N Schupf

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Apolipoprotein E and familial longevity
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurobiol Aging 34:1287-91. 2013
  2. pmc Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Med Genet 7:24. 2006
  3. ncbi request reprint Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome
    N Schupf
    Department of Psychology and Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurosci Lett 301:199-203. 2001
  4. pmc Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, G H Sergievsky Center, New York, NY, USA
    Dement Geriatr Cogn Disord 25:476-82. 2008
  5. pmc Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, PO Box 16, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:1007-13. 2007
  6. pmc Change in plasma Aß peptides and onset of dementia in adults with Down syndrome
    N Schupf
    Taub Institute for Research on AD and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Neurology 75:1639-44. 2010
  7. ncbi request reprint Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurosci Lett 406:298-302. 2006
  8. ncbi request reprint Onset of dementia is associated with age at menopause in women with Down's syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Ann Neurol 54:433-8. 2003
  9. ncbi request reprint Genetic and host factors for dementia in Down's syndrome
    Nicole Schupf
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Br J Psychiatry 180:405-10. 2002
  10. pmc Risk of epilepsy in offspring of affected women: association with maternal spontaneous abortion
    N Schupf
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Neurology 57:1642-9. 2001

Research Grants

Detail Information

Publications74

  1. pmc Apolipoprotein E and familial longevity
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurobiol Aging 34:1287-91. 2013
    ..Our findings support the hypothesis that both reduction in the frequency of the ε4 allele and increase in the frequency of the ε2 allele contribute to longevity...
  2. pmc Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Med Genet 7:24. 2006
    ..Down syndrome (DS) is caused by trisomy 21 (+21), but the aberrations in gene expression resulting from this chromosomal aneuploidy are not yet completely understood...
  3. ncbi request reprint Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome
    N Schupf
    Department of Psychology and Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurosci Lett 301:199-203. 2001
    ....
  4. pmc Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, G H Sergievsky Center, New York, NY, USA
    Dement Geriatr Cogn Disord 25:476-82. 2008
    ..Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD...
  5. pmc Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, PO Box 16, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:1007-13. 2007
    ..Individuals with Down syndrome have increased levels of beta-amyloid peptides and an increased risk for AD...
  6. pmc Change in plasma Aß peptides and onset of dementia in adults with Down syndrome
    N Schupf
    Taub Institute for Research on AD and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Neurology 75:1639-44. 2010
    ..To examine changes in levels of plasma amyloid-β (Aβ) peptides, Aβ42 and Aβ40, in relation to onset of Alzheimer disease (AD) in adults with Down syndrome (DS)...
  7. ncbi request reprint Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurosci Lett 406:298-302. 2006
    ..Our findings support the hypothesis that reductions in estrogen following menopause can contribute to the cascade of pathological processes leading to AD...
  8. ncbi request reprint Onset of dementia is associated with age at menopause in women with Down's syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Ann Neurol 54:433-8. 2003
    ..Our findings support the hypothesis that reductions in estrogens after menopause contribute to the cascade of pathological processes leading to AD...
  9. ncbi request reprint Genetic and host factors for dementia in Down's syndrome
    Nicole Schupf
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Br J Psychiatry 180:405-10. 2002
    ..The high risk for dementia in adults with Down's syndrome has been attributed to triplication and overexpression of the gene for amyloid precursor protein (APP). But the wide variation in age at onset must be due to other risk factors...
  10. pmc Risk of epilepsy in offspring of affected women: association with maternal spontaneous abortion
    N Schupf
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Neurology 57:1642-9. 2001
    ....
  11. ncbi request reprint Specificity of the fivefold increase in AD in mothers of adults with Down syndrome
    N Schupf
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Neurology 57:979-84. 2001
    ....
  12. pmc Body mass index, dementia, and mortality in the elderly
    J A Luchsinger
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    J Nutr Health Aging 12:127-31. 2008
    ..To explore the association between body mass index and mortality in the elderly taking the diagnosis of dementia into account...
  13. pmc Type 2 diabetes and late-onset Alzheimer's disease
    D Cheng
    Department of Epidemiology, Joseph P Mailman School of Public Health, Columbia University, 630 West 168th St, New York, NY 10032, USA
    Dement Geriatr Cogn Disord 31:424-30. 2011
    ..To confirm in a cohort recruited in 1999-2001 our finding in a cohort recruited in 1992-1994 relating type 2 diabetes (T2D) to late-onset Alzheimer's disease (LOAD)...
