L Sher

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls
    Leo Sher
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Psychoneuroendocrinology 28:559-73. 2003
  2. ncbi request reprint Aetiology and pathogenesis of mood disorders
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    QJM 96:309-13. 2003
  3. pmc Early response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder
    L Sher
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, MD, USA
    J Psychiatry Neurosci 26:336-8. 2001
  4. ncbi request reprint Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 28:1712-9. 2003
  5. ncbi request reprint Pleiotropy of the serotonin transporter gene for seasonality and neuroticism
    L Sher
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, Maryland, USA
    Psychiatr Genet 10:125-30. 2000
  6. ncbi request reprint Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 4:89-92. 1999
  7. ncbi request reprint Suicidal behavior in adolescents with comorbid depression and alcohol abuse
    D Ganz
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY, USA
    Minerva Pediatr 61:333-47. 2009
  8. ncbi request reprint A circadian signal of change of season in patients with seasonal affective disorder
    T A Wehr
    Section o Biological Rhythms, Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1390, USA
    Arch Gen Psychiatry 58:1108-14. 2001
  9. ncbi request reprint Suicidal behavior in adolescents with post-traumatic stress disorder
    D Ganz
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    Minerva Pediatr 62:363-70. 2010
  10. ncbi request reprint The concept of post-traumatic mood disorder and its implications for adolescent suicidal behavior
    L Sher
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Minerva Pediatr 60:1393-9. 2008

Detail Information

Publications89

  1. ncbi request reprint Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls
    Leo Sher
    Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Psychoneuroendocrinology 28:559-73. 2003
    ..The lack of difference in the response to fenfluramine administration between unipolar and bipolar depressed patients may indicate that overall serotonergic function in unipolar and bipolar depressed patients is similarly impaired...
  2. ncbi request reprint Aetiology and pathogenesis of mood disorders
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    QJM 96:309-13. 2003
  3. pmc Early response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder
    L Sher
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, MD, USA
    J Psychiatry Neurosci 26:336-8. 2001
    ..To determine if the antidepressant effect of 1 hour of light therapy is predictive of the response after 1 and 2 weeks of treatment in patients with seasonal affective disorder (SAD)...
  4. ncbi request reprint Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 28:1712-9. 2003
    ..Low CSF HVA suggests that impaired dopaminergic activity is associated with a history of alcoholism in persons with current MDE...
  5. ncbi request reprint Pleiotropy of the serotonin transporter gene for seasonality and neuroticism
    L Sher
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, Maryland, USA
    Psychiatr Genet 10:125-30. 2000
    ..Sibling-pair analysis confirmed that the effects of the 5-HTTLPR are due to genetic pleiotropy rather than population stratification...
  6. ncbi request reprint Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A
    M A Enoch
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 4:89-92. 1999
    ..However, these results should be treated with caution until replicated because of the possibility of false-positive findings in case-control association studies...
  7. ncbi request reprint Suicidal behavior in adolescents with comorbid depression and alcohol abuse
    D Ganz
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY, USA
    Minerva Pediatr 61:333-47. 2009
    ..There is a lot that can be done by clinicians, legal and educational professionals and society at large that may help to prevent and treat such problems...
  8. ncbi request reprint A circadian signal of change of season in patients with seasonal affective disorder
    T A Wehr
    Section o Biological Rhythms, Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1390, USA
    Arch Gen Psychiatry 58:1108-14. 2001
    ....
  9. ncbi request reprint Suicidal behavior in adolescents with post-traumatic stress disorder
    D Ganz
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    Minerva Pediatr 62:363-70. 2010
    ..However, when prescribing medications, physicians do need to be careful to consider the weaknesses and strengths of each of the pharmacological options as they apply to adolescents presenting with PTSD and suicidality...
  10. ncbi request reprint The concept of post-traumatic mood disorder and its implications for adolescent suicidal behavior
    L Sher
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Minerva Pediatr 60:1393-9. 2008
    ..Priorities for intervening to reduce adolescent suicidal behavior lie with interventions focused upon the improved recognition, treatment and management of adolescents with psychiatric disorders including PTMD...
  11. pmc Association between familial suicidal behavior and frequency of attempts among depressed suicide attempters
    D Lizardi
    School of Social Work, Columbia University, New York, NY 10027, USA
    Acta Psychiatr Scand 119:406-10. 2009
    ..The current study aimed to examine whether a family history of suicidal acts predicts severity of suicide attempts...
