approach to spatial covariance modeling of functional brain imaging data: ordinal trend analysis
    Christian Habeck
    Cognitive Neuroscience Division, Taub Institute, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neural Comput 17:1602-45. 2005
    ..In sum, OrT has potential applications to not only studies of young adults and their cognitive abilities, but also studies of normal aging and neurological and psychiatric disease...
  77. ncbi request reprint HIV-associated cognitive impairment before and after the advent of combination therapy
    Ned Sacktor
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Neurovirol 8:136-42. 2002
    ..Even though HAART has reduced the incidence of HIV dementia, HIV-associated cognitive impairment continues to be a major clinical problem among individuals with advanced infection...
  78. pmc Cognitive reserve and lifestyle
    Nikolaos Scarmeas
    Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, and College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Clin Exp Neuropsychol 25:625-33. 2003
    ..It is possible that aspects of life experience like engagement in leisure activities may result in functionally more efficient cognitive networks and therefore provide a CR that delays the onset of clinical manifestations of dementia...
  79. ncbi request reprint fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    Nikolaos Scarmeas
    Neurology 65:1514-5; author reply 1514-5. 2005
  80. ncbi request reprint Explicit contamination contributes to aging effects in episodic priming: behavioral and ERP evidence
    Domonick J Wegesin
    Department of Neurology, Columbia University, G H Sergievsky Center, 19th Floor, 630 West 168 Street, New York, NY 10032, USA
    J Gerontol B Psychol Sci Soc Sci 59:P317-24. 2004
    ..Given the apparent vulnerability to contamination by explicit memory, we suggest caution when researchers use an episodic priming paradigm to assess aging effects in implicit memory...
  81. pmc Covariance PET patterns in early Alzheimer's disease and subjects with cognitive impairment but no dementia: utility in group discrimination and correlations with functional performance
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuroimage 23:35-45. 2004
    ..Expression of covariance patterns correlates with cognitive and functional performance measures, holding promise for meaningful associations with underlying biopathological processes...
  82. pmc Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease
    Nikolaos Scarmeas
    Columbia Presbyterian Medical Center, 622 West 168th Street, PH 19th Floor, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 4:374-80. 2004
    ..In this article, we review some of the relevant literature of the noted associations between markers of cognitive reserve and AD and discuss the possible mechanisms that may explain these associations...
  83. ncbi request reprint A comparison of family history of psychiatric disorders among patients with early- and late-onset Alzheimer's disease
    Gayatri Devi
    New York Memory and Healthy Aging Services, New York 10021, USA
    J Neuropsychiatry Clin Neurosci 16:57-62. 2004
    ..Family history studies may underestimate familial aggregation of EOAD...
  84. pmc Delusions and hallucinations are associated with worse outcome in Alzheimer disease
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, New York, NY 10032, USA
    Arch Neurol 62:1601-8. 2005
    ..According to all previous literature, they are not associated with mortality...
  85. ncbi request reprint An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection
    Jeffrey J Sevigny
    Department of Neurology and Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 64:97-102. 2007
    ..Several markers of immune activation have been identified as potential prognostic markers for human immunodeficiency virus (HIV)-associated morbidity and mortality, but the results from studies are conflicting...
  86. ncbi request reprint Obesity enhances verbal memory in postmenopausal women with Down syndrome
    Bindu N Patel
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 25:159-66. 2004
    ..Our results support the hypothesis that higher endogenous estrogen levels after menopause are associated with better performance on verbal memory...
  87. ncbi request reprint Stroke and the risk of Alzheimer disease
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, Columbia University, New York
    Arch Neurol 60:1707-12. 2003
    ..Alzheimer disease (AD) and stroke are common in elderly individuals, but the relation between these 2 disorders remains uncertain...
  88. pmc Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer's disease
    Iris Asllani
    Department of Radiology, Columbia University, New York, New York 10032, USA
    J Cereb Blood Flow Metab 28:725-36. 2008
    ..When tested on extensive split-half analysis to map out the replicability of both multivariate and univariate approaches, the expression of the pattern from multivariate analysis was superior to that of the univariate...
  89. pmc Disruptive behavior as a predictor in Alzheimer disease
    Nikolaos Scarmeas
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 64:1755-61. 2007
    ..Disruptive behavior is common in Alzheimer disease (AD). There are conflicting reports regarding its ability to predict cognitive decline, functional decline, institutionalization, and mortality...
  90. ncbi request reprint Medication management skill in HIV: I. Evidence for adaptation of medication management strategies in people with cognitive impairment. II. Evidence for a pervasive lay model of medication efficacy
    Steven M Albert
    Gertrude H Sergievsky Center and Department of Neurology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    AIDS Behav 7:329-38. 2003
    ..A performance test of medication management sheds light on the ways patients take medicines and how beliefs about medicines affect medication regimens...
  91. ncbi request reprint Acquisition, recall, and forgetting of verbal information in long-term memory by young, middle-aged, and elderly individuals
    Hasker P Davis
    Department of Psychology, University of Colorado, Colorado Springs 80933, USA
    Cortex 39:1063-91. 2003
    ..The importance of testing across the life span and using tests that examine a variety of memory components and processes for establishing norms and clarifying age-related deficits are discussed...
  92. pmc APOE genotype and cerebral blood flow in healthy young individuals
    Nikolaos Scarmeas
    JAMA 290:1581-2. 2003
  93. ncbi request reprint Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementia
    Enrique Noe
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
    Mov Disord 19:60-7. 2004
    ....