  14. ncbi request reprint Decline in cognitive and functional skills increases mortality risk in nondemented elderly
    N Schupf
    G H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, USA
    Neurology 65:1218-26. 2005
    ..To investigate the relation between rate of decline in cognitive and functional/physical abilities and risk of death in nondemented elderly...
  15. ncbi request reprint Preservation of cognitive and functional ability as markers of longevity
    Nicole Schupf
    G H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease, Department of Epidemiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurobiol Aging 25:1231-40. 2004
    ..The results of the present study identify phenotypes associated with preserved cognitive and functional abilities which may serve as markers for longevity...
  16. pmc Relation of plasma lipids to all-cause mortality in Caucasian, African-American and Hispanic elders
    Jennifer L Akerblom
    Department of Epidemiology, Columbia University, New York, USA
    Age Ageing 37:207-13. 2008
    ..to investigate the relation of plasma lipids to all-cause mortality in a multi-ethnic cohort of non-demented elderly...
  17. ncbi request reprint Effect of menopause on cognitive performance in women with Down syndrome
    B N Patel
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neuroreport 12:2659-62. 2001
    ..Our results support the hypothesis that cognitive declines in postmenopausal women are associated with estrogen deficiency rather than with age...
  18. ncbi request reprint Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community
    Jennifer J Manly
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 62:1739-46. 2005
    ....
  19. ncbi request reprint Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk
    R Mayeux
    Taub Alzheimer s Disease Research Center, School of Public Health, Columbia University, New York, NY 10032, USA
    Neurology 61:1185-90. 2003
    ..Plasma A[beta]42 levels were also used to link microsatellite genetic markers to a putative AD genetic locus on chromosome 10 and were observed in patients with incipient sporadic AD...
  20. ncbi request reprint Mortality and apolipoprotein E in Hispanic, African-American, and Caucasian elders
    J H Lee
    G H Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Am J Med Genet 103:121-7. 2001
    ..To better understand the observed ethnic differences in mortality risk by genotype, a detailed prospective study is needed to examine the relationships among APOE, other candidate genes, health conditions, and eventual death...
  21. doi request reprint Aromatase variants modify risk for Alzheimer's disease in a multiethnic female cohort
    S C Janicki
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, New York, N Y, USA
    Dement Geriatr Cogn Disord 35:340-6. 2013
    ..We investigated the influence of CYP19 polymorphisms on risk for AD in a multiethnic cohort of women, with individual ethnicity assessed by genetic population ancestry informative markers (AIMs) as well as by self-identified ethnicity...
  22. ncbi request reprint Association between mild parkinsonian signs and mild cognitive impairment in a community
    E D Louis
    The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease, New York, NY, USA
    Neurology 64:1157-61. 2005
    ..Mild parkinsonian signs (MPS) are associated with prevalent and incident dementia but it is not known whether they are associated with mild cognitive impairment (MCI)...
  23. pmc Frequency and course of mild cognitive impairment in a multiethnic community
    Jennifer J Manly
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY, USA
    Ann Neurol 63:494-506. 2008
    ....
  24. doi request reprint Association of C-reactive protein with cognitive impairment
    James M Noble
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Arch Neurol 67:87-92. 2010
    ..High-sensitivity C-reactive protein (hsCRP) is a biomarker of cardiovascular risk that is suggested to be a biomarker for cognitive impairment...
  25. pmc Memory after silent stroke: hippocampus and infarcts both matter
    S Blum
    Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA
    Neurology 78:38-46. 2012
    ..However, the contribution of vascular lesions, such as brain infarcts, to hippocampal integrity and age-associated memory decline remains unclear...
  26. pmc Subclinical cerebrovascular disease in mild cognitive impairment
    J A Luchsinger
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Neurology 73:450-6. 2009
    ..Cerebrovascular disease (CVD) may contribute to mild cognitive impairment (MCI). We sought to determine the relation of white matter hyperintensity (WMH) volume and infarcts in brain MRI to MCI in a community-based sample...
  27. pmc The heritability of abstract reasoning in Caribbean Latinos with familial Alzheimer disease
    Beverly Johnson
    Taub Institute on Alzheimer s Disease and the Aging Brain, New York, NY, USA
    Dement Geriatr Cogn Disord 24:411-7. 2007
    ..To better understand the genetic influence on component phenotypes of AD, we estimated the heritability (h(2)) of abstract reasoning and examined its relation with apolipoprotein epsilon 4 (APOE-epsilon 4)...
