P Christian Schulze

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Reduced handgrip strength as a marker of frailty predicts clinical outcomes in patients with heart failure undergoing ventricular assist device placement
    Christine J Chung
    Division of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York Electronic address
    J Card Fail 20:310-5. 2014
  2. ncbi Protein catabolism and impairment of skeletal muscle insulin signalling in heart failure
    P Christian Schulze
    Division of Cardiology, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    Clin Sci (Lond) 119:465-6. 2010
  3. pmc Dynamics in insulin resistance and plasma levels of adipokines in patients with acute decompensated and chronic stable heart failure
    P Christian Schulze
    Division of Cardiology, New York Presbyterian Hospital Columbia University Medical Center, New York, New York 10032, USA
    J Card Fail 17:1004-11. 2011
  4. doi Markers of extracellular matrix turnover and the development of right ventricular failure after ventricular assist device implantation in patients with advanced heart failure
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    J Heart Lung Transplant 31:37-45. 2012
  5. pmc Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice
    Konstantinos Drosatos
    Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circ Heart Fail 6:550-62. 2013
  6. pmc Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure
    Aalap Chokshi
    Columbia University Medical Center, Center for Advanced Cardiac Care, Department of Medicine, Division of Cardiology, 622 W 168th St, PH 10, Room 203, New York, NY 10032, USA
    Circulation 125:2844-53. 2012
  7. pmc Liver dysfunction as a predictor of outcomes in patients with advanced heart failure requiring ventricular assist device support: Use of the Model of End-stage Liver Disease (MELD) and MELD eXcluding INR (MELD-XI) scoring system
    Jonathan A Yang
    Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA
    J Heart Lung Transplant 31:601-10. 2012
  8. pmc Relation of preoperative serum albumin levels to survival in patients undergoing left ventricular assist device implantation
    Tomoko S Kato
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York Electronic address
    Am J Cardiol 112:1484-8. 2013
  9. pmc Hepatic dysfunction in ambulatory patients with heart failure: application of the MELD scoring system for outcome prediction
    Margaret S Kim
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    J Am Coll Cardiol 61:2253-61. 2013
  10. pmc Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy
    Raffay S Khan
    Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Cardiovasc Pharmacol 61:345-54. 2013

Collaborators

Detail Information

Publications42

  1. ncbi Reduced handgrip strength as a marker of frailty predicts clinical outcomes in patients with heart failure undergoing ventricular assist device placement
    Christine J Chung
    Division of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York Electronic address
    J Card Fail 20:310-5. 2014
    ..We evaluated handgrip strength as a marker of muscle function and frailty for prediction of clinical outcomes after ventricular assist device (VAD) implantation in patients with advanced HF...
  2. ncbi Protein catabolism and impairment of skeletal muscle insulin signalling in heart failure
    P Christian Schulze
    Division of Cardiology, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    Clin Sci (Lond) 119:465-6. 2010
    ....
  3. pmc Dynamics in insulin resistance and plasma levels of adipokines in patients with acute decompensated and chronic stable heart failure
    P Christian Schulze
    Division of Cardiology, New York Presbyterian Hospital Columbia University Medical Center, New York, New York 10032, USA
    J Card Fail 17:1004-11. 2011
    ..It is not known whether metabolic dysfunction and adipocyte activation worsen in the setting of acute clinical decompensation, or conversely, improve with clinical recovery...
  4. doi Markers of extracellular matrix turnover and the development of right ventricular failure after ventricular assist device implantation in patients with advanced heart failure
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    J Heart Lung Transplant 31:37-45. 2012
    ..The association between ECM turnover and right ventricular failure (RVF) development after left ventricular assist device (LVAD) implantation in patients with advanced heart failure (HF) was investigated...
  5. pmc Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice
    Konstantinos Drosatos
    Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circ Heart Fail 6:550-62. 2013
    ..Cardiac dysfunction with sepsis is associated with both inflammation and reduced fatty acid oxidation. We hypothesized that energy deprivation accounts for sepsis-related cardiac dysfunction...
  6. pmc Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure
    Aalap Chokshi
    Columbia University Medical Center, Center for Advanced Cardiac Care, Department of Medicine, Division of Cardiology, 622 W 168th St, PH 10, Room 203, New York, NY 10032, USA
    Circulation 125:2844-53. 2012
    ..We hypothesized that cardiac accumulation of toxic lipid intermediates inhibits insulin signaling in advanced heart failure and that mechanical unloading of the failing myocardium corrects impaired cardiac metabolism...
