N Scarmeas

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Mediterranean diet and risk for Alzheimer's disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, New York, NY 10032, USA
    Ann Neurol 59:912-21. 2006
  2. pmc Nutrient intake and plasma β-amyloid
    Y Gu
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Neurology 78:1832-40. 2012
  3. pmc Mediterranean diet and Alzheimer disease mortality
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurology 69:1084-93. 2007
  4. pmc Motor signs during the course of Alzheimer disease
    N Scarmeas
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, and Department of Neurology, New York, NY 10032, USA
    Neurology 63:975-82. 2004
  5. pmc Physical activity, diet, and risk of Alzheimer disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain and Department of Neurology, Columbia University Medical Center, 622 W 168th St, New York, NY 10032, USA
    JAMA 302:627-37. 2009
  6. pmc Seizures in Alzheimer disease: who, when, and how common?
    Nikolaos Scarmeas
    Department of Neurology, Columbia University Medical Center, 622 W 168 St, PH Bldg, 19th Floor, New York, NY 10032, USA
    Arch Neurol 66:992-7. 2009
  7. pmc Motor signs predict poor outcomes in Alzheimer disease
    N Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurology 64:1696-703. 2005
  8. pmc Invited commentary: lipoproteins and dementia - is it the apolipoprotein A-I?
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Am J Epidemiol 165:993-7. 2007
  9. pmc APOE related alterations in cerebral activation even at college age
    N Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 76:1440-4. 2005
  10. pmc Delusions and hallucinations are associated with worse outcome in Alzheimer disease
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, New York, NY 10032, USA
    Arch Neurol 62:1601-8. 2005

Research Grants

Detail Information

Publications76

  1. pmc Mediterranean diet and risk for Alzheimer's disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, New York, NY 10032, USA
    Ann Neurol 59:912-21. 2006
    ..We sought to investigate the association between MeDi and risk for AD...
  2. pmc Nutrient intake and plasma β-amyloid
    Y Gu
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Neurology 78:1832-40. 2012
    ..However, little is known about the possible associations of dietary factors with plasma Aβ40 or Aβ42. The aim of the current study was to evaluate the association between nutrient intake and plasma Aβ levels...
  3. pmc Mediterranean diet and Alzheimer disease mortality
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurology 69:1084-93. 2007
    ..We previously reported that the Mediterranean diet (MeDi) is related to lower risk for Alzheimer disease (AD). Whether MeDi is associated with subsequent AD course and outcomes has not been investigated...
  4. pmc Motor signs during the course of Alzheimer disease
    N Scarmeas
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, and Department of Neurology, New York, NY 10032, USA
    Neurology 63:975-82. 2004
    ..Motor signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline, mortality, and cost of care...
  5. pmc Physical activity, diet, and risk of Alzheimer disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain and Department of Neurology, Columbia University Medical Center, 622 W 168th St, New York, NY 10032, USA
    JAMA 302:627-37. 2009
    ..Both higher adherence to a Mediterranean-type diet and more physical activity have been independently associated with lower Alzheimer disease (AD) risk but their combined association has not been investigated...
  6. pmc Seizures in Alzheimer disease: who, when, and how common?
    Nikolaos Scarmeas
    Department of Neurology, Columbia University Medical Center, 622 W 168 St, PH Bldg, 19th Floor, New York, NY 10032, USA
    Arch Neurol 66:992-7. 2009
    ..The incidence of seizures in AD and predictors of which patients with AD might be more predisposed to them is based primarily on retrospective studies and is not well established...
  7. pmc Motor signs predict poor outcomes in Alzheimer disease
    N Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurology 64:1696-703. 2005
    ..To examine whether the presence of motor signs has predictive value for important outcomes in Alzheimer disease (AD)...
  8. pmc Invited commentary: lipoproteins and dementia - is it the apolipoprotein A-I?
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Am J Epidemiol 165:993-7. 2007
    ..In this commentary, the epidemiology and biology of apolipoprotein A-I in relation to dementia is reviewed...
  9. pmc APOE related alterations in cerebral activation even at college age
    N Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 76:1440-4. 2005
    ..The association between the APOE genotype and cognitive performance varies at different ages. APOE related changes in brain activation have been recently reported for middle aged and elderly subjects...
  10. pmc Delusions and hallucinations are associated with worse outcome in Alzheimer disease
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, New York, NY 10032, USA
    Arch Neurol 62:1601-8. 2005
    ..According to all previous literature, they are not associated with mortality...
