Regina Santella

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. doi request reprint Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts
    Y J Zhang
    Division of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA E mail
    Biomarkers 5:295-306. 2000
  2. pmc Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry
    Letitia D Smith
    Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Breast Cancer Res 13:R14. 2011
  3. pmc Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk
    Jing Shen
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Breast Cancer Res 8:R71. 2006
  4. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
  5. ncbi request reprint Approaches to DNA/RNA Extraction and whole genome amplification
    Regina M Santella
    Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 15:1585-7. 2006
  6. ncbi request reprint DNA adducts, DNA repair genotype/phenotype and cancer risk
    Regina M Santella
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 West 168th St, New York, NY 10032, USA
    Mutat Res 592:29-35. 2005
  7. ncbi request reprint DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer
    David O Kennedy
    Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
    J Natl Cancer Inst 97:127-32. 2005
  8. ncbi request reprint Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 64:7634-9. 2004
  9. ncbi request reprint A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk
    Kathryn E Talbott
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
    Breast Cancer Res Treat 111:481-7. 2008
  10. doi request reprint Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008

Research Grants

  1. Biological Markers of Aflatoxin Exposure and Methylation
    Regina M Santella; Fiscal Year: 2010
  2. BIOLOGICAL MARKERS OF AFLATOXIN EXPOSURE
    Regina Santella; Fiscal Year: 2007
  3. Center for Environmental Health in Northern Manhattan
    Regina Santella; Fiscal Year: 2007
  4. BIOLOGICAL MARKERS OF AFLATOXIN EXPOSURE
    Regina Santella; Fiscal Year: 2004
  5. BIOLOGICAL MARKERS OF AFLATOXIN EXPOSURE
    Regina Santella; Fiscal Year: 2000