  28. pmc The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort
    Joseph H Lee
    Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 64:501-6. 2007
    ..To investigate the association between Alzheimer disease (AD) and variant alleles in SORL1 using a series of single nucleotide polymorphisms (SNPs) in an urban, multiethnic, community-based population...
  29. pmc Nutrient intake and plasma β-amyloid
    Y Gu
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Neurology 78:1832-40. 2012
    ..However, little is known about the possible associations of dietary factors with plasma Aβ40 or Aβ42. The aim of the current study was to evaluate the association between nutrient intake and plasma Aβ levels...
  30. pmc Metabolic syndrome and dementia risk in a multiethnic elderly cohort
    Majon Muller
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Dement Geriatr Cogn Disord 24:185-92. 2007
    ..The metabolic syndrome (MeSy) may be related to Alzheimer's disease (AD). Our aims were to investigate the association of the MeSy with incident dementia in a multiethnic elderly cohort in the United States...
  31. pmc Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome
    Joseph H Lee
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neurosci Lett 425:105-9. 2007
    ..Thus, further studies are needed to identify functional variants that influence risk for AD in this uniquely vulnerable population...
  32. ncbi request reprint Dementia of the Alzheimer's type and accelerated aging in Down syndrome
    D A Devenny
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    Sci Aging Knowledge Environ 2005:dn1. 2005
    ..This case shows the difficulty in diagnosing dementia in an individual with mental retardation who suffered comorbid episodes of depression and psychosis...
  33. pmc Survival in Alzheimer disease: a multiethnic, population-based study of incident cases
    E P Helzner
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Neurology 71:1489-95. 2008
    ..To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study...
  34. pmc Plasma Aβ and PET PiB binding are inversely related in mild cognitive impairment
    D P Devanand
    Divisions of Geriatric Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Neurology 77:125-31. 2011
    ..To evaluate the relations between PET Pittsburgh compound B (PiB-PET) binding (amyloid imaging) and plasma Aβ in patients with mild cognitive impairment (MCI) and similarly aged controls...
  35. ncbi request reprint Relationship between plasma lipids and all-cause mortality in nondemented elderly
    Nicole Schupf
    G H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Am Geriatr Soc 53:219-26. 2005
    ..To investigate the relationship between plasma lipids and risk of death from all causes in nondemented elderly...
  36. pmc Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road Staten Island, NY 10314, United States
    Neurosci Lett 440:340-3. 2008
    ....
  37. ncbi request reprint Obesity enhances verbal memory in postmenopausal women with Down syndrome
    Bindu N Patel
    Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 25:159-66. 2004
    ..Our results support the hypothesis that higher endogenous estrogen levels after menopause are associated with better performance on verbal memory...
  38. ncbi request reprint Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics
    Lucia Olarte
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 63:1586-90. 2006
    ..The primary effect of the apolipoprotein E epsilon4 (APOE epsilon4) allele is on the age at onset of Alzheimer disease (AD)...
  39. pmc Shorter telomeres may indicate dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 31:765-71. 2010
    ..Our findings suggest that it may be feasible to use telomere shortening as a biomarker for accurately inferring dementia status...
  40. ncbi request reprint Incidence and temporal patterns of adaptive behavior change in adults with mental retardation
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Am J Ment Retard 107:161-74. 2002
    ....
  41. pmc Plasma lipid levels in the elderly are not associated with the risk of mild cognitive impairment
    Christiane Reitz
    Gertrude H Sergievsky Center, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, N Y, USA
    Dement Geriatr Cogn Disord 25:232-7. 2008
    ..Baseline data were collected from 1992 to 1994, follow-up data were collected at 18-month intervals...
  42. ncbi request reprint Incidence and prevalence of dementia in elderly adults with mental retardation without down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Am J Ment Retard 109:126-41. 2004
    ....
  43. pmc Essential tremor is associated with dementia: prospective population-based study in New York
    Sujata P Thawani
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Neurology 73:621-5. 2009
    ..Furthermore, an association between ET and dementia has been reported in a single population-based study in Spain. This has not been confirmed elsewhere...
  44. pmc Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 25:172-8. 2010
    ..Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia...
  45. pmc Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Arch Neurol 67:564-9. 2010
    ..Elevated blood pressure (BP) and fluctuation in BP may lead to cerebrovascular disease through ischemic changes and compromised cerebral autoregulation...
  46. pmc Hormonal influences on cognition and risk for Alzheimer's disease
    Sarah C Janicki
    G H Sergievsky Center, Columbia University Medical Center, 622 West 168th Street, PH 19, New York, NY 10019, USA
    Curr Neurol Neurosci Rep 10:359-66. 2010
    ..Future trials are needed to determine whether alternate timing, dosage, formulation, or method of administration of hormone replacement can reduce the risk of dementia...
  47. pmc A summary risk score for the prediction of Alzheimer disease in elderly persons
    Christiane Reitz
    The Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:835-41. 2010
    ..To develop a simple summary risk score for the prediction of Alzheimer disease in elderly persons based on their vascular risk profiles...
  48. ncbi request reprint Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia
    Lawrence S Honig
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain and the Gertrude H Sergievsky Center, New York, NY, USA
    Ann Neurol 60:181-7. 2006
    ..Reduced telomere length may be a marker of biological aging. We hypothesized that telomere length might thus relate to increased risk for dementia and mortality...
  49. pmc Plasma ß-amyloid and cognitive decline
    Stephanie A Cosentino
    The Gertrude H Sergievsky Center, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 67:1485-90. 2010
    ..To determine if plasma β-amyloid (Aβ) levels (1) can be linked to specific cognitive changes that constitute conversion to Alzheimer disease (AD) and (2) correspond to cognitive change independent of dementia...
  50. pmc Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:1491-7. 2010
    ..To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models...
  51. pmc Telephone-based identification of mild cognitive impairment and dementia in a multicultural cohort
    Jennifer J Manly
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, 630 W 168th Street, New York, NY 10032, USA
    Arch Neurol 68:607-14. 2011
    ..Telephone-based interviews can be used for screening and to obtain key study outcomes when participants in longitudinal studies die or cannot be seen in person, but must be validated among ethnically and educationally diverse people...
  52. ncbi request reprint Combined effect of age and severity on the risk of dementia in Parkinson's disease
    Gilberto Levy
    Gertrude H Sergievsky Center, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Ann Neurol 51:722-9. 2002
    ..2) did not. These findings suggest that the increased risk of incident dementia in Parkinson's disease associated with age and severity of extrapyramidal signs is related primarily to their combined effect rather than separate effects...
  53. pmc Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    Arch Neurol 66:834-40. 2009
    ..The validity of a self-reported stroke remains inconclusive...
  54. pmc Mediterranean diet and mild cognitive impairment
    Nikolaos Scarmeas
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 66:216-25. 2009
    ..Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored...
  55. pmc Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs
    Elan D Louis
    Unit 198, Department of Neurology, Columbia University, 710 W 168th St, New York, NY 10032, USA
    Arch Neurol 65:1649-54. 2008
    ..Also, if MPS are a marker for developing Alzheimer-type changes, hippocampal volume on MRI might be diminished in individuals with MPS...
  56. ncbi request reprint Functional correlates of mild parkinsonian signs in the community-dwelling elderly: poor balance and inability to ambulate independently
    Elan D Louis
    The Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Mov Disord 21:411-6. 2006
    ..The elderly in whom these signs have been detected are 50% more likely to complain of poor balance and 90% more likely to require a cane, walker, or wheelchair than are their counterparts without these signs...
  57. pmc Measures of adiposity and dementia risk in elderly persons
    Jose A Luchsinger
    Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:392-8. 2007
    ....
  58. ncbi request reprint Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 390:93-7. 2005
    ..These results suggest that the apolipoprotein E epsilon4 allele has an independent and strong relation to early mortality...
  59. ncbi request reprint Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 27:941-5. 2006
    ..From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status...
  60. ncbi request reprint Mild parkinsonian signs and plasma homocysteine concentration in community-dwelling elderly individuals
    Elan D Louis
    The Gertrude H Sergievsky Center, Department of Neurology, Columbia University, New York, NY 10032, USA
    Arch Neurol 64:1646-51. 2007
    ..To determine whether plasma homocysteine (Hcy) concentration is associated with mild parkinsonian signs (MPS) in community-dwelling elderly individuals...
  61. ncbi request reprint Functional correlates and prevalence of mild parkinsonian signs in a community population of older people
    Elan D Louis
    The Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 62:297-302. 2005
    ..Mild parkinsonian signs (MPS) are associated with incident dementia and an increased risk of mortality. To our knowledge, the functional correlates of MPS have not been studied...
  62. ncbi request reprint Genetic influences on life span and survival among elderly African-Americans, Caribbean Hispanics, and Caucasians
    Joseph H Lee
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    Am J Med Genet A 128:159-64. 2004
    ..Identifying the genes associated with life span and survival will provide insight into how the genes interact with environment to influence aging in humans...
  63. pmc Physical activity, diet, and risk of Alzheimer disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain and Department of Neurology, Columbia University Medical Center, 622 W 168th St, New York, NY 10032, USA
    JAMA 302:627-37. 2009
    ..Both higher adherence to a Mediterranean-type diet and more physical activity have been independently associated with lower Alzheimer disease (AD) risk but their combined association has not been investigated...
  64. ncbi request reprint Cognitive decline and literacy among ethnically diverse elders
    Jennifer J Manly
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    J Geriatr Psychiatry Neurol 18:213-7. 2005
    ..The results of this study suggest that in an ethnically diverse cohort, literacy level should be considered as a mediator of the interactions of biological and environmental factors on cognitive decline...
  65. pmc Olfactory identification deficits and MCI in a multi-ethnic elderly community sample
    D P Devanand
    Division of Geriatric Psychiatry, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neurobiol Aging 31:1593-600. 2010
    ..These findings indicate that the predictive utility of olfactory identification deficits for decline from no MCI to MCI and AD needs to be assessed in longitudinal studies of elderly community samples...
  66. pmc Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan
    Adam M Brickman
    Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Arch Neurol 65:1053-61. 2008
    ..Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease...
  67. doi request reprint Do neuropsychological tests have the same meaning in Spanish speakers as they do in English speakers?
    Karen L Siedlecki
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neuropsychology 24:402-11. 2010
    ..The purpose of this study was to examine whether neuropsychological tests translated into Spanish measure the same cognitive constructs as the original English versions...
  68. pmc Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome
    Warren B Zigman
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    Neurosci Lett 416:279-84. 2007
    ..402, p=.095, 95% CI: .138, 1.173). If the protective effects of statins can be further validated, these findings suggest that their use may delay or prevent AD onset in vulnerable populations...
  69. pmc Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:14052-7. 2008
    ..Our results suggest individuals with elevated plasma Abeta42 are at increased risk of AD and that with the onset of disease, the decline in some forms of Abeta may reflect compartmentalization of Abeta peptides in the brain...
  70. ncbi request reprint Dementia in adults with mental retardation: assessment at a single point in time
    Wayne Silverman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Am J Ment Retard 109:111-25. 2004
    ..Findings suggest that procedures of this type could soon contribute to more accurate and rapid diagnoses of dementia...
  71. doi request reprint Successful aging in a 70-year-old man with down syndrome: a case study
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Intellect Dev Disabil 46:215-28. 2008
    ..The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome...
  72. ncbi request reprint Unbalanced placental expression of imprinted genes in human intrauterine growth restriction
    J McMinn
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Placenta 27:540-9. 2006
    ..non-IUGR placentae...
  73. doi request reprint Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation
    Kristi Kerkel
    Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA
    Nat Genet 40:904-8. 2008
    ..This recurrent phenomenon of sequence-dependent ASM has practical implications for mapping and interpreting associations of noncoding SNPs and haplotypes with human phenotypes...
  74. ncbi request reprint Mitotic index in Down's syndrome with and without dementia
    Edmund C Jenkins
    Am J Med Genet A 125:315-7. 2004

Research Grants10

  1. EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME
    Nicole Schupf; Fiscal Year: 2007
    ..The proposed studies will clarify biological mechanisms relating variations in estrogen to the development of AD. ..
  2. EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME
    Nicole Schupf; Fiscal Year: 2003
    ..The results of this study will provide important information about the role of estrogen in the etiology of AD and the optimal strategy for the development of clinical trials of hormone replacement therapy in women with DS. ..
  3. EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME
    Nicole Schupf; Fiscal Year: 2009
    ..The proposed studies will clarify biological mechanisms relating variations in estrogen to the development of AD. ..