  7. pmc Liver dysfunction as a predictor of outcomes in patients with advanced heart failure requiring ventricular assist device support: Use of the Model of End-stage Liver Disease (MELD) and MELD eXcluding INR (MELD-XI) scoring system
    Jonathan A Yang
    Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, 622 W 168th Street, New York, NY 10032, USA
    J Heart Lung Transplant 31:601-10. 2012
    ..We evaluated the effect of liver dysfunction on outcomes after ventricular assist device (VAD) implantation and the dynamic changes in liver dysfunction that occur during VAD support...
  8. pmc Relation of preoperative serum albumin levels to survival in patients undergoing left ventricular assist device implantation
    Tomoko S Kato
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York Electronic address
    Am J Cardiol 112:1484-8. 2013
    ..Attention to albumin levels by correcting nutrition, inflammation, and hepatic function could be an effective way to improve prognosis in patients evaluated for LVAD implantation...
  9. pmc Hepatic dysfunction in ambulatory patients with heart failure: application of the MELD scoring system for outcome prediction
    Margaret S Kim
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    J Am Coll Cardiol 61:2253-61. 2013
    ....
  10. pmc Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy
    Raffay S Khan
    Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Cardiovasc Pharmacol 61:345-54. 2013
    ..Thus, dietary FO reverses fibrosis and improves cardiac function and survival of ACS1 mice but does not benefit all forms of lipid-mediated cardiomyopathy...
  11. pmc Risk stratification of ambulatory patients with advanced heart failure undergoing evaluation for heart transplantation
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Center for Advanced Cardiac Care, Columbia University Medical Center, New York, NY 10032, USA
    J Heart Lung Transplant 32:333-40. 2013
    ..We hypothesized that right ventricular stroke work index (RVSWI), pulmonary capillary wedge pressure (PCWP) and the model for end-stage liver disease-albumin score (MELD-A) would be additive prognostic predictors...
  12. ncbi Increased levels of retinol binding protein 4 in patients with advanced heart failure correct after hemodynamic improvement through ventricular assist device placement
    Nelson Chavarria
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ J 76:2148-52. 2012
    ..Retinol binding protein 4 (RBP4) is an adipose tissue-derived protein with pro-diabetogenic effects. The aim of the present study was to investigate the relationship of RBP4 in patients with heart failure...
  13. doi Cardiac transplantation in patients with hypertrophic cardiomyopathy
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    Am J Cardiol 110:568-74. 2012
    ..In conclusion, the post-transplant survival of those with HC did not differ from those of the subjects who underwent transplant for other non-HC indications...
  14. pmc Hepatic dysfunction and survival after orthotopic heart transplantation: application of the MELD scoring system for outcome prediction
    Aalap Chokshi
    Department of Medicine, Division of Cardiology, New York Presbyterian Hospital Columbia University Medical Center, New York, NY 10032, USA
    J Heart Lung Transplant 31:591-600. 2012
    ..Advanced HF is associated with congestive hepatopathy and progressive functional and ultrastructural changes of the liver. We hypothesized that hepatic dysfunction is associated with impaired clinical outcome after heart transplantation...
  15. doi Outcome of patients with cardiac sarcoidosis undergoing cardiac transplantation--single-center retrospective analysis
    Hirokazu Akashi
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA
    J Cardiol 60:407-10. 2012
    ..Recent data from the United Network for Organ Sharing dataset suggest that the clinical outcome of cardiac sarcoidosis patients is equivalent or even better than that of the general HTx population...
  16. doi Pre-operative echocardiographic features associated with persistent mitral regurgitation after left ventricular assist device implantation
    Shuichi Kitada
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    J Heart Lung Transplant 32:897-904. 2013
    ..However, a certain number of patients continue to have significant mitral regurgitation (MR) under LVAD support. We investigated pre-operative echocardiographic features associated with persistent MR after LVAD implantation...
  17. pmc Adipose tissue inflammation and adiponectin resistance in patients with advanced heart failure: correction after ventricular assist device implantation
    Raffay S Khan
    Division of Preventive Medicine and Nutrition, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 5:340-8. 2012
    ....
  18. pmc Preoperative serum albumin levels predict 1-year postoperative survival of patients undergoing heart transplantation
    Tomoko S Kato
    Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 6:785-91. 2013
    ..The purpose of this study was to investigate the impact of pretransplant serum albumin concentration on post-transplant outcome in heart transplant recipients...