Detail Information

Publications88

  1. doi request reprint Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts
    Y J Zhang
    Division of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA E mail
    Biomarkers 5:295-306. 2000
    ..These results suggest that one factor influencing carcinogen-DNA adducts is levels of specific P450 enzymes. However, adduct formation in vivo is a complex processes dependent upon numerous genetic and environmental factors. ..
  2. pmc Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry
    Letitia D Smith
    Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Breast Cancer Res 13:R14. 2011
    ..We sought to test the value of selecting women for BRCA1 mutation testing on the basis of family history and/or breast tumour morphology criteria as well as the value of testing for large genomic alterations in BRCA1...
  3. pmc Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk
    Jing Shen
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Breast Cancer Res 8:R71. 2006
    ..926, COX-2 .5209, and COX-2 .8473) may reduce overall breast cancer risk or risk for subtypes of breast cancer by modulating the inflammatory response and may interact with aspirin or any NSAID use...
  4. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
    ....
  5. ncbi request reprint Approaches to DNA/RNA Extraction and whole genome amplification
    Regina M Santella
    Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 15:1585-7. 2006
    ..Finally, a major issue in quality control is the careful labeling and handling of samples...
  6. ncbi request reprint DNA adducts, DNA repair genotype/phenotype and cancer risk
    Regina M Santella
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 West 168th St, New York, NY 10032, USA
    Mutat Res 592:29-35. 2005
    ..Analysis of samples from these two studies have demonstrated the utility of measurement of DNA adducts as biomarkers of exposure and that DNA repair capacity, measured by genotyping or phenotyping, can influence risk...
  7. ncbi request reprint DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer
    David O Kennedy
    Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
    J Natl Cancer Inst 97:127-32. 2005
    ..Interindividual differences in DNA repair capacity may influence cancer risk. We tested whether the nucleotide excision repair pathway was deficient in breast cancer case patients by analyzing sister pairs...
  8. ncbi request reprint Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 64:7634-9. 2004
    ....
  9. ncbi request reprint A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk
    Kathryn E Talbott
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA
    Breast Cancer Res Treat 111:481-7. 2008
    ..The finding supports the potential role of variation in estrogen biosynthesis genes in premenopausal breast cancer risk...
  10. doi request reprint Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008
    ..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...
  11. ncbi request reprint Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma
    Yu Jing Zhang
    Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health, Columbia University, 700 West 168th Street, New York, NY 10032, USA
    Int J Cancer 103:440-4. 2003
    ..The role of chemical carcinogens in hypermethylation needs further investigation...
  12. ncbi request reprint Improving organochlorine biomarker models for cancer research
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 14:2224-36. 2005
    ..e., PCB) or long discontinued (i.e., DDE)...
  13. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls
    Shu Yuan Chen
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Int J Cancer 99:14-21. 2002
    ..2-187.2) compared to those who had low DNA adduct levels. These results suggest that PAHs may play a role in human hepatocarcinogenesis in conjunction with HBsAg carrier status, GSTM1 and GSTP1 genotypes and exposure to 4-ABP and AFB(1)...
  14. ncbi request reprint Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Cancer Lett 221:135-43. 2005
    ..The mechanism by which environmental exposures induce epigenetic changes in HCC needs further analysis...
  15. pmc B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer
    Xinran Xu
    Department of Community and Preventive Medicine, Box 1043, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Epidemiol Biomarkers Prev 17:2109-16. 2008
    ..Our results indicate that one-carbon metabolism may be an important pathway that could be targeted to improve breast cancer survival...
  16. ncbi request reprint A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users
    Xinran Xu
    Departments of Community and Preventive Medicine and Epidemiology and Medicine, Columbia University, New York, NY, USA
    Am J Clin Nutr 85:1098-102. 2007
    ..Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions...
  17. pmc Gene-environment interactions between DNA repair polymorphisms and exposure to the carcinogen vinyl chloride
    Yongliang Li
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Biomarkers 14:148-55. 2009
    ....
  18. ncbi request reprint The role of XRCC1 polymorphisms in base excision repair of etheno-DNA adducts in French vinyl chloride workers
    Yongliang Li
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Int J Occup Med Environ Health 19:45-52. 2006
    ....
  19. pmc Plasma protein carbonyls and breast cancer risk in sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry
    Jennifer Zipprich
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Cancer Res 69:2966-72. 2009
    ..4; 95% confidence interval (CI), 0.8-2.7; Q3 OR, 2.4; 95% CI, 1.1-4.9; Q4 OR, 1.9; 95% CI, 0.8-4.2], although not in a dose-dependent manner. These data suggest that oxidative damage is a risk factor for breast cancer in high-risk women...
  20. pmc Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 West 168th Street, RM19 418, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 18:846-53. 2009
    ..However, in this larger study, the effect of combined AFB1 exposure and HBV infection is more consistent with an additive than a multiplicative model...
  21. ncbi request reprint Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: the influence of tobacco smoke
    Beatrice Faraglia
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Carcinogenesis 24:719-25. 2003
    ..In this study, genetic polymorphisms did not significantly affect the formation of 4-ABP-DNA adducts in breast cancer cases, perhaps due to the small number of samples...
  22. ncbi request reprint Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Departments of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Carcinogenesis 28:995-9. 2007
