Wei Shen

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. doi request reprint Comparison of the relationship between bone marrow adipose tissue and volumetric bone mineral density in children and adults
    Wei Shen
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, NY, USA Electronic address
    J Clin Densitom 17:163-9. 2014
  2. pmc Comparison among T1-weighted magnetic resonance imaging, modified dixon method, and magnetic resonance spectroscopy in measuring bone marrow fat
    Wei Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14K, New York, NY 10025, USA
    J Obes 2013:298675. 2013
  3. pmc A single MRI slice does not accurately predict visceral and subcutaneous adipose tissue changes during weight loss
    Wei Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, New York, USA
    Obesity (Silver Spring) 20:2458-63. 2012
  4. pmc MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults
    W Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, NY 10025, USA
    Eur J Clin Nutr 66:983-8. 2012
  5. pmc Ethnic and sex differences in bone marrow adipose tissue and bone mineral density relationship
    W Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Osteoporos Int 23:2293-301. 2012
  6. pmc Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA study
    Wei Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14H, New York, New York 10025, USA
    J Clin Endocrinol Metab 97:1337-46. 2012
  7. pmc Visceral adipose tissue: relationships between single slice areas at different locations and obesity-related health risks
    W Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Int J Obes (Lond) 31:763-9. 2007
  8. pmc Pediatric obesity phenotyping by magnetic resonance methods
    Wei Shen
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    Curr Opin Clin Nutr Metab Care 8:595-601. 2005
  9. ncbi request reprint Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, NY, USA
    J Appl Physiol (1985) 97:2333-8. 2004
  10. pmc Visceral adipose tissue: relations between single-slice areas and total volume
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, and the Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, 1090 Amsterdam Avenue, New York, NY 10025, USA
    Am J Clin Nutr 80:271-8. 2004

Detail Information

Publications67

  1. doi request reprint Comparison of the relationship between bone marrow adipose tissue and volumetric bone mineral density in children and adults
    Wei Shen
    Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, NY, USA Electronic address
    J Clin Densitom 17:163-9. 2014
    ....
  2. pmc Comparison among T1-weighted magnetic resonance imaging, modified dixon method, and magnetic resonance spectroscopy in measuring bone marrow fat
    Wei Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14K, New York, NY 10025, USA
    J Obes 2013:298675. 2013
    ..Our aim is to compare the measurements of bone marrow fat among T1-weighted magnetic resonance imaging (MRI), modified Dixon method (also called fat fraction MRI (FFMRI)), and magnetic resonance spectroscopy (MRS)...
  3. pmc A single MRI slice does not accurately predict visceral and subcutaneous adipose tissue changes during weight loss
    Wei Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, New York, USA
    Obesity (Silver Spring) 20:2458-63. 2012
    ..For certain study designs, multislice imaging may be more cost-effective than single slice imaging in detecting changes for VAT and SAT...
  4. pmc MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults
    W Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, NY 10025, USA
    Eur J Clin Nutr 66:983-8. 2012
    ..This cross-sectional study compared the BMAT and BMD relationship between a younger adult group at or approaching peak bone mass (PBM; age 18.0-39.9 years) and an older group with potential bone loss (PoBL; age 40.0-88.0 years)...
  5. pmc Ethnic and sex differences in bone marrow adipose tissue and bone mineral density relationship
    W Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Osteoporos Int 23:2293-301. 2012
    ..This suggests that the mechanisms that regulate the differentiation and proliferation of bone marrow stromal cells may differ in these populations...
  6. pmc Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA study
    Wei Shen
    New York Obesity Nutrition Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14H, New York, New York 10025, USA
    J Clin Endocrinol Metab 97:1337-46. 2012
    ..It is unknown whether visceral adipose tissue (VAT), sc adipose tissue (SAT), and skeletal muscle had an effect on the relationship between BMAT and BMD...
  7. pmc Visceral adipose tissue: relationships between single slice areas at different locations and obesity-related health risks
    W Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Int J Obes (Lond) 31:763-9. 2007
    ..At present, it is unknown whether the area with the highest correlation is also the most strongly associated with obesity-related health risk...
  8. pmc Pediatric obesity phenotyping by magnetic resonance methods
    Wei Shen
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    Curr Opin Clin Nutr Metab Care 8:595-601. 2005
    ..The aim is to provide an investigator-focused overview of magnetic resonance methods for use in the study of pediatric body composition and metabolism...
