Research Topics
| Susan SteinbergSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Oxidative stress and sarcomeric proteinsSusan F Steinberg
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W, 168 St, New York, NY 10032, USA
Circ Res 112:393-405. 2013....- Cardiac actions of protein kinase C isoformsSusan F Steinberg
Department of Pharmacology, Columbia University, New York, New York, USA
Physiology (Bethesda) 27:130-9. 2012..This review focuses on newer concepts regarding PKC isoform-specific activation mechanisms and actions that have implications for the development of PKC-targeted therapeutics... - Regulation of protein kinase D1 activitySusan F Steinberg
Department of Pharmacology, Columbia University, New York, NY 10032, USA
Mol Pharmacol 81:284-91. 2012..These modifications represent novel targets for the development of PKD1-directed pharmaceuticals for the treatment of cancers and cardiovascular disorders... 
beta(2)-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid raftsSusan F Steinberg
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, NY 10032, USA
J Mol Cell Cardiol 37:407-15. 2004....- The cardiovascular actions of protease-activated receptorsSusan F Steinberg
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
Mol Pharmacol 67:2-11. 2005..This review focuses on the cardiovascular actions of PARs that play a role in normal cardiovascular physiology and that are likely to contribute to cardiovascular diseases... - Distinctive activation mechanisms and functions for protein kinase CdeltaSusan F Steinberg
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
Biochem J 384:449-59. 2004..Collectively, these studies argue that the conventional model for PKCdelta activation must be broadened to allow for stimulus-specific differences in PKCdelta signalling during growth factor stimulation and oxidant stress... - Compartmentation of G protein-coupled signaling pathways in cardiac myocytesS F Steinberg
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Annu Rev Pharmacol Toxicol 41:751-73. 2001.... - Structural basis of protein kinase C isoform functionSusan F Steinberg
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Physiol Rev 88:1341-78. 2008..e., that impart functional specificity) should provide the basis for the design of novel PKC isoform-specific activator or inhibitor compounds that can achieve therapeutically useful changes in PKC signaling in cells... - Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activationKonstantinos Drosatos
Dept of Medicine, Columbia University, 630 West 168th St, New York, NY 10032, USA
Am J Physiol Endocrinol Metab 300:E489-99. 2011..Thus, several lipids that are increased in the setting of lipotoxicity can produce abnormalities in β-AR responsiveness. This can be attributed to PKC activation and reduced β-AR levels... - Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytesVitalyi O Rybin
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 279:19350-61. 2004..The stimulus-specific modes for PKC delta signaling identified in this study allow for distinct PKC delta-mediated phosphorylation events and responses during growth factor stimulation and oxidant stress in cardiomyocytes... - Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916Vitalyi O Rybin
Department of Pharmacology, Columbia University, New York, New York 10032, USA
J Biol Chem 284:2332-43. 2009..Rather, autophosphorylation at Ser916 is required for subsequent autophosphorylation at Ser748. Finally, this study exposes a novel role for Ser916 and/or Ser748 autophosphorylation to terminate the cellular PKD1 signaling response... - Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoformsLin Yang
Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Biol Chem 280:207-14. 2005..Our results identify two mechanisms leading to regulation of Ca(v)1.2 activity by PKC: pre-association of the channel with PKC isoforms and phosphorylation of specific sites within the alpha(1c) subunit... - Alpha1-adrenergic receptors activate AKT via a Pyk2/PDK-1 pathway that is tonically inhibited by novel protein kinase C isoforms in cardiomyocytesJianfen Guo
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
Circ Res 99:1367-75. 2006..We also implicate nPKCs as molecular switches that control the balance of signaling via proapoptotic JNK and antiapoptotic PDK-1/AKT pathways, exposing a novel mechanism for nPKC-dependent regulation of cardiac hypertrophy and failure... - Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytesVitalyi O Rybin
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 282:23631-8. 2007..Collectively, these results identify a novel PKCdelta-Thr(505) autophosphorylation mechanism that is triggered by PKCepsilon overexpression and involves Src-dependent PKCdelta-Tyr(311)/Tyr(332) phosphorylation... - p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytesJianfen Guo
