Susan Steinberg

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Oxidative stress and sarcomeric proteins
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W 168 St, New York, NY 10032, USA
    Circ Res 112:393-405. 2013
  2. pmc Cardiac actions of protein kinase C isoforms
    Susan F Steinberg
    Department of Pharmacology, Columbia University, New York, New York, USA
    Physiology (Bethesda) 27:130-9. 2012
  3. pmc Regulation of protein kinase D1 activity
    Susan F Steinberg
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Mol Pharmacol 81:284-91. 2012
  4. ncbi request reprint beta(2)-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, NY 10032, USA
    J Mol Cell Cardiol 37:407-15. 2004
  5. ncbi request reprint The cardiovascular actions of protease-activated receptors
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Mol Pharmacol 67:2-11. 2005
  6. pmc Distinctive activation mechanisms and functions for protein kinase Cdelta
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Biochem J 384:449-59. 2004
  7. ncbi request reprint Compartmentation of G protein-coupled signaling pathways in cardiac myocytes
    S F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Annu Rev Pharmacol Toxicol 41:751-73. 2001
  8. pmc Structural basis of protein kinase C isoform function
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Physiol Rev 88:1341-78. 2008
  9. pmc Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation
    Konstantinos Drosatos
    Dept of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 300:E489-99. 2011
  10. ncbi request reprint Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:19350-61. 2004

Research Grants

  1. Protein kinase C-delta actions in cardiomyocytes
    Susan Steinberg; Fiscal Year: 2007
  2. p66Shc Signaling Functions in Cardiomyocytes
    Susan F Steinberg; Fiscal Year: 2010
  3. b1-/b2-Adrenergic Receptor Mechanisms in Cardiomyocytes
    Susan Steinberg; Fiscal Year: 2007
  4. PROTEASE-ACTIVATED RECEPTOR ACTIONS IN CARDIOMYOCYTES
    Susan Steinberg; Fiscal Year: 2004
  5. Protein kinase C-delta actions in cardiomyocytes
    Susan F Steinberg; Fiscal Year: 2010

Collaborators

  • R B Robinson
  • M R Rosen
  • Gerald W Dorn
  • Andrea Barbuti
  • J D Molkentin
  • Steven Marx
  • Tomoyoshi Kobayashi
  • Nazira Ozgen
  • MARK ALAN SUSSMAN
  • E Hirsch
  • R J Solaro
  • Gavin Y Oudit
  • C Kahn
  • Matthias P Wymann
  • Vitalyi O Rybin
  • Jianfen Guo
  • Abdelkarim Sabri
  • Hasnae Elouardighi
  • Zoya Gertsberg
  • Marius P Sumandea
  • Steven J Feinmark
  • Konstantinos Drosatos
  • Yelena Kryukova
  • Paul Pfleiderer
  • Erin Harleton
  • Chaojian Wang
  • Khadija Rafiq
  • Maria Obreztchikova
  • Jihong Qu
  • Lin Yang
  • Jaime Melendez
  • Brenda A Wilson
  • Erik Schaefer
  • Patricia Andrade-Gordon
  • Elena Pak
  • Lev Protas
  • Jacob Short
  • Yang Xiang
  • Michael A Crackower
  • Shuiqing Yu
  • Raffay Khan
  • Kalyani G Bharadwaj
  • Ira J Goldberg
  • Yunying Hu
  • Walter J Koch
  • William S Blaner
  • Anastasios Lymperopoulos
  • Shota Ikeda
  • Rajiv Agarwal
  • Hongfeng Jiang
  • Lin Cong
  • Aaron C Hinken
  • Kristoffer Valerie
  • C William Balke
  • Marie Hanscom
  • Gail Sievert
  • Vitalyi Rybin
  • Mengfei Ho
  • Vitali O Rybin
  • Guoxia Liu
  • Sergey I Zakharov
  • John P Morrow
  • Hava Avraham
  • Christopher Turner
  • Sasha G Alcott
  • Sasha Alcott
  • Andrew L Darrow
  • Peter W Grabham
  • Richard D Palmiter
  • Julian C Braz
  • Claudia Derian
  • Kathleen Kinnally
  • Rajan Sah
  • Seigo Izumo
  • Hai Ying M Cheng
  • Jeffery L Benovic
  • Akira Suzuki
  • Renu Sarao
  • Luigi Fratta
  • Brian Kobilka
  • Peter H Backx
  • Hui Sun
  • Antonio J Oliveira-dos-Santos
  • Takehiko Sasaki
  • Giuseppe Lembo
  • Tetsuo Shioi
  • Josef M Penninger
  • Junko Irie-Sasaki
  • Ivona Kozieradzki

