SCOTT A contact SMALL

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Imaging hippocampal function across the human life span: is memory decline normal or not?
    Scott A Small
    The Taub Institute on Alzheimer s Disease and the Aging Brain, Deparment of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Ann Neurol 51:290-5. 2002
  2. ncbi request reprint Acquisition, recall, and forgetting of verbal information in long-term memory by young, middle-aged, and elderly individuals
    Hasker P Davis
    Department of Psychology, University of Colorado, Colorado Springs 80933, USA
    Cortex 39:1063-91. 2003
  3. ncbi request reprint Imaging the Abeta-related neurotoxicity of Alzheimer disease
    Herman Moreno
    Department of Neurology, Robert S Furchgott Center for Neural and Behavioral Sciences, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    Arch Neurol 64:1467-77. 2007
  4. pmc Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1
    Rachel F Lane
    Department of Neurology, Mount Sinai School of Medicine, New York NY 10029, USA
    Mol Neurodegener 5:62. 2010
  5. pmc Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
    Sandra I Vieira
    Neuroscience, Centre for Cell Biology, Health Sciences Department SACS, University of Aveiro, Aveiro 3810, Portugal
    Mol Neurodegener 5:40. 2010
  6. pmc Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 60:534-42. 2008
  7. pmc Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 65:323-8. 2008
  8. ncbi request reprint Evaluating the function of hippocampal subregions with high-resolution MRI in Alzheimer's disease and aging
    S A Small
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Microsc Res Tech 51:101-8. 2000
  9. ncbi request reprint Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neuron 52:15-31. 2006
  10. ncbi request reprint Model-guided microarray implicates the retromer complex in Alzheimer's disease
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, and the Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Ann Neurol 58:909-19. 2005

