Research Topics
Species | YAAKOV contact STERNSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Cognitive reserve in ageing and Alzheimer's diseaseYaakov Stern
Cognitive Neuroscience Division, Department of Neurology and Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA Electronic address
Lancet Neurol 11:1006-12. 2012..Greater understanding of the concept of cognitive reserve could lead to interventions to slow cognitive ageing or reduce the risk of dementia...
Space Fortress game training and executive control in older adults: a pilot interventionYaakov Stern
Taub Institute, Columbia University, Cognitive Neuroscience Division, New York, NY 10032, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 18:653-77. 2011..Future SF interventions need to carefully consider increasing the duration and or the intensity of the intervention by providing at-home game training, reducing the motor demands of the game, and selecting appropriate outcome measures...- Task difficulty modulates young-old differences in network expressionYaakov Stern
Cognitive Neuroscience Division of the Taub Institute for the Study of Alzheimer s Disease and the Aging Brain, Columbia University College ofPhysicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
Brain Res 1435:130-45. 2012..These findings suggest that neuroimaging studies comparing task-related activation across groups with different cognitive abilities must be interpreted in light of the relative difficulty of the task for each group... 
An investigation of clinical correlates of Lewy bodies in autopsy-proven Alzheimer diseaseY Stern
Department of Neurology and Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 58:460-5. 2001....- A common neural network for cognitive reserve in verbal and object working memory in young but not oldYaakov Stern
Cognitive Neuroscience Division of the Taub Institute, NY, USA
Cereb Cortex 18:959-67. 2008..This spatial pattern could represent a general neural instantiation of CR that is affected by the aging process... - The concept of cognitive reserve: a catalyst for researchYaakov Stern
Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
J Clin Exp Neuropsychol 25:589-93. 2003 - Rate of memory decline in AD is related to education and occupation: cognitive reserve?Y Stern
Department of Neurology, The Gertrude H Sergievsky Center, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Neurology 53:1942-7. 1999..To determine whether the rate of decline in performance on a memory test is more rapid in AD patients with higher versus lower educational and occupational attainment... - What is cognitive reserve? Theory and research application of the reserve conceptYaakov Stern
G H Sergievsky Center, The Taub Institute, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Int Neuropsychol Soc 8:448-60. 2002..Epidemiologic and imaging data that help to develop and support the concept of reserve are presented... - Cognitive reserve and Alzheimer diseaseYaakov Stern
Cognitive Neuroscience Division of the Taub Institute, New York, NY 10032, USA
Alzheimer Dis Assoc Disord 20:112-7. 2006..There is also the possibility that directly enhancing CR may help forestall the diagnosis of AD... - Exploring the neural basis of cognitive reserveYaakov Stern
Department of Neurology, Taub Institute for Research in Alzheimer s Disease and the Aging Brain and College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Clin Exp Neuropsychol 25:691-701. 2003..This differential processing may help explain individual differences in capacity, and may underlie reserve against age-related or other pathologic changes... - Brain networks associated with cognitive reserve in healthy young and old adultsYaakov Stern
Cognitive Neuroscience Division, Taub Institute, College of Physicians and Surgeons, Columbia University, New York, USA
Cereb Cortex 15:394-402. 2005..Thus, for the old subjects this topography may represent an altered, compensatory network that is used to maintain function in the face of age-related physiological changes... - Different brain networks mediate task performance in normal aging and AD: defining compensationY Stern
Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
Neurology 55:1291-7. 2000..To determine whether the pathologic mechanisms of AD alter the brain networks subserving performance of a verbal recognition task... - Prospective comparative study of the evolution of probable Alzheimer's disease and Parkinson's disease dementiaY Stern
Gertrude H Sergievsky Center, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032
J Int Neuropsychol Soc 4:279-84. 1998..We conclude that while pAD and PD dementia are similar in many respects, differences in their evolution support previous observation of unique features in the 2 dementias and suggest different underlying pathologies... - Factors associated with incident human immunodeficiency virus-dementiaY Stern