  12. ncbi request reprint Genetic studies of seasonal affective disorder and seasonality
    L Sher
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, MD, USA
    Compr Psychiatry 42:105-10. 2001
    ..Vulnerability to SAD and disease pathology may be influenced by many genes, perhaps on several chromosomes...
  13. ncbi request reprint Alcoholism and suicidal behavior: a clinical overview
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Acta Psychiatr Scand 113:13-22. 2006
    ..The purpose of this paper was to provide a clinical review of the literature on the relation of alcoholism to suicidal behavior...
  14. ncbi request reprint Evidence from the waking electroencephalogram that short sleepers live under higher homeostatic sleep pressure than long sleepers
    D Aeschbach
    Section on Biological Rhythms, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuroscience 102:493-502. 2001
    ..The homeostat-independent enhancement of theta/low-frequency alpha activity in the waking electroencephalogram in the short sleepers may be genetically determined or be the result of long-term adaptation to chronically short sleep...
  15. ncbi request reprint The role of genetic factors in the etiology of seasonal affective disorder and seasonality
    L Sher
    Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD 20892 1390, USA
    J Affect Disord 53:203-10. 1999
    ..Future research may clarify the role of different genes in the development of SAD...
  16. ncbi request reprint Free thyroxine and thyroid-stimulating hormone levels in patients with seasonal affective disorder and matched controls
    L Sher
    Section on Biological Rhythms, National Institute of Mental Health, Bethesda, MD 20892 1390, USA
    J Affect Disord 56:195-9. 1999
    ..Future research will be needed to determine whether the difference in thyroid function between SAD patients and controls is an epiphenomenon or is related to the biological mechanisms that cause symptoms of SAD...
  17. ncbi request reprint Type D personality: the heart, stress, and cortisol
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    QJM 98:323-9. 2005
    ..Further studies of the psychological and biological features of type D individuals may help develop treatment approaches to improve the psychological and physical health of individuals with type D personality...
  18. ncbi request reprint The role of endogenous opioids in the placebo effect in post-traumatic stress disorder
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Forsch Komplementarmed Klass Naturheilkd 11:354-9. 2004
    ..Further studies of the neurobiology of the placebo effect on patients with PTSD and other psychiatric disorders may produce interesting and important results...
  19. ncbi request reprint DRD4 receptor gene exon III polymorphism in inpatient suicidal adolescents
    G Zalsman
    Geha Mental Health Center, Petach Tikva, Tel Aviv, Israel
    J Neural Transm 111:1593-603. 2004
    ..003). The relevance of this finding to increased depression severity in suicidal adolescents, if replicated, is as yet unclear...
  20. ncbi request reprint Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients
    G Zalsman
    Adolescent Inpatient Department and Research Unit, Geha Mental Health Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neural Transm 112:309-15. 2005
    ..40; p=.027) and a negative correlation between platelet count and trait anxiety (n=32, r=-.42; p=.034) were observed...
  21. ncbi request reprint Preventing suicide
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    QJM 97:677-80. 2004
  22. ncbi request reprint Recognizing alcohol and drug abuse in patients with eating disorders
    A H Conason
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    QJM 99:335-9. 2006
    ..More studies are needed to understand psychobiological mechanisms of this comorbidity, and to develop treatments for individuals with comorbid eating disorders and substance misuse...
  23. ncbi request reprint Alcohol and suicidal behavior in adolescents
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, NY, USA
    Minerva Pediatr 58:333-9. 2006
    ..Future studies of psychological and neurobiological mechanisms of suicidality in adolescents with alcohol and/or substance abuse are merited...
  24. ncbi request reprint Depression and suicidal behavior in alcohol abusing adolescents: possible role of selenium deficiency
    L Sher
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY, USA
    Minerva Pediatr 60:201-9. 2008
    ..Healthy nutrition and possibly mineral supplementations should be a part of the treatment plan of adolescents with alcohol use disorders especially when alcohol misuse is comorbid with depression...
  25. ncbi request reprint Alcohol consumption and suicide
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    QJM 99:57-61. 2006
    ..Middle-age and older men with alcohol dependence and mood disorders are at particularly high risk...
  26. ncbi request reprint Clinical features of depressed patients with or without a family history of alcoholism
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    Acta Psychiatr Scand 112:266-71. 2005
    ..To compare clinical features of depressed subjects without alcoholism but with a family history of alcoholism to a depressed group without alcoholism and without a family history of alcoholism...
  27. ncbi request reprint Childhood abuse, adult alcohol use disorders and suicidal behaviour
    N Makhija
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    QJM 100:305-9. 2007
    ....