Research Grants

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Imaging hippocampal function across the human life span: is memory decline normal or not?
    Scott A Small
    The Taub Institute on Alzheimer s Disease and the Aging Brain, Deparment of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Ann Neurol 51:290-5. 2002
    ..These results show that memory decline is caused by different mechanisms and suggests how memory decline should be approached clinically...
  2. ncbi request reprint Acquisition, recall, and forgetting of verbal information in long-term memory by young, middle-aged, and elderly individuals
    Hasker P Davis
    Department of Psychology, University of Colorado, Colorado Springs 80933, USA
    Cortex 39:1063-91. 2003
    ..The importance of testing across the life span and using tests that examine a variety of memory components and processes for establishing norms and clarifying age-related deficits are discussed...
  3. ncbi request reprint Imaging the Abeta-related neurotoxicity of Alzheimer disease
    Herman Moreno
    Department of Neurology, Robert S Furchgott Center for Neural and Behavioral Sciences, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
    Arch Neurol 64:1467-77. 2007
    ..Although numerous imaging studies have observed brain dysfunction in AD, whether these imaged defects reflect Abeta-related neurotoxicity remains unknown...
  4. pmc Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1
    Rachel F Lane
    Department of Neurology, Mount Sinai School of Medicine, New York NY 10029, USA
    Mol Neurodegener 5:62. 2010
    ..abstract:..
  5. pmc Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
    Sandra I Vieira
    Neuroscience, Centre for Cell Biology, Health Sciences Department SACS, University of Aveiro, Aveiro 3810, Portugal
    Mol Neurodegener 5:40. 2010
    ..Further, the motif(s) in APP that regulate its sorting to the TGN have not been characterized...
  6. pmc Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 60:534-42. 2008
    ..This model may account for the results of recent drug trials and, if confirmed, may guide future drug development...
  7. pmc Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 65:323-8. 2008
    ..Herein, these findings will be reviewed, the details of the retromer sorting pathway will be discussed, and a biological model that can account for the disease's regional selectivity will be elaborated...
  8. ncbi request reprint Evaluating the function of hippocampal subregions with high-resolution MRI in Alzheimer's disease and aging
    S A Small
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Microsc Res Tech 51:101-8. 2000
    ..Testing the protocol in other clinical populations is needed to demonstrate its efficacy in evaluating the neuronal integrity of all hippocampal subregions...
  9. ncbi request reprint Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Neuron 52:15-31. 2006
    ..Accumulated evidence indicates that sorting pathways may be uniquely vulnerable to disease pathogenesis, and recent studies have begun to reveal disease-related defects in the regulation of protein sorting...
  10. ncbi request reprint Model-guided microarray implicates the retromer complex in Alzheimer's disease
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, and the Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Ann Neurol 58:909-19. 2005
    ..Reviewing our findings in the context of recent studies suggests how downregulation of the retromer complex in AD can regulate local levels of Abeta peptide...
  11. pmc Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging
    Scott A Small
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:7181-6. 2004
    ..This pattern isolates the locus of age-related hippocampal dysfunction and differentiates normal aging from Alzheimer's disease...
  12. ncbi request reprint The longitudinal axis of the hippocampal formation: its anatomy, circuitry, and role in cognitive function
    Scott A Small
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Rev Neurosci 13:183-94. 2002
    ..Recent imaging studies investigating the long axis as a circuit are summarized, pointing to specific mechanisms that can account for how the hippocampus associates separate sensory input during memory acquisition and recall...
  13. ncbi request reprint Imaging Alzheimer's disease
    Scott A Small
    Department of Neurology, Columbia University College of Physicians and Surgeons, PH 19th Floor, 630 West 168 Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 3:385-92. 2003
    ..A focus on these two features--the neurobiologic correlates of imaging and the pathophysiology of Alzheimer's disease--has provided the organizing principle of this review...
  14. ncbi request reprint Measuring correlates of brain metabolism with high-resolution MRI: a promising approach for diagnosing Alzheimer disease and mapping its course
    Scott A Small
    Taub Institute on Alzheimer s Disease and the Aging Brain, The Center for Neurobiology and Behavior, Columbia University College of Psysicians and Surgeons, New York, New York 10032, USA
    Alzheimer Dis Assoc Disord 17:154-61. 2003
    ..Here, these attempts will be reviewed, highlighting the advantages but also the potential pitfalls of imaging a dysfunctional brain...
  15. ncbi request reprint Circuit mechanisms underlying memory encoding and retrieval in the long axis of the hippocampal formation
    S A Small
    The Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, 630 West 168 Street, New York, New York 10032, USA
    Nat Neurosci 4:442-9. 2001
    ..Interpreted in the context of hippocampal anatomy and physiology, these findings reveal hippocampal circuit mechanisms that underlie memory encoding and retrieval...
  16. pmc Linking hippocampal structure and function to memory performance in an aging population
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:1385-92. 2009
    ..Magnetic resonance imaging is used to assess structure and function in the hippocampal formation...
  17. ncbi request reprint Reading level attenuates differences in neuropsychological test performance between African American and White elders
    Jennifer J Manly
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Int Neuropsychol Soc 8:341-8. 2002
    ....
  18. pmc Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs
    Elan D Louis
    Unit 198, Department of Neurology, Columbia University, 710 W 168th St, New York, NY 10032, USA
    Arch Neurol 65:1649-54. 2008
    ..Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS...
  19. pmc Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan
    Adam M Brickman
    Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Arch Neurol 65:1053-61. 2008
    ..Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease...
  20. pmc The brain in the age of old: the hippocampal formation is targeted differentially by diseases of late life
    William Wu
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Ann Neurol 64:698-706. 2008
    ..To rely on the anatomical organization of the hippocampal formation in understanding whether and how late-life diseases such as diabetes and stroke contribute to age-related cognitive decline...
  21. pmc An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
    Ana C Pereira
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:5638-43. 2007
    ....
  22. pmc Pinpointing synaptic loss caused by Alzheimer's disease with fMRI
    Adam M Brickman
    Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Behav Neurol 21:93-100. 2009
    ..In this review, we will compare and contrast both approaches for pinpointing when and where synaptic loss in AD begins and for monitoring therapeutic efficacy...
  23. pmc Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia
    Inna Gaisler-Salomon
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 34:2305-22. 2009
    ....
  24. pmc How high-resolution basal-state functional imaging can guide the development of new pharmacotherapies for schizophrenia
    Inna Gaisler-Salomon
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Schizophr Bull 35:1037-44. 2009
    ....
  25. pmc Frequency of subclinical heart disease in elderly persons with dementia
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Am J Geriatr Cardiol 16:183-8. 2007
    ..With the increasing prevalence of Alzheimer's disease and vascular dementia, clinicians have to be more attentive to the presence of structural heart disease and its complications in persons with these conditions...
  26. pmc Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
    Alim Muhammad
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:7327-32. 2008
    ..By recapitulating features of the disease, these animal models suggest that retromer deficiency observed in late-onset Alzheimer's disease can contribute to disease pathogenesis...
  27. ncbi request reprint CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity
    Kelly Kent
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Hippocampus 17:1003-11. 2007
    ..These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function...
  28. ncbi request reprint Imaging-guided microarray: isolating molecular profiles that dissociate Alzheimer's disease from normal aging
    Ana Carolina Pereira
    Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Ann N Y Acad Sci 1097:225-38. 2007
    ..Then, we will review preliminary findings applying imaging-guided microarray to AD and normal aging, in an attempt to isolate molecular profiles that dissociate the two main causes of age-related hippocampal dysfunction...
  29. ncbi request reprint Technology Insight: imaging amyloid plaques in the living brain with positron emission tomography and MRI
    Dan E Huddleston
    Columbia University Medical Center, New York, NY, USA
    Nat Clin Pract Neurol 1:96-105. 2005
    ..In this article, we review the studies that report on these recent technical advances, and discuss their potential importance in clarifying the diagnostic and pathogenic relevance of amyloid plaques to Alzheimer's disease...
  30. ncbi request reprint Combining brain imaging with microarray: isolating molecules underlying the physiologic disorders of the brain
    Aimee Pierce
    The Taub Institute on Alzheimer s Disease and the Aging Brain, The Center for Neurobiology and Behavior, and the Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Neurochem Res 29:1145-52. 2004
    ..Here we show how brain imaging and microarray can be used as complimentary techniques that together can characterize the cellular and molecular aspects of this class of diseases...
  31. pmc Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex
    Rachel F Lane
    Department of Neurology and Alzheimer s Disease Research Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 30:13110-5. 2010
    ..003) in the brains of female Sorcs1 hypomorphic mice. From these data, we propose that dysfunction of SorCS1 may contribute to both the APP/Aβ disturbance underlying AD and the insulin/glucose disturbance underlying DM...
  32. pmc Mapping brain function using a 30-day interval between baseline and activation: a novel arterial spin labeling fMRI approach
    Ajna Borogovac
    Department of Biomedical Engineering, Columbia University, New York, New York, USA
    J Cereb Blood Flow Metab 30:1721-33. 2010
    ..Taken together, these results indicate that CBFd measure could be better suited than net CBF to map long-term changes in brain function...
  33. ncbi request reprint Imaging the earliest stages of Alzheimer's disease
    William Wu
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, New York, NY 10032, USA
    Curr Alzheimer Res 3:529-39. 2006
    ..Here, we will first define the neurobiological meaning of 'function' and then review the different approaches that measure brain dysfunction in Alzheimer' disease...
  34. pmc Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders
    Scott A Schobel
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 66:938-46. 2009
    ..Because schizophrenia and related disorders have a chronic time course and subtle histopathology, it is difficult to identify which brain regions are differentially targeted...
  35. ncbi request reprint Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound
    James J Choi
    Department Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrason Imaging 30:189-200. 2008
    ..In conclusion, a BBB-impermeable molecule was noninvasively, transiently and reproducibly delivered to the hippocampus of Alzheimer's APP/PS1 mice...
  36. ncbi request reprint Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice
    James J Choi
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Ultrasound Med Biol 33:95-104. 2007
    ....
  37. ncbi request reprint Alzheimer disease, in living color
    Scott A Small
    Nat Neurosci 8:404-5. 2005

