Research Topics
Genomes and Genes | C D SternSummaryAffiliation: Columbia University Country: USA Publications
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Publications
Early chick embryos in vitroC D Stern
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Int J Dev Biol 41:379-87. 1997..We conclude that the original technique still compares favorably with its alternatives...- Clocked gene expression in somite formationC D Stern
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Bioessays 20:528-31. 1998..The discovery of this clock of gene expression emphasizes the importance of temporally regulated events in the establishment of spatial patterns... - Cerberus regulates left-right asymmetry of the embryonic head and heartL Zhu
Department of Genetics and Development, Columbia University, 701 West 168th Street 1602, New York, New York 10032, USA
Curr Biol 9:931-8. 1999..In Xenopus, these proteins have been shown to antagonise members of the transforming growth factor beta (TGF-beta) and Wnt families of signalling proteins... - Neural induction. A bird's eye viewA Streit
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Trends Genet 15:20-4. 1999..Here we take a critical view of the evidence for and against the view that BMP inhibition is a sufficient trigger for neural induction in different vertebrates... - Molecular interactions continuously define the organizer during the cell movements of gastrulationK Joubin
Department of Genetics and Development, and Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
Cell 98:559-71. 1999..These interactions define the organizer as a position in the embryo, whose cellular makeup is constantly changing, and explain the phenomenon of organizer regeneration... - Initiation of neural induction by FGF signalling before gastrulationA Streit
Department of Genetics and Development, Columbia University, New York, New York 10032, USA
Nature 406:74-8. 2000..We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction... - Goosecoid regulates the neural inducing strength of the mouse nodeL Zhu
Department of Genetics and Development, Columbia University, 701 West 168th Street, New York, New York, 10032, USA
Dev Biol 216:276-81. 1999..We propose that goosecoid does play a role in regulating the neural inducing strength of the node and that regulative mechanisms exist which mask the early phenotypic consequences of goosecoid mutations in the intact mouse embryo... - Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryoI Skromne
Department of Genetics and Development, Columbia University, 701 West 168th Street, New York, NY 10032, USA
Development 128:2915-27. 2001.... - SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during developmentD Vasiliauskas
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, NY 10032, USA
Mech Dev 82:79-94. 1999..We also describe a human homologue of cSWiP-1 and a mouse gene, mSWiP-2, that is more distantly related to SWiP-1, suggesting that SWiP-1 belongs to a novel subfamily of WD-proteins... - Induction of primitive streak and Hensen's node by the posterior marginal zone in the early chick embryoR F Bachvarova
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021, USA
Development 125:3521-34. 1998..We conclude that the marginal zone posterior to Koller's sickle can induce a streak and node, without contributing cells to the induced streak... - Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factorsD Vasiliauskas
Department of Genetics and Development, Columbia University, 701 West 168th Street 1602, New York, NY 10032, USA
Mech Dev 98:133-7. 2000..HES-6 is also expressed in the trunk, in the dorsal root ganglia and in the myotomes. In the limb buds HES-6 is expressed in skeletal muscle and presumptive tendons... - Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryoA Streit
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Development 125:507-19. 1998..These results suggest that the regulation of BMP signalling by chordin plays a role in primitive streak formation and that chordin is not sufficient to induce neural tissue... - Formation and maintenance of the organizer among the vertebratesK Joubin
Department of Genetics and Development and Center for Neurobiology and Behavior, Columbia University, New York, USA
Int J Dev Biol 45:165-75. 2001..We also suggest that these mechanisms are required to ensure the appropriate location of the organizer property in the gastrula, where cells are continuously moving... - The prechordal region lacks neural inducing ability, but can confer anterior character to more posterior neuroepitheliumA C Foley
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Development 124:2983-96. 1997..The competence of neuroectoderm to respond to anteriorizing signals declines by stages 7-9, but both posteriorizing signals and the ability of neuroectoderm to respond to them persist after this stage... - Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryoC D Stern
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Dev Biol 172:192-205. 1995.... 
Evolution of vertebrate forebrain development: how many different mechanisms?A C Foley
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
J Anat 199:35-52. 2001..Moreover, while reconciling the two main models, our findings provide stronger support for Nieuwkoop's ideas than for the concept of multiple organisers, each inducing a distinct region of the CNS...- Combined whole-mount in situ hybridization and immunohistochemistry in avian embryosA Streit
Department of Genetics and Development, Columbia University, 701 West 168th Street, No. 1602, New York, New York 10032, USA
Methods 23:339-44. 2001..Here we present a protocol that permits the simultaneous localization of RNA transcripts and immunocytochemical localization of proteins in the chick embryo... - Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions during early chick developmentC Thery
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Dev Genet 17:90-101. 1995..Interestingly, c-met is often more closely associated with HGF1/MSP than with its known ligand, HGF/SF, raising the possibility that c-met expression may be induced by HGF1/MSP...