  28. ncbi request reprint Depression and alcoholism
    L Sher
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    QJM 97:237-40. 2004
  29. doi request reprint Brain-derived neurotrophic factor and suicidal behavior
    L Sher
    Department of Psychiatry, Mount Sinai School of Medicine, James J Peters Veterans Administration Medical Center, 130 West Kingsbridge Road, Bronx, New York 10468, USA
    QJM 104:455-8. 2011
    ..It is to be hoped that the studies of the neurobiology of suicidal behavior will lead to the development of new methods of suicide prevention...
  30. ncbi request reprint The placebo effect on mood and behavior: possible role of opioid and dopamine modulation of the hypothalamic-pituitary-adrenal system
    L Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York 10032, USA
    Forsch Komplementarmed Klass Naturheilkd 10:61-8. 2003
    ..Future studies of the neurobiology of the placebo response may yield interesting and important results...
  31. ncbi request reprint Functional magnetic resonance imaging in studies of the neurobiology of suicidal behavior in adolescents with alcohol use disorders
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Adolesc Med Health 19:11-8. 2007
    ....
  32. pmc Does first episode polarity predict risk for suicide attempt in bipolar disorder?
    Sadia R Chaudhury
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, 1051 Riverside Drive, Box 42, New York, NY 10032, United States
    J Affect Disord 104:245-50. 2007
    ..We tested the hypothesis that the polarity of a patient's first mood episode would be a marker for BD subtypes with differential risk for suicidality...
  33. ncbi request reprint Ethnicity and the relationship between adolescent alcohol use and suicidal behavior
    Shelly A Groves
    Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Adolesc Med Health 19:19-25. 2007
    ..Cultural differences in alcohol consumption may account for disparities, however future research is needed to further examine cultural trends in suicidal behavior and alcoholism...
  34. ncbi request reprint Substance use, suicidality, and adolescent-onset schizophrenia: an Israeli 10-year retrospective study
    Gal Shoval
    Adolescent Inpatient Unit, Geha Mental Health Center, Petah Tiqva, Israel
    J Child Adolesc Psychopharmacol 16:767-75. 2006
    ..The aim of this study was to investigate the link between the use of specific types of substances and suicidality in adolescent inpatients with schizophrenia and schizoaffective disorder...
  35. ncbi request reprint A 10-year retrospective study of inpatient adolescents with schizophrenia/schizoaffective disorder and substance use
    Gal Shoval
    Department of Child and Adolescent Psychiatry, Geha Mental Health Center, Petah Tiqva 49100, Israel
    Compr Psychiatry 48:1-7. 2007
    ..Adolescent inpatients with schizophrenia and schizoaffective who use substances possess differential clinical characteristics and particular correlates that justify adopting a specific approach to this high-risk clinical subgroup...
  36. ncbi request reprint Correlates of suicide attempt history in bipolar disorder: a stress-diathesis perspective
    Michael F Grunebaum
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Bipolar Disord 8:551-7. 2006
    ..We sought to identify such factors and to consider them within a stress-diathesis model of suicidal behavior...
  37. ncbi request reprint Combined dexamethasone suppression-corticotropin-releasing hormone stimulation test in studies of depression, alcoholism, and suicidal behavior
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, USA
    ScientificWorldJournal 6:1398-404. 2006
    ..The combined DEX-CRH test may become a useful neuroendocrinological tool for evaluating psychiatric patients...
  38. ncbi request reprint Aggression and substance abuse in bipolar disorder
    Michael F Grunebaum
    Department of Neuroscience, New York State Psychiatric Institute and Columbia University, New York, NY 10032, USA
    Bipolar Disord 8:496-502. 2006
    ..We also explored the chronology of onset of mood and SUD...
  39. ncbi request reprint Clinical predictors of suicidal acts after major depression in bipolar disorder: a prospective study
    Hanga Galfalvy
    Department of Neuroscience, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Bipolar Disord 8:586-95. 2006
    ..This study determined the clinical predictors of suicidal behavior during a 2-year follow-up of patients with bipolar disorder presenting with a major depressive episode (MDE)...
  40. ncbi request reprint A comparison of the medical lethality of suicide attempts in bipolar and major depressive disorders
    Gil Zalsman
    Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Bipolar Disord 8:558-65. 2006
    ....
  41. ncbi request reprint Risk and protective factors for suicide in patients with alcoholism
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, USA
    ScientificWorldJournal 6:1405-11. 2006
    ..Future studies are necessary to determine which interventions may reduce suicidal behavior in alcoholism...