  11. pmc Mediterranean diet and mild cognitive impairment
    Nikolaos Scarmeas
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 66:216-25. 2009
    ..Higher adherence to the Mediterranean diet (MeDi) may protect from Alzheimer disease (AD), but its association with mild cognitive impairment (MCI) has not been explored...
  12. pmc Education and rates of cognitive decline in incident Alzheimer's disease
    N Scarmeas
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, 622 West 168th Street, PH 19th Floor, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 77:308-16. 2006
    ..We wanted to assess the relationship between education and rates of decline in AD...
  13. pmc Imaging studies and APOE genotype in persons at risk for Alzheimer's disease
    Nikolaos Scarmeas
    Columbia University Medical Center, 622 West 168th Street, PH 19th Floor, New York, NY 10032, USA
    Curr Psychiatry Rep 8:11-7. 2006
    ..APOE-related findings in imaging studies of nondemented subjects may be the result of incipient AD pathologic changes or of genetic heterogeneity in brain structure and function...
  14. pmc Mediterranean diet, Alzheimer disease, and vascular mediation
    Nikolaos Scarmeas
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 63:1709-17. 2006
    ..To examine the association between the Mediterranean diet (MeDi) and Alzheimer disease (AD) in a different AD population and to investigate possible mediation by vascular pathways. Design, Setting, Patients, and..
  15. pmc Disruptive behavior as a predictor in Alzheimer disease
    Nikolaos Scarmeas
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 64:1755-61. 2007
    ..Disruptive behavior is common in Alzheimer disease (AD). There are conflicting reports regarding its ability to predict cognitive decline, functional decline, institutionalization, and mortality...
  16. pmc APOE-dependent PET patterns of brain activation in Alzheimer disease
    N Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University New York, NY 10032, USA
    Neurology 63:913-5. 2004
    ..The APOE genotype seems to play a role in cerebral physiologic activity even after onset of clinical manifestations of AD...
  17. pmc Covariance PET patterns in early Alzheimer's disease and subjects with cognitive impairment but no dementia: utility in group discrimination and correlations with functional performance
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuroimage 23:35-45. 2004
    ..Expression of covariance patterns correlates with cognitive and functional performance measures, holding promise for meaningful associations with underlying biopathological processes...
  18. pmc Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease
    Nikolaos Scarmeas
    Columbia Presbyterian Medical Center, 622 West 168th Street, PH 19th Floor, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 4:374-80. 2004
    ..In this article, we review some of the relevant literature of the noted associations between markers of cognitive reserve and AD and discuss the possible mechanisms that may explain these associations...
  19. pmc Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, University of California at Davis, Sacramento, USA
    Ann Neurol 69:257-68. 2011
    ..Cerebrovascular disease is 1 of the possible mechanisms of the previously reported relationship between Mediterranean-type diet (MeDi) and Alzheimer's disease (AD). We sought to investigate the association between MeDi and MRI infarcts...
  20. pmc Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Arch Neurol 60:359-65. 2003
    ..This has been interpreted as suggesting that cognitive reserve allows these patients to cope better with the pathologic changes in AD...
  21. pmc Cognitive reserve and lifestyle
    Nikolaos Scarmeas
    Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, and College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Clin Exp Neuropsychol 25:625-33. 2003
    ..It is possible that aspects of life experience like engagement in leisure activities may result in functionally more efficient cognitive networks and therefore provide a CR that delays the onset of clinical manifestations of dementia...
  22. pmc Physical activity and Alzheimer disease course
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, NY 10032, USA
    Am J Geriatr Psychiatry 19:471-81. 2011
    ..To examine the association between physical activity (PA) and Alzheimer disease (AD) course...
  23. pmc Cortical basal ganglionic degeneration
    N Scarmeas
    College of Physicians and Surgeons of Columbia University, New York Presbyterian Hospital, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, the Sergievsky Center, New York, NY 12345, USA
    Sci Aging Knowledge Environ 2001:dn1. 2001
    ..CBGD is characterized by Parkinson's-like motor symptoms and by deficits of movement and cognition, indicating focal brain pathology. Neuronal cell loss is ultimately responsible for the neurological symptoms...
  24. pmc Cognitive reserve-mediated modulation of positron emission tomographic activations during memory tasks in Alzheimer disease
    Nikolaos Scarmeas
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Arch Neurol 61:73-8. 2004
    ..Epidemiological data and evidence from positron emission tomography suggest that it may be mediated through education or IQ...
