Research Topics
| Wei ShenSummaryAffiliation: Columbia University Country: USA Publications
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Publications
A single MRI slice does not accurately predict visceral and subcutaneous adipose tissue changes during weight lossWei Shen
New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, New York, USA
Obesity (Silver Spring) 20:2458-63. 2012..For certain study designs, multislice imaging may be more cost-effective than single slice imaging in detecting changes for VAT and SAT...- MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adultsW Shen
New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, NY 10025, USA
Eur J Clin Nutr 66:983-8. 2012..This cross-sectional study compared the BMAT and BMD relationship between a younger adult group at or approaching peak bone mass (PBM; age 18.0-39.9 years) and an older group with potential bone loss (PoBL; age 40.0-88.0 years)... - Ethnic and sex differences in bone marrow adipose tissue and bone mineral density relationshipW Shen
New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
Osteoporos Int 23:2293-301. 2012..This suggests that the mechanisms that regulate the differentiation and proliferation of bone marrow stromal cells may differ in these populations... - Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA studyWei Shen
New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14H, New York, New York 10025, USA
J Clin Endocrinol Metab 97:1337-46. 2012..It is unknown whether visceral adipose tissue (VAT), sc adipose tissue (SAT), and skeletal muscle had an effect on the relationship between BMAT and BMD... 
Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional imageWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, NY, USA
J Appl Physiol 97:2333-8. 2004..Measurement of a single abdominal image can thus provide estimates of total body SM and AT for group studies of healthy adults...- Pediatric obesity phenotyping by magnetic resonance methodsWei Shen
New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
Curr Opin Clin Nutr Metab Care 8:595-601. 2005..The aim is to provide an investigator-focused overview of magnetic resonance methods for use in the study of pediatric body composition and metabolism... - Waist circumference correlates with metabolic syndrome indicators better than percentage fatWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
Obesity (Silver Spring) 14:727-36. 2006.... - Visceral adipose tissue: relationships between single slice areas at different locations and obesity-related health risksW Shen
Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
Int J Obes (Lond) 31:763-9. 2007..At present, it is unknown whether the area with the highest correlation is also the most strongly associated with obesity-related health risk... - MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian womenW Shen
Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14H, New York, NY 10025, USA
Osteoporos Int 18:641-7. 2007..Previous research using regional magnetic resonance spectroscopy methods to measure BMAT has reported inconsistent findings on the relationship between BMAT and dual-energy absorptiometry (DXA)-measured bone mineral density (BMD)... - Between-slice intervals in quantification of adipose tissue and muscle in childrenWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
Int J Pediatr Obes 6:149-56. 2011..However, a smaller slice interval protocol would be more accurate for comparison of VAT or IMAT among individual children... - Visceral adipose tissue: relations between single-slice areas and total volumeWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital, and the Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, 1090 Amsterdam Avenue, New York, NY 10025, USA
Am J Clin Nutr 80:271-8. 2004..However, the location of the slice with the strongest relation to VAT volume is not established... - Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging studyWei Shen
Obesity Research Center, St, Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY, USA
Nutr Metab (Lond) 6:17. 2009..abstract:.. - Measurement of intramyocellular lipid levels with 2-D magnetic resonance spectroscopic imaging at 1.5 TW Shen
Weight Control Unit, St Luke s Roosevelt Hospital, 1090 Amsterdam Ave, 14th Floor, New York, NY 10025, USA
Acta Diabetol 40:S51-4. 2003..This approach provided the spatial resolution and voxel placement flexibility permitting optimal separation of IMCL and extramyocellular lipid. Our findings demonstrate the potential of the SI approach... - Volume estimates by imaging methods: model comparisons with visible woman as the referenceWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, USA
Obes Res 11:217-25. 2003..To compare the accuracy of four volume estimation models to actual tissue and organ volumes measured in the visible woman... - Adipose tissue quantification by imaging methods: a proposed classificationWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