  94. ncbi request reprint An event-related fMRI study of the neural networks underlying the encoding, maintenance, and retrieval phase in a delayed-match-to-sample task
    Christian Habeck
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, 622 West 168th Street, PH 18, New York, NY 10032, USA
    Brain Res Cogn Brain Res 23:207-20. 2005
    ..The load-related activation patterns from encoding and retrieval phase and their relationship to behavior are also discussed...

Research Grants38

  1. Predictors of Severity in Alzheimer's Disease
    Yaakov Stern; Fiscal Year: 2009
    ..We will determine whether the accuracy of our prediction algorithms increases when we incorporate clinical features that correlate with these pathologic measures. ..
  2. PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2004
    ..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..
  3. PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2001
    ..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..
  4. Imaging of Cognition, Learning and Memory in Aging
    Yaakov Stern; Fiscal Year: 2007
    ..abstract_text> ..
  5. BEHV AND IMAGING APPROCHES TO IMPLICIT MEMORY IN AGING
    Yaakov Stern; Fiscal Year: 2001
    ..This proposal represents a unique combination of expertise across collaborators and will make a major contribution to our understanding of age-related changes in memory. ..
  6. PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2002
    ..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..
  7. BEHV AND IMAGING APPROCHES TO IMPLICIT MEMORY IN AGING
    Yaakov Stern; Fiscal Year: 2002
    ..This proposal represents a unique combination of expertise across collaborators and will make a major contribution to our understanding of age-related changes in memory. ..
  8. PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2003
    ..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..
  9. Imaging of Cognition, Learning and Memory in Aging
    Yaakov Stern; Fiscal Year: 2004
    ..abstract_text> ..
  10. PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2005
    ..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..
  11. Imaging of Cognition, Learning and Memory in Aging
    Yaakov Stern; Fiscal Year: 2007
    ..Evaluatehow response to task load varies as a function of variables known to mediate cognitive reserve, including IQ and education, in order to identify neural networks associated with cognitive reserve and compensation. ..
  12. Predictors of Severity in Alzheimer's Disease
    Yaakov Stern; Fiscal Year: 2006
    ..We will determine whether the accuracy of our prediction algorithms increases when we incorporate clinical features that correlate with these pathologic measures. ..
  13. Combined exercise and cognitive training intervention in normal aging
    Yaakov Stern; Fiscal Year: 2009
    ..The possibility that this intervention may markedly improve day-to-day function in healthy elders has enormous potential significance for public health. ..
  14. BEHV AND IMAGING APPROCHES TO IMPLICIT MEMORY IN AGING
    Yaakov Stern; Fiscal Year: 1999
    ..This proposal represents a unique combination of expertise across collaborators and will make a major contribution to our understanding of age-related changes in memory. ..
  15. IMAGING COMPENSATION AND RESERVE IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 1999
    ..In addition, the methodologic issues we raise are applicable to all functional imaging studies of cognitive task performance in patient populations. ..
  16. PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2000
    ..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..
  17. PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2006
    ..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..
  18. NEUROPSYCHOLOGY AND COGNITION IN AGING
    Yaakov Stern; Fiscal Year: 2007
    ..The original program worked with 2 trainees at any one time. We received a minority supplement to add a third trainee. We now propose to make this change permanent in order to work with 3 trainees at any one time. ..
  19. Predictors of Severity in Alzheimer's Disease
    Yaakov Stern; Fiscal Year: 2010
    ..We will determine whether the accuracy of our prediction algorithms increases when we incorporate clinical features that correlate with these pathologic measures. ..
  20. Imaging of Cognition, Learning and Memory in Aging
    Yaakov Stern; Fiscal Year: 2006
    ..abstract_text> ..
  21. Imaging of Cognition, Learning and Memory in Aging
    Yaakov Stern; Fiscal Year: 2005
    ..abstract_text> ..
  22. Exercise, aging, and cognition: Effect and mechanisms
    YAAKOV contact STERN; Fiscal Year: 2010
    ..Therefore, the possibility that exercise improves cognition in younger subjects has enormous potential significance for public health. ..
  23. IMAGING COMPENSATION AND RESERVE IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2000
    ..In addition, the methodologic issues we raise are applicable to all functional imaging studies of cognitive task performance in patient populations. ..
  24. IMAGING COMPENSATION AND RESERVE IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 2001
    ..In addition, the methodologic issues we raise are applicable to all functional imaging studies of cognitive task performance in patient populations. ..
  25. BEHV AND IMAGING APPROCHES TO IMPLICIT MEMORY IN AGING
    Yaakov Stern; Fiscal Year: 2003
    ..This proposal represents a unique combination of expertise across collaborators and will make a major contribution to our understanding of age-related changes in memory. ..
  26. BEHV AND IMAGING APPROCHES TO IMPLICIT MEMORY IN AGING
    Yaakov Stern; Fiscal Year: 2000
    ..This proposal represents a unique combination of expertise across collaborators and will make a major contribution to our understanding of age-related changes in memory. ..
  27. Predictors of Severity in Alzheimer's Disease
    Yaakov Stern; Fiscal Year: 2007
    ..We will determine whether the accuracy of our prediction algorithms increases when we incorporate clinical features that correlate with these pathologic measures. ..
  28. Combined exercise and cognitive training intervention in normal aging
    Yaakov Stern; Fiscal Year: 2010
    ..The possibility that this intervention may markedly improve day-to-day function in healthy elders has enormous potential significance for public health. ..
  29. PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASE
    Yaakov Stern; Fiscal Year: 1999
    ..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..