  25. pmc Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (carriers of the epsilon4 allele)
    Nikolaos Scarmeas
    Departments of Neurology, College of Physicians and Surgeons of Columbia University Medical Center 622 West 168th St, PH 19th floor New York, NY 10032, USA
    Am J Geriatr Psychiatry 12:596-605. 2004
    ..The authors investigated APOE-mediated differential brain activation in a group of healthy elderly subjects...
  26. pmc APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease
    S Cosentino
    Cognitive Neuroscience Division of the Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Neurology 70:1842-9. 2008
    ..To determine whether APOE epsilon 4 predicts rate of cognitive change in incident and prevalent Alzheimer disease (AD)...
  27. ncbi request reprint Impairment of nonverbal recognition in Alzheimer disease: a PET O-15 study
    K E Anderson
    Cognitive Neuroscience Division, Taub Institute for Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Neurology 69:32-41. 2007
    ..To characterize deficits in nonverbal recognition memory and functional brain changes associated with these deficits in Alzheimer disease (AD)...
  28. pmc Association between the APOE genotype and psychopathologic symptoms in Alzheimer's disease
    N Scarmeas
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, New York, NY, USA
    Neurology 58:1182-8. 2002
    ..Previous studies investigating the association between APOE genotype and psychiatric symptomatology in AD have reported contradictory results...
  29. pmc Patient dependence and longitudinal changes in costs of care in Alzheimer's disease
    Carolyn W Zhu
    Geriatric Research, Education, and Clinical Center GRECC, James J Peters VA Medical Center, Bronx, NY, NY 10468, USA
    Dement Geriatr Cogn Disord 26:416-23. 2008
    ..To examine the incremental effect of patients' dependence on others, on cost of medical and nonmedical care, and on informal caregiving hours over time...
  30. pmc Influence of leisure activity on the incidence of Alzheimer's disease
    N Scarmeas
    Cognitive Neuroscience Division of the Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurology 57:2236-42. 2001
    ..CONCLUSIONS: The data suggest that engagement in leisure activities may reduce the risk of incident dementia, possibly by providing a reserve that delays the onset of clinical manifestations of the disease...
  31. pmc Survival in Alzheimer disease: a multiethnic, population-based study of incident cases
    E P Helzner
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Neurology 71:1489-95. 2008
    ..To describe factors associated with survival in Alzheimer disease (AD) in a multiethnic, population-based longitudinal study...
  32. pmc Contribution of vascular risk factors to the progression in Alzheimer disease
    Elizabeth P Helzner
    Gertrude H Sergievsky Center, Columbia University Medical Center, NY, New York, USA
    Arch Neurol 66:343-8. 2009
    ....
  33. pmc Food combination and Alzheimer disease risk: a protective diet
    Yian Gu
    The Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Arch Neurol 67:699-706. 2010
    ..Because foods are not consumed in isolation, dietary pattern (DP) analysis of food combination, taking into account the interactions among food components, may offer methodological advantages...
  34. ncbi request reprint Depressive symptoms in Alzheimer's disease: natural course and temporal relation to function and cognitive status
    Roee Holtzer
    Cognitive Neuroscience Division, Taub Institute, G H Gertrude Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA
    J Am Geriatr Soc 53:2083-9. 2005
    ..To examine the natural course of depressive symptoms in patients with probable Alzheimer's disease (AD), specifically, the temporal relationship between depressive symptoms, function, and cognitive status...
  35. pmc Mediterranean diet and essential tremor. A case-control study
    Nikolaos Scarmeas
    Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neuroepidemiology 29:170-7. 2007
    ..Higher adherence to the Mediterranean diet (MeDi) has been related to lower Alzheimer's disease risk. Some dietary factors have been studied in patients with essential tremor (ET), but the MeDi's effect has not been investigated...
  36. pmc Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, New York, NY 10032, USA
    Neuroimage 19:1215-27. 2003
    ..Brain regions where systematic relationships between CR and brain activation differ as a function of aging are loci where compensation for aging has occurred. They may mediate differential ability to cope with brain changes in aging...
  37. pmc Verbal fluency predicts mortality in Alzheimer disease
    Stephanie Cosentino
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, NY, USA
    Cogn Behav Neurol 19:123-9. 2006
    ..To assess the predictive value of neuropsychologic profiles, at diagnosis, for mortality in incident Alzheimer disease (AD)...
