J R Sparrow

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint A2E, a fluorophore of RPE lipofuscin: can it cause RPE degeneration?
    Janet R Sparrow
    Department of Ophthalmology and Chemistry, Columbia University, New York, NY 10032, USA
    Adv Exp Med Biol 533:205-11. 2003
  2. pmc The bisretinoids of retinal pigment epithelium
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Prog Retin Eye Res 31:121-35. 2012
  3. pmc A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration
    Kee Dong Yoon
    Department of Ophthalmology, Columbia University, New York, New York, USA
    PLoS ONE 7:e41309. 2012
  4. pmc Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols
    Kee Dong Yoon
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Mol Vis 17:1839-49. 2011
  5. ncbi request reprint Bisretinoid degradation and the ubiquitin-proteasome system
    Janet R Sparrow
    Department of Ophthalmology and Cell Biology, Columbia University, 630 W 168 Street, 10032, New York, NY, USA
    Adv Exp Med Biol 801:593-600. 2014
  6. pmc Quantitative fundus autofluorescence in mice: correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 54:2812-20. 2013
  7. pmc Complement dysregulation in AMD: RPE-Bruch's membrane-choroid
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Mol Aspects Med 33:436-45. 2012
  8. pmc A method of drusen measurement based on the geometry of fundus reflectance
    R Theodore Smith
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Biomed Eng Online 2:10. 2003
  9. ncbi request reprint RPE lipofuscin and its role in retinal pathobiology
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Exp Eye Res 80:595-606. 2005
  10. pmc Fundus autofluorescence and the bisretinoids of retina
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Photochem Photobiol Sci 9:1480-9. 2010

Collaborators

Detail Information

Publications61

  1. ncbi request reprint A2E, a fluorophore of RPE lipofuscin: can it cause RPE degeneration?
    Janet R Sparrow
    Department of Ophthalmology and Chemistry, Columbia University, New York, NY 10032, USA
    Adv Exp Med Biol 533:205-11. 2003
  2. pmc The bisretinoids of retinal pigment epithelium
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Prog Retin Eye Res 31:121-35. 2012
    ..Accordingly, we will discuss recent findings that implicate the photodegradation of bisretinoid in the etiology of age-related macular degeneration...
  3. pmc A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration
    Kee Dong Yoon
    Department of Ophthalmology, Columbia University, New York, New York, USA
    PLoS ONE 7:e41309. 2012
    ..These results indicate that photodegraded RPE bisretinoid is likely to be a previously unknown source of MG and GO in the eye...
  4. pmc Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols
    Kee Dong Yoon
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Mol Vis 17:1839-49. 2011
    ..We tested for the reactivity of photooxidation and photodegradation products of A2E with thiol-containing glutathione (GSH)...
  5. ncbi request reprint Bisretinoid degradation and the ubiquitin-proteasome system
    Janet R Sparrow
    Department of Ophthalmology and Cell Biology, Columbia University, 630 W 168 Street, 10032, New York, NY, USA
    Adv Exp Med Biol 801:593-600. 2014
    ..With HRP-mediated degradation of A2E, there was a small negative impact on cell viability that was not mitigated by elevating gluthathione in the cell...
  6. pmc Quantitative fundus autofluorescence in mice: correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 54:2812-20. 2013
    ....
  7. pmc Complement dysregulation in AMD: RPE-Bruch's membrane-choroid
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Mol Aspects Med 33:436-45. 2012
    ..One recurring theme is the potential for disease promotion by diverse types of oxidation products...
  8. pmc A method of drusen measurement based on the geometry of fundus reflectance
    R Theodore Smith
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Biomed Eng Online 2:10. 2003
    ..Current manual methods of drusen measurement are laborious and subjective. Our purpose was to expedite clinical research with an accurate, reliable digital method...
  9. ncbi request reprint RPE lipofuscin and its role in retinal pathobiology
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Exp Eye Res 80:595-606. 2005
    ..Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues...