  42. ncbi request reprint Preventing suicide in adolescents with alcohol use disorders
    Nita J Makhija
    Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    Int J Adolesc Med Health 19:53-9. 2007
    ..Through beginning prevention efforts at a young age, it is hopeful that both alcohol misuse and adolescent suicide can be reduced...
  43. ncbi request reprint Depressed patients with co-occurring alcohol use disorders: a unique patient population
    Leo Sher
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 69:907-15. 2008
    ..Few studies have assessed the impact of comorbid alcohol use disorders (AUDs) on clinical aspects of major depression. We compared depressed subjects with and without co-occurring AUDs with respect to demographic and clinical parameters...
  44. pmc Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?
    Juan J Carballo
    Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, United States
    J Affect Disord 109:57-63. 2008
    ..Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects...
  45. ncbi request reprint Withdrawal symptoms do not predict relapse among subjects treated for cannabis dependence
    Mikkel Arendt
    Centre for Basic Psychiatric Research, Aarhus University Hospital, Risskov, Denmark
    Am J Addict 16:461-7. 2007
    ..Withdrawal scores at baseline did not predict relapse during follow-up...
  46. ncbi request reprint Cerebrospinal fluid monoamine metabolites and suicide
    Leo Sher
    Nord J Psychiatry 61:233-4. 2007
  47. pmc Perceived reasons for living at index hospitalization and future suicide attempt
    Dana Lizardi
    Columbia University School of Social Work, New York, New York 10027, USA
    J Nerv Ment Dis 195:451-5. 2007
    ..Perceived reasons for living serve as protective factors against suicide attempt in women and not in men...
  48. pmc Positron emission tomography study of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without comorbid lifetime alcohol dependence
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Eur Neuropsychopharmacol 17:608-15. 2007
    ..The fact that the observed group difference disappeared after the fenfluramine challenge suggests that serotonergic mechanisms play a role in the observed differences between the groups...
  49. ncbi request reprint Preventing suicide among depressed patients in primary care practice
    Juan J Carballo
    Aust N Z J Psychiatry 41:295-6. 2007
  50. ncbi request reprint Psychological autopsy studies: the role of alcohol use in adolescent and young adult suicides
    Lucas Giner
    Department of Psychiatry, University of Seville, Spain
    Int J Adolesc Med Health 19:99-113. 2007
    ..Alcohol abusers seem to be prone to both suicide attempts and completions. The relationship between alcohol abuse and suicide in adolescence is complex...
  51. ncbi request reprint Triggers for suicidal behavior in depressed older adolescents and young adults: do alcohol use disorders make a difference?
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Int J Adolesc Med Health 19:91-8. 2007
    ..We compared demographic and clinical characteristics, prevalence of interpersonal triggers and the number of triggers for suicidal behavior in depressed late adolescents and young adults with or without comorbid alcohol use disorders...
  52. doi request reprint Quality of depression among suicidal inpatient youth
    Anat Brunstein Klomek
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Arch Suicide Res 12:133-40. 2008
    ..The distinctive quality of depression among suicidal adolescents suggests assessment and treatment strategies for these individuals...
  53. ncbi request reprint Pathological personality traits and suicidal ideation among older adolescents and young adults with alcohol misuse: a pilot case-control study in a primary care setting
    Juan J Carballo
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Int J Adolesc Med Health 19:79-89. 2007
    ..To compare the clinical and demographic characteristics of older adolescents and young adults with and without alcohol misuse in a primary care setting...
  54. ncbi request reprint Parental alcoholism predicts suicidal behavior in adolescents and young adults with cannabis dependence
    Mikkel Arendt
    Centre for Basic Psychiatric Research, Aarhus University Hospital, Risskov, Denmark
    Int J Adolesc Med Health 19:67-77. 2007
    ..Little is known about the association between cannabis abuse/dependence, comorbid alcohol and substance use, depression, suicidal ideation and suicidal behavior...
  55. ncbi request reprint The role of the pediatrician in preventing suicide in adolescents with alcohol use disorders
    Juan J Carballo
    Division of Child Psychiatry, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Int J Adolesc Med Health 19:61-5. 2007
    ....
  56. ncbi request reprint The role of the hypothalamic-pituitary-adrenal axis dysfunction in the pathophysiology of alcohol misuse and suicidal behavior in adolescents
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Adolesc Med Health 19:3-9. 2007
    ..Furthermore, study of biological markers may help us towards an understanding of the neurophysiological substrates of severe dysphoric mood states, alcohol and substance abuse, and suicidal behavior in adolescents...