Department of Neurology and Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 58:473-9. 2001..Antecedents to human immunodeficiency virus-dementia (HIV-D) are poorly understood... - Cognitive reserveYaakov Stern
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
Neuropsychologia 47:2015-28. 2009..It then focuses on methodologic issues that are important when attempting to elucidate the neural underpinnings of cognitive reserve using imaging studies, and reviews some of our group's work in order to demonstrate these issues... - Mortality in patients with dementia after ischemic strokeDavid W Desmond
Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Neurology 59:537-43. 2002..The authors investigated dementia as a predictor of long-term survival among patients with ischemic stroke... - The neuropsychological profiles of mild Alzheimer's disease and questionable dementia as compared to age-related cognitive declineElise Caccappolo-van Vliet
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Int Neuropsychol Soc 9:720-32. 2003..Areas of lower functioning in QD subjects as compared to elderly controls included category fluency and visuospatial ability... - Incidence of dementia after ischemic stroke: results of a longitudinal studyDavid W Desmond
Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Stroke 33:2254-60. 2002..We conducted the present study to investigate the incidence and clinical predictors of dementia after ischemic stroke... - Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban communityJennifer J Manly
Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
Arch Neurol 62:1739-46. 2005.... - Predicting age-related dual-task effects with individual differences on neuropsychological testsRoee Holtzer
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA
Neuropsychology 19:18-27. 2005..The authors conclude that compromised central executive may underlie age-related decline in dual-task performance... - H215O PET study of impairment of nonverbal recognition with normal agingKaren E Anderson
Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
J Neuropsychiatry Clin Neurosci 17:192-200. 2005..Elderly subjects did not show the relationship between parahippocampal flow and SLS, which was observed in younger subjects. These differences suggest that age-related functional brain changes partly explain performance deficits... - Relation of cognitive reserve and task performance to expression of regional covariance networks in an event-related fMRI study of nonverbal memoryChristian Habeck
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Neuroimage 20:1723-33. 2003..e., there were reserve-related physiological differences that presumably would persist were there no subject differences in task performance. This suggests that this network may represent a neural correlate of CR... - Patient dependence and longitudinal changes in costs of care in Alzheimer's diseaseCarolyn W Zhu
Geriatric Research, Education, and Clinical Center GRECC, James J Peters VA Medical Center, Bronx, NY, NY 10468, USA
Dement Geriatr Cogn Disord 26:416-23. 2008..To examine the incremental effect of patients' dependence on others, on cost of medical and nonmedical care, and on informal caregiving hours over time... - APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individualsBenjamin Tycko
Department of Pathology, Division of Neuropathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Arch Neurol 61:1434-9. 2004..Polymorphisms in regulatory sequences of APOE have also been related to AD, but the effects are inconsistent across studies... - Do neuropsychological tests have the same meaning in Spanish speakers as they do in English speakers?Karen L Siedlecki
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
Neuropsychology 24:402-11. 2010..The purpose of this study was to examine whether neuropsychological tests translated into Spanish measure the same cognitive constructs as the original English versions... - Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjectsNikolaos Scarmeas
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA
Neuroimage 19:1215-27. 2003..Brain regions where systematic relationships between CR and brain activation differ as a function of aging are loci where compensation for aging has occurred. They may mediate differential ability to cope with brain changes in aging... - Sources of errors on visuoperceptual tasks: role of education, literacy, and search strategyDesiree A Byrd
G. H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Brain Cogn 58:251-7. 2005.... - Incidence and predictors of seizures in patients with Alzheimer's diseaseJoan C Amatniek