  10. pmc Fundus autofluorescence and the bisretinoids of retina
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Photochem Photobiol Sci 9:1480-9. 2010
    ..However, two retinoids of the visual cycle, all-trans-retinyl ester and all-trans-retinal, did not exhibit fluorescence at 488 nm excitation...
  11. doi request reprint A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Adv Exp Med Biol 613:393-8. 2008
  12. pmc Phospholipid meets all-trans-retinal: the making of RPE bisretinoids
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    J Lipid Res 51:247-61. 2010
    ..The propensity of these compounds to negatively impact on the cells has been linked to the pathogenesis of some retinal disorders including juvenile onset recessive Stargardt disease and age-related macular degeneration...
  13. doi request reprint Bisretinoids of RPE lipofuscin: trigger for complement activation in age-related macular degeneration
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Adv Exp Med Biol 703:63-74. 2010
    ..As such, these photooxidative processes, in a setting of complement dysregulation could contribute to chronic inflammation underlying AMD pathogenesis...
  14. ncbi request reprint The retinal pigment epithelium in health and disease
    J R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Curr Mol Med 10:802-23. 2010
    ..The magnitude of the demands imposed on this single layer of cells in order to execute these tasks, will become apparent to the reader of this review as will the number of clinical disorders that take origin from these cells...
  15. ncbi request reprint Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 West 128th Street, New York, NY 10032, USA
    J Cataract Refract Surg 30:873-8. 2004
    ....
  16. ncbi request reprint A2E, a byproduct of the visual cycle
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Vision Res 43:2983-90. 2003
    ....
  17. ncbi request reprint The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells
    J R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 41:1981-9. 2000
    ..To determine whether the lipofuscin fluorophore A2E participates in blue light-induced damage to retinal pigmented epithelial (RPE) cells...
  18. ncbi request reprint DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue-light illumination
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 44:2245-51. 2003
    ..This study was designed to determine whether DNA is a target of the cellular damage...
  19. ncbi request reprint Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 43:1222-7. 2002
    ..The purpose of this study was to evaluate the role of oxidative mechanisms in mediating the cellular damage...
  20. ncbi request reprint A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture
    J R Sparrow
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 40:2988-95. 1999
    ..To study A2E, a component of retinal pigmented epithelial (RPE) cell lipofuscin, after its internalization by cultured human RPE cells...
  21. ncbi request reprint A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation
    Janet R Sparrow
    Department of Ophthalmology and Chemistry, Columbia University, New York, New York 10028, USA
    J Biol Chem 278:18207-13. 2003
    ..Conversely, vitamin C and ginkgolide B were not efficient quenchers of singlet oxygen under these conditions...
  22. pmc Therapy for macular degeneration: insights from acne
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY 10028, USA
    Proc Natl Acad Sci U S A 100:4353-4. 2003
  23. ncbi request reprint Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2
    J R Sparrow
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Invest Ophthalmol Vis Sci 42:1356-62. 2001
    ..The purpose of this study was to evaluate caspase-3 and Bcl-2 as executor and modulator, respectively, of the cell death program that is initiated in A2E-containing cells in response to blue light...
  24. ncbi request reprint Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin
    Shimon Ben-Shabat
    Department of Chemistry, Columbia University, New York, NY 10028, USA
    J Biol Chem 277:7183-90. 2002
    ..The identities of additional minor components of retinal pigment epithelium lipofuscin, A2E isomers with cis olefins at positions other than the C13-C14 double bond, are also described...
  25. ncbi request reprint Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin
    Young P Jang
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:39732-9. 2005
    ..Because the cytotoxicity of endoperoxide moieties is well known, the production of endoperoxide-containing oxo-A2E may account, at least in part, for cellular damage ensuing from A2E photooxidation...
  26. pmc Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway
    So R Kim
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Biochemistry 46:10122-9. 2007
    ..An understanding of the biosynthetic pathways of retinal pigment epithelial lipofuscin pigments is critical to the development of therapies for macular degeneration that are based on limiting the formation of these damaging compounds...
  27. pmc The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model
    So R Kim
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:19273-8. 2007
    ..The latter findings are significant to an understanding of the adverse effects of retinal pigment epithelial cell lipofuscin...