Research Grants9

  1. LONGITUDINAL ANALYSIS OF AGE RELATED MEMORY DECLINE
    Scott Small; Fiscal Year: 2004
    ..The second research goal is to validate-that the fMRI method can dissociate different etiologies by following the clinical course of individuals with memory decline prospectively. ..
  2. MRI and mouse models of Alzheimer's disease and aging
    Scott Small; Fiscal Year: 2007
    ..With these advantages in mind, we have constructed an MRI laboratory tailored exclusively to mouse MRI, and have optimized CBV approaches for subregional analysis of the hippocampus. ..
  3. Neural and Behavioral Profiles of Cognitive Aging
    Scott Small; Fiscal Year: 2009
    ..More than just understanding mechanisms of dysfunction, the ultimate goal of this proposal is learn how to ameliorate cognitive aging. ..
  4. Histone acetylation and cognitive aging
    Scott A Small; Fiscal Year: 2010
    ..More than just understanding mechanisms of dysfunction, the ultimate goal of this proposal is learn how to ameliorate cognitive aging. ..
  5. MRI and mouse models of Alzheimer's disease and aging
    Scott Small; Fiscal Year: 2009
    ..With these advantages in mind, we have constructed an MRI laboratory tailored exclusively to mouse MRI, and have optimized CBV approaches for subregional analysis of the hippocampus. ..
  6. fMRI and Mouse Models of Alzheimer's Disease
    Scott A Small; Fiscal Year: 2010
    ....
  7. Exercise, Age-Related Memory Decline, and Hippocampal Function.
    SCOTT A contact SMALL; Fiscal Year: 2010
    ....