  38. ncbi request reprint An observational study of cognitive impairment in amyotrophic lateral sclerosis
    Gregory A Rippon
    Department of Neurology, Gertrude H Sergievsky Center, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Eleanor and Lou Gehrig MDA ALS Research Center, New York, NY, USA
    Arch Neurol 63:345-52. 2006
    ..Clinical and pathologic features overlap in frontotemporal lobar dementia and ALS. Demographics, respiratory status, bulbar site of onset, and disease severity are potential risk factors for cognitive impairment in ALS...
  39. ncbi request reprint Identification and differential vulnerability of a neural network in sleep deprivation
    Sandra Bell-McGinty
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, 630 West 168th Street, PH 18, New York, USA
    Cereb Cortex 14:496-502. 2004
    ..A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation...
  40. pmc Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III
    J M Noble
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY, USA
    J Neurol Neurosurg Psychiatry 80:1206-11. 2009
    ..Dementia is a major public health problem likely related to a complex interaction between genetics and diseases associated with systemic inflammation, including diabetes, smoking and stroke...
  41. ncbi request reprint Clinical trial of an air-circulating cooling blanket for fever control in critically ill neurologic patients
    S Mayer
    Division of Critical Care Neurology, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurology 56:292-8. 2001
    ..To evaluate the efficacy of an air-circulating cooling blanket for reducing body temperature in febrile neuro-ICU patients treated with acetaminophen...
  42. pmc Randomized double-blind placebo-controlled donepezil augmentation in antidepressant-treated elderly patients with depression and cognitive impairment: a pilot study
    Gregory H Pelton
    Late Life Depression Clinic, The Memory Disorders Center, and The Division of Geriatric Psychiatry, New York State Psychiatric Institute, NY, USA
    Int J Geriatr Psychiatry 23:670-6. 2008
    ..To assess combined antidepressant and cognitive enhancer treatment in elderly patients presenting with depression plus cognitive impairment...
  43. pmc Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Campus Box 16, New York, NY 10032, USA
    Arch Neurol 65:1202-8. 2008
    ..To determine if baseline measurements of cerebral atrophy and severity of white matter hyperintensity (WMH) predict the rate of future cognitive decline in patients with Alzheimer disease (AD)...
  44. ncbi request reprint Leisure activity and cognitive decline in incident Alzheimer disease
    Elizabeth P Helzner
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 64:1749-54. 2007
    ..High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD)...
  45. pmc Plasma ß-amyloid and cognitive decline
    Stephanie A Cosentino
    The Gertrude H Sergievsky Center, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 67:1485-90. 2010
    ..To determine if plasma β-amyloid (Aβ) levels (1) can be linked to specific cognitive changes that constitute conversion to Alzheimer disease (AD) and (2) correspond to cognitive change independent of dementia...
  46. pmc A forward application of age associated gray and white matter networks
    Adam M Brickman
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Hum Brain Mapp 29:1139-46. 2008
    ..405, P = 0.024). The findings suggest that the previously derived age-associated covariance pattern for gray matter is reliable and may provide information that is more functionally meaningful than chronological age...
  47. ncbi request reprint Diet and Alzheimer's disease
    Jose A Luchsinger
    Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, PH9E 105, 630 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 7:366-72. 2007
    ..The existing evidence does not support the recommendation of specific supplements, foods, or diets for the prevention of AD...
  48. pmc Brain networks associated with cognitive reserve in healthy young and old adults
    Yaakov Stern
    Cognitive Neuroscience Division, Taub Institute, College of Physicians and Surgeons, Columbia University, New York, USA
    Cereb Cortex 15:394-402. 2005
    ..Thus, for the old subjects this topography may represent an altered, compensatory network that is used to maintain function in the face of age-related physiological changes...
  49. ncbi request reprint An event-related fMRI study of the neural networks underlying the encoding, maintenance, and retrieval phase in a delayed-match-to-sample task
    Christian Habeck
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, 622 West 168th Street, PH 18, New York, NY 10032, USA
    Brain Res Cogn Brain Res 23:207-20. 2005
    ..The load-related activation patterns from encoding and retrieval phase and their relationship to behavior are also discussed...
  50. ncbi request reprint Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment
    D P Devanand
    Department of Biological Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Neurol 62:975-80. 2005
    ..In cognitively impaired patients without dementia, the utility of apolipoprotein E (APOE) genotyping is unclear...
  51. ncbi request reprint PET network abnormalities and cognitive decline in patients with mild cognitive impairment
    Davangere P Devanand
    Department of Biological Psychiatry, College of Physicians and Surgeons, New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 31:1327-34. 2006
    ..Independent replication in larger samples is needed before clinical application can be considered...