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Epilepsia 47:867-72. 2006..Younger individuals, African Americans, and those with more-severe disease or focal epileptiform findings on EEG were more likely to have unprovoked seizures... - Frequency and course of mild cognitive impairment in a multiethnic communityJennifer J Manly
Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY, USA
Ann Neurol 63:494-506. 2008.... - Identification and differential vulnerability of a neural network in sleep deprivationSandra Bell-McGinty
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, USA
Cereb Cortex 14:496-502. 2004..A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation... - Verbal fluency predicts mortality in Alzheimer diseaseStephanie Cosentino
Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, NY, USA
Cogn Behav Neurol 19:123-9. 2006..The prognostic value of these tests may derive from their general psychometric properties, or may reflect the measures' sensitivity to an early or critical level of compromise to frontal networks... - Contribution of vascular risk factors to the progression in Alzheimer diseaseElizabeth P Helzner
Gertrude H Sergievsky Center, Columbia University Medical Center, NY, New York, USA
Arch Neurol 66:343-8. 2009.... - Performance degradation and altered cerebral activation during dual performance: evidence for a bottom-up attentional systemYunglin Gazes
Cognitive Neuroscience Division, Taub Institute, Columbia University, New York, NY 10032, USA
Behav Brain Res 210:229-39. 2010..Furthermore, the ventral attention system, rather than the dorsal attention system, was found to mediate task coordination between tracking and visual detection... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - The heritability of abstract reasoning in Caribbean Latinos with familial Alzheimer diseaseBeverly Johnson
Taub Institute on Alzheimer s Disease and the Aging Brain, New York, NY, USA
Dement Geriatr Cogn Disord 24:411-7. 2007..To better understand the genetic influence on component phenotypes of AD, we estimated the heritability (h(2)) of abstract reasoning and examined its relation with apolipoprotein epsilon 4 (APOE-epsilon 4)... - Aging does not affect brain patterns of repetition effects associated with perceptual priming of novel objectsAnja Soldan
Columbia University Medical Center, New York, NY, USA
J Cogn Neurosci 20:1762-76. 2008.... - A prospective cohort study of neuropsychological test performance in ALSPaul H Gordon
Department of Neurology, Columbia University, New York, NY, USA
Amyotroph Lateral Scler 11:312-20. 2010..The strongest neuropsychological predictors of cognitive status were measures of executive, episodic memory and language function. Cognitively impaired patients had shorter survival time... - Inducible nitric oxide synthase promoter polymorphism affords protection against cognitive dysfunction after carotid endarterectomyGene T Yocum
Department of Anesthesiology, Columbia University, New York, NY 10032, USA
Stroke 40:1597-603. 2009..We investigated whether the 4-repeat variant (iNOS(+)) affects the incidence of cognitive dysfunction after CEA... - Depressive symptoms in Alzheimer's disease: natural course and temporal relation to function and cognitive statusRoee Holtzer
Cognitive Neuroscience Division, Taub Institute, G.H. Gertrude Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA
J Am Geriatr Soc 53:2083-9. 2005..Examination of the temporal relationship between depressive symptoms and risk factors suggests that decline in function but not in cognition precedes the first episode of depressive symptoms in patients with probable AD... - An observational study of cognitive impairment in amyotrophic lateral sclerosisGregory A Rippon
Department of Neurology, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Eleanor and Lou Gehrig MDA/ALS Research Center, New York, NY, USA
Arch Neurol 63:345-52. 2006..CONCLUSIONS: Nearly a third of the patients with ALS showed evidence of cognitive impairment in a pattern consistent with frontotemporal lobar dementia. Cognitive performance was not related to site of onset or survival... - Evidence for age-related changes to temporal attention and memory from the choice time production taskCynthia M Gooch
Division of Cognitive Neuroscience, Taub Institute, Columbia University, New York, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16:285-310. 2009..Results from each experiment separately show age-related changes to attention and memory in temporal processing using different measures and manipulations in the same task... - The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohortJoseph H Lee
Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Arch Neurol 64:501-6. 2007..To investigate the association between Alzheimer disease (AD) and variant alleles in SORL1 using a series of single nucleotide polymorphisms (SNPs) in an urban, multiethnic, community-based population... - Ischemic stroke and depressionDavid W Desmond
Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
J Int Neuropsychol Soc 9:429-39. 2003..SIGH-D item analyses suggested that a reliance on nonsomatic rather than somatic symptoms would result in the most accurate diagnoses of depression after ischemic stroke... - Food combination and Alzheimer disease risk: a protective dietYian Gu
The Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Arch Neurol 67:699-706. 2010..Because foods are not consumed in isolation, dietary pattern (DP) analysis of food combination, taking into account the interactions among food components, may offer methodological advantages... - Do risk factors for Alzheimer's disease predict dementia in Parkinson's disease? An exploratory studyGilberto Levy
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Mov Disord 17:250-7. 2002..The association of smoking with incident dementia in PD deserves further study... - Construct validity of cognitive reserve in a multiethnic cohort: The Northern Manhattan StudyKaren L Siedlecki
Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Int Neuropsychol Soc 15:558-69. 2009.... - Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiativeOwen Carmichael
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Arch Neurol 67:1370-8. 2010.... - Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer diseaseJoseph H Lee
Gertrude H. Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 63:1591-8. 2006..The highest LOD score was found at chromosome 3q28. At least 2 other independent studies have observed support for significant linkage at chromosome 3q28, highlighting this region as a locus for further genetic exploration... - Effects of hormone replacement therapy and aging on cognition: evidence for executive dysfunctionDomonick J Wegesin
G H Sergievsky Center, Columbia University New York, New York, 10032, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:301-28. 2007..Overall, findings support the hypothesis that estrogen use may temper age-related cognitive decline by helping to maintain functions subserved by the frontal lobes... - Memory and executive function impairment predict dementia in Parkinson's diseaseGilberto Levy
Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA
Mov Disord 17:1221-6. 2002..Our results indicate that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD... - Leisure activity and cognitive decline in incident Alzheimer diseaseElizabeth P Helzner
Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
Arch Neurol 64:1749-54. 2007..High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD)... - Longitudinal assessment of patient dependence in Alzheimer diseaseAdam M Brickman
Department of Neurology, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 59:1304-8. 2002..The scale is a valuable instrument for outcomes research, efficacy trials, and behavioral research in AD... - Age effects on load-dependent brain activations in working memory for novel materialRoee Holtzer
Ferkauf Graduate School of Psychology, Yeshiva University, NY, USA
Brain Res 1249:148-61. 2009..Delineating how these theories work in concert can increase knowledge of age-related effects on working memory... - Psychopathological features in Alzheimer's disease: course and relationship with cognitive statusRoee Holtzer
Sergievsky Center, New York, New York 10032, USA
J Am Geriatr Soc 51:953-60. 2003..These findings provide important information to clinicians and caregivers regarding the course, predictability, and possible treatment of psychopathological behaviors in patients with probable AD... - Onset of dementia is associated with age at menopause in women with Down's syndromeNicole Schupf
The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
Ann Neurol 54:433-8. 2003..Our findings support the hypothesis that reductions in estrogens after menopause contribute to the cascade of pathological processes leading to AD... - Examining the multifactorial nature of cognitive aging with covariance analysis of positron emission tomography dataKaren L Siedlecki
Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Int Neuropsychol Soc 15:973-81. 2009..The findings from this study are consistent with the multifactorial nature of cognitive aging... - Distinct spatial patterns of brain activity associated with memory storage and searchEric Zarahn
The Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Columbia University, New York, NY 10032, USA
Neuroimage 33:794-804. 2006..These patterns were significantly different, suggesting that memory search and working memory maintenance are mediated by distinct neural mechanisms... - Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesisNikolaos Scarmeas