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Circ Res 104:660-9. 2009..The novel alpha(1)-AR- and ROS-dependent pathway involving p66Shc identified in this study is likely to contribute to cardiomyocyte remodeling and the evolution of heart failure... - Phorbol 12-myristate 13-acetate-dependent protein kinase C delta-Tyr311 phosphorylation in cardiomyocyte caveolaeVitalyi O Rybin
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Biol Chem 283:17777-88. 2008..Collectively, these results identify stimulus-specific PKCdelta localization and tyrosine phosphorylation mechanisms that could be targeted for therapeutic advantage... - Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failureAbdelkarim Sabri
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Cell Biochem 251:97-101. 2003.... - Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and cardiomyocytesAbdelkarim Sabri
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Circ Res 91:532-9. 2002..PAR-1 responses in cardiac fibroblasts and cardiomyocytes are predicted to contribute importantly to remodeling during cardiac injury and/or inflammation... - Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylationsVitalyi O Rybin
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 278:14555-64. 2003.... - Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heartNazira Ozgen
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 283:17009-19. 2008.... - beta(1)-Receptors increase cAMP and induce abnormal Ca(i) cycling in the German shepherd sudden death modelSusan F Steinberg
Center for Molecular Therapeutics, Departments of Pharmacology, Medicine and Pediatrics, College of Physicians and Surgeons of Columbia University, New York 10032, USA
Am J Physiol Heart Circ Physiol 282:H1181-8. 2002..The propensity to develop arrhythmias is not induced by beta(2)-receptors (or a rise in calcium alone), but rather occurs in the context of beta(1)-receptor activation of the cAMP-dependent pathway... - Reactive oxygen species decrease cAMP response element binding protein expression in cardiomyocytes via a protein kinase D1-dependent mechanism that does not require Ser133 phosphorylationNazira Ozgen
Center for Molecular Therapeutics, Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Mol Pharmacol 76:896-902. 2009..A PKD1-dependent mechanism that links oxidative stress to decreased CREB protein abundance is predicted to contribute to the pathogenesis of heart failure by influencing cardiac growth and apoptosis responses... - Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295Vitalyi O Rybin
Department of Pharmacology, Columbia University, New York, New York 10032, USA
Biochemistry 48:4642-51. 2009..Collectively, these studies identify novel regulatory autophosphorylations on PKCdelta that serve as markers and regulators of PKCdelta activity... - Distinct signaling functions for Shc isoforms in the heartMaria Obreztchikova
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 281:20197-204. 2006.... - Raf-1: a novel cardiac troponin T kinasePaul Pfleiderer
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Muscle Res Cell Motil 30:67-72. 2009..These studies identify Raf-dependent cTnT-Thr(206) phosphorylation as a novel mechanism that would link growth factor-dependent signaling pathways to dynamic changes in cardiac contractile function... - Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3Vitalyi O Rybin
Department of Pharmacology and Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Am J Physiol Heart Circ Physiol 285:H325-32. 2003.... - Developmental changes in beta2-adrenergic receptor signaling in ventricular myocytes: the role of Gi proteins and caveolae microdomainsVitalyi O Rybin
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Mol Pharmacol 63:1338-48. 2003..Neither compartmentalization nor changes in Gi expression fully explain the ontogenic changes in beta2-AR responsiveness in the rat ventricle... - Age-dependent differences in the inhibition of HCN2 current in rat ventricular myocytes by the tyrosine kinase inhibitor erbstatinYelena Kryukova
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Pflugers Arch 457:821-30. 2009.... - Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytesJianfen Guo
Department of Pharmacology, College of Physicians and Surgeons, Columbia Univ, 630 West 168 St, New York, NY 10032, USA
Am J Physiol Cell Physiol 299:C770-8. 2010.... - G protein betagamma dimer expression in cardiomyocytes: developmental acquisition of Gbeta3Vitalyi O Rybin
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
Biochem Biophys Res Commun 368:408-13. 2008.... - Mechanisms of protease-activated receptor-4 actions in cardiomyocytes. Role of Src tyrosine kinaseAbdelkarim Sabri
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 278:11714-20. 2003.... - Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibilityAbdelkarim Sabri