  9. ncbi request reprint Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, NY, USA
    J Appl Physiol (1985) 97:2333-8. 2004
    ..Measurement of a single abdominal image can thus provide estimates of total body SM and AT for group studies of healthy adults...
  10. pmc Visceral adipose tissue: relations between single-slice areas and total volume
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, and the Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, 1090 Amsterdam Avenue, New York, NY 10025, USA
    Am J Clin Nutr 80:271-8. 2004
    ..However, the location of the slice with the strongest relation to VAT volume is not established...
  11. pmc Between-slice intervals in quantification of adipose tissue and muscle in children
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
    Int J Pediatr Obes 6:149-56. 2011
    ..However, a smaller slice interval protocol would be more accurate for comparison of VAT or IMAT among individual children...
  12. pmc Waist circumference correlates with metabolic syndrome indicators better than percentage fat
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    Obesity (Silver Spring) 14:727-36. 2006
    ....
  13. pmc Adipose tissue quantification by imaging methods: a proposed classification
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Obes Res 11:5-16. 2003
    ..This analysis leads us to propose an updated classification of total body and regional adipose tissue, providing a well-defined basis for correlating imaging studies of specific adipose tissue depots with molecular processes...
  14. pmc Volume estimates by imaging methods: model comparisons with visible woman as the reference
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, New York, USA
    Obes Res 11:217-25. 2003
    ..To compare the accuracy of four volume estimation models to actual tissue and organ volumes measured in the visible woman...
  15. pmc MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women
    W Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14H, New York, NY 10025, USA
    Osteoporos Int 18:641-7. 2007
    ..Previous research using regional magnetic resonance spectroscopy methods to measure BMAT has reported inconsistent findings on the relationship between BMAT and dual-energy absorptiometry (DXA)-measured bone mineral density (BMD)...
  16. pmc Sexual dimorphism of adipose tissue distribution across the lifespan: a cross-sectional whole-body magnetic resonance imaging study
    Wei Shen
    Obesity Research Center, St, Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Nutr Metab (Lond) 6:17. 2009
    ..abstract:..
  17. pmc Measurement of intramyocellular lipid levels with 2-D magnetic resonance spectroscopic imaging at 1.5 T
    W Shen
    Weight Control Unit, St Luke s Roosevelt Hospital, 1090 Amsterdam Ave, 14th Floor, New York, NY 10025, USA
    Acta Diabetol 40:S51-4. 2003
    ..This approach provided the spatial resolution and voxel placement flexibility permitting optimal separation of IMCL and extramyocellular lipid. Our findings demonstrate the potential of the SI approach...
  18. ncbi request reprint Body-composition differences between African American and white women: relation to resting energy requirements
    Alfredo Jones
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, Weight Control Unit, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
    Am J Clin Nutr 79:780-6. 2004
    ..Body composition differs between African American (AA) and white women, and the resting metabolic rate (RMR) is likely to be lower in AA women than in white women...
  19. pmc Adiposity is increased among high-functioning, non-ambulatory patients with spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
    Neuromuscul Disord 20:448-52. 2010
    ....
  20. pmc Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents
    Jaehee Kim
    Obesity Research Center, St Luke s Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am J Clin Nutr 84:1014-20. 2006
    ..Skeletal muscle (SM) is an important compartment but is difficult to quantify in children and adolescents...
  21. pmc Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa
    Laurel E S Mayer
    Department of Psychiatry, Columbia University Medical Center, and New York State Psychiatric Institute, New York, NY, USA
    Am J Clin Nutr 90:1132-7. 2009
    ..Whether these abnormalities persist over time remains unknown...
  22. pmc Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI
    Eliza B Geer
    Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1055, New York, New York 10029, USA
    J Clin Endocrinol Metab 97:1702-11. 2012
    ..Cushing's Disease (CD) alters fat distribution, muscle mass, adipokine profile, and cardiovascular risk factors. It is not known whether remission entirely reverses these changes...
