HELEN B SIMPSON

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Statistical choices can affect inferences about treatment efficacy: a case study from obsessive-compulsive disorder research
    Helen Blair Simpson
    Department of Psychiatry, Columbia University, USA
    J Psychiatr Res 42:631-8. 2008
  2. doi request reprint Development of a patient adherence scale for exposure and response prevention therapy
    Helen Blair Simpson
    Anxiety Disorders Clinic, New York Psychiatric Institute, Unit 69, 1051 Riverside Drive, New York, NY 10032, USA
    Behav Ther 41:30-7. 2010
  3. doi request reprint Adding motivational interviewing to exposure and ritual prevention for obsessive-compulsive disorder: an open pilot trial
    Helen Blair Simpson
    Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, NY, USA
    Cogn Behav Ther 37:38-49. 2008
  4. ncbi request reprint Response versus remission in obsessive-compulsive disorder
    Helen Blair Simpson
    New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 67:269-76. 2006
  5. doi request reprint Challenges using motivational interviewing as an adjunct to exposure therapy for obsessive-compulsive disorder
    Helen Blair Simpson
    New York State Psychiatric Institute, New York, NY, USA
    Behav Res Ther 48:941-8. 2010
  6. ncbi request reprint Standard criteria for relapse are needed in obsessive-compulsive disorder
    Helen Blair Simpson
    Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, New York 10032, USA
    Depress Anxiety 21:1-8. 2005
  7. pmc Patient adherence predicts outcome from cognitive behavioral therapy in obsessive-compulsive disorder
    Helen Blair Simpson
    Columbia University New York State Psychiatric Institute, 1051 Riverside Drive, Unit 69, New York, NY 10032, USA
    J Consult Clin Psychol 79:247-52. 2011
  8. ncbi request reprint Post-treatment effects of exposure therapy and clomipramine in obsessive-compulsive disorder
    H Blair Simpson
    New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Depress Anxiety 19:225-33. 2004
  9. doi request reprint Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome
    Antonio Mantovani
    Division of Experimental Therapeutics, Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY, USA Division of Psychiatry, Department of Neuroscience, Siena University, Siena, Italy Electronic address
    Psychiatry Res 210:1026-32. 2013
  10. doi request reprint Prevalence and correlates of shoplifting in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    Carlos Blanco
    New York State Psychiatric Institute Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Psychiatry 165:905-13. 2008