Detail Information

Publications43

  1. pmc Oxidative stress and sarcomeric proteins
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W 168 St, New York, NY 10032, USA
    Circ Res 112:393-405. 2013
    ....
  2. pmc Cardiac actions of protein kinase C isoforms
    Susan F Steinberg
    Department of Pharmacology, Columbia University, New York, New York, USA
    Physiology (Bethesda) 27:130-9. 2012
    ..This review focuses on newer concepts regarding PKC isoform-specific activation mechanisms and actions that have implications for the development of PKC-targeted therapeutics...
  3. pmc Regulation of protein kinase D1 activity
    Susan F Steinberg
    Department of Pharmacology, Columbia University, New York, NY 10032, USA
    Mol Pharmacol 81:284-91. 2012
    ..These modifications represent novel targets for the development of PKD1-directed pharmaceuticals for the treatment of cancers and cardiovascular disorders...
  4. ncbi request reprint beta(2)-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, NY 10032, USA
    J Mol Cell Cardiol 37:407-15. 2004
    ....
  5. ncbi request reprint The cardiovascular actions of protease-activated receptors
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Mol Pharmacol 67:2-11. 2005
    ..This review focuses on the cardiovascular actions of PARs that play a role in normal cardiovascular physiology and that are likely to contribute to cardiovascular diseases...
  6. pmc Distinctive activation mechanisms and functions for protein kinase Cdelta
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Biochem J 384:449-59. 2004
    ..Collectively, these studies argue that the conventional model for PKCdelta activation must be broadened to allow for stimulus-specific differences in PKCdelta signalling during growth factor stimulation and oxidant stress...
  7. ncbi request reprint Compartmentation of G protein-coupled signaling pathways in cardiac myocytes
    S F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Annu Rev Pharmacol Toxicol 41:751-73. 2001
    ....
  8. pmc Structural basis of protein kinase C isoform function
    Susan F Steinberg
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Physiol Rev 88:1341-78. 2008
    ..e., that impart functional specificity) should provide the basis for the design of novel PKC isoform-specific activator or inhibitor compounds that can achieve therapeutically useful changes in PKC signaling in cells...
  9. pmc Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation
    Konstantinos Drosatos
    Dept of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 300:E489-99. 2011
    ..Thus, several lipids that are increased in the setting of lipotoxicity can produce abnormalities in β-AR responsiveness. This can be attributed to PKC activation and reduced β-AR levels...
  10. ncbi request reprint Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:19350-61. 2004
    ..The stimulus-specific modes for PKC delta signaling identified in this study allow for distinct PKC delta-mediated phosphorylation events and responses during growth factor stimulation and oxidant stress in cardiomyocytes...
  11. pmc Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916
    Vitalyi O Rybin
    Department of Pharmacology, Columbia University, New York, New York 10032, USA
    J Biol Chem 284:2332-43. 2009
    ..Rather, autophosphorylation at Ser916 is required for subsequent autophosphorylation at Ser748. Finally, this study exposes a novel role for Ser916 and/or Ser748 autophosphorylation to terminate the cellular PKD1 signaling response...
  12. ncbi request reprint Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms
    Lin Yang
    Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Biol Chem 280:207-14. 2005
    ..Our results identify two mechanisms leading to regulation of Ca(v)1.2 activity by PKC: pre-association of the channel with PKC isoforms and phosphorylation of specific sites within the alpha(1c) subunit...
  13. ncbi request reprint Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytes
    Jianfen Guo
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Circ Res 99:1367-75. 2006
    ..We also implicate nPKCs as molecular switches that control the balance of signaling via proapoptotic JNK and antiapoptotic PDK-1/AKT pathways, exposing a novel mechanism for nPKC-dependent regulation of cardiac hypertrophy and failure...
  14. pmc Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:23631-8. 2007
    ..Collectively, these results identify a novel PKCdelta-Thr(505) autophosphorylation mechanism that is triggered by PKCepsilon overexpression and involves Src-dependent PKCdelta-Tyr(311)/Tyr(332) phosphorylation...
  15. pmc p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes
    Jianfen Guo
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circ Res 104:660-9. 2009
    ..The novel alpha(1)-AR- and ROS-dependent pathway involving p66Shc identified in this study is likely to contribute to cardiomyocyte remodeling and the evolution of heart failure...