Obes Res 11:5-16. 2003..This analysis leads us to propose an updated classification of total body and regional adipose tissue, providing a well-defined basis for correlating imaging studies of specific adipose tissue depots with molecular processes... - Body-composition differences between African American and white women: relation to resting energy requirementsAlfredo Jones
Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, Weight Control Unit, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
Am J Clin Nutr 79:780-6. 2004.... - Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosaLaurel E S Mayer
Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York, NY, USA
Am J Clin Nutr 90:1132-7. 2009..Whether these abnormalities persist over time remains unknown... - Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescentsJaehee Kim
Obesity Research Center, St Luke's-Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Am J Clin Nutr 84:1014-20. 2006..A new DXA SM prediction model was developed for prepubertal and pubertal subjects (Tanner stage </=4) aged >/=5 y. DXA thus provides an important opportunity for quantifying total-body SM mass across most of the human life span... - Adiposity is increased among high-functioning, non-ambulatory patients with spinal muscular atrophyDouglas M Sproule
Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
Neuromuscul Disord 20:448-52. 2010.... - Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRIEliza B Geer
Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1055, New York, New York 10029, USA
J Clin Endocrinol Metab 97:1702-11. 2012..Cushing's Disease (CD) alters fat distribution, muscle mass, adipokine profile, and cardiovascular risk factors. It is not known whether remission entirely reverses these changes... - Skeletal muscle mass in acromegaly assessed by magnetic resonance imaging and dual-photon x-ray absorptiometryPamela U Freda
Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
J Clin Endocrinol Metab 94:2880-6. 2009..GH and IGF-I are nitrogen retaining and anabolic, but the impact of long-term exposure to supraphysiological GH and IGF-I, either from endogenous overproduction in acromegaly or exogenous sources, on skeletal muscle (SM) mass is not clear... - Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adultsJaehee Kim
Obesity Research Center, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
J Appl Physiol 97:655-60. 2004..The DXA-based models are accurate for predicting IMAT-free SM in selected populations and thus provide a new opportunity for quantifying SM in physiological and epidemiological investigations... - A cellular-level approach to predicting resting energy expenditure across the adult yearsZiMian Wang
Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, USA
Am J Clin Nutr 81:799-806. 2005..Although the model predicted REE well in young persons, it overpredicted REE by approximately 11% in elderly adults. This overprediction may occur because of a decline in the fraction of organs and tissues as cell mass with aging... - Combination of BMI and Waist Circumference for Identifying Cardiovascular Risk Factors in WhitesShankuan Zhu
New York Obesity Research Center, St Luke s Roosevelt Hospital Center and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
Obes Res 12:633-45. 2004..The present study sought to identify the combination of BMI and WC that has the strongest association with CVD risk factors in whites... 
Thigh muscle volume measured by magnetic resonance imaging is stable over a 6-month interval in spinal muscular atrophyDouglas M Sproule
Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
J Child Neurol 26:1252-9. 2011..Relative constancy of muscle volume estimation and correlation with established functional measures suggest a role for segmental magnetic resonance imaging as a biomarker of treatment effect in future therapeutic trials...- Four-compartment cellular level body composition model: comparison of two approachesWei Shen
Obesity Research Center, St. Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons and Institute of Human Nutrition, Weight Control Unit, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
Obes Res 13:58-65. 2005.... - Dual-energy x-ray absorptiometry-measured lean soft tissue mass: differing relation to body cell mass across the adult life spanMarie-Pierre St-Onge
St. Luke's-Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
J Gerontol A Biol Sci Med Sci 59:796-800. 2004..001) than women; quadratic and cubic age terms were also significant or approached significance. Thus, the fraction of LST as BCM is smaller in older adults, a finding that has implications for the interpretation of DEXA results... - Percentage body fat ranges associated with metabolic syndrome risk: results based on the third National Health and Nutrition Examination Survey (1988-1994)Shankuan Zhu