  19. doi Value of peak exercise oxygen consumption combined with B-type natriuretic peptide levels for optimal timing of cardiac transplantation
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 6:6-14. 2013
    ..B-type natriuretic peptide (BNP) is a useful prognostic marker in patients with heart failure...
  20. pmc Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice
    Li Liu
    Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Lipid Res 53:1482-92. 2012
    ..Moreover, the beneficial effects of DGAT1 illustrate the interrelationship of several lipid metabolic pathways and the difficulty of assigning benefit to an isolated change in one potentially toxic lipid species...
  21. doi Preoperative assessment of high-risk candidates to predict survival after heart transplantation
    P Christian Schulze
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 6:527-34. 2013
    ..Alternate waiting list strategies expand listing criteria for patients awaiting heart transplantation (HTx). We retrospectively analyzed clinical events and outcome of patients listed as high-risk recipients for HTx...
  22. doi Impact of long term left ventricular assist device therapy on donor allocation in cardiac transplantation
    Nir Uriel
    Divisions of Cardiology, College of Physicians and Surgeons, Columbia University, NewYork, New York, USA
    J Heart Lung Transplant 32:188-95. 2013
    ..Left Ventricular Assist Devices (LVAD) are increasingly used as a bridge to transplant (BTT) for patients with advanced congestive heart failure (CHF) and are assigned United Network for Organ Sharing (UNOS) high priority status (1B or 1A)...
  23. pmc Dynamics of bone turnover markers in patients with heart failure and following haemodynamic improvement through ventricular assist device implantation
    Christina Wu
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Eur J Heart Fail 14:1356-65. 2012
    ..We hypothesized that mechanical unloading through implantation of a ventricular assist device (VAD) with subsequent haemodynamic improvement would correct abnormal bone metabolism in patients with advanced HF...
  24. ncbi Right ventricular stroke work index as a negative predictor of mortality and initial hospital stay after lung transplantation
    Hilary F Armstrong
    Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, NY, USA
    J Heart Lung Transplant 32:603-8. 2013
    ..RV stroke work index (RVSWI) calculates RV workload and contractility. We hypothesized that patients with higher RV workload capacity, indicated by higher RVSWI, would have better outcomes after LTx...
  25. doi Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation
    Tomoko S Kato
    Columbia University Medical Center, Department of Medicine, Division of Cardiology, 622 West 168th St, New York, NY 10032, USA
    Stroke 43:872-4. 2012
    ..Stroke is a major adverse event after left ventricular assist device (LVAD) surgery. The purpose of this study was to describe differences in hemispheric distribution of stroke in LVAD patients...
  26. pmc Impact of pulmonary hypertension on exercise performance in patients with interstitial lung disease undergoing evaluation for lung transplantation
    Hilary F Armstrong
    Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, New York, USA
    Respirology 19:675-82. 2014
    ..The purpose of the present study was to determine and compare the potential correlations between CPET, 6-min walk test (6MWT), pulmonary function testing (PFT) and PH in patients with ILD being evaluated for lung transplantation...
  27. ncbi Regional differences in recipient waitlist time and pre- and post-transplant mortality after the 2006 United Network for Organ Sharing policy changes in the donor heart allocation algorithm
    P Christian Schulze
    Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York Electronic address
    JACC Heart Fail 2:166-77. 2014
    ..This study examined the impact of the United Network for Organ Sharing (UNOS) policy changes for regional differences in waitlist time and mortality before and after heart transplantation...
  28. ncbi Palmitic acid and DGAT1 deficiency enhance osteoclastogenesis, while oleic acid-induced triglyceride formation prevents it
    Zoi Drosatos-Tampakaki
    Division of Periodontics, Columbia University College of Dental Medicine, New York, NY, USA
    J Bone Miner Res 29:1183-95. 2014
    ..Thus, we propose that TNFα mediates saturated fatty acid-induced osteoclastogenesis that can be prevented by DGAT activation or supplementation with OA...
  29. doi Pre-operative and post-operative risk factors associated with neurologic complications in patients with advanced heart failure supported by a left ventricular assist device
    Tomoko S Kato
    Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York, USA
    J Heart Lung Transplant 31:1-8. 2012
    ..Neurologic complications (NCs) are the major adverse events after left ventricular assist device (LVAD) surgery. Pre-operative and post-operative factors associated with NCs in patients with LVADs were investigated...