  16. pmc Phorbol 12-myristate 13-acetate-dependent protein kinase C delta-Tyr311 phosphorylation in cardiomyocyte caveolae
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Biol Chem 283:17777-88. 2008
    ..Collectively, these results identify stimulus-specific PKCdelta localization and tyrosine phosphorylation mechanisms that could be targeted for therapeutic advantage...
  17. ncbi request reprint Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure
    Abdelkarim Sabri
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cell Biochem 251:97-101. 2003
    ....
  18. ncbi request reprint Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and cardiomyocytes
    Abdelkarim Sabri
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circ Res 91:532-9. 2002
    ..PAR-1 responses in cardiac fibroblasts and cardiomyocytes are predicted to contribute importantly to remodeling during cardiac injury and/or inflammation...
  19. ncbi request reprint Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:14555-64. 2003
    ....
  20. pmc Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart
    Nazira Ozgen
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 283:17009-19. 2008
    ....
  21. ncbi request reprint beta(1)-Receptors increase cAMP and induce abnormal Ca(i) cycling in the German shepherd sudden death model
    Susan F Steinberg
    Center for Molecular Therapeutics, Departments of Pharmacology, Medicine and Pediatrics, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Am J Physiol Heart Circ Physiol 282:H1181-8. 2002
    ..The propensity to develop arrhythmias is not induced by beta(2)-receptors (or a rise in calcium alone), but rather occurs in the context of beta(1)-receptor activation of the cAMP-dependent pathway...
  22. pmc Reactive oxygen species decrease cAMP response element binding protein expression in cardiomyocytes via a protein kinase D1-dependent mechanism that does not require Ser133 phosphorylation
    Nazira Ozgen
    Center for Molecular Therapeutics, Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Pharmacol 76:896-902. 2009
    ..A PKD1-dependent mechanism that links oxidative stress to decreased CREB protein abundance is predicted to contribute to the pathogenesis of heart failure by influencing cardiac growth and apoptosis responses...
  23. pmc Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295
    Vitalyi O Rybin
    Department of Pharmacology, Columbia University, New York, New York 10032, USA
    Biochemistry 48:4642-51. 2009
    ..Collectively, these studies identify novel regulatory autophosphorylations on PKCdelta that serve as markers and regulators of PKCdelta activity...
  24. pmc Distinct signaling functions for Shc isoforms in the heart
    Maria Obreztchikova
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 281:20197-204. 2006
    ....
  25. pmc Raf-1: a novel cardiac troponin T kinase
    Paul Pfleiderer
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Muscle Res Cell Motil 30:67-72. 2009
    ..These studies identify Raf-dependent cTnT-Thr(206) phosphorylation as a novel mechanism that would link growth factor-dependent signaling pathways to dynamic changes in cardiac contractile function...
  26. ncbi request reprint Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3
    Vitalyi O Rybin
    Department of Pharmacology and Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Physiol Heart Circ Physiol 285:H325-32. 2003
    ....
  27. ncbi request reprint Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomains
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Mol Pharmacol 63:1338-48. 2003
    ..Neither compartmentalization nor changes in Gi expression fully explain the ontogenic changes in beta2-AR responsiveness in the rat ventricle...
  28. pmc Age-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatin
    Yelena Kryukova
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Pflugers Arch 457:821-30. 2009
    ....
  29. pmc Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes
    Jianfen Guo
    Department of Pharmacology, College of Physicians and Surgeons, Columbia Univ, 630 West 168 St, New York, NY 10032, USA
    Am J Physiol Cell Physiol 299:C770-8. 2010
    ....
  30. pmc G protein betagamma dimer expression in cardiomyocytes: developmental acquisition of Gbeta3
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Biochem Biophys Res Commun 368:408-13. 2008
    ....
  31. ncbi request reprint Mechanisms of protease-activated receptor-4 actions in cardiomyocytes. Role of Src tyrosine kinase
    Abdelkarim Sabri
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:11714-20. 2003
    ....
  32. pmc Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility
    Abdelkarim Sabri
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circ Res 90:850-7. 2002
    ..Because inhibition of Akt enhances cardiomyocyte susceptibility to apoptosis, this pathway is predicted to contribute to the transition from hypertrophy to cardiac decompensation and could be targeted for therapy in heart failure...
