Research Topics
| Igor ShuryakSummaryAffiliation: Columbia University Country: USA Publications
| Collaborators
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Detail Information
Publications
Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBAIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America
PLoS ONE 6:e28559. 2011..The model provides a mechanistic and quantitative explanation which is consistent with the data and may provide useful insight into human carcinogenesis...- A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radioduransIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
J Theor Biol 261:305-17. 2009..Our model of radiogenic oxidative stress is consistent with these data and can potentially be generalized to other organisms and lower radiation doses... - The balance between initiation and promotion in radiation-induced murine carcinogenesisIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Radiat Res 174:357-66. 2010..Also similar to findings in humans, initiation dominates the ERR at young ages in mice, when there are few background pre-malignant cells, and promotion becomes important at older ages... 
Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radioduransIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
Radiat Environ Biophys 49:693-703. 2010..These results suggest that synergism between oxidative stress and DNA damage may play an important role not only during γ-ray exposure, but during high-LET radiation exposure as well...- Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell deathIgor Shuryak
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Radiat Res 178:17-24. 2012..Enhanced understanding of these causes can stimulate research on novel radioprotection strategies... - Predicting the risk of secondary lung malignancies associated with whole-breast radiation therapyJohn Ng
Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
Int J Radiat Oncol Biol Phys 83:1101-6. 2012..In this study, a biologically based secondary malignancy model was used to quantify the risk of secondary lung malignancies (SLMs) associated with several common methods of delivering whole-breast radiation therapy (RT)... - Impact of reduced patient life expectancy on potential cancer risks from radiologic imagingDavid J Brenner
Center for Radiological Research and Department of Medicine and Radiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
Radiology 261:193-8. 2011.... - Adapting the γ-H2AX assay for automated processing in human lymphocytes. 1. Technological aspectsHelen C Turner
Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
Radiat Res 175:282-90. 2011..This study demonstrates for the first time the optimization and use of our robotically based biodosimetry workstation to successfully quantify γ-H2AX total fluorescence in irradiated peripheral lymphocytes... - Cancer risks after radiation exposure in middle ageIgor Shuryak
Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA
J Natl Cancer Inst 102:1628-36. 2010..These observations are inconsistent with most standard models of radiation-induced cancer, which predict that relative risks decrease monotonically with increasing age at exposure, at all ages...