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Arch Neurol 60:359-65. 2003..This has been interpreted as suggesting that cognitive reserve allows these patients to cope better with the pathologic changes in AD... - Separating function from structure in perfusion imaging of the aging brainIris Asllani
Program for Imaging and Cognitive Sciences in the Department of Radiology, Columbia University, New York, New York, USA
Hum Brain Mapp 30:2927-35. 2009.... - The effects of aging on time reproduction in delayed free-recallBrian C Rakitin
Division of Cognitive Neuroscience, Taub Institute, Columbia University, New York, NY 10032, United States
Brain Cogn 58:17-34. 2005.... - Mediterranean diet and mild cognitive impairmentNikolaos Scarmeas
Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
Arch Neurol 66:216-25. 2009..Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored... - Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOEStavra N Romas
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 59:87-91. 2002.... - Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairmentD P Devanand
Department of Biological Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Arch Neurol 62:975-80. 2005..In cognitively impaired patients without dementia, the utility of apolipoprotein E (APOE) genotyping is unclear... - Comparison of patient and caregiver reports of patient activity participation and its relationship to mental health in patients with Alzheimer's diseaseKaren L Siedlecki
Cognitive Neuroscience Division, Taub Institute, Columbia University, New York, NY 10032, USA
J Gerontol B Psychol Sci Soc Sci 64:687-95. 2009..Predictors of patient-rated activity participation did not differ as a function of age or cognition... - Inter- and intraindividual variability in recognition memory: effects of aging and estrogen useDomonick J Wegesin
Division of Cognitive Neuroscience, Gertrude H Sergievsky Center and Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
Neuropsychology 18:646-57. 2004..Overall, age-related increases in variability differed with the type of variability measured, and estrogen use, but not est + prog use, appeared to reduce age-related increases in at least 1 form of variability... - Structural MRI covariance patterns associated with normal aging and neuropsychological functioningAdam M Brickman
Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 20032, USA
Neurobiol Aging 28:284-95. 2007..The results suggest that identifiable networks of grey and white matter regions systematically decline with age and that pattern expression is linked to age-related cognitive decline... - Imaging studies and APOE genotype in persons at risk for Alzheimer's diseaseNikolaos Scarmeas
Columbia University Medical Center, 622 West 168th Street, PH 19th Floor, New York, NY 10032, USA
Curr Psychiatry Rep 8:11-7. 2006..APOE-related findings in imaging studies of nondemented subjects may be the result of incipient AD pathologic changes or of genetic heterogeneity in brain structure and function... - Older adults' reports of formal care hours and administrative recordsSteven M Albert
Gertrude H Sergievsky Center, PH 19, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Gerontologist 44:186-92. 2004..We examined these issues in a New York City sample by assessing older adults' reports of weekly home care hours and Medicaid billing records... - Plasma ß-amyloid and cognitive declineStephanie A Cosentino
The Gertrude H Sergievsky Center, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
Arch Neurol 67:1485-90. 2010..To determine if plasma β-amyloid (Aβ) levels (1) can be linked to specific cognitive changes that constitute conversion to Alzheimer disease (AD) and (2) correspond to cognitive change independent of dementia... - Mediterranean diet, Alzheimer disease, and vascular mediationNikolaos Scarmeas
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
Arch Neurol 63:1709-17. 2006..To examine the association between the Mediterranean diet (MeDi) and Alzheimer disease (AD) in a different AD population and to investigate possible mediation by vascular pathways. Design, Setting, Patients, and.. - Age-related changes in source memory retrieval: an ERP replication and extensionDomonick J Wegesin
Division of Cognitive Neuroscience, G H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
Brain Res Cogn Brain Res 13:323-38. 2002..These results are consistent with the frontal lobe deficit hypothesis of aging and provide some evidence that old and young may use distinct cortical networks during source memory retrieval... - Cognitive reserve in agingA M Tucker
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, USA
Curr Alzheimer Res 8:354-60. 2011..Thus, even late-stage interventions hold promise to boost cognitive reserve and thus reduce the prevalence of Alzheimer's disease and other age-related problems... - A controlled prospective study of neuropsychological dysfunction following carotid endarterectomyEric J Heyer