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Circ Res 90:850-7. 2002..Because inhibition of Akt enhances cardiomyocyte susceptibility to apoptosis, this pathway is predicted to contribute to the transition from hypertrophy to cardiac decompensation and could be targeted for therapy in heart failure... - Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa,LLev Protas
Department of Pharmacology, Columbia University, 630 W 168th St, New York, NY 10032, USA
Circ Res 93:972-9. 2003..Rather, these results suggest that the in vivo NPY-dependent postnatal increase in ICa,L density in cardiac myocytes results from regulation ICa,L properties by NPY... - Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanismAbdelkarim Sabri
Departments of Pharmacology and Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Biol Chem 278:23944-54. 2003..Collectively, these studies describe novel cardiac actions of cathepsin G that do not require PARs and are predicted to assume functional importance at sites of interstitial inflammation in the heart... - Immunoblotting PKC-delta: a cautionary note from the benchVitalyi O Rybin
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St, New York, NY 10032, USA
Am J Physiol Cell Physiol 290:C750-6. 2006..These findings related to PKC-delta may be symptomatic of a more pervasive feature of immunoblot analysis studies of phosphoproteins in general... - Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin IMarius P Sumandea
Department of Internal Medicine, Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA
J Biol Chem 283:22680-9. 2008.... - Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytesYang Xiang
Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford Medical Center, Palo Alto, CA 94305, USA
J Biol Chem 277:34280-6. 2002..These observations suggest that beta(2)ARs are normally restricted to caveolae in myocyte membranes and that this localization is essential for physiologic signaling of this receptor subtype... - Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillinJaime Melendez
The Children s Hospital Research Foundation, Division of Molecular Cardiovascular Biology, Cincinnati, OH 45229, USA
J Biol Chem 279:53516-23. 2004.... - Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikisKhadija Rafiq
Cardiovascular Research Center, Department of Anatomy and Cell Biology, Temple University, 3420 N Broad St, Philadelphia, PA 19140, USA
Circ Res 102:32-41. 2008..These results show that Cat.G-induced cardiomyocyte apoptosis involves an increase in EGFR-dependent activation of SHP2 that promotes focal adhesion kinase dephosphorylation and subsequent cardiomyocyte anoikis... - Cardiac hypertrophy served with protein kinase Cepsilon: delta isoform substitution available at additional costSusan F Steinberg
Circ Res 96:711-3. 2005 - Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathwaysMichael A Crackower
IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, c o Dr Bohr Gasse 7, A 1030, Vienna, Austria
Cell 110:737-49. 2002..These data show that PTEN has an important in vivo role in cardiomyocyte hypertrophy and GPCR signaling and identify a function for the PTEN-PI3Kgamma pathway in the modulation of heart muscle contractility... - Alpha(1)-adrenergic receptor subtype function in cardiomyocytes: lessons from genetic models in miceSusan F Steinberg
J Mol Cell Cardiol 34:1141-5. 2002 - Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failureGavin Y Oudit
Department of Physiology, University Health Network, University of Toronto, 620 University Ave, Toronto, Ontario M5G 2C1, Canada
Circulation 108:2147-52. 2003..Thus, PI3Kgamma may represent a novel therapeutic target for the treatment of decreased cardiac function in heart failure...
Research Grants
- Protein kinase C-delta actions in cardiomyocytesSusan Steinberg; Fiscal Year: 2007..The distinct PKCd actions in cardiomyocytes subjected to oxidative stress vs. growth factor signaling have important implications for the design and evaluation of PKC8-targeted therapeutics. ..
- p66Shc Signaling Functions in CardiomyocytesSusan F Steinberg; Fiscal Year: 2010..The long-term goal is to expose novel molecular strategies that can be used to reduce p66Shc expression and/or interdict p66Shc actions to prevent or slow the natural history of clinically important cardiovascular disorders. ..
- b1-/b2-Adrenergic Receptor Mechanisms in CardiomyocytesSusan Steinberg; Fiscal Year: 2007..As such, these studies are likely to suggest novel clinical strategies that might be pursued (or should be avoided) for the management of chronic heart failure in humans. ..
- PROTEASE-ACTIVATED RECEPTOR ACTIONS IN CARDIOMYOCYTESSusan Steinberg; Fiscal Year: 2004....
- Protein kinase C-delta actions in cardiomyocytesSusan F Steinberg; Fiscal Year: 2010....