Research Topics
Genomes and Genes | ROBERT SCHWABESummaryAffiliation: Columbia University Country: USA Publications
Research Grants
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Publications
Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytesRobert F Schwabe
Department of Medicine, Biochemistry, and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Am J Physiol Gastrointest Liver Physiol 283:G204-11. 2002..These results indicate that GSK-3 protects hepatocytes from TNF-alpha-induced apoptosis through p65 phosphorylation and upregulation of NF-kappaB transactivation...- Toll-like receptor signaling in the liverRobert F Schwabe
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Gastroenterology 130:1886-900. 2006 - Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosisTatiana Kisseleva
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Hepatol 45:429-38. 2006..Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to the population of HSCs... 
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4Dianne H Dapito
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Cancer Cell 21:504-16. 2012..Gut sterilization restricted to late stages of hepatocarcinogenesis reduced HCC, suggesting that the intestinal microbiota and TLR4 represent therapeutic targets for HCC prevention in advanced liver disease...- IKKbeta phosphorylates p65 at S468 in transactivaton domain 2Robert F Schwabe
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
FASEB J 19:1758-60. 2005.... - Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytesRobert F Schwabe
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
FASEB J 18:720-2. 2004..This study demonstrates that JNK augments TNF-alpha-induced apoptosis in hepatocytes through a signaling pathway that is distinct from the pathway by which it regulates proliferation... - Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathwaysRobert F Schwabe
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Am J Physiol Gastrointest Liver Physiol 290:G583-9. 2006..In light of recent findings, pharmacological inhibitors of JNK and IKK and antioxidants may be promising new tools for the treatment of hepatitis, ischemia-reperfusion injury, and hepatocellular carcinoma... - Targeting liver cancer: first steps toward a miRacle?Robert F Schwabe
Department of Medicine, Columbia University, New York, NY 10032, USA
Cancer Cell 20:698-9. 2011..These results establish microRNAs as novel players in early stages of hepatocarcinogenesis and as potential targets for the treatment of hepatocellular carcinoma... 
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesisJohannes Kluwe
Department of Medicine, Columbia University, College of Physicians and Surgeons, NewYork, New York, USA
Gut 60:1260-8. 2011..The loss of lipid droplets and retinoids is a hallmark of HSC activation, but it remains unclear whether this loss promotes HSC activation, liver fibrogenesis or carcinogenesis...- Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supplyZhi Zhong
Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, 29425, USA
Transplantation 82:241-50. 2006..Defective liver regeneration in small grafts is associated with an inhibition of the c-Jun N-terminal kinase/c-Jun and CyD1 pathways and compromised energy production... - Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligationYosuke Osawa
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Liver Int 26:1138-47. 2006..CONCLUSION: Systemic profibrogenic mediators from the injury site affect the residual non-injured liver... - Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cellsFrank Tacke
Medical Clinic III, University Hospital Aachen, Aachen, Germany
Dig Dis Sci 52:3404-15. 2007..Elevated systemic and hepatic levels of BMP7 in patients with chronic liver disease may contribute to progression of liver fibrogenesis in vivo... - Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosisSoren V Siegmund
Department of Medicine II, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
Am J Physiol Gastrointest Liver Physiol 294:G357-62. 2008..Here we will summarize current findings on the role of the hepatic endocannabinoid system in liver fibrosis and discuss emerging options for its therapeutic exploitation... - The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen speciesSoren V Siegmund
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
FASEB J 21:2798-806. 2007..These findings suggest that 2-AG may act as an antifibrogenic mediator in the liver by inducing cell death in activated HSCs but not hepatocytes... - Gene expression profiles during hepatic stellate cell activation in culture and in vivoSamuele De Minicis
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Gastroenterology 132:1937-46. 2007..In this study, we determine gene expression changes in 3 different models of HSC activation and investigate whether HSC culture activation reproduces gene expression changes of HSC in vivo activation... - Nuclear factor-kappaB in the liver: friend or foe?Robert F Schwabe
Gastroenterology 132:2601-4. 2007 - TLR4 enhances TGF-beta signaling and hepatic fibrosisEkihiro Seki