Research Grants

Detail Information

Publications26

  1. ncbi request reprint Statistical choices can affect inferences about treatment efficacy: a case study from obsessive-compulsive disorder research
    Helen Blair Simpson
    Department of Psychiatry, Columbia University, USA
    J Psychiatr Res 42:631-8. 2008
    ..The use of appropriate statistical methods in psychiatric trials can advance public health by ensuring that valid inferences are made about treatment efficacy...
  2. doi request reprint Development of a patient adherence scale for exposure and response prevention therapy
    Helen Blair Simpson
    Anxiety Disorders Clinic, New York Psychiatric Institute, Unit 69, 1051 Riverside Drive, New York, NY 10032, USA
    Behav Ther 41:30-7. 2010
    ..Future research will need to test the scale's reliability and validity in a larger sample of patients over the course of treatment...
  3. doi request reprint Adding motivational interviewing to exposure and ritual prevention for obsessive-compulsive disorder: an open pilot trial
    Helen Blair Simpson
    Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, NY, USA
    Cogn Behav Ther 37:38-49. 2008
    ..Challenges in combining these treatments and maintaining the integrity of each as well as limitations of the study are discussed...
  4. ncbi request reprint Response versus remission in obsessive-compulsive disorder
    Helen Blair Simpson
    New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 67:269-76. 2006
    ..To investigate rates of response and remission in adults with obsessive-compulsive disorder (OCD) after 12 weeks of evidence-based treatment...
  5. doi request reprint Challenges using motivational interviewing as an adjunct to exposure therapy for obsessive-compulsive disorder
    Helen Blair Simpson
    New York State Psychiatric Institute, New York, NY, USA
    Behav Res Ther 48:941-8. 2010
    ..We recommend that MI be further evaluated in OCD by exploring alternative modes of delivery and by focusing on patients less ready for change than the current sample...
  6. ncbi request reprint Standard criteria for relapse are needed in obsessive-compulsive disorder
    Helen Blair Simpson
    Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, New York 10032, USA
    Depress Anxiety 21:1-8. 2005
    ..Standard criteria for relapse are needed in OCD to facilitate comparisons between studies (enabling better treatment guidelines) and to advance research on mechanisms of relapse and relapse prevention...
  7. pmc Patient adherence predicts outcome from cognitive behavioral therapy in obsessive-compulsive disorder
    Helen Blair Simpson
    Columbia University New York State Psychiatric Institute, 1051 Riverside Drive, Unit 69, New York, NY 10032, USA
    J Consult Clin Psychol 79:247-52. 2011
    ..To examine the effects of patient adherence on outcome from exposure and response prevention (EX/RP) therapy in adults with obsessive-compulsive disorder (OCD)...
  8. ncbi request reprint Post-treatment effects of exposure therapy and clomipramine in obsessive-compulsive disorder
    H Blair Simpson
    New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Depress Anxiety 19:225-33. 2004
    ..The CMI relapse rate was lower than previously reported. Nonetheless, responders receiving intensive EX/RP with or without CMI fared significantly better 12 weeks after treatment discontinuation than responders receiving CMI alone...
  9. doi request reprint Modulation of motor cortex excitability in obsessive-compulsive disorder: an exploratory study on the relations of neurophysiology measures with clinical outcome
    Antonio Mantovani
    Division of Experimental Therapeutics, Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY, USA Division of Psychiatry, Department of Neuroscience, Siena University, Siena, Italy Electronic address
    Psychiatry Res 210:1026-32. 2013
    ..Correlations of neurophysiology measures with therapeutic outcome are supportive of the role of SMA in the modulation of OCD symptoms. ..
  10. doi request reprint Prevalence and correlates of shoplifting in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    Carlos Blanco
    New York State Psychiatric Institute Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Psychiatry 165:905-13. 2008
    ..This study presented nationally representative data on the lifetime prevalence, correlates, and comorbidity of shoplifting among adults in the United States...
  11. pmc Rationale for the application of exposure and response prevention to the treatment of anorexia nervosa
    Joanna E Steinglass
    Columbia University, New York State Psychiatric Institute, New York 10032, New York, USA
    Int J Eat Disord 44:134-41. 2011
    ..Anorexia nervosa (AN) is a life threatening and difficult to treat illness with a high relapse rate. Current treatments are inadequate and new approaches to treatment are needed...
  12. pmc Prevalence and correlates of fire-setting in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)
    Carlos Blanco
    Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Box 69, New York, NY 10032, USA
    J Clin Psychiatry 71:1218-25. 2010
    ..To estimate the prevalence, sociodemographic correlates, comorbidity, and rates of mental health service utilization of fire-setters in the general population...
  13. ncbi request reprint Striatal dopamine D(2) receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings
    Franklin R Schneier
    Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, NY 10032, USA
    Depress Anxiety 25:1-7. 2008
    ..Prior findings of decreased D(2) receptor availability in noncomorbid OCD were not confirmed. Decreased D(2) receptor availability was also associated with trait detachment, supporting prior findings in samples of healthy subjects...
  14. ncbi request reprint A controlled trial of paroxetine for chronic PTSD, dissociation, and interpersonal problems in mostly minority adults
    Randall D Marshall
    New York State Psychiatric Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Depress Anxiety 24:77-84. 2007
    ..Paroxetine was well tolerated and superior to placebo in ameliorating the symptoms of chronic PTSD, associated features of PTSD, dissociative symptoms, and interpersonal problems in the first trial conducted primarily in minority adults...
  15. pmc Pre-meal anxiety and food intake in anorexia nervosa
    Joanna E Steinglass
    New York State Psychiatric Institute, New York, NY 10032, USA
    Appetite 55:214-8. 2010
    ..The association between pre-meal anxiety and intake among weight-restored individuals with AN suggests a potential target for relapse prevention treatment...
  16. ncbi request reprint Citalopram treatment of social anxiety disorder with comorbid major depression
    Franklin R Schneier
    Anxiety Disorders Clinic, New York State Psychiatric Institute, New York, New York 10032, USA
    Depress Anxiety 17:191-6. 2003
    ..The overlap of social anxiety disorder with atypical features of depression may primarily be due to the shared feature of rejection sensitivity...
  17. doi request reprint Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder
    Antonio Mantovani
    Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 13:217-27. 2010
    ..The results of the first randomized sham-controlled trial of SMA stimulation in the treatment of resistant OCD support further investigation into the potential therapeutic applications of rTMS in this disabling condition...
  18. pmc Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls
    Jonathan D Huppert
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Depress Anxiety 26:39-45. 2009
    ....
  19. ncbi request reprint Fluoxetine in children and adolescents with OCD: a placebo-controlled trial
    Michael R Liebowitz
    New York State Psychiatric Institute, Department of Psychiatry, Columbia University, New York 10032, USA
    J Am Acad Child Adolesc Psychiatry 41:1431-8. 2002
    ..To examine the safety and efficacy of fluoxetine in child and adolescent obsessive-compulsive disorder (OCD)...
  20. ncbi request reprint Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652
    H Blair Simpson
    Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 54:1414-21. 2003
    ..This study examined whether brain serotonin transporter (SERT) availability is altered in OCD using positron emission tomography (PET) and the SERT PET radiotracer [(11)C]McN 5652...
  21. ncbi request reprint Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder
    Edna B Foa
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Psychiatry 162:151-61. 2005
    ..Serotonin reuptake inhibitors (SRIs) and cognitive behavior therapy by exposure and ritual prevention are both established treatments for OCD, yet their relative and combined efficacy have not been demonstrated conclusively...
  22. ncbi request reprint Practice guideline for the treatment of patients with obsessive-compulsive disorder
    Lorrin M Koran
    Am J Psychiatry 164:5-53. 2007
  23. ncbi request reprint Treatment of obsessive-compulsive disorder by U.S. psychiatrists
    Carlos Blanco
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 67:946-51. 2006
    ..To examine the treatment of obsessive-compulsive disorder (OCD) by a nationally representative sample of psychiatrists...
  24. doi request reprint A randomized, controlled trial of cognitive-behavioral therapy for augmenting pharmacotherapy in obsessive-compulsive disorder
    Helen Blair Simpson
    Anxiety Disorders Clinic, New York State Psychiatric Institute, Unit 69, 1051 Riverside Dr, New York, NY 10032, USA
    Am J Psychiatry 165:621-30. 2008
    ..The purpose of this study was to examine the effects of augmenting SRIs with exposure and ritual prevention, an established cognitive-behavioral therapy (CBT) for OCD...
  25. ncbi request reprint Are there reliable neuropsychological deficits in obsessive-compulsive disorder?
    Helen Blair Simpson
    New York State Psychiatric Institute, Unit 69, 1051 Riverside Drive, New York, NY, USA
    J Psychiatr Res 40:247-57. 2006
    ..Whether there are reliable neuropsychological deficits in OCD that can be easily identified in a clinical sample and that contribute to functional impairment remains unclear and requires further study...

