ROBERT SCHWABE

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes
    Robert F Schwabe
    Department of Medicine, Biochemistry, and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Gastrointest Liver Physiol 283:G204-11. 2002
  2. ncbi request reprint Toll-like receptor signaling in the liver
    Robert F Schwabe
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Gastroenterology 130:1886-900. 2006
  3. ncbi request reprint Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis
    Tatiana Kisseleva
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Hepatol 45:429-38. 2006
  4. pmc Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    Dianne H Dapito
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Cell 21:504-16. 2012
  5. ncbi request reprint IKKbeta phosphorylates p65 at S468 in transactivaton domain 2
    Robert F Schwabe
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    FASEB J 19:1758-60. 2005
  6. ncbi request reprint Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes
    Robert F Schwabe
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    FASEB J 18:720-2. 2004
  7. ncbi request reprint Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways
    Robert F Schwabe
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 290:G583-9. 2006
  8. pmc Targeting liver cancer: first steps toward a miRacle?
    Robert F Schwabe
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cancer Cell 20:698-9. 2011
  9. doi request reprint Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis
    Johannes Kluwe
    Department of Medicine, Columbia University, College of Physicians and Surgeons, NewYork, New York, USA
    Gut 60:1260-8. 2011
  10. ncbi request reprint Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply
    Zhi Zhong
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, 29425, USA
    Transplantation 82:241-50. 2006