    ..These results suggest that elevated levels of urinary 8-oxodG may be related to increasing level of aflatoxin exposure but may also indicate enhanced repair of oxidative DNA damage and therefore lower risk of HCC...
  23. ncbi request reprint A cross-sectional study of polycyclic aromatic hydrocarbon-DNA adducts and polymorphism of glutathione S-transferases among heavy smokers by race/ethnicity
    Kera F Weiserbs
    Department of Epidemiology Mailman School of Public Health of Columbia University New York, NY 10032, USA
    Biomarkers 8:142-55. 2003
    ..Although the mechanism is unclear, ethnic differences in DNA damage levels may in part explain why African-Americans have higher lung cancer incidence rates than other ethnic groups...
  24. pmc Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Carcinogenesis 29:971-6. 2008
    ..These results suggest that elevated levels of urinary 15-F(2t)-IsoP may be related to increasing level of aflatoxin exposure and are associated with an increased risk of HCC...
  25. pmc Double-strand breaks repair in lymphoblastoid cell lines from sisters discordant for breast cancer from the New York site of the BCFR
    Nicola Machella
    Department of Environmental Health Sciences, Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Carcinogenesis 29:1367-72. 2008
    ..37, 95% CI = 0.51-3.70 and OR = 2.32, 95% CI = 0.57-9.38, P = 0.24). These data suggest that individual differences in EJ capacity may represent a risk factor predisposing women to breast cancer...
  26. ncbi request reprint OGG1 polymorphisms and breast cancer risk
    Pavel Rossner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Cancer Epidemiol Biomarkers Prev 15:811-5. 2006
    ..In addition, data on functionality of these polymorphisms are crucial to understand if these modest differences are important...
  27. pmc Choline metabolism and risk of breast cancer in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FASEB J 22:2045-52. 2008
    ..We observed a significant interaction between dietary betaine intake and the PEMT rs7926 polymorphism (P(interaction)=0.04). Our findings suggest that choline metabolism may play an important role in breast cancer etiology...
  28. pmc Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study
    Frederica P Perera
    Department of Environmental Health Sciences, Columbia Center for Children s Environmental Health, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 15:1417-9. 2006
  29. ncbi request reprint Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Carcinogenesis 28:1504-9. 2007
    ..Although the pathway is a network of interrelated enzymes, redundancy exists; evaluating the rate-limiting enzyme and its interaction with environment and other genes within the same pathway is critical in assessing breast cancer risk...
  30. pmc Aberrant methylation of RASSF1A in plasma DNA before breast cancer diagnosis in the Breast Cancer Family Registry
    Hulya Yazici
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 18:2723-5. 2009
    ..These results, if replicated, suggest that aberrant promoter hypermethylation in serum/plasma DNA may be common among high-risk women and may be present years before cancer diagnosis...
  31. ncbi request reprint High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Mol Carcinog 35:85-92. 2002
    ..No association was found between methylation status and p53 status. These results suggest the hypothesis that exposure to environmental carcinogens may be involved in altered methylation of genes involved in cancer development...
  32. ncbi request reprint One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer
    Jia Chen
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 65:1606-14. 2005
    ..96) or total folate intake (OR, 1.71; 95% CI, 1.08-2.71). From a public heath perspective, it is important to identify risk factors, such as low B vitamin consumption, that may guide an effective prevention strategy against the disease...
  33. ncbi request reprint In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns
    Frederica Perera
    Columbia University School of Public Health, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 11:1134-7. 2002
    ..These results provide the first demonstration of a molecular link between somatic mutation in the newborn and transplacental exposure to common air pollutants, a finding that is relevant to cancer risk assessment...
  34. doi request reprint The definition of life: a survey of obstetricians and neonatologists in New York City hospitals regarding extremely premature births
    Sharon M Ramsay
    Mailman School of Public Health, Columbia University, 2726 State Highway 12, Oxford, NY 13830, USA
    Matern Child Health J 15:446-52. 2011
    ..Whereas reporting requirements are based on definitions of live birth and fetal death, physicians make resuscitation and other clinical decisions regarding extremely premature infants based on definitions of viability...
  35. pmc Activated checkpoint kinase 2 expression and risk for oral squamous cell carcinoma
    Angela J Yoon
    College of Dental Medicine, Division of Oral and Maxillofacial Pathology, Columbia University Medical Center, 630 West 168th Street, PH15W 1562, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 16:2768-72. 2007
    ..Included in both groups were lesions with histologically confirmed dysplasia and those that lacked histologic evidence of atypia...
  36. ncbi request reprint Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas
    Mary Beth Terry
    Mailman School of Public Health, Department of Epidemiology, Columbia University, 722 West 168th Street, Room 724A, New York, NY 10032, USA
    Cancer Causes Control 18:1039-46. 2007
    ..The alcohol dehydrogenase gene has several polymorphisms which may lead to faster conversion of ethanol to acetaldehyde, which may increase cancer risk...
  37. ncbi request reprint Short telomere length and breast cancer risk: a study in sister sets
    Jing Shen
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Cancer Res 67:5538-44. 2007
    ..3; 95% CI, 0.5-3.6 for Q4 versus Q1). If these associations are replicated in larger studies, they provide modest epidemiologic evidence that shortened telomere length may be associated with breast cancer risk...
  38. ncbi request reprint Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Clin Cancer Res 13:2378-84. 2007
    ..We explored the possible diagnostic value of aberrant promoter hypermethylation of three tumor suppressor genes in serum DNA for early detection of HCC...
  39. pmc Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients
    Yoon Hee Cho
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168 St New York, NY 10032, USