Research Topics
Species | SCOTT A contact SMALLSummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Detail Information
Publications
Imaging hippocampal function across the human life span: is memory decline normal or not?Scott A Small
The Taub Institute on Alzheimer s Disease and the Aging Brain, Deparment of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Ann Neurol 51:290-5. 2002..These results show that memory decline is caused by different mechanisms and suggests how memory decline should be approached clinically...- Acquisition, recall, and forgetting of verbal information in long-term memory by young, middle-aged, and elderly individualsHasker P Davis
Department of Psychology, University of Colorado, Colorado Springs 80933, USA
Cortex 39:1063-91. 2003..The importance of testing across the life span and using tests that examine a variety of memory components and processes for establishing norms and clarifying age-related deficits are discussed... - Imaging the Abeta-related neurotoxicity of Alzheimer diseaseHerman Moreno
Department of Neurology, Robert S Furchgott Center for Neural and Behavioral Sciences, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
Arch Neurol 64:1467-77. 2007..Although numerous imaging studies have observed brain dysfunction in AD, whether these imaged defects reflect Abeta-related neurotoxicity remains unknown... 
Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1Rachel F Lane
Department of Neurology, Mount Sinai School of Medicine, New York NY 10029, USA
Mol Neurodegener 5:62. 2010..abstract:..- Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediatedSandra I Vieira
Neuroscience, Centre for Cell Biology, Health Sciences Department SACS, University of Aveiro, Aveiro 3810, Portugal
Mol Neurodegener 5:40. 2010..Further, the motif(s) in APP that regulate its sorting to the TGN have not been characterized... - Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesisScott A Small
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neuron 60:534-42. 2008..This model may account for the results of recent drug trials and, if confirmed, may guide future drug development... - Retromer sorting: a pathogenic pathway in late-onset Alzheimer diseaseScott A Small
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Arch Neurol 65:323-8. 2008..Herein, these findings will be reviewed, the details of the retromer sorting pathway will be discussed, and a biological model that can account for the disease's regional selectivity will be elaborated... - Evaluating the function of hippocampal subregions with high-resolution MRI in Alzheimer's disease and agingS A Small
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Microsc Res Tech 51:101-8. 2000..Testing the protocol in other clinical populations is needed to demonstrate its efficacy in evaluating the neuronal integrity of all hippocampal subregions... - Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesisScott A Small
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Neuron 52:15-31. 2006..Accumulated evidence indicates that sorting pathways may be uniquely vulnerable to disease pathogenesis, and recent studies have begun to reveal disease-related defects in the regulation of protein sorting... - Model-guided microarray implicates the retromer complex in Alzheimer's diseaseScott A Small
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, and the Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY, USA
Ann Neurol 58:909-19. 2005..Reviewing our findings in the context of recent studies suggests how downregulation of the retromer complex in AD can regulate local levels of Abeta peptide... - Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to agingScott A Small
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 101:7181-6. 2004..This pattern isolates the locus of age-related hippocampal dysfunction and differentiates normal aging from Alzheimer's disease... - The longitudinal axis of the hippocampal formation: its anatomy, circuitry, and role in cognitive functionScott A Small
The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Rev Neurosci 13:183-94. 2002..Recent imaging studies investigating the long axis as a circuit are summarized, pointing to specific mechanisms that can account for how the hippocampus associates separate sensory input during memory acquisition and recall... - Imaging Alzheimer's diseaseScott A Small
Department of Neurology, Columbia University College of Physicians and Surgeons, PH 19th Floor, 630 West 168 Street, New York, NY 10032, USA
Curr Neurol Neurosci Rep 3:385-92. 2003..A focus on these two features--the neurobiologic correlates of imaging and the pathophysiology of Alzheimer's disease--has provided the organizing principle of this review... - Measuring correlates of brain metabolism with high-resolution MRI: a promising approach for diagnosing Alzheimer disease and mapping its courseScott A Small
Taub Institute on Alzheimer s Disease and the Aging Brain, The Center for Neurobiology and Behavior, Columbia University College of Psysicians and Surgeons, New York, New York 10032, USA
Alzheimer Dis Assoc Disord 17:154-61. 2003..Here, these attempts will be reviewed, highlighting the advantages but also the potential pitfalls of imaging a dysfunctional brain... - Circuit mechanisms underlying memory encoding and retrieval in the long axis of the hippocampal formationS A Small
The Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, 630 West 168 Street, New York, New York 10032, USA
Nat Neurosci 4:442-9. 2001..Interpreted in the context of hippocampal anatomy and physiology, these findings reveal hippocampal circuit mechanisms that underlie memory encoding and retrieval... - Linking hippocampal structure and function to memory performance in an aging populationChristiane Reitz
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Arch Neurol 66:1385-92. 2009..Magnetic resonance imaging is used to assess structure and function in the hippocampal formation... - Reading level attenuates differences in neuropsychological test performance between African American and White eldersJennifer J Manly
Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Int Neuropsychol Soc 8:341-8. 2002.... - Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signsElan D Louis
Unit 198, Department of Neurology, Columbia University, 710 W 168th St, New York, NY 10032, USA
Arch Neurol 65:1649-54. 2008..Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS... - Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern ManhattanAdam M Brickman
Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Arch Neurol 65:1053-61. 2008..Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease... - The brain in the age of old: the hippocampal formation is targeted differentially by diseases of late lifeWilliam Wu
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
Ann Neurol 64:698-706. 2008..To rely on the anatomical organization of the hippocampal formation in understanding whether and how late-life diseases such as diabetes and stroke contribute to age-related cognitive decline... - An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrusAna C Pereira
The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 104:5638-43. 2007.... - Pinpointing synaptic loss caused by Alzheimer's disease with fMRIAdam M Brickman
Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Behav Neurol 21:93-100. 2009..In this review, we will compare and contrast both approaches for pinpointing when and where synaptic loss in AD begins and for monitoring therapeutic efficacy... - Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophreniaInna Gaisler-Salomon
Department of Psychiatry, Columbia University, New York, NY 10032, USA
Neuropsychopharmacology 34:2305-22. 2009.... - How high-resolution basal-state functional imaging can guide the development of new pharmacotherapies for schizophreniaInna Gaisler-Salomon
Department of Psychiatry, Columbia University, New York, NY 10032, USA
Schizophr Bull 35:1037-44. 2009.... - Frequency of subclinical heart disease in elderly persons with dementiaChristiane Reitz
Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
Am J Geriatr Cardiol 16:183-8. 2007..With the increasing prevalence of Alzheimer's disease and vascular dementia, clinicians have to be more attentive to the presence of structural heart disease and its complications in persons with these conditions... - Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulationAlim Muhammad
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 105:7327-32. 2008..By recapitulating features of the disease, these animal models suggest that retromer deficiency observed in late-onset Alzheimer's disease can contribute to disease pathogenesis... - CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activityKelly Kent
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Hippocampus 17:1003-11. 2007..These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function... - Imaging-guided microarray: isolating molecular profiles that dissociate Alzheimer's disease from normal agingAna Carolina Pereira
Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Ann N Y Acad Sci 1097:225-38. 2007..Then, we will review preliminary findings applying imaging-guided microarray to AD and normal aging, in an attempt to isolate molecular profiles that dissociate the two main causes of age-related hippocampal dysfunction... - Technology Insight: imaging amyloid plaques in the living brain with positron emission tomography and MRIDan E Huddleston
Columbia University Medical Center, New York, NY, USA
Nat Clin Pract Neurol 1:96-105. 2005..In this article, we review the studies that report on these recent technical advances, and discuss their potential importance in clarifying the diagnostic and pathogenic relevance of amyloid plaques to Alzheimer's disease... - Combining brain imaging with microarray: isolating molecules underlying the physiologic disorders of the brainAimee Pierce
The Taub Institute on Alzheimer's Disease and the Aging Brain, The Center for Neurobiology and Behavior, and the Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Neurochem Res 29:1145-52. 2004..Here we show how brain imaging and microarray can be used as complimentary techniques that together can characterize the cellular and molecular aspects of this class of diseases... - Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complexRachel F Lane
Department of Neurology and Alzheimer s Disease Research Center, Mount Sinai School of Medicine, New York, New York 10029, USA
J Neurosci 30:13110-5. 2010..003) in the brains of female Sorcs1 hypomorphic mice. From these data, we propose that dysfunction of SorCS1 may contribute to both the APP/Aβ disturbance underlying AD and the insulin/glucose disturbance underlying DM... - Mapping brain function using a 30-day interval between baseline and activation: a novel arterial spin labeling fMRI approachAjna Borogovac
Department of Biomedical Engineering, Columbia University, New York, New York, USA
J Cereb Blood Flow Metab 30:1721-33. 2010..Taken together, these results indicate that CBFd measure could be better suited than net CBF to map long-term changes in brain function... - Imaging the earliest stages of Alzheimer's diseaseWilliam Wu
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA
Curr Alzheimer Res 3:529-39. 2006..Here, we will first define the neurobiological meaning of 'function' and then review the different approaches that measure brain dysfunction in Alzheimer' disease... - Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disordersScott A Schobel
Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Arch Gen Psychiatry 66:938-46. 2009..Because schizophrenia and related disorders have a chronic time course and subtle histopathology, it is difficult to identify which brain regions are differentially targeted... - Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasoundJames J Choi
Department Biomedical Engineering, Columbia University, New York, NY 10027, USA
Ultrason Imaging 30:189-200. 2008..In conclusion, a BBB-impermeable molecule was noninvasively, transiently and reproducibly delivered to the hippocampus of Alzheimer's APP/PS1 mice... - Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in miceJames J Choi
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
Ultrasound Med Biol 33:95-104. 2007.... - Alzheimer disease, in living colorScott A Small
Nat Neurosci 8:404-5. 2005
Research Grants
- LONGITUDINAL ANALYSIS OF AGE RELATED MEMORY DECLINEScott Small; Fiscal Year: 2004..The second research goal is to validate-that the fMRI method can dissociate different etiologies by following the clinical course of individuals with memory decline prospectively. ..
- MRI and mouse models of Alzheimer's disease and agingScott Small; Fiscal Year: 2007..With these advantages in mind, we have constructed an MRI laboratory tailored exclusively to mouse MRI, and have optimized CBV approaches for subregional analysis of the hippocampus. ..
- Neural and Behavioral Profiles of Cognitive AgingScott Small; Fiscal Year: 2009..More than just understanding mechanisms of dysfunction, the ultimate goal of this proposal is learn how to ameliorate cognitive aging. ..
- Histone acetylation and cognitive agingScott A Small; Fiscal Year: 2010..More than just understanding mechanisms of dysfunction, the ultimate goal of this proposal is learn how to ameliorate cognitive aging. ..
- MRI and mouse models of Alzheimer's disease and agingScott Small; Fiscal Year: 2009..With these advantages in mind, we have constructed an MRI laboratory tailored exclusively to mouse MRI, and have optimized CBV approaches for subregional analysis of the hippocampus. ..
- fMRI and Mouse Models of Alzheimer's DiseaseScott A Small; Fiscal Year: 2010....
- Exercise, Age-Related Memory Decline, and Hippocampal Function.SCOTT A contact SMALL; Fiscal Year: 2010....