New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
Am J Clin Nutr 78:228-35. 2003..Increasing attention has focused on the association between body fatness and related metabolic risk factors. The quantitative link between percentage body fat (%BF) and the risk of metabolic syndrome is unknown... - Total body protein: a new cellular level mass and distribution prediction modelZiMian Wang
Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
Am J Clin Nutr 78:979-84. 2003.... - Increased fat mass and high incidence of overweight despite low body mass index in patients with spinal muscular atrophyDouglas M Sproule
Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, Harkness Pavilion, HP 514, 180 Fort Washington Avenue, New York, NY 10032 3791, USA
Neuromuscul Disord 19:391-6. 2009..Children with SMA have reduced lean and increased fat mass compared to healthy children. Obesity is a potentially important modifiable source of morbidity in SMA... - Body composition in premature adrenarche by structural MRI, 1H MRS and DXANatasha Leibel
Department of Pediatrics, New York Presbyterian Hospital, New York, NY 10032, USA
J Pediatr Endocrinol Metab 22:301-7. 2009..Visceral adiposity and increased intramyocellular lipid (IMCL) are associated with insulin resistance and increased risk of cardiovascular disease... - Bioelectrical impedance analysis can be a useful screen for excess adiposity in spinal muscular atrophyDouglas M Sproule
Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York 10032 3791, USA
J Child Neurol 25:1348-54. 2010..Although insufficiently accurate for use as a research tool, bioelectrical impedance can have application as a well-tolerated, noninvasive, easily used screening tool for excess adiposity in patients with spinal muscular atrophy... - Muscle volume estimation by magnetic resonance imaging in spinal muscular atrophyDouglas M Sproule
Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York 10032 3791, USA
J Child Neurol 26:309-17. 2011..14) than type 3. Reproducibility, tolerability, and strong correlation with clinical measures make magnetic resonance imaging a candidate biomarker for clinical research... - MRI assessment of lean and adipose tissue distribution in female patients with Cushing's diseaseEliza B Geer
Department of Medicine, Mount Sinai Medical Center, St Luke s Roosevelt Hospital, Columbia University, New York, NY 10029, USA
Clin Endocrinol (Oxf) 73:469-75. 2010..Whole-body magnetic resonance imaging (MRI) was used to examine lean and AT distribution in female patients with CD to further understand the role of glucocorticoid excess in the development of abnormal AT distribution and obesity... - Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegalyPamela U Freda
Department of Medicine, Columbia University, College of Physicians and Surgeons, 650 West 168th Street, New York, NY 10032, USA
J Clin Endocrinol Metab 93:2334-43. 2008..GH and IGF-I are important regulators of metabolism and body composition. In acromegaly, a state of GH and IGF-I excess, the lipolytic and insulin antagonistic effects of GH may alter adipose tissue (AT) distribution... - Gender differences in insulin resistance, body composition, and energy balanceEliza B Geer
Division of Endocrinology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Gend Med 6:60-75. 2009..Adipose tissue distribution, in particular the presence of elevated visceral and hepatic adiposity, plays a central role in the development of insulin resistance and obesity-related complications... - Reproducibility of single- and multi-voxel 1H MRS measurements of intramyocellular lipid in overweight and lean subjects under conditions of controlled dietary calorie and fat intakeWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, USA
NMR Biomed 21:498-506. 2008.... - Application of imaging and other noninvasive techniques in determining adipose tissue massWei Shen
Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
Methods Mol Biol 456:39-54. 2008..Other modalities, including dual-energy absorptiometry and magnetic resonance spectroscopy, provide whole-body or regional fat measures instead of adipose tissue mass quantification... - Body composition in pediatrics to geriatrics: a lesson for nutritional monitoringSteven B Heymsfield
New York Obesity Research Center, St. Luke's-Roosevelt Hospital, Columbia University, and Institute of Human Nutrition, College of Physicians and Surgeons, New York, N.Y, USA
Nestle Nutr Workshop Ser Clin Perform Programme 7:239-50; discussion 250-5. 2002 - Avoiding pitfalls in anatomic ACL reconstructionAlexis Chiang Colvin
Department of Orthopaedics, Mount Sinai Medical Center, New York, NY 10029, USA
Knee Surg Sports Traumatol Arthrosc 17:956-63. 2009..This article reviews potential mistakes in DB ACL reconstruction and describes our way of avoiding them... - Three-compartment model: critical evaluation based on neutron activation analysisAnaliza M Silva