  52. pmc Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer's disease
    Iris Asllani
    Department of Radiology, Columbia University, New York, New York 10032, USA
    J Cereb Blood Flow Metab 28:725-36. 2008
    ..When tested on extensive split-half analysis to map out the replicability of both multivariate and univariate approaches, the expression of the pattern from multivariate analysis was superior to that of the univariate...
  53. ncbi request reprint Single-dose levodopa administration and aging independently disrupt time production
    Brian C Rakitin
    Columbia University, New York, NY 10032, USA
    J Cogn Neurosci 18:376-87. 2006
    ..Moreover, the levodopa timing effect cannot be attributed to the effects of dopaminergic function on psychomotor speed...
  54. ncbi request reprint A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy
    Marla J Hamberger
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Epilepsia 48:1283-91. 2007
    ..To determine whether an acetylcholinesterase inhibitor, such as donepezil, would improve memory or other cognitive/psychological functions in epilepsy patients with subjective memory complaints...
  55. ncbi request reprint The progression of cognition, psychiatric symptoms, and functional abilities in dementia with Lewy bodies and Alzheimer disease
    Karina Stavitsky
    Gertrude H Sergievsky Center and Department of Neurology, Columbia University Medical Center, New York, NY, USA
    Arch Neurol 63:1450-6. 2006
    ..Although dementia with Lewy bodies (DLB) may be one of most common forms of dementia, relatively little is known about its cognitive and functional course...
  56. pmc Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study
    Joshua R Steinerman
    Departments of Neurology, Columbia University Medical Center, 630 W 168th St, P and S Box 16, New York, NY 10032, USA
    Arch Neurol 65:906-12. 2008
    ..To determine whether beta-amyloid (Abeta) peptides segregated into distinct biochemical compartments would differentially correlate with clinical severity of Alzheimer disease (AD)...
  57. pmc Are there sensitive time periods for dementia caregivers? The occurrence of behavioral and psychological symptoms in the early stages of dementia
    K A Ornstein
    Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Int Psychogeriatr 25:1453-62. 2013
    ..Future longitudinal analyses of the dementia caregiving relationship should continue to examine the negative impact of persistent agitation/aggression in the diagnosis of early stage dementia on caregivers. ..
  58. pmc Dietary patterns in Alzheimer's disease and cognitive aging
    Y Gu
    The Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Curr Alzheimer Res 8:510-9. 2011
    ..Further studies are warranted, though, to confirm the findings in different population settings, to address some methodological issues, and possibly utilize the information for future clinical trial design...
  59. pmc Application of pet imaging to diagnosis of Alzheimer's disease and mild cognitive impairment
    James M Noble
    Department of Neurology, Harlem Hospital Center, Columbia University College of Physicians and Surgeons, New York 10037, USA
    Int Rev Neurobiol 84:133-49. 2009
    ..From this we advise scenarios for use of PET in primary settings and referral centers, approach to its interpretation, and outline a clinical prediction model based on findings...
  60. ncbi request reprint An event-related fMRI study of the neurobehavioral impact of sleep deprivation on performance of a delayed-match-to-sample task
    Christian Habeck
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, 630 West 168th Street, PH 18, New York, NY 10032, USA
    Brain Res Cogn Brain Res 18:306-21. 2004
    ..Subject decreases in pattern expression were correlated with reductions in recognition accuracy (p<0.05), increased intra-individual variability in reaction time (p<0.005) and increased lapsing (p<0.005)...
  61. ncbi request reprint Risk factors for fever in the neurologic intensive care unit
    Christopher Commichau
    Division of Critical Care Neurology, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurology 60:837-41. 2003
    ..To identify risk factors for fever among patients treated in a neurologic intensive care unit (NICU)...
  62. ncbi request reprint Premorbid weight, body mass, and varsity athletics in ALS
    N Scarmeas
    Department of Neurology, Neurological Institute of Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Neurology 59:773-5. 2002
    ..For slimness, the odds ratio (OR) was 2.21; 95% CI, 1.40 to 3.47. For varsity athletics, the OR was 1.70; CI, 1.04 to 2.76...
  63. pmc The relation of patient dependence to home health aide use in Alzheimer's disease
    Rachel K Scherer
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Department of Neurology, Columbia University Medical Center, 630 West 168th St, P and S Box 16, New York, NY 10032, USA
    J Gerontol A Biol Sci Med Sci 63:1005-9. 2008
    ..The objective of this study was to examine whether the Dependence Scale can predict home health aide (HHA) use...