  23. pmc Skeletal muscle mass in acromegaly assessed by magnetic resonance imaging and dual-photon x-ray absorptiometry
    Pamela U Freda
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Endocrinol Metab 94:2880-6. 2009
    ..GH and IGF-I are nitrogen retaining and anabolic, but the impact of long-term exposure to supraphysiological GH and IGF-I, either from endogenous overproduction in acromegaly or exogenous sources, on skeletal muscle (SM) mass is not clear...
  24. ncbi request reprint A cellular-level approach to predicting resting energy expenditure across the adult years
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Clin Nutr 81:799-806. 2005
    ..Although the model predicted REE well in young persons, it overpredicted REE by approximately 11% in elderly adults. This overprediction may occur because of a decline in the fraction of organs and tissues as cell mass with aging...
  25. ncbi request reprint Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults
    Jaehee Kim
    Obesity Research Center, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    J Appl Physiol 97:655-60. 2004
    ..The DXA-based models are accurate for predicting IMAT-free SM in selected populations and thus provide a new opportunity for quantifying SM in physiological and epidemiological investigations...
  26. ncbi request reprint Combination of BMI and Waist Circumference for Identifying Cardiovascular Risk Factors in Whites
    Shankuan Zhu
    New York Obesity Research Center, St Luke s Roosevelt Hospital Center and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
    Obes Res 12:633-45. 2004
    ..The present study sought to identify the combination of BMI and WC that has the strongest association with CVD risk factors in whites...
  27. doi request reprint Thigh muscle volume measured by magnetic resonance imaging is stable over a 6-month interval in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, NY 10032 3791, USA
    J Child Neurol 26:1252-9. 2011
    ..Relative constancy of muscle volume estimation and correlation with established functional measures suggest a role for segmental magnetic resonance imaging as a biomarker of treatment effect in future therapeutic trials...
  28. ncbi request reprint Dual-energy x-ray absorptiometry-measured lean soft tissue mass: differing relation to body cell mass across the adult life span
    Marie Pierre St-Onge
    St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Gerontol A Biol Sci Med Sci 59:796-800. 2004
    ..001) than women; quadratic and cubic age terms were also significant or approached significance. Thus, the fraction of LST as BCM is smaller in older adults, a finding that has implications for the interpretation of DEXA results...
  29. ncbi request reprint Percentage body fat ranges associated with metabolic syndrome risk: results based on the third National Health and Nutrition Examination Survey (1988-1994)
    Shankuan Zhu
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, USA
    Am J Clin Nutr 78:228-35. 2003
    ..Increasing attention has focused on the association between body fatness and related metabolic risk factors. The quantitative link between percentage body fat (%BF) and the risk of metabolic syndrome is unknown...
  30. pmc Four-compartment cellular level body composition model: comparison of two approaches
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons and Institute of Human Nutrition, Weight Control Unit, 1090 Amsterdam Avenue, 14th Floor, New York, NY 10025, USA
    Obes Res 13:58-65. 2005
    ..The aim of this study was to develop and compare two DXA-based four-compartment [body weight=body cell mass (BCM)+extracellular fluid (ECF)+extracellular solids (ECS)+fat] cellular level models...
  31. pmc Body composition in premature adrenarche by structural MRI, 1H MRS and DXA
    Natasha Leibel
    Department of Pediatrics, New York Presbyterian Hospital, New York, NY 10032, USA
    J Pediatr Endocrinol Metab 22:301-7. 2009
    ..Visceral adiposity and increased intramyocellular lipid (IMCL) are associated with insulin resistance and increased risk of cardiovascular disease...
  32. doi request reprint Bioelectrical impedance analysis can be a useful screen for excess adiposity in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York 10032 3791, USA
    J Child Neurol 25:1348-54. 2010
    ..Although insufficiently accurate for use as a research tool, bioelectrical impedance can have application as a well-tolerated, noninvasive, easily used screening tool for excess adiposity in patients with spinal muscular atrophy...
  33. pmc Increased fat mass and high incidence of overweight despite low body mass index in patients with spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, Harkness Pavilion, HP 514, 180 Fort Washington Avenue, New York, NY 10032 3791, USA
    Neuromuscul Disord 19:391-6. 2009
    ..Children with SMA have reduced lean and increased fat mass compared to healthy children. Obesity is a potentially important modifiable source of morbidity in SMA...