  30. pmc Cardiac lipotoxicity: molecular pathways and therapeutic implications
    Konstantinos Drosatos
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Curr Heart Fail Rep 10:109-21. 2013
    ....
  31. pmc Effects of continuous-flow versus pulsatile-flow left ventricular assist devices on myocardial unloading and remodeling
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 4:546-53. 2011
    ..We analyzed the effects of ventricular decompression by continuous-flow versus pulsatile-flow LVADs on myocardial structure and function in this population...
  32. pmc Chronic ethanol consumption increases cardiomyocyte fatty acid uptake and decreases ventricular contractile function in C57BL/6J mice
    Chunguang Hu
    The Department of Medicine, Division of Digestive and Liver Disease, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Mol Cell Cardiol 59:30-40. 2013
    ..This model recapitulates important features of human alcoholic cardiomyopathy and illustrates a potentially important pathophysiologic link between cardiac lipid metabolism and function...
  33. doi PET imaging may provide a novel biomarker and understanding of right ventricular dysfunction in patients with idiopathic pulmonary arterial hypertension
    Sabahat Bokhari
    Division of Cardiology, Department of Medicine, New York Presbyterian Hospital at Columbia University Medical Center, New York, NY 10032, USA
    Circ Cardiovasc Imaging 4:641-7. 2011
    ..The objective is to develop PET metabolic imaging of the RV as a noninvasive tool in patients with PAH...
  34. ncbi Supplementation of glutamine and omega-3 polyunsaturated fatty acids as a novel therapeutic intervention targeting metabolic dysfunction and exercise intolerance in patients with heart failure
    Khurram Shahzad
    Department of Medicine, Division of Cardiology, New York Presbyterian Hospital Columbia University MedicalCenter, USA
    Curr Clin Pharmacol 6:288-94. 2011
    ..These two compounds are of particular interest due to their synergistic role on oxidative metabolism, lipolysis and inflammation...
  35. pmc Lipid metabolism and toxicity in the heart
    Ira J Goldberg
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 15:805-12. 2012
    ..Finally, the known relationships between heart lipid metabolism and dysfunction in humans will be summarized...
  36. pmc The risk of adverse events associated with atropine administration during dobutamine stress echocardiography in cardiac transplant patients: a 28-year single-center experience
    James Wang Ji
    Division of Cardiology, Columbia University Medical Center, New York, New York
    J Card Fail 19:762-7. 2013
    ..Although dobutamine stress echocardiography (DSE) is performed in heart transplant patients, the safety profile of atropine administration in DSE in this setting is unclear...
  37. pmc Exercise as a nonpharmacologic intervention in patients with heart failure
    Christine J Chung
    Department of Medicine, Columbia University Medical Center, New York, NY, USA
    Phys Sportsmed 39:37-43. 2011
    ....
  38. pmc Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction
    Konstantinos Drosatos
    Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Biol Chem 286:36331-9. 2011
    ..We conclude that activation of JNK signaling reduces fatty acid oxidation and prevents the peroxisome proliferator-activated receptor α down-regulation that occurs with LPS...
  39. pmc Metabolism of the right ventricle and the response to hypertrophy and failure
    S Elissa Altin
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York 10032, USA
    Prog Cardiovasc Dis 55:229-33. 2012
    ....
  40. pmc Metabolic and structural impairment of skeletal muscle in heart failure
    Cynthia Zizola
    Division of Cardiology, Department of Medicine, Center for Advanced Cardiac Care, Columbia University Medical Center, 622 West 168th Street, PH 10, Room 203, New York, NY, 10032, USA
    Heart Fail Rev 18:623-30. 2013
    ..The impact of heart failure upon skeletal muscle and exercise performance will be discussed with a focus on molecular, structural, and functional derangements in skeletal muscle of patients with heart failure. ..
  41. doi Epicardial fat volume in patients with left ventricular systolic dysfunction
    Tuba Khawaja
    Division of Cardiology, Department of Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, USA
    Am J Cardiol 108:397-401. 2011
    ..In conclusion, our data demonstrate a stepwise decrease in EFV in patients with impaired cardiac function...
  42. pmc Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance
    Ji Yeon Shin
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168 th Street, New York, NY 10032, USA Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 630 West 168 th Street, New York, NY 10032, USA
    Dev Cell 26:591-603. 2013
    ..They also highlight how dissecting differences between mouse and human phenotypes can provide fundamental insights into disease mechanisms. ..