  57. ncbi request reprint A prospective study of the association of cerebrospinal fluid monoamine metabolite levels with lethality of suicide attempts in patients with bipolar disorder
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    Bipolar Disord 8:543-50. 2006
    ....
  58. ncbi request reprint The relationship of aggression to suicidal behavior in depressed patients with a history of alcoholism
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Addict Behav 30:1144-53. 2005
    ..The reason for higher rate of suicide and suicide attempts in comorbid subjects is uncertain. We explored clinical characteristics that may be associated with this increased suicidality...
  59. ncbi request reprint The concept of post-traumatic mood disorder
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917 Box 42, New York, NY 10032, United States
    Med Hypotheses 65:205-10. 2005
    ....
  60. ncbi request reprint Higher cortisol levels in spring and fall in patients with major depression
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:529-34. 2005
    ..This study sought to determine whether there is a seasonal effect on clinical parameters, baseline cortisol and prolactin levels, and cortisol and prolactin responses to fenfluramine administration in subjects with major depression...
  61. ncbi request reprint Posttraumatic mood disorder: a new concept
    Leo Sher
    Can J Psychiatry 50:127-8. 2005
  62. ncbi request reprint Higher cerebrospinal fluid homovanillic acid levels in depressed patients with comorbid posttraumatic stress disorder
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Eur Neuropsychopharmacol 15:203-9. 2005
    ..Higher dopaminergic activity may contribute to alterations in memory and other cognitive functions, anhedonia, and hypervigilance observed in PTSD...
  63. ncbi request reprint The number of previous depressive episodes is positively associated with cortisol response to fenfluramine administration
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Ann N Y Acad Sci 1032:283-6. 2004
    ..Our finding highlights the importance of possible cumulative effects of repeated episodes of major depression. Prevention and early recognition of depressive episodes may prevent these cumulative adverse effects...
  64. ncbi request reprint Prenatal alcohol exposure, circadian rhythm, and serotonin
    Leo Sher
    Med Hypotheses 63:1081. 2004
  65. ncbi request reprint Age effects on cortisol levels in depressed patients with and without comorbid post-traumatic stress disorder, and healthy volunteers
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    J Affect Disord 82:53-9. 2004
    ..Therefore, we examined the effect of age on the hypothalamic-pituitary-adrenal (HPA) system in depressed patients with and without PTSD...
  66. ncbi request reprint Type D personality, stress, and cortisol
    Leo Sher
    J Psychosom Res 57:117-8. 2004
  67. ncbi request reprint Cortisol and recurrent depressive episodes
    Leo Sher
    Gen Hosp Psychiatry 26:241-2. 2004
  68. ncbi request reprint Daily hassles, cortisol, and the pathogenesis of depression
    Leo Sher
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, PO Box 42, New York, NY 10032, USA
    Med Hypotheses 62:198-202. 2004
    ....
  69. ncbi request reprint Post-traumatic stress disorder: the importance of recognition
    Leo Sher
    Aust N Z J Psychiatry 38:84. 2004
  70. ncbi request reprint Alcoholism and seasonal affective disorder
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Compr Psychiatry 45:51-6. 2004
    ..Both mental health and drug and alcohol professionals should be provided with education to assist with appropriate identification, management, and referral of patients presenting with comorbid alcoholism and SAD...
  71. ncbi request reprint Life events, cortisol, and depression
    Leo Sher
    Psychother Psychosom 72:289-90. 2003
  72. ncbi request reprint Alcohol use and suicide rates
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Med Hypotheses 65:1010-2. 2005
    ..There may be a broad-based social characteristic related to social stress which is associated with high rates of a variety of stress-related behaviors, including heavy alcohol use and suicide...
  73. ncbi request reprint Alcohol and adolescent suicide
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42, New York, NY 10032, USA
    Int J Adolesc Med Health 17:197-203. 2005
    ..Future studies of psychological and neurobiological mechanisms of suicidality in adolescents with alcohol and/or substance abuse are merited...
  74. ncbi request reprint Family-based association study of 5-HT(2A) receptor T102C polymorphism and suicidal behavior in Ashkenazi inpatient adolescents
    Gil Zalsman
    Child and Adolescent Division, Geha Mental Health Center, Petach Tikva, and a Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Adolesc Med Health 17:231-8. 2005
    ..This study used a family-based method and one homogenous ethnic group to overcome ethnic stratification in order to test this association...