  34. doi request reprint Muscle volume estimation by magnetic resonance imaging in spinal muscular atrophy
    Douglas M Sproule
    Division of Pediatric Neurosciences, Department of Neurology, SMA Clinical Research Center, Columbia University Medical Center, New York, New York 10032 3791, USA
    J Child Neurol 26:309-17. 2011
    ..14) than type 3. Reproducibility, tolerability, and strong correlation with clinical measures make magnetic resonance imaging a candidate biomarker for clinical research...
  35. ncbi request reprint Total body protein: a new cellular level mass and distribution prediction model
    ZiMian Wang
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    Am J Clin Nutr 78:979-84. 2003
    ....
  36. pmc MRI assessment of lean and adipose tissue distribution in female patients with Cushing's disease
    Eliza B Geer
    Department of Medicine, Mount Sinai Medical Center, St Luke s Roosevelt Hospital, Columbia University, New York, NY 10029, USA
    Clin Endocrinol (Oxf) 73:469-75. 2010
    ..Whole-body magnetic resonance imaging (MRI) was used to examine lean and AT distribution in female patients with CD to further understand the role of glucocorticoid excess in the development of abnormal AT distribution and obesity...
  37. pmc Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly
    Pamela U Freda
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 650 West 168th Street, New York, NY 10032, USA
    J Clin Endocrinol Metab 93:2334-43. 2008
    ..GH and IGF-I are important regulators of metabolism and body composition. In acromegaly, a state of GH and IGF-I excess, the lipolytic and insulin antagonistic effects of GH may alter adipose tissue (AT) distribution...
  38. pmc Gender differences in insulin resistance, body composition, and energy balance
    Eliza B Geer
    Division of Endocrinology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gend Med 6:60-75. 2009
    ..Adipose tissue distribution, in particular the presence of elevated visceral and hepatic adiposity, plays a central role in the development of insulin resistance and obesity-related complications...
  39. pmc Reproducibility of single- and multi-voxel 1H MRS measurements of intramyocellular lipid in overweight and lean subjects under conditions of controlled dietary calorie and fat intake
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University, New York, USA
    NMR Biomed 21:498-506. 2008
    ....
  40. doi request reprint Application of imaging and other noninvasive techniques in determining adipose tissue mass
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, USA
    Methods Mol Biol 456:39-54. 2008
    ..Other modalities, including dual-energy absorptiometry and magnetic resonance spectroscopy, provide whole-body or regional fat measures instead of adipose tissue mass quantification...
  41. ncbi request reprint Body composition in pediatrics to geriatrics: a lesson for nutritional monitoring
    Steven B Heymsfield
    New York Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University, and Institute of Human Nutrition, College of Physicians and Surgeons, New York, N Y, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 7:239-50; discussion 250-5. 2002
  42. doi request reprint Avoiding pitfalls in anatomic ACL reconstruction
    Alexis Chiang Colvin
    Department of Orthopaedics, Mount Sinai Medical Center, New York, NY 10029, USA
    Knee Surg Sports Traumatol Arthrosc 17:956-63. 2009
    ..This article reviews potential mistakes in DB ACL reconstruction and describes our way of avoiding them...
  43. pmc Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects
    Rebecca Scherzer
    University of California, San Francisco, CA 94121, USA
    Am J Clin Nutr 88:1088-96. 2008
    ....
  44. pmc Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects
    Rebecca Scherzer
    Northern California Institute for Research and Education, San Francisco, CA, USA
    Am J Clin Nutr 87:1809-17. 2008
    ..Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects...
  45. ncbi request reprint Three-compartment model: critical evaluation based on neutron activation analysis
    Analiza M Silva
    Exercise and Health Laboratory, Faculty of Human Movement, Technical University of Lisbon, 1495 688 Lisbon, Portugal
    Am J Physiol Endocrinol Metab 287:E962-9. 2004
    ..The present study results provide a critical evaluation of potential errors in the classic 3C model and present new formulas for use in selected populations...
  46. ncbi request reprint [Polymorphism analysis of the goat growth hormone gene in the 5' regulatory sequence]
    Mei yu Li
    College of Animal Science and Technology, Laiyang Agricultural University, Lai Yang Shan Dong 265200
    Yi Chuan 26:831-5. 2004
    ..The results above-mentioned first confirmed that there were polymorphisms in 5' region of GH gene...