  64. pmc Comparison of costs of care between patients with Alzheimer's disease and dementia with Lewy bodies
    Carolyn W Zhu
    Geriatric Research, Education, and Clinical Center and Program of Research on Serious Physical and Mental Illness, Targeted Research Enhancement Program, James J Peters VA Medical Center, Bronx, NY, USA
    Alzheimers Dement 4:280-4. 2008
    ..This cross-sectional analysis of baseline data from the Predictors II Study took place in three university-based AD centers in the U.S...
  65. pmc APOE genotype and cerebral blood flow in healthy young individuals
    Nikolaos Scarmeas
    JAMA 290:1581-2. 2003
  66. ncbi request reprint Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia
    Lawrence S Honig
    Neurology 64:1102; author reply 1102. 2005
  67. pmc The effects of patient function and dependence on costs of care in Alzheimer's disease
    Carolyn W Zhu
    Geriatric Research, Education, and Clinical Center, Program of Research on Serious Physical and Mental Illness, James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
    J Am Geriatr Soc 56:1497-503. 2008
    ..To estimate incremental effects of patients' dependence and function on costs of care during the early stages of Alzheimer's disease (AD) and to compare strengths of their relationships with different cost components...
  68. ncbi request reprint Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions
    Georgios M Hadjigeorgiou
    Neurogenetics Unit, Department of Neurology, School of Medicine, University of Thessaly, Larissa 41222, Greece
    J Orthop Res 25:1087-93. 2007
    ..43; 95%CI = 1.04-1.97; p for trend = 0.03). We conclude that individuals with PON1 192QQ genotype may have increased risk for ONFH and WMLeOn...
  69. ncbi request reprint Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset
    Georgios M Hadjigeorgiou
    Neurogenetics Unit, Department of Neurology, Medical School, University of Thessaly, Larissa, Greece
    Mov Disord 21:534-9. 2006
    ..For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD...
  70. ncbi request reprint fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    Nikolaos Scarmeas
    Neurology 65:1514-5; author reply 1514-5. 2005
  71. pmc Clinical characteristics and longitudinal changes of informal cost of Alzheimer's disease in the community
    Carolyn W Zhu
    Geriatric Research, Education, and Clinical Center and Program of Research on Serious Physical and Mental Illness, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    J Am Geriatr Soc 54:1596-602. 2006
    ..Each additional point on the BDRS increased informal caregiving costs 5.4%. Average annual informal cost was estimated at $25,381 per patient, increasing from $20,589 at baseline to $43,030 in Year 4...
  72. pmc Home health and informal care utilization and costs over time in Alzheimer's disease
    Carolyn W Zhu
    Geriatric Research, Education, and Clinical Center GRECC, James J Peters VA Medical Center, Bronx, NY 10468, USA
    Home Health Care Serv Q 27:1-20. 2008
    ....
  73. ncbi request reprint CA 19-9 levels predict results of staging laparoscopy in pancreatic cancer
    Andreas Karachristos
    Department of Surgery, Temple University Hospital, Philadelphia, Pennsylvania, USA
    J Gastrointest Surg 9:1286-92. 2005
    ..On the contrary, patients with elevated CA 19-9 have an increased probability of metastatic disease, and these patients may benefit from diagnostic laparoscopy...
  74. ncbi request reprint Serum beta2-microglobulin levels in hepatitis B e antigen-negative chronic hepatitis B patients under long term lamivudine monotherapy: relationship with virological breakthrough
    Ioannis S Elefsiniotis
    Department of Hepatogastroenterology, University of Athens, Helena Venizelou Hospital, Athens, Greece
    Can J Gastroenterol 18:307-13. 2004
    ..To evaluate the predictive value of serum beta2-microglobulin (beta2m) levels for virological breakthrough in hepatitis B e antigen-negative chronic hepatitis B patients under long term lamivudine monotherapy...
  75. pmc Mediterranean diet and mortality in a US population
    Nikolaos Scarmeas
    Arch Intern Med 168:1823-4. 2008
  76. doi request reprint Patient's age modifies the impact of the proposed predictors of sustained virological response in chronic hepatitis C patients treated with PEG-interferon plus ribavirin
    Ioannis S Elefsiniotis
    Department of Internal Medicine, Hepatology Unit, Hippokration Hospital, Athens, Greece
    Eur J Intern Med 19:266-70. 2008
    ..000 IU/ml), chronic hepatitis C (CHC) patients treated under real-life conditions in Greece...

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