  75. ncbi request reprint Alcohol and suicide: neurobiological and clinical aspects
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, USA
    ScientificWorldJournal 6:700-6. 2006
    ..The management of suicidal patients with alcohol use disorders is also discussed. It is to be hoped that the efforts of clinicians will reduce morbidity and mortality associated with alcohol misuse...
  76. pmc CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Eur Neuropsychopharmacol 17:12-5. 2007
    ..We sought to study the relationship of CSF monoamine metabolites to lethality of suicidal acts in depressed subjects with comorbid alcoholism...
  77. ncbi request reprint Are BPI and BPII suicide attempters distinct neuropsychologically?
    Jill M Harkavy-Friedman
    New York State Psychiatric Institute and Columbia University, USA
    J Affect Disord 94:255-9. 2006
    ..Neuropsychological functioning is a means of understanding similarities and differences between diagnostic groups...
  78. ncbi request reprint Prevalence of alcohol misuse among adolescents and young adults evaluated in a primary care setting
    Juan J Carballo
    Puerta de Hierro Hospital, Universidad Autonoma, Madrid, Spain
    Int J Adolesc Med Health 18:197-202. 2006
    ..To determine the prevalence of alcohol misuse among older adolescents and young adults evaluated in a primary care setting using the CAGE questionnaire...
  79. ncbi request reprint Modified dexamethasone suppression-corticotropin-releasing hormone stimulation test: A pilot study of young healthy volunteers and implications for alcoholism research in adolescents and young adults
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Int J Adolesc Med Health 18:133-7. 2006
    ..Therefore, studies of the HPA system in persons at risk for alcoholism may help understand the neurobiological mechanisms of predisposition to alcoholism...
  80. ncbi request reprint The relationship between the frequency of alcohol use and suicide rates in young people
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Int J Adolesc Med Health 18:81-5. 2006
    ..We examined the relationship between the percentage of frequently drinking high school students and suicide rates among 15-24 year olds in 17 countries...
  81. ncbi request reprint Functional magnetic resonance imaging in studies of neurocognitive effects of alcohol use on adolescents and young adults
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Int J Adolesc Med Health 18:3-7. 2006
    ..fMRI may be uniquely powerful in the delineation of the underlying pathophysiology of alcohol use disorders in adolescents and young adults...
  82. ncbi request reprint Serotonin and suicidal behavior in patients with comorbid depression and alcoholism
    Leo Sher
    Am J Addict 15:198. 2006
  83. ncbi request reprint Relation between rates of geriatric suicide and consumption of alcohol beverages in European countries
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY, USA
    ScientificWorldJournal 6:383-7. 2006
    ....
  84. ncbi request reprint Plasma serotonin levels and suicidal behavior in adolescents
    Samuel Tyano
    Child and Adolescent Division, Geha Mental Health Center, Petach Tikva, Israel
    Eur Neuropsychopharmacol 16:49-57. 2006
    ..The biological mechanism behind the serotonin dysregulation in suicidal adolescents requires further investigation...
  85. ncbi request reprint Dopamine and the pathophysiology of suicidal behavior in alcoholism
    Leo Sher
    Med Hypotheses 66:1043-4. 2006
  86. ncbi request reprint Clinical characteristics of inpatient adolescents with severe obsessive-compulsive disorder
    Gal Shoval
    Adolescent Inpatient Unit, Geha Mental Health Center, Petah Tiqva, Israel
    Depress Anxiety 23:62-70. 2006
    ..These characteristics should be taken into account when developing a treatment plan for these difficult-to-treat inpatients...
  87. ncbi request reprint Lower cerebrospinal fluid homovanillic acid levels in depressed suicide attempters
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, Box 42, New York, NY 10032, USA
    J Affect Disord 90:83-9. 2006
    ....
  88. ncbi request reprint Relation between rates of suicide in 15-24-year-olds and per capita consumption of alcohol beverages in European countries
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, 1051 Riverside Drive, Suite 2917, Box 42 New York, NY 10032, USA
    Int J Adolesc Med Health 17:291-4. 2005
    ..Further studies are necessary to clarify the relation between suicide rates in different age groups and consumption of alcohol beverages...
  89. ncbi request reprint Relationships between seasonality and alcohol use: a genetic hypothesis
    Leo Sher
    Med Hypotheses 59:85-8. 2002
    ..SAD may be a subtype of mood disorder that is closely related to alcoholism. More studies are needed to better understand the mechanisms involved in the relationship between seasonality and alcohol use...