Research Grants13

  1. IMPROVING THE OUTCOME OF PATIENTS WITH OCD
    Helen Simpson; Fiscal Year: 2004
    ..The long-term goal of this work is to improve the outcome of patients with OCD. ..
  2. Imaging the Serotonin System in Obsessive-Compulsive Disorder
    Helen Simpson; Fiscal Year: 2009
    ..Data from this study will advance our understanding of the brain mechanisms of OCD and help build a neurobiological foundation for the development of better treatments for this disabling condition. ..
  3. Maximizing Treatment Outcome in OCD
    Helen Simpson; Fiscal Year: 2009
    ..The long-term goal of the proposed study is to provide clinicians with specific guidelines for how to maximize treatment outcome and help people with OCD lead productive and high quality lives. ..
  4. Imaging the Serotonin System in Obsessive-Compulsive Disorder
    Helen Simpson; Fiscal Year: 2007
    ..Data from this study will advance our understanding of the brain mechanisms of OCD and help build a neurobiological foundation for the development of better treatments for this disabling condition. ..
  5. Maximizing Treatment Outcome in OCD
    Helen Simpson; Fiscal Year: 2007
    ..The long-term goal of the proposed study is to provide clinicians with specific guidelines for how to maximize treatment outcome and help people with OCD lead productive and high quality lives. ..
  6. Enhancing CBT Adherence in Refractory Obsessive Compulsive Disorder with MI
    Helen Simpson; Fiscal Year: 2007
    ..During Years 2 and 3, we will conduct an open trial of this EX/RP+MI intervention in 24 EX/RP-resistant OCD outpatients who had a poor response to prior EX/RP treatment. ..
  7. Maximizing Treatment Outcome in OCD
    HELEN B SIMPSON; Fiscal Year: 2010
    ..The long-term goal of the proposed study is to provide clinicians with specific guidelines for how to maximize treatment outcome and help people with OCD lead productive and high quality lives. ..