  33. ncbi request reprint Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa,L
    Lev Protas
    Department of Pharmacology, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Circ Res 93:972-9. 2003
    ..Rather, these results suggest that the in vivo NPY-dependent postnatal increase in ICa,L density in cardiac myocytes results from regulation ICa,L properties by NPY...
  34. ncbi request reprint Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanism
    Abdelkarim Sabri
    Departments of Pharmacology and Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:23944-54. 2003
    ..Collectively, these studies describe novel cardiac actions of cathepsin G that do not require PARs and are predicted to assume functional importance at sites of interstitial inflammation in the heart...
  35. ncbi request reprint Immunoblotting PKC-delta: a cautionary note from the bench
    Vitalyi O Rybin
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Am J Physiol Cell Physiol 290:C750-6. 2006
    ..These findings related to PKC-delta may be symptomatic of a more pervasive feature of immunoblot analysis studies of phosphoproteins in general...
  36. pmc Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I
    Marius P Sumandea
    Department of Internal Medicine, Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 283:22680-9. 2008
    ....
  37. ncbi request reprint Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes
    Yang Xiang
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford Medical Center, Palo Alto, CA 94305, USA
    J Biol Chem 277:34280-6. 2002
    ..These observations suggest that beta(2)ARs are normally restricted to caveolae in myocyte membranes and that this localization is essential for physiologic signaling of this receptor subtype...
  38. ncbi request reprint Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin
    Jaime Melendez
    The Children s Hospital Research Foundation, Division of Molecular Cardiovascular Biology, Cincinnati, OH 45229, USA
    J Biol Chem 279:53516-23. 2004
    ....
  39. ncbi request reprint Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis
    Khadija Rafiq
    Cardiovascular Research Center, Department of Anatomy and Cell Biology, Temple University, 3420 N Broad St, Philadelphia, PA 19140, USA
    Circ Res 102:32-41. 2008
    ..These results show that Cat.G-induced cardiomyocyte apoptosis involves an increase in EGFR-dependent activation of SHP2 that promotes focal adhesion kinase dephosphorylation and subsequent cardiomyocyte anoikis...
  40. ncbi request reprint Cardiac hypertrophy served with protein kinase Cepsilon: delta isoform substitution available at additional cost
    Susan F Steinberg
    Circ Res 96:711-3. 2005
  41. ncbi request reprint Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    Michael A Crackower
    IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, c o Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Cell 110:737-49. 2002
    ..These data show that PTEN has an important in vivo role in cardiomyocyte hypertrophy and GPCR signaling and identify a function for the PTEN-PI3Kgamma pathway in the modulation of heart muscle contractility...
  42. ncbi request reprint Alpha(1)-adrenergic receptor subtype function in cardiomyocytes: lessons from genetic models in mice
    Susan F Steinberg
    J Mol Cell Cardiol 34:1141-5. 2002
  43. ncbi request reprint Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure
    Gavin Y Oudit
    Department of Physiology, University Health Network, University of Toronto, 620 University Ave, Toronto, Ontario M5G 2C1, Canada
    Circulation 108:2147-52. 2003
    ..Signaling via the G-protein-coupled beta-adrenergic receptors has been implicated in cardiac hypertrophy and heart failure, suggesting that PI3Kgamma might play a role in the pathogenesis of heart disease...

Research Grants16

  1. Protein kinase C-delta actions in cardiomyocytes
    Susan Steinberg; Fiscal Year: 2007
    ..The distinct PKCd actions in cardiomyocytes subjected to oxidative stress vs. growth factor signaling have important implications for the design and evaluation of PKC8-targeted therapeutics. ..
  2. p66Shc Signaling Functions in Cardiomyocytes
    Susan F Steinberg; Fiscal Year: 2010
    ..The long-term goal is to expose novel molecular strategies that can be used to reduce p66Shc expression and/or interdict p66Shc actions to prevent or slow the natural history of clinically important cardiovascular disorders. ..
  3. b1-/b2-Adrenergic Receptor Mechanisms in Cardiomyocytes
    Susan Steinberg; Fiscal Year: 2007
    ..As such, these studies are likely to suggest novel clinical strategies that might be pursued (or should be avoided) for the management of chronic heart failure in humans. ..
  4. PROTEASE-ACTIVATED RECEPTOR ACTIONS IN CARDIOMYOCYTES
    Susan Steinberg; Fiscal Year: 2004
    ....
  5. Protein kinase C-delta actions in cardiomyocytes
    Susan F Steinberg; Fiscal Year: 2010
    ....