Douglas M Sproule

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes: basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome
    Douglas M Sproule
    Columbia University, Pediatric Neurology, 180 Fort Washington Ave, Harkness Pavilion, 5th Floor, New York, NY 10032, USA
    Ann N Y Acad Sci 1142:133-58. 2008
  2. ncbi Increased fat mass and high incidence of overweight despite low body mass index in patients with spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, Harkness Pavilion, HP 514, 180 Fort Washington Avenue, New York, NY 10032 3791, USA
    Neuromuscul Disord 19:391-6. 2009
  3. ncbi Bioelectrical impedance analysis can be a useful screen for excess adiposity in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York 10032 3791, USA
    J Child Neurol 25:1348-54. 2010
  4. ncbi Adiposity is increased among high-functioning, non-ambulatory patients with spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
    Neuromuscul Disord 20:448-52. 2010
  5. ncbi Thigh muscle volume measured by magnetic resonance imaging is stable over a 6-month interval in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
    J Child Neurol 26:1252-9. 2011
  6. ncbi Muscle volume estimation by magnetic resonance imaging in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York 10032 3791, USA
    J Child Neurol 26:309-17. 2011
  7. ncbi Age at disease onset predicts likelihood and rapidity of growth failure among infants and young children with spinal muscular atrophy types 1 and 2
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
    J Child Neurol 27:845-51. 2012
  8. ncbi Independent mobility after early introduction of a power wheelchair in spinal muscular atrophy
    Sally Dunaway
    1Neurology Department, Columbia University Medical Center, New York, NY, USA
    J Child Neurol 28:576-82. 2013
  9. ncbi Prospective cohort study of spinal muscular atrophy types 2 and 3
    Petra Kaufmann
    Department of Neurology, Columbia University, New York, USA
    Neurology 79:1889-97. 2012
  10. ncbi Spinal muscular atrophy type III: trying to understand subtle functional change over time--a case report
    Sally Dunaway
    SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032, USA
    J Child Neurol 27:779-85. 2012

Collaborators

Detail Information

Publications14

  1. ncbi Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes: basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome
    Douglas M Sproule
    Columbia University, Pediatric Neurology, 180 Fort Washington Ave, Harkness Pavilion, 5th Floor, New York, NY 10032, USA
    Ann N Y Acad Sci 1142:133-58. 2008
    ..Although therapeutic options for MELAS and other mitochondrial diseases remain limited, and recent trials have been disappointing, we also consider current and potential therapeutic modalities...
  2. ncbi Increased fat mass and high incidence of overweight despite low body mass index in patients with spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, Harkness Pavilion, HP 514, 180 Fort Washington Avenue, New York, NY 10032 3791, USA
    Neuromuscul Disord 19:391-6. 2009
    ..Children with SMA have reduced lean and increased fat mass compared to healthy children. Obesity is a potentially important modifiable source of morbidity in SMA...
  3. ncbi Bioelectrical impedance analysis can be a useful screen for excess adiposity in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York 10032 3791, USA
    J Child Neurol 25:1348-54. 2010
    ..Although insufficiently accurate for use as a research tool, bioelectrical impedance can have application as a well-tolerated, noninvasive, easily used screening tool for excess adiposity in patients with spinal muscular atrophy...
  4. ncbi Adiposity is increased among high-functioning, non-ambulatory patients with spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
    Neuromuscul Disord 20:448-52. 2010
    ....
  5. ncbi Thigh muscle volume measured by magnetic resonance imaging is stable over a 6-month interval in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
    J Child Neurol 26:1252-9. 2011
    ..Relative constancy of muscle volume estimation and correlation with established functional measures suggest a role for segmental magnetic resonance imaging as a biomarker of treatment effect in future therapeutic trials...
  6. ncbi Muscle volume estimation by magnetic resonance imaging in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York 10032 3791, USA
    J Child Neurol 26:309-17. 2011
    ..14) than type 3. Reproducibility, tolerability, and strong correlation with clinical measures make magnetic resonance imaging a candidate biomarker for clinical research...
  7. ncbi Age at disease onset predicts likelihood and rapidity of growth failure among infants and young children with spinal muscular atrophy types 1 and 2
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
    J Child Neurol 27:845-51. 2012
    ..Most late onset (> 6 months) subjects avoided growth failure. Early clinical symptoms predict feeding dysfunction and growth failure. Immediate, proactive nutritional intervention is indicated for patients with early symptom onset...
  8. ncbi Independent mobility after early introduction of a power wheelchair in spinal muscular atrophy
    Sally Dunaway
    1Neurology Department, Columbia University Medical Center, New York, NY, USA
    J Child Neurol 28:576-82. 2013
    ..9 months (range: 73-458 days). Introduction of early power mobility is feasible in spinal muscular atrophy patients under age 2 years and should be introduced in late infancy when children typically acquire locomotor skills...
  9. ncbi Prospective cohort study of spinal muscular atrophy types 2 and 3
    Petra Kaufmann
    Department of Neurology, Columbia University, New York, USA
    Neurology 79:1889-97. 2012
    ..To characterize the natural history of spinal muscular atrophy type 2 and type 3 (SMA 2/3) beyond 1 year and to report data on clinical and biological outcomes for use in trial planning...
  10. ncbi Spinal muscular atrophy type III: trying to understand subtle functional change over time--a case report
    Sally Dunaway
    SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032, USA
    J Child Neurol 27:779-85. 2012
    ..However, she walked with assistance 2 years longer than expected. Our report highlights possible precipitating factors that could affect the natural history of spinal muscular atrophy type III...
  11. ncbi Monitoring of cerebral vasodilatory capacity with transcranial Doppler carbon dioxide inhalation in patients with severe carotid artery disease
    Randolph S Marshall
    The Neurological Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Stroke 34:945-9. 2003
    ....
  12. ncbi Wolff-Parkinson-White syndrome in Patients With MELAS
    Douglas M Sproule
    Division of Pediatric Neurology, Department of Neurology, Columbia University, New York, NY, USA
    Arch Neurol 64:1625-7. 2007
    ..Tissues with high energy demands, such as the heart, are susceptible to the effects of mitochondrial DNA point mutations...
  13. ncbi Therapeutic developments in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, Harkness Pavilion, HP 514, 180 Fort Washington Avenue, New York, NY 10032 3791, USA
    Ther Adv Neurol Disord 3:173-85. 2010
    ..The recent advances in preclinical research and the development of a wider range of animal models for SMA continue to provide cautious optimism that effective treatments for SMA will eventually emerge...
  14. ncbi Scoliosis surgery in children with neuromuscular disease: findings from the US National Inpatient Sample, 1997 to 2003
    Alexandra I Barsdorf
    Division of Pediatric Neurosciences, Department of Neurology, Spinal Muscular Atrophy Clinical Research Center, Columbia University Medical Center, 180 Fort Washington Ave, New York, NY 10032 3791, USA
    Arch Neurol 67:231-5. 2010
    ..Scoliosis is a frequent complication of pediatric neuromuscular disease (NMD). Scoliosis surgery in children with NMD is thought to carry greater morbidity and mortality...