David Shechter

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi ATM and ATR check in on origins: a dynamic model for origin selection and activation
    David Shechter
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Department of Genetics and Development, Hammer Health Sciences Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell Cycle 4:235-8. 2005
  2. ncbi Regulation of DNA replication by ATR: signaling in response to DNA intermediates
    David Shechter
    Department of Genetics and Development, Hammer Health Sciences Center, Room 1620, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    DNA Repair (Amst) 3:901-8. 2004
  3. ncbi ATR and ATM regulate the timing of DNA replication origin firing
    David Shechter
    Integrated Program in Cellular, Molecular, and Biophysical Studies, and Department of Genetics and Development, Hammer Health Sciences Center, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Nat Cell Biol 6:648-55. 2004
  4. ncbi A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint
    David Shechter
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:749-54. 2009
  5. ncbi An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    Vincenzo Costanzo
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Mol Cell 11:203-13. 2003
  6. ncbi Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts
    Laura A Banaszynski
    The Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA
    Methods 51:3-10. 2010
  7. ncbi Analysis of histones in Xenopus laevis. I. A distinct index of enriched variants and modifications exists in each cell type and is remodeled during developmental transitions
    David Shechter
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 284:1064-74. 2009
  8. ncbi DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process
    David Shechter
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Biol Chem 279:45586-93. 2004
  9. ncbi WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
    Andrew Xiao
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    Nature 457:57-62. 2009
  10. ncbi MCM proteins and checkpoint kinases get together at the fork
    David Shechter
    Department of Genetics and Development, Columbia University, 701 West 168th Street, New York, NY 10032
    Proc Natl Acad Sci U S A 101:10845-6. 2004

Collaborators

Detail Information

Publications11

  1. ncbi ATM and ATR check in on origins: a dynamic model for origin selection and activation
    David Shechter
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Department of Genetics and Development, Hammer Health Sciences Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell Cycle 4:235-8. 2005
    ..Origin selection, activation, and replicon progression are therefore constrained in both space and time via feedback from the cell cycle and ongoing replication...
  2. ncbi Regulation of DNA replication by ATR: signaling in response to DNA intermediates
    David Shechter
    Department of Genetics and Development, Hammer Health Sciences Center, Room 1620, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    DNA Repair (Amst) 3:901-8. 2004
    ..The data reviewed strongly support the hypothesis that ATR is activated in response to persistent RPA-bound single-stranded DNA, a common intermediate of unstressed and damaged DNA replication and metabolism...
  3. ncbi ATR and ATM regulate the timing of DNA replication origin firing
    David Shechter
    Integrated Program in Cellular, Molecular, and Biophysical Studies, and Department of Genetics and Development, Hammer Health Sciences Center, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Nat Cell Biol 6:648-55. 2004
    ....
  4. ncbi A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint
    David Shechter
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:749-54. 2009
    ..We propose that this isoform may be involved in modulating the cellular response to the rapid early cell cycles in externally developing species...
  5. ncbi An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    Vincenzo Costanzo
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Mol Cell 11:203-13. 2003
    ..The checkpoint does not require pre-RC assembly but requires loading of the single-strand binding protein, RPA, on chromatin. This is the biochemical demonstration of a DNA damage checkpoint that targets Cdc7/Dbf4 protein kinase...
  6. ncbi Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts
    Laura A Banaszynski
    The Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA
    Methods 51:3-10. 2010
    ..We expect that these methods will be of use in promoting further understanding of embryonic chromatin in a unique experimental system...
  7. ncbi Analysis of histones in Xenopus laevis. I. A distinct index of enriched variants and modifications exists in each cell type and is remodeled during developmental transitions
    David Shechter
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 284:1064-74. 2009
    ..Overall, our observations suggest that each metazoan cell type may have a unique histone modification signature correlated with its differentiation status...
  8. ncbi DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process
    David Shechter
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Biol Chem 279:45586-93. 2004
    ..These data support the hypothesis that the Mcm protein complex functions as the replicative helicase...
  9. ncbi WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
    Andrew Xiao
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    Nature 457:57-62. 2009
    ..Our work demonstrates a new mechanism that regulates the DNA damage response and expands our knowledge of domains that contain intrinsic tyrosine kinase activity...
  10. ncbi MCM proteins and checkpoint kinases get together at the fork
    David Shechter
    Department of Genetics and Development, Columbia University, 701 West 168th Street, New York, NY 10032
    Proc Natl Acad Sci U S A 101:10845-6. 2004
  11. ncbi Analysis of histones in Xenopus laevis. II. mass spectrometry reveals an index of cell type-specific modifications on H3 and H4
    Joshua J Nicklay
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 284:1075-85. 2009
    ..Our results are consistent with a histone code index for each cell type and uncover potential cross-talk between modifications on a single tail...