D L Silver

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi SR-BI and protein-protein interactions in hepatic high density lipoprotein metabolism
    David L Silver
    Columbia University, Department of Medicine, 630 West 168 Street College of Physicians and Surgeons room 8 401, New York, NY 10032, USA
    Rev Endocr Metab Disord 5:327-33. 2004
  2. ncbi Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover
    D L Silver
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 274:4140-6. 1999
  3. ncbi A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver
    David L Silver
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    J Biol Chem 277:34042-7. 2002
  4. ncbi The cellular biology of scavenger receptor class B type I
    D L Silver
    The Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Curr Opin Lipidol 12:497-504. 2001
  5. ncbi Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels
    David L Silver
    Department of Medicine, Division of Molecular Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 278:28528-32. 2003
  6. ncbi High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion
    D L Silver
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY 10032, USA
    J Biol Chem 276:25287-93. 2001
  7. ncbi Receptors and lipid transfer proteins in HDL metabolism
    D L Silver
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Ann N Y Acad Sci 902:103-11; discussion 111-2. 2000
  8. pmc Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptake
    D L Silver
    The Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 105:151-9. 2000
  9. ncbi Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1
    N Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 275:33053-8. 2000
  10. ncbi Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1
    Debin Lan
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:23390-6. 2005

Collaborators

Detail Information

Publications23

  1. ncbi SR-BI and protein-protein interactions in hepatic high density lipoprotein metabolism
    David L Silver
    Columbia University, Department of Medicine, 630 West 168 Street College of Physicians and Surgeons room 8 401, New York, NY 10032, USA
    Rev Endocr Metab Disord 5:327-33. 2004
  2. ncbi Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover
    D L Silver
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 274:4140-6. 1999
    ..The studies reveal a specific HDL particle catabolic pathway that is down-regulated in ob/ob mice and suggest that HDL apolipoprotein turnover may be regulated by obesity and/or leptin signaling...
  3. ncbi A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver
    David L Silver
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    J Biol Chem 277:34042-7. 2002
    ....
  4. ncbi The cellular biology of scavenger receptor class B type I
    D L Silver
    The Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Curr Opin Lipidol 12:497-504. 2001
    ....
  5. ncbi Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels
    David L Silver
    Department of Medicine, Division of Molecular Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 278:28528-32. 2003
    ..Thus, SPAP may be an endogenous regulator of cellular PDZK1 levels by regulating PDZK1 turnover...
  6. ncbi High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion
    D L Silver
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY 10032, USA
    J Biol Chem 276:25287-93. 2001
    ..A distinct process not mediated by SR-BI is involved in uptake and degradation of apoE-free HDL in hepatocytes...
  7. ncbi Receptors and lipid transfer proteins in HDL metabolism
    D L Silver
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Ann N Y Acad Sci 902:103-11; discussion 111-2. 2000
    ..Lastly, we highlight our findings that overexpression of SR-BI in LDL receptor-deficient mice results in decreased atherosclerosis...
  8. pmc Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptake
    D L Silver
    The Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 105:151-9. 2000
    ..The findings show a major defect in HDL uptake and recycling in ob/ob hepatocytes and suggest that HDL recycling through the ERC plays a role in the determination of plasma HDL protein and cholesterol levels...
  9. ncbi Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1
    N Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 275:33053-8. 2000
    ..Plasma membrane ABC1 may act as a phospholipid/cholesterol flippase, providing lipid to bound apoA-I, or to the outer membrane hemileaflet...
  10. ncbi Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1
    Debin Lan
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 280:23390-6. 2005
    ..The further elucidation of this novel degradation pathway may provide new insights into the physiological and pathophysiological regulation of hepatic SR-BI...
  11. ncbi Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure
    Yu Sun
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:5813-20. 2003
    ..ABCA1-mediated cholesterol and phospholipid efflux may be uncoupled in pathological states associated with high SCD activity, as in hyperinsulinemic obese mice, or in animals treated with LXR activators...
  12. ncbi Scavenger receptor-BI inhibits ATP-binding cassette transporter 1- mediated cholesterol efflux in macrophages
    W Chen
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 275:30794-800. 2000
    ..SR-BI and ABC1 appear to have distinct and competing roles in mediating cholesterol flux between HDL and macrophages. In nonpolarized cells, SR-BI promotes the reuptake of cholesterol actively effluxed by ABC1, creating a futile cycle...
  13. ncbi ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein
    N Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 276:23742-7. 2001
    ..The data suggest that the binding of apoA-I to ABCA1 leads to the formation of phospholipid-apoA-I complexes, which subsequently promote cholesterol efflux in an autocrine or paracrine fashion...
  14. pmc A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I
    Nan Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 111:99-107. 2003
    ..Inhibition of ABCA1 degradation by calpain could represent a novel therapeutic approach to increasing macrophage cholesterol efflux and decreasing atherosclerosis...
  15. ncbi A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse
    Suheeta Roy
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Hepatology 41:887-95. 2005
    ..Leptin resistance due to obesity leads to a maladaptive response whereby newly synthesized cholesterol in the liver is eliminated via bile...
  16. pmc The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
    J Nakae
    Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 108:1359-67. 2001
    ..These findings are consistent with the possibility that Foxo1 is involved in insulin regulation of glucose production by mediating the ability of insulin to decrease the glucocorticoid/cAMP response of G6p...
  17. pmc Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2
    David A Gross
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
    PLoS ONE 5:e10796. 2010
    ..Taken together, these studies indicate that FIT2 is a 6 transmembrane domain-containing protein whose conformation likely regulates its activity in mediating lipid droplet formation...
  18. ncbi Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface
    Pijun Wang
    Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:30143-9. 2005
    ..Because its ability to transport substances into the cell requires surface expression, this must be considered in any assessment of physiologic function...
  19. pmc Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling
    Chatchawin Assanasen
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 115:969-77. 2005
    ..Thus, HDL signaling requires cholesterol binding and efflux and C-terminal domains of SR-BI, and SR-BI serves as a cholesterol sensor on the plasma membrane...
  20. pmc Evolutionarily conserved gene family important for fat storage
    Bert Kadereit
    Department of Biochemistry and the Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:94-9. 2008
    ..Together these studies identify and characterize a conserved gene family that is important in the fundamental process of storing fat...
  21. doi The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity
    Weifei Zhu
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, USA
    Circ Res 102:480-7. 2008
    ..Thus, PDZK1 is uniquely required for HDL/SR-BI signaling in endothelium, and through these mechanisms, it is critically involved in the maintenance of endothelial monolayer integrity...
  22. pmc Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor
    Hongwen Zhou
    Department of Endocrinology, 1st Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Biochim Biophys Acta 1761:1482-8. 2006
    ..01, respectively). These results suggest that CETP expression in mouse increases direct removal of HDL CE in the liver and this process is independent of SR-BI, LRP, and possibly LDLR...
  23. doi PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice
    Tomoko Sugiura
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa, Japan
    Drug Metab Dispos 36:1181-8. 2008
    ..These findings also raise the possibility that intestinal absorption of the substrate drugs for PEPT1 and OCTN2 is governed by the protein network of these transporters and their adaptor PDZK1...