Department of Anesthesiology, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 59:217-22. 2002.... - fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer diseaseNikolaos Scarmeas
Neurology 65:1514-5; author reply 1514-5. 2005 - HIV-associated cognitive impairment before and after the advent of combination therapyNed Sacktor
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Neurovirol 8:136-42. 2002..Even though HAART has reduced the incidence of HIV dementia, HIV-associated cognitive impairment continues to be a major clinical problem among individuals with advanced infection... - Cognitive reserve and lifestyleNikolaos Scarmeas
Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, and College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Clin Exp Neuropsychol 25:625-33. 2003..It is possible that aspects of life experience like engagement in leisure activities may result in functionally more efficient cognitive networks and therefore provide a CR that delays the onset of clinical manifestations of dementia... - Stroke and the risk of Alzheimer diseaseLawrence S Honig
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, Columbia University, New York
Arch Neurol 60:1707-12. 2003..Alzheimer disease (AD) and stroke are common in elderly individuals, but the relation between these 2 disorders remains uncertain... - An event-related fMRI study of the neural networks underlying the encoding, maintenance, and retrieval phase in a delayed-match-to-sample taskChristian Habeck
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, 622 West 168th Street, PH 18, New York, NY 10032, USA
Brain Res Cogn Brain Res 23:207-20. 2005..The load-related activation patterns from encoding and retrieval phase and their relationship to behavior are also discussed... - Explicit contamination contributes to aging effects in episodic priming: behavioral and ERP evidenceDomonick J Wegesin
Department of Neurology, Columbia University, G H Sergievsky Center, 19th Floor, 630 West 168 Street, New York, NY 10032, USA
J Gerontol B Psychol Sci Soc Sci 59:P317-24. 2004..Given the apparent vulnerability to contamination by explicit memory, we suggest caution when researchers use an episodic priming paradigm to assess aging effects in implicit memory... - Delusions and hallucinations are associated with worse outcome in Alzheimer diseaseNikolaos Scarmeas
Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, New York, NY 10032, USA
Arch Neurol 62:1601-8. 2005..According to all previous literature, they are not associated with mortality... - Cognitive reserve: implications for diagnosis and prevention of Alzheimer's diseaseNikolaos Scarmeas
Columbia Presbyterian Medical Center, 622 West 168th Street, PH 19th Floor, New York, NY 10032, USA
Curr Neurol Neurosci Rep 4:374-80. 2004..In this article, we review some of the relevant literature of the noted associations between markers of cognitive reserve and AD and discuss the possible mechanisms that may explain these associations... - A comparison of family history of psychiatric disorders among patients with early- and late-onset Alzheimer's diseaseGayatri Devi
New York Memory and Healthy Aging Services, New York 10021, USA
J Neuropsychiatry Clin Neurosci 16:57-62. 2004..Family history studies may underestimate familial aggregation of EOAD... - Obesity enhances verbal memory in postmenopausal women with Down syndromeBindu N Patel
Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
Neurobiol Aging 25:159-66. 2004..Our results support the hypothesis that higher endogenous estrogen levels after menopause are associated with better performance on verbal memory... - Comparison of dementia with Lewy bodies to Alzheimer's disease and Parkinson's disease with dementiaEnrique Noe
Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, USA
Mov Disord 19:60-7. 2004.... - Covariance PET patterns in early Alzheimer's disease and subjects with cognitive impairment but no dementia: utility in group discrimination and correlations with functional performanceNikolaos Scarmeas
Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Neuroimage 23:35-45. 2004..Expression of covariance patterns correlates with cognitive and functional performance measures, holding promise for meaningful associations with underlying biopathological processes... - An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infectionJeffrey J Sevigny
Department of Neurology and Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Arch Neurol 64:97-102. 2007..Several markers of immune activation have been identified as potential prognostic markers for human immunodeficiency virus (HIV)-associated morbidity and mortality, but the results from studies are conflicting... - Medication management skill in HIV: I. Evidence for adaptation of medication management strategies in people with cognitive impairment. II. Evidence for a pervasive lay model of medication efficacySteven M Albert