  47. pmc NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis
    Wei Shen
    Departments of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Pathol 167:1105-17. 2005
    ..Our findings suggest that the use of cyclooxygenase-2-specific inhibitors to treat skeletal muscle injuries warrants caution because they may interfere with muscle healing...
  48. ncbi request reprint Differential behavior of simple and complex cells in visual cortex during a brief IOP elevation
    Xin Chen
    Vision Research Laboratory, Center for Brain Science Research, Department of Ophthalmology and Vision Science and State Key Laboratory of Medical Neurobiology, School of Life Sciences, Fudan University, Shanghai, China
    Invest Ophthalmol Vis Sci 46:2611-9. 2005
    ..To study and compare responses of different types of cortical neurons in the primary visual cortex in cats to grating stimuli before and during brief elevation of intraocular pressure (IOP)...
  49. ncbi request reprint Dynamical influence of Cordyceps sinensis on the activity of hepatic insulinase of experimental liver cirrhosis
    Xia Zhang
    Department of Gastroenterology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China
    Hepatobiliary Pancreat Dis Int 3:99-101. 2004
    ..The activity of insulin degrading enzyme could reflect the metabolism of insulin. This study was to detect the dynamical effects and mechanisms of CS on the activity of hepatic insulinase in CCl4 induced liver cirrhosis in rats...
  50. ncbi request reprint [Influence of Cordyceps sinensis on pancreatic islet beta cells in rats with experimental liver fibrogenesis]
    Xia Zhang
    Department of Gestroenterology, The Second Affiliated Clinical College of Chongqing University of Medical Sciences, Chongqing 400010, China
    Zhonghua Gan Zang Bing Za Zhi 11:93-4. 2003
    ..To investigate the effect of Cordyceps sinensis (CS) on pancreatic islet B cells of experimental hepatic fibrogenesis rats...
  51. ncbi request reprint Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebrum: evidence for posttranscriptional regulation
    Wei Shen
    Department of Biological Sciences, University of Delaware, Newark, Del 19716, USA
    Dev Neurosci 25:421-35. 2003
    ..The apparent posttranscriptional regulation of CKB in early postnatal cerebrum contrasts with the transcriptional regulation controlling accumulation of CKB protein in postnatal developing cerebellum...
  52. ncbi request reprint [Preparation of lung targeting azithromycin liposomes and its tissue distribution in mice]
    Jian Song Wang
    Institute of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
    Yao Xue Xue Bao 40:274-8. 2005
    ..To prepare lung targeting azithromycin cationic liposomes and to observe its tissue distribution in mice...
  53. ncbi request reprint [Genetic structure and phylogeny status of Chaidamu goat population]
    Xi Feng Zhang
    Animal Science College, Northwest Sci Tech University of Agriculture and Foresty Yangling 712100, China
    Yi Chuan 27:75-9. 2005
    ..4085 approximately 0.5318. Phylogeny status was investigated through clustering by Ward's method on Chaidamu Goats and other domestic goats. All these indicated that Chaidamu Goats was a domestic goat with less intensively selected breed...
  54. ncbi request reprint [Genetic effect of the marker assisted selection on economic traits of goats]
    Wei Shen
    College of Animal Science and Technology, Northwest Sci Tech University of Agriculture and Forestry, Yangling, Shaanxi 712 100, China
    Yi Chuan 26:625-30. 2004
    ..For multi-goal traits, CY0818/A0 type and OPW19/C1 type were superior RAPD markers of body weight and Cashmere yield, CY0818/G1 type was superior one of body weight and Cashmere fineness...
  55. ncbi request reprint [A clinical analysis of liver disease patients with abnormal glucose metabolism]
    Xia Zhang
    Department of Gastroenterology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China
    Zhonghua Gan Zang Bing Za Zhi 14:289-92. 2006
    ..To study the clinical features of liver disease patients with abnormal glucose metabolism...
  56. ncbi request reprint [Experiment on induction of fibroblasts on 3-D cell-foam structures to express osteoblastic phenotype and its mechanism]
    Chuan He
    Shanghai Institute of Traumatology and Orthopaedics, Shanghai 200025, China
    Zhonghua Wai Ke Za Zhi 44:271-4. 2006
    ....