  28. pmc Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease
    Yalin Wu
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    J Biol Chem 284:20155-66. 2009
    ..Efforts to clarify the composition of RPE lipofuscin are important because these compounds are targets of gene-based and drug therapies that aim to alleviate ABCA4-related retinal disease...
  29. ncbi request reprint Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration
    S Ben-Shabat
    Department of Chemistry, Columbia University, New York, NY 10027, USA
    Bioorg Med Chem Lett 11:1533-40. 2001
    ..Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death...
  30. pmc Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells
    Chandima Abeywickrama
    Department of Chemistry, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 104:14610-5. 2007
    ..The changes in fluorescence emission upon antibody binding could reflect several processes including restrictions on trans-cis isomerization and intersystem crossing of photo-excited A2E...
  31. pmc Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells
    Young P Jang
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 81:529-36. 2005
    ..Cells that had taken up anthocyanins also exhibited a resistance to the membrane permeabilization that occurs as a result of the detergent-like action of A2E...
  32. pmc Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration
    Yalin Wu
    Department of Ophthalmology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:7275-80. 2010
    ..Whereas various processes play a role in drusen formation, these findings are indicative of a contribution from lipofuscin photooxidation in RPE...
  33. ncbi request reprint A2E, a fluorophore of RPE lipofuscin, can destabilize membrane
    Janet R Sparrow
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Adv Exp Med Biol 572:63-8. 2006
  34. pmc Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium
    Jilin Zhou
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:16182-7. 2006
    ..These findings link four factors that have been posited as being associated with AMD: inflammation, oxidative damage, drusen, and RPE lipofuscin...
  35. pmc Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate
    Nathan E Fishkin
    Department of Chemistry, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:7091-6. 2005
    ....
  36. ncbi request reprint Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin
    So Ra Kim
    Department of Ophthalmology, Columbia University, NY 10032, USA
    Exp Eye Res 82:828-39. 2006
    ....
  37. ncbi request reprint Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment
    Jilin Zhou
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Rejuvenation Res 9:256-63. 2006
    ..The present results indicate that the indirect antioxidant activity of plant-derived phase 2 inducers also may be potentially important...
  38. pmc Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light
    Barbro S Westlund
    Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Apoptosis 14:31-41. 2009
    ..This study indicates that c-Abl and p53 are important for execution of the cell death program initiated in A2E-laden RPE cells exposed to blue light, while JNK might play an anti-apoptotic role...
  39. ncbi request reprint Photographic patterns in macular images: representation by a mathematical model
    R Theodore Smith
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    J Biomed Opt 9:162-72. 2004
    ..A two-zone elliptic quadratic polynomial model can approximate foveal data, and can also reconstruct it from small subsets, allowing improved macular image analysis...
  40. pmc Mechanisms involved in A2E oxidation
    So Ra Kim
    Department of Ophthalmology, Columbia University, 630 W 168th Street, NY 10032, USA
    Exp Eye Res 86:975-82. 2008
    ..Superoxide anion may be generated by irradiation of A2E but is not involved in the early events that oxidize A2E. Superoxide can contribute to the further oxidation of already-oxidized A2E...
  41. pmc Complement activation by bisretinoid constituents of RPE lipofuscin
    Jilin Zhou
    Department of Ophthalmology, Columbia University, New York, New York 10032, USA
    Invest Ophthalmol Vis Sci 50:1392-9. 2009
    ..Questions pertain to the trigger(s) responsible for the complement-associated events. The authors previously reported that photooxidation products of A2E can activate complement. Here they have further explored these events...
  42. pmc Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E
    So Ra Kim
    Department of Ophthalmology, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 101:11668-72. 2004
    ..Here we show that an amino acid variant in murine Rpe65, a visual-cycle protein required for the regeneration of 11-cis-retinal, is associated with reduced A2E accumulation...
  43. ncbi request reprint Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement
    Shimon Ben-Shabat
    Department of Chemistry, Columbia University, New York, NY 10027, USA
    Angew Chem Int Ed Engl 41:814-7. 2002
  44. pmc Scotopic sensitivity and color vision with a blue-light-absorbing intraocular lens
    Vivienne C Greenstein
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    J Cataract Refract Surg 33:667-72. 2007
    ..To investigate possible adverse effects of a yellow-tinted intraocular lens (IOL) on scotopic sensitivity and hue discrimination...
  45. doi request reprint OT-674 suppresses photooxidative processes initiated by an RPE lipofuscin fluorophore
    Jilin Zhou
    Department of Ophthalmology, Columbia University, New York, NY, USA
    Photochem Photobiol 84:75-80. 2008
    ..As oxidative damage to RPE cells is considered to be a risk factor for AMD, antioxidant therapy with OT-674 may serve a protective role...
  46. pmc Autofluorescence characteristics of normal foveas and reconstruction of foveal autofluorescence from limited data subsets
    R Theodore Smith
    Department of Ophthalmology, Columbia University, New York, NY 10032, USA
    Invest Ophthalmol Vis Sci 46:2940-6. 2005
    ..To develop mathematical and geometric models of the nonuniform autofluorescence (AF) patterns of foveas of normal subjects and to reconstruct these models from limited subsets of data...
  47. ncbi request reprint A blue-blocking intraocular lens should be used in cataract surgery
    Richard E Braunstein
    Edward S Harkness Eye Institute, Columbia University, New York, NY 10032, USA
    Arch Ophthalmol 123:547-9. 2005
  48. ncbi request reprint Chlorophyll derivatives as visual pigments for super vision in the red
    Ilyas Washington
    Columbia University, Department of Chemistry, New York, NY 10027, USA
    Photochem Photobiol Sci 6:775-9. 2007
    ..Electroretinographic b-wave amplitudes recorded in response to red and blue light were two-fold greater in mice administered chlorin e(6), which accumulated in photoreceptor outer segments...
  49. ncbi request reprint Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells
    Jilin Zhou
    Department of Ophthalmology, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Exp Eye Res 80:567-80. 2005
    ....
  50. pmc A method of drusen measurement based on reconstruction of fundus background reflectance
    R T Smith
    Harkness Eye Institute, Columbia University College of Pysicians and Surgeons, New York, NY 10032, USA
    Br J Ophthalmol 89:87-91. 2005
    ..Current manual methods of drusen segmentation and quantification are laborious and subjective. The authors introduced a digital method and tested it for accuracy and reliability...
  51. pmc How much blue light should an IOL transmit?
    M A Mainster
    Department of Ophthalmology, University of Kansas Medical School, Kansas City, KS 66160 7379, USA
    Br J Ophthalmol 87:1523-9. 2003
    ....
  52. pmc Experimental approaches to the study of A2E, a bisretinoid lipofuscin chromophore of retinal pigment epithelium
    Janet R Sparrow
    Departments of Ophthalmology and Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Methods Mol Biol 652:315-27. 2010
    ..This approach allows for a population of RPE cells that have accumulated the lipofuscin fluorophore A2E in addition to A2E-free cells...
  53. ncbi request reprint Photochemistry of A1E, a retinoid with a conjugated pyridinium moiety: competition between pericyclic photooxygenation and pericyclization
    Steffen Jockusch
    Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027, USA
    J Am Chem Soc 126:4646-52. 2004
    ..If the singlet oxygen produced is quenched by the protonated solvent molecules faster than singlet oxygen reacts with A1E, then cyclization dominates...
  54. ncbi request reprint A2-rhodopsin: a new fluorophore isolated from photoreceptor outer segments
    Nathan Fishkin
    Department of Chemistry, Columbia University, New York, NY 10027, USA
    Org Biomol Chem 1:1101-5. 2003
    ....
  55. ncbi request reprint Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments
    Nathan Fishkin
    Department of Chemistry, Columbia University, New York, NY 10027, USA
    Chirality 16:637-41. 2004
    ..This further suggested that despite the large energy difference between the two interacting chromophores, the dominant source of optical activity in the CD spectrum is the nondegenerate exciton mechanism...
  56. ncbi request reprint Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ageing Res Rev 4:315-38. 2005
    ..We discuss how microbes capable of degrading them can be isolated, characterised and their relevant enzymes engineered for this purpose and ways to avoid potential side-effects...
  57. ncbi request reprint SOD2 knockdown mouse model of early AMD
    Verline Justilien
    Department of Molecular Genetics, University of Florida, Gainesville, Florida, USA
    Invest Ophthalmol Vis Sci 48:4407-20. 2007
    ..To test the hypothesis that oxidative injury to the retinal pigment epithelium (RPE) may lead to retinal damage similar to that associated with the early stages of age-related macular degeneration (AMD)...
  58. ncbi request reprint Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation
    Pranab Maiti
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 45:852-60. 2006
    ..These antagonists will also be used to probe the molecular function of RPE65 in vision...
  59. pmc The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells
    Xinyu Zhang
    United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 49:3622-30. 2008
    ..The objective of this study was to investigate the effect of oxidative stress on the UPP in cultured human retina pigment epithelial cells...
  60. pmc Retinal pigment epithelium lipofuscin proteomics
    Kwok Peng Ng
    Cole Eye Institute and Lerner Research Institute, Cleveland Clinic Foundation, Case Western Reserve University, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 7:1397-405. 2008
    ....
  61. pmc Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice
    Mariacarmela Allocca
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    J Clin Invest 118:1955-64. 2008
    ..The possibility of packaging large genes in AAV greatly expands the therapeutic potential of this vector system...

Research Grants13

  1. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet Sparrow; Fiscal Year: 2006
    ..The long-term goals of this work are to develop therapies that would reduce the formation of A2E, destroy the formed molecule within the RPE cell, or counter the deleterious effects of its accumulation. ..
  2. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet R Sparrow; Fiscal Year: 2010
    ....
  3. NEUTROPHINS AND RETINAL DEVELOPMENT
    Janet Sparrow; Fiscal Year: 1999
    ..The use of neurotrophins in conjunction with gene therapy or transplantation may also have potential for reversing retinal degenerative changes and lead to the restoration of vision. ..
  4. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet Sparrow; Fiscal Year: 2009
    ....
  5. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet Sparrow; Fiscal Year: 2005
    ..The long-term goals of this work are to develop therapies that would reduce the formation of A2E, destroy the formed molecule within the RPE cell, or counter the deleterious effects of its accumulation. ..
  6. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet Sparrow; Fiscal Year: 2004
    ..The long-term goals of this work are to develop therapies that would reduce the formation of A2E, destroy the formed molecule within the RPE cell, or counter the deleterious effects of its accumulation. ..
  7. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet Sparrow; Fiscal Year: 2003
    ..The long-term goals of this work are to develop therapies that would reduce the formation of A2E, destroy the formed molecule within the RPE cell, or counter the deleterious effects of its accumulation. ..
  8. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet Sparrow; Fiscal Year: 2002
    ..If it can be demonstrated that the amassing of synthetic A2E by RPE cells is significant in terms of RPE cell function, treatments could be aimed at preventing its formation or destroying the formed molecule within the RPE cells. ..
  9. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet Sparrow; Fiscal Year: 2001
    ..If it can be demonstrated that the amassing of synthetic A2E by RPE cells is significant in terms of RPE cell function, treatments could be aimed at preventing its formation or destroying the formed molecule within the RPE cells. ..
  10. NEUTROPHINS AND RETINAL DEVELOPMENT
    Janet Sparrow; Fiscal Year: 2001
    ..The use of neurotrophins in conjunction with gene therapy or transplantation may also have potential for reversing retinal degenerative changes and lead to the restoration of vision. ..
  11. NEUTROPHINS AND RETINAL DEVELOPMENT
    Janet Sparrow; Fiscal Year: 2000
    ..The use of neurotrophins in conjunction with gene therapy or transplantation may also have potential for reversing retinal degenerative changes and lead to the restoration of vision. ..
  12. IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
    Janet Sparrow; Fiscal Year: 2000
    ..If it can be demonstrated that the amassing of synthetic A2E by RPE cells is significant in terms of RPE cell function, treatments could be aimed at preventing its formation or destroying the formed molecule within the RPE cells. ..