Igor Shuryak

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 6:e28559. 2011
  2. pmc A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    J Theor Biol 261:305-17. 2009
  3. pmc The balance between initiation and promotion in radiation-induced murine carcinogenesis
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 174:357-66. 2010
  4. doi request reprint Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radiodurans
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 49:693-703. 2010
  5. pmc Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 178:17-24. 2012
  6. doi request reprint Predicting the risk of secondary lung malignancies associated with whole-breast radiation therapy
    John Ng
    Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 83:1101-6. 2012
  7. doi request reprint Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging
    David J Brenner
    Center for Radiological Research and Department of Medicine and Radiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Radiology 261:193-8. 2011
  8. pmc Adapting the γ-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects
    Helen C Turner
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 175:282-90. 2011
  9. pmc Cancer risks after radiation exposure in middle age
    Igor Shuryak
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA
    J Natl Cancer Inst 102:1628-36. 2010

Collaborators

Detail Information

Publications9

  1. pmc Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 6:e28559. 2011
    ..The model provides a mechanistic and quantitative explanation which is consistent with the data and may provide useful insight into human carcinogenesis...
  2. pmc A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    J Theor Biol 261:305-17. 2009
    ..Our model of radiogenic oxidative stress is consistent with these data and can potentially be generalized to other organisms and lower radiation doses...
  3. pmc The balance between initiation and promotion in radiation-induced murine carcinogenesis
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 174:357-66. 2010
    ..Also similar to findings in humans, initiation dominates the ERR at young ages in mice, when there are few background pre-malignant cells, and promotion becomes important at older ages...
  4. doi request reprint Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radiodurans
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 49:693-703. 2010
    ..These results suggest that synergism between oxidative stress and DNA damage may play an important role not only during γ-ray exposure, but during high-LET radiation exposure as well...
  5. pmc Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 178:17-24. 2012
    ..Enhanced understanding of these causes can stimulate research on novel radioprotection strategies...
  6. doi request reprint Predicting the risk of secondary lung malignancies associated with whole-breast radiation therapy
    John Ng
    Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 83:1101-6. 2012
    ..In this study, a biologically based secondary malignancy model was used to quantify the risk of secondary lung malignancies (SLMs) associated with several common methods of delivering whole-breast radiation therapy (RT)...
  7. doi request reprint Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging
    David J Brenner
    Center for Radiological Research and Department of Medicine and Radiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Radiology 261:193-8. 2011
    ....
  8. pmc Adapting the γ-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects
    Helen C Turner
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 175:282-90. 2011
    ..This study demonstrates for the first time the optimization and use of our robotically based biodosimetry workstation to successfully quantify γ-H2AX total fluorescence in irradiated peripheral lymphocytes...
  9. pmc Cancer risks after radiation exposure in middle age
    Igor Shuryak
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA
    J Natl Cancer Inst 102:1628-36. 2010
    ..These observations are inconsistent with most standard models of radiation-induced cancer, which predict that relative risks decrease monotonically with increasing age at exposure, at all ages...