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Nat Med 13:1324-32. 2007..Accordingly, Myd88-deficient mice have decreased hepatic fibrosis. Thus, modulation of TGF-beta signaling by a TLR4-MyD88-NF-kappaB axis provides a novel link between proinflammatory and profibrogenic signals... - Fatty acid amide hydrolase determines anandamide-induced cell death in the liverSoren V Siegmund
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
J Biol Chem 281:10431-8. 2006..In conclusion, FAAH and GSH are determinants of AEA-mediated cell death in the liver... - TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cellsYoung Soo Kim
Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
Hepatology 36:1498-508. 2002..Inhibition of NF-kappaB unmasks a TRAIL-induced apoptotic signaling cascade that involves FADD, caspase 8, the MPT, and caspase 3... - c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regenerationRobert F Schwabe
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Hepatology 37:824-32. 2003..In conclusion, our data show that JNK drives G0 to G1 transition in hepatocytes and that cyclin D1 is a downstream target of the JNK pathway during liver regeneration... - Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cellsYong Han Paik
Department of Medicine, University of North Carolina at Chapel Hill, USA
Hepatology 37:1043-55. 2003..In conclusion, human activated HSCs utilize components of TLR4 signal transduction cascade to stimulate NF-kappaB and JNK and up-regulate chemokines and adhesion molecules. Thus, HSCs are a potential mediator of LPS-induced liver injury... - Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migrationRobert F Schwabe
Columbia University College of Physicians and Surgeons, 630 West 168th St, PH8East, Rm 105J, New York, NY 10032 3784, USA
Am J Physiol Gastrointest Liver Physiol 285:G949-58. 2003..In conclusion, RANTES and CCR5 represent potential mediators of 1) HSC migration and proliferation and 2) a cross-talk between HSCs and leukocytes during fibrogenesis... - Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the ratThorsten G Lehmann
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7038, USA
Transplantation 76:28-37. 2003.... - NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosisRamon Bataller
Department of Medicine, Columbia University College of Physicians and Surgeons, 622 West 168th Street, New York, New York 10032, USA
J Clin Invest 112:1383-94. 2003..Moreover, expression of smooth muscle alpha-actin and expression of TGF-beta1 were reduced in p47phox-/- mice. Thus, NADPH oxidase mediates the actions of Ang II on HSCs and plays a critical role in liver fibrogenesis... - Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosisYankun Li
Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
J Biol Chem 280:21763-72. 2005..Moreover, this model may help explain the relationship between FC accumulation and inflammation in vulnerable plaques... - Anandamide induces necrosis in primary hepatic stellate cellsSoren V Siegmund
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Hepatology 41:1085-95. 2005..The anti-proliferative effects and the selective killing of HSCs, but not hepatocytes, indicate that AEA may be used as a potential anti-fibrogenic tool... - Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alphaYosuke Osawa
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 280:27879-87. 2005..NCDase prevented apoptosis both by reducing C16-ceramide and by activation of AKT through S1P formation. Therefore, the cross-talk between sphingolipids and AKT pathway may determine hepatocyte apoptosis by TNF-alpha... - NF-kappaB-inducing kinase restores defective IkappaB kinase activity and NF-kappaB signaling in intestinal epithelial cellsMaria Pia Russo
Department of Medicine, Division of Gastroenterology and Hepatology, CB 7032, Medical Biomolecular Research Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
Cell Signal 16:741-50. 2004..These data show that altered NF-kappaB signaling is associated with impaired stimulation of an upstream IKK activator... - Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylationDirk Haller
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 278:23851-60. 2003..We concluded that the TGF-beta1/Smad signaling pathway helps maintain normal intestinal homeostasis to commensal luminal enteric bacteria by regulating NF-kappaB signaling in IEC through altered histone acetylation... - Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosisBrendan N Reid
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 283:13087-99. 2008.... - Cell death in the liver-all roads lead to JNKRobert F Schwabe
Gastroenterology 131:314-6. 2006 - Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the ratThorsten G Lehmann
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Liver Transpl 12:550-9. 2006..In conclusion, overexpression of SOD1 in RSL prevents primary non-function of reduced-size liver grafts and accelerates liver regeneration...
Research Grants
- Toll-Like Receptor Signaling in Hepatic FibrogenesisRobert F Schwabe; Fiscal Year: 2010....
- Role of the Gut Microbiota and TLR4 in Alcoholic HepatocarcinogenesisRobert F Schwabe; Fiscal Year: 2010..abstract_text> ..
- The Endocannabinoid System in hepatic Injury and FibrosisROBERT SCHWABE; Fiscal Year: 2007....
- The Endocannabinoid System in hepatic Injury and FibrosisRobert F Schwabe; Fiscal Year: 2010....