Exercise and Health Laboratory, Faculty of Human Movement, Technical University of Lisbon, 1495-688 Lisbon, Portugal
Am J Physiol Endocrinol Metab 287:E962-9. 2004..The present study results provide a critical evaluation of potential errors in the classic 3C model and present new formulas for use in selected populations... - Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjectsRebecca Scherzer
University of California, San Francisco, CA 94121, USA
Am J Clin Nutr 88:1088-96. 2008.... - Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjectsRebecca Scherzer
Northern California Institute for Research and Education, San Francisco, CA, USA
Am J Clin Nutr 87:1809-17. 2008..Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects... - Differential behavior of simple and complex cells in visual cortex during a brief IOP elevationXin Chen
Vision Research Laboratory, Center for Brain Science Research, Department of Ophthalmology and Vision Science and State Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University, Shanghai, China
Invest Ophthalmol Vis Sci 46:2611-9. 2005..The results may suggest differential behavior of neurons tin the parvo and magno pathways of the primate... - Tuning the erosion rate of artificial protein hydrogels through control of network topologyWei Shen
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125, USA
Nat Mater 5:153-8. 2006..Thus, the erosion rate can be tuned over several orders of magnitude in artificial protein hydrogels, opening the door to diverse biomedical applications... - [Influence of Cordyceps sinensis on pancreatic islet beta cells in rats with experimental liver fibrogenesis]Xia Zhang
Department of Gestroenterology, The Second Affiliated Clinical College of Chongqing University of Medical Sciences, Chongqing 400010, China
Zhonghua Gan Zang Bing Za Zhi 11:93-4. 2003..64muU/ml 3.95muU/ml, q=66.94, p<0.001; 140.44muU/ml 38.53muU/ml vs 52.94muU/ml 13.12muU/ml, q=12.98, p<0.01). CONCLUSION: Cordyceps sinensis can increase the basal insulin level of the islets in CCl(4)-induced liver fibrosis rats... - [Genetic effect of the marker assisted selection on economic traits of goats]Wei Shen
College of Animal Science and Technology, Northwest Sci Tech University of Agriculture and Forestry, Yangling, Shaanxi 712 100, China
Yi Chuan 26:625-30. 2004..For multi-goal traits, CY0818/A0 type and OPW19/C1 type were superior RAPD markers of body weight and Cashmere yield, CY0818/G1 type was superior one of body weight and Cashmere fineness... - Dynamical influence of Cordyceps sinensis on the activity of hepatic insulinase of experimental liver cirrhosisXia Zhang
Department of Gastroenterology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China
Hepatobiliary Pancreat Dis Int 3:99-101. 2004..The activity of insulin degrading enzyme could reflect the metabolism of insulin. This study was to detect the dynamical effects and mechanisms of CS on the activity of hepatic insulinase in CCl4 induced liver cirrhosis in rats... - NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosisWei Shen
Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Pathol 167:1105-17. 2005..Our findings suggest that the use of cyclooxygenase-2-specific inhibitors to treat skeletal muscle injuries warrants caution because they may interfere with muscle healing... - [Genetic structure and phylogeny status of Chaidamu goat population]Xi-Feng Zhang
Animal Science College, Northwest Sci-Tech University of Agriculture and Foresty Yangling 712100, China
Yi Chuan 27:75-9. 2005..4085 approximately 0.5318. Phylogeny status was investigated through clustering by Ward's method on Chaidamu Goats and other domestic goats. All these indicated that Chaidamu Goats was a domestic goat with less intensively selected breed... - [Preparation of lung targeting azithromycin liposomes and its tissue distribution in mice]Jian Song Wang
Institute of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
Yao Xue Xue Bao 40:274-8. 2005..To prepare lung targeting azithromycin cationic liposomes and to observe its tissue distribution in mice... - [Polymorphism analysis of the goat growth hormone gene in the 5' regulatory sequence]Mei-Yu Li
College of Animal Science and Technology, Laiyang Agricultural University, Lai Yang Shan Dong 265200
Yi Chuan 26:831-5. 2004..The results above-mentioned first confirmed that there were polymorphisms in 5' region of GH gene... - [A clinical analysis of liver disease patients with abnormal glucose metabolism]Xia Zhang
Department of Gastroenterology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China
Zhonghua Gan Zang Bing Za Zhi 14:289-92. 2006..To study the clinical features of liver disease patients with abnormal glucose metabolism... - [Experiment on induction of fibroblasts on 3-D cell-foam structures to express osteoblastic phenotype and its mechanism]Chuan He