  57. ncbi request reprint Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury
    Wei Shen
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Cell Physiol 214:405-12. 2008
    ..Macrophages, TGF-beta1, and the COX-2 pathway products may regulate one another's levels and have profound influence on the whole muscle healing process...
  58. ncbi request reprint Eyes of a lower vertebrate are susceptible to the visual environment
    Wei Shen
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Invest Ophthalmol Vis Sci 48:4829-37. 2007
    ..This study examined the sensitivity of the tilapia eye to positive and negative lenses. It further investigated the sensitivity of the fish eye to form deprivation by examining the effect of fish weight...
  59. ncbi request reprint Tuning the erosion rate of artificial protein hydrogels through control of network topology
    Wei Shen
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125, USA
    Nat Mater 5:153-8. 2006
    ..Thus, the erosion rate can be tuned over several orders of magnitude in artificial protein hydrogels, opening the door to diverse biomedical applications...
  60. pmc 2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis
    David R Sell
    Department of Pathology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
    Biochem J 404:269-77. 2007
    ..We conclude that 2-aminoadipic acid is a more reliable marker for protein oxidation than its precursor, allysine. Its mechanism of formation in each of these conditions needs to be elucidated...
  61. doi request reprint Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls
    David R Sell
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 7288, USA
    Ann N Y Acad Sci 1126:205-9. 2008
    ..Allysine, in turn, is readily converted by oxidation into 2-aminoadipic acid, which accumulates to high levels in skin (i.e., > 2 nmol/mg collagen)...
  62. pmc Approximation of total visceral adipose tissue with a single magnetic resonance image
    Ellen W Demerath
    Lifespan Health Research Center, Department of Community Health, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA
    Am J Clin Nutr 85:362-8. 2007
    ....
  63. ncbi request reprint Prevalence of depressive symptoms in postmenopausal women with low bone mineral density and/or prevalent vertebral fracture: results from the Multiple Outcomes of Raloxifene Evaluation (MORE) study
    Stuart L Silverman
    Cedars Sinai Medical Center, UCLA, Greater Los Angeles Veterans Administration Health System, Los Angeles, California, USA
    J Rheumatol 34:140-4. 2007
    ..To examine the prevalence of depressive symptoms in a cross-sectional study of postmenopausal women with osteoporosis with and without prevalent vertebral fracture...
  64. ncbi request reprint Quantitative analysis of brain optical images with 2D C0 complexity measure
    Yang Cao
    Center for Brain Science Research, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    J Neurosci Methods 159:181-6. 2007
    ..This suggests that 2D C0 could be used as a new quantitative measure for analyzing the intrinsic signal optical images...
  65. ncbi request reprint Inhibited skeletal muscle healing in cyclooxygenase-2 gene-deficient mice: the role of PGE2 and PGF2alpha
    Wei Shen
    Growth and Development Laboratory, Children s Hospital of Pittsburgh, 4100 Rangos Research Center, 3460 Fifth Ave, PA 15213 2583, USA
    J Appl Physiol (1985) 101:1215-21. 2006
    ..It suggests that the decision to use NSAIDs to treat muscle injuries warrants critical evaluation because NSAIDs might impair muscle healing by inhibiting the fusion of myogenic precursor cells...
  66. ncbi request reprint Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5mg and 10mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial
    Hartmut Porst
    Private Practice of Urology and Andrology, Hamburg, Germany
    Eur Urol 50:351-9. 2006
    ..Because the 17.5-h half-life of tadalafil enables therapeutic plasma levels to be sustained with daily administration, tadalafil is a good candidate for once daily dosing therapy...
  67. ncbi request reprint Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis
    Jinhong Zhu
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Rangos Research Center, and Department of Bioengineering, University of Pittsburgh, Pennsylvania 15213 2583, USA
    J Biol Chem 282:25852-63. 2007
    ..In summary, these findings define a fibrogenic property of myostatin and suggest the existence of co-regulatory relationships between transforming growth factor-beta1, myostatin, and decorin...

Research Grants1

  1. Central Obesity and Health Risk: Optimal MRI Measurement & Location in Children
    Wei Shen; Fiscal Year: 2007
    ..Our findings could potentially set standards for the evaluation of total body and regional AT in pediatrics, and improve study power. ..