Gertrude H Sergievsky Center and Department of Neurology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
AIDS Behav 7:329-38. 2003..A performance test of medication management sheds light on the ways patients take medicines and how beliefs about medicines affect medication regimens... - Acquisition, recall, and forgetting of verbal information in long-term memory by young, middle-aged, and elderly individualsHasker P Davis
Department of Psychology, University of Colorado, Colorado Springs 80933, USA
Cortex 39:1063-91. 2003..The importance of testing across the life span and using tests that examine a variety of memory components and processes for establishing norms and clarifying age-related deficits are discussed... - Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer's diseaseIris Asllani
Department of Radiology, Columbia University, New York, New York 10032, USA
J Cereb Blood Flow Metab 28:725-36. 2008..When tested on extensive split-half analysis to map out the replicability of both multivariate and univariate approaches, the expression of the pattern from multivariate analysis was superior to that of the univariate... - Disruptive behavior as a predictor in Alzheimer diseaseNikolaos Scarmeas
Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
Arch Neurol 64:1755-61. 2007..Disruptive behavior is common in Alzheimer disease (AD). There are conflicting reports regarding its ability to predict cognitive decline, functional decline, institutionalization, and mortality... - APOE genotype and cerebral blood flow in healthy young individualsNikolaos Scarmeas
JAMA 290:1581-2. 2003 - A new approach to spatial covariance modeling of functional brain imaging data: ordinal trend analysisChristian Habeck
Cognitive Neuroscience Division, Taub Institute, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neural Comput 17:1602-45. 2005..In sum, OrT has potential applications to not only studies of young adults and their cognitive abilities, but also studies of normal aging and neurological and psychiatric disease...
Research Grants
- Predictors of Severity in Alzheimer's DiseaseYaakov Stern; Fiscal Year: 2009..We will determine whether the accuracy of our prediction algorithms increases when we incorporate clinical features that correlate with these pathologic measures. ..
- NEUROPSYCHOLOGY AND COGNITION IN AGINGYaakov Stern; Fiscal Year: 2007..The original program worked with 2 trainees at any one time. We received a minority supplement to add a third trainee. We now propose to make this change permanent in order to work with 3 trainees at any one time. ..
- PREDICTORS OF SEVERITY IN ALZHEIMERS DISEASEYaakov Stern; Fiscal Year: 2006..We will then determine whether incorporating these clinical features into our prediction algorithms increases their accuracy. ..
- Predictors of Severity in Alzheimer's DiseaseYaakov Stern; Fiscal Year: 2007..We will determine whether the accuracy of our prediction algorithms increases when we incorporate clinical features that correlate with these pathologic measures. ..
- Imaging of Cognition, Learning and Memory in AgingYaakov Stern; Fiscal Year: 2007..abstract_text> ..
- Imaging of Cognition, Learning and Memory in AgingYaakov Stern; Fiscal Year: 2007..Evaluatehow response to task load varies as a function of variables known to mediate cognitive reserve, including IQ and education, in order to identify neural networks associated with cognitive reserve and compensation. ..
- Predictors of Severity in Alzheimer's DiseaseYaakov Stern; Fiscal Year: 2010..We will determine whether the accuracy of our prediction algorithms increases when we incorporate clinical features that correlate with these pathologic measures. ..
- Combined exercise and cognitive training intervention in normal agingYaakov Stern; Fiscal Year: 2010..The possibility that this intervention may markedly improve day-to-day function in healthy elders has enormous potential significance for public health. ..
- BEHV AND IMAGING APPROCHES TO IMPLICIT MEMORY IN AGINGYaakov Stern; Fiscal Year: 2003..This proposal represents a unique combination of expertise across collaborators and will make a major contribution to our understanding of age-related changes in memory. ..
- IMAGING COMPENSATION AND RESERVE IN ALZHEIMERS DISEASEYaakov Stern; Fiscal Year: 2001..In addition, the methodologic issues we raise are applicable to all functional imaging studies of cognitive task performance in patient populations. ..
- Exercise, aging, and cognition: Effect and mechanismsYAAKOV contact STERN; Fiscal Year: 2010..Therefore, the possibility that exercise improves cognition in younger subjects has enormous potential significance for public health. ..