Shanghai Institute of Traumatology and Orthopaedics, Shanghai 200025, China
Zhonghua Wai Ke Za Zhi 44:271-4. 2006..TNF-alpha provides the essential condition for BMP2's target effect on fibroblasts, and combined use of TNF-alpha and BMP2 is one of the regulating factors... - Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injuryWei Shen
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Cell Physiol 214:405-12. 2008..Macrophages, TGF-beta1, and the COX-2 pathway products may regulate one another's levels and have profound influence on the whole muscle healing process... - Eyes of a lower vertebrate are susceptible to the visual environmentWei Shen
School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
Invest Ophthalmol Vis Sci 48:4829-37. 2007..This study examined the sensitivity of the tilapia eye to positive and negative lenses. It further investigated the sensitivity of the fish eye to form deprivation by examining the effect of fish weight... - Approximation of total visceral adipose tissue with a single magnetic resonance imageEllen W Demerath
Lifespan Health Research Center, Department of Community Health, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA
Am J Clin Nutr 85:362-8. 2007.... - Prevalence of depressive symptoms in postmenopausal women with low bone mineral density and/or prevalent vertebral fracture: results from the Multiple Outcomes of Raloxifene Evaluation (MORE) studyStuart L Silverman
Cedars Sinai Medical Center, UCLA, Greater Los Angeles Veterans Administration Health System, Los Angeles, California, USA
J Rheumatol 34:140-4. 2007..To examine the prevalence of depressive symptoms in a cross-sectional study of postmenopausal women with osteoporosis with and without prevalent vertebral fracture... - Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonylsDavid R Sell
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 7288, USA
Ann N Y Acad Sci 1126:205-9. 2008..Allysine, in turn, is readily converted by oxidation into 2-aminoadipic acid, which accumulates to high levels in skin (i.e., > 2 nmol/mg collagen)... - Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosisJinhong Zhu
Stem Cell Research Center, Children s Hospital of Pittsburgh, Rangos Research Center, and Department of Bioengineering, University of Pittsburgh, Pennsylvania 15213 2583, USA
J Biol Chem 282:25852-63. 2007..In summary, these findings define a fibrogenic property of myostatin and suggest the existence of co-regulatory relationships between transforming growth factor-beta1, myostatin, and decorin... - Quantitative analysis of brain optical images with 2D C0 complexity measureYang Cao
Center for Brain Science Research, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China
J Neurosci Methods 159:181-6. 2007..This suggests that 2D C0 could be used as a new quantitative measure for analyzing the intrinsic signal optical images... - Inhibited skeletal muscle healing in cyclooxygenase-2 gene-deficient mice: the role of PGE2 and PGF2alphaWei Shen
Growth and Development Laboratory, Children s Hospital of Pittsburgh, 4100 Rangos Research Center, 3460 Fifth Ave, PA 15213 2583, USA
J Appl Physiol 101:1215-21. 2006..It suggests that the decision to use NSAIDs to treat muscle injuries warrants critical evaluation because NSAIDs might impair muscle healing by inhibiting the fusion of myogenic precursor cells... - Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5mg and 10mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trialHartmut Porst
Private Practice of Urology and Andrology, Hamburg, Germany
Eur Urol 50:351-9. 2006..Because the 17.5-h half-life of tadalafil enables therapeutic plasma levels to be sustained with daily administration, tadalafil is a good candidate for once daily dosing therapy... - Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebrum: evidence for posttranscriptional regulationWei Shen
Department of Biological Sciences, University of Delaware, Newark, Del. 19716, USA
Dev Neurosci 25:421-35. 2003..The apparent posttranscriptional regulation of CKB in early postnatal cerebrum contrasts with the transcriptional regulation controlling accumulation of CKB protein in postnatal developing cerebellum... - 2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsisDavid R Sell
Department of Pathology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
Biochem J 404:269-77. 2007..We conclude that 2-aminoadipic acid is a more reliable marker for protein oxidation than its precursor, allysine. Its mechanism of formation in each of these conditions needs to be elucidated...
Research Grants
- Central Obesity and Health Risk: Optimal MRI Measurement & Location in ChildrenWei Shen; Fiscal Year: 2007..Our findings could potentially set standards for the evaluation of total body and regional AT in pediatrics, and improve study power. ..