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes
    Robert F Schwabe
    Department of Medicine, Biochemistry, and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Gastrointest Liver Physiol 283:G204-11. 2002
    ..These results indicate that GSK-3 protects hepatocytes from TNF-alpha-induced apoptosis through p65 phosphorylation and upregulation of NF-kappaB transactivation...
  2. ncbi request reprint Toll-like receptor signaling in the liver
    Robert F Schwabe
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Gastroenterology 130:1886-900. 2006
  3. ncbi request reprint Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis
    Tatiana Kisseleva
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Hepatol 45:429-38. 2006
    ..Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to the population of HSCs...
  4. pmc Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    Dianne H Dapito
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Cell 21:504-16. 2012
    ..Gut sterilization restricted to late stages of hepatocarcinogenesis reduced HCC, suggesting that the intestinal microbiota and TLR4 represent therapeutic targets for HCC prevention in advanced liver disease...
  5. ncbi request reprint IKKbeta phosphorylates p65 at S468 in transactivaton domain 2
    Robert F Schwabe
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    FASEB J 19:1758-60. 2005
    ....
  6. ncbi request reprint Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes
    Robert F Schwabe
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    FASEB J 18:720-2. 2004
    ..This study demonstrates that JNK augments TNF-alpha-induced apoptosis in hepatocytes through a signaling pathway that is distinct from the pathway by which it regulates proliferation...
  7. ncbi request reprint Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways
    Robert F Schwabe
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 290:G583-9. 2006
    ..In light of recent findings, pharmacological inhibitors of JNK and IKK and antioxidants may be promising new tools for the treatment of hepatitis, ischemia-reperfusion injury, and hepatocellular carcinoma...
  8. pmc Targeting liver cancer: first steps toward a miRacle?
    Robert F Schwabe
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cancer Cell 20:698-9. 2011
    ..These results establish microRNAs as novel players in early stages of hepatocarcinogenesis and as potential targets for the treatment of hepatocellular carcinoma...
  9. doi request reprint Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis
    Johannes Kluwe
    Department of Medicine, Columbia University, College of Physicians and Surgeons, NewYork, New York, USA
    Gut 60:1260-8. 2011
    ..The loss of lipid droplets and retinoids is a hallmark of HSC activation, but it remains unclear whether this loss promotes HSC activation, liver fibrogenesis or carcinogenesis...
  10. ncbi request reprint Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply
    Zhi Zhong
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, 29425, USA
    Transplantation 82:241-50. 2006
    ..Small-for-size liver grafts have decreased survival compared to full-size grafts. This study investigated mechanisms of suppression of liver regeneration in small-for-size grafts...
  11. ncbi request reprint Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation
    Yosuke Osawa
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Liver Int 26:1138-47. 2006
    ..However, it remains unclear if these factors act locally at the site of injury or also affect HSCs distant to the site of injury...
  12. ncbi request reprint Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aachen, Germany
    Dig Dis Sci 52:3404-15. 2007
    ..Elevated systemic and hepatic levels of BMP7 in patients with chronic liver disease may contribute to progression of liver fibrogenesis in vivo...
  13. ncbi request reprint Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis
    Soren V Siegmund
    Department of Medicine II, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Am J Physiol Gastrointest Liver Physiol 294:G357-62. 2008
    ..Here we will summarize current findings on the role of the hepatic endocannabinoid system in liver fibrosis and discuss emerging options for its therapeutic exploitation...
  14. ncbi request reprint The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
    Soren V Siegmund
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    FASEB J 21:2798-806. 2007
    ..These findings suggest that 2-AG may act as an antifibrogenic mediator in the liver by inducing cell death in activated HSCs but not hepatocytes...
  15. ncbi request reprint Gene expression profiles during hepatic stellate cell activation in culture and in vivo
    Samuele De Minicis
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Gastroenterology 132:1937-46. 2007
    ..In this study, we determine gene expression changes in 3 different models of HSC activation and investigate whether HSC culture activation reproduces gene expression changes of HSC in vivo activation...
  16. ncbi request reprint Nuclear factor-kappaB in the liver: friend or foe?
    Robert F Schwabe
    Gastroenterology 132:2601-4. 2007
  17. ncbi request reprint TLR4 enhances TGF-beta signaling and hepatic fibrosis
    Ekihiro Seki
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Med 13:1324-32. 2007
    ..Accordingly, Myd88-deficient mice have decreased hepatic fibrosis. Thus, modulation of TGF-beta signaling by a TLR4-MyD88-NF-kappaB axis provides a novel link between proinflammatory and profibrogenic signals...
  18. ncbi request reprint Fatty acid amide hydrolase determines anandamide-induced cell death in the liver
    Soren V Siegmund
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Biol Chem 281:10431-8. 2006
    ..In conclusion, FAAH and GSH are determinants of AEA-mediated cell death in the liver...
  19. ncbi request reprint TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells
    Young Soo Kim
    Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Hepatology 36:1498-508. 2002
    ..Inhibition of NF-kappaB unmasks a TRAIL-induced apoptotic signaling cascade that involves FADD, caspase 8, the MPT, and caspase 3...
  20. ncbi request reprint c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration
    Robert F Schwabe
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hepatology 37:824-32. 2003
    ..In conclusion, our data show that JNK drives G0 to G1 transition in hepatocytes and that cyclin D1 is a downstream target of the JNK pathway during liver regeneration...
  21. ncbi request reprint Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    Yong Han Paik
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Hepatology 37:1043-55. 2003
    ..In conclusion, human activated HSCs utilize components of TLR4 signal transduction cascade to stimulate NF-kappaB and JNK and up-regulate chemokines and adhesion molecules. Thus, HSCs are a potential mediator of LPS-induced liver injury...
  22. ncbi request reprint Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration
    Robert F Schwabe
    Columbia University College of Physicians and Surgeons, 630 West 168th St, PH8East, Rm 105J, New York, NY 10032 3784, USA
    Am J Physiol Gastrointest Liver Physiol 285:G949-58. 2003
    ..In conclusion, RANTES and CCR5 represent potential mediators of 1) HSC migration and proliferation and 2) a cross-talk between HSCs and leukocytes during fibrogenesis...
  23. ncbi request reprint Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat
    Thorsten G Lehmann
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7038, USA
    Transplantation 76:28-37. 2003
    ..The purpose of this study was to identify the isoform with the highest effectiveness against ischemia/reperfusion injury after transplantation of fatty livers, which are particularly susceptible...
  24. pmc NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis
    Ramon Bataller
    Department of Medicine, Columbia University College of Physicians and Surgeons, 622 West 168th Street, New York, New York 10032, USA
    J Clin Invest 112:1383-94. 2003
    ..Moreover, expression of smooth muscle alpha-actin and expression of TGF-beta1 were reduced in p47phox-/- mice. Thus, NADPH oxidase mediates the actions of Ang II on HSCs and plays a critical role in liver fibrogenesis...
  25. ncbi request reprint Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis
    Yankun Li
    Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    J Biol Chem 280:21763-72. 2005
    ..Moreover, this model may help explain the relationship between FC accumulation and inflammation in vulnerable plaques...
  26. ncbi request reprint Anandamide induces necrosis in primary hepatic stellate cells
    Soren V Siegmund
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Hepatology 41:1085-95. 2005
    ..The anti-proliferative effects and the selective killing of HSCs, but not hepatocytes, indicate that AEA may be used as a potential anti-fibrogenic tool...
  27. ncbi request reprint Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha
    Yosuke Osawa
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 280:27879-87. 2005
    ..NCDase prevented apoptosis both by reducing C16-ceramide and by activation of AKT through S1P formation. Therefore, the cross-talk between sphingolipids and AKT pathway may determine hepatocyte apoptosis by TNF-alpha...
  28. ncbi request reprint NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cells
    Maria Pia Russo
    Department of Medicine, Division of Gastroenterology and Hepatology, CB 7032, Medical Biomolecular Research Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Cell Signal 16:741-50. 2004
    ..These data show that altered NF-kappaB signaling is associated with impaired stimulation of an upstream IKK activator...
  29. ncbi request reprint Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation
    Dirk Haller
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:23851-60. 2003
    ..We concluded that the TGF-beta1/Smad signaling pathway helps maintain normal intestinal homeostasis to commensal luminal enteric bacteria by regulating NF-kappaB signaling in IEC through altered histone acetylation...
  30. pmc Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis
    Brendan N Reid
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 283:13087-99. 2008
    ....
  31. ncbi request reprint Cell death in the liver-all roads lead to JNK
    Robert F Schwabe
    Gastroenterology 131:314-6. 2006
  32. ncbi request reprint Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat
    Thorsten G Lehmann
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Liver Transpl 12:550-9. 2006
    ..In conclusion, overexpression of SOD1 in RSL prevents primary non-function of reduced-size liver grafts and accelerates liver regeneration...

Research Grants8

  1. Toll-Like Receptor Signaling in Hepatic Fibrogenesis
    Robert F Schwabe; Fiscal Year: 2010
    ....
  2. Role of the Gut Microbiota and TLR4 in Alcoholic Hepatocarcinogenesis
    Robert F Schwabe; Fiscal Year: 2010
    ..abstract_text> ..
  3. The Endocannabinoid System in hepatic Injury and Fibrosis
    ROBERT SCHWABE; Fiscal Year: 2007
    ....
  4. The Endocannabinoid System in hepatic Injury and Fibrosis
    Robert F Schwabe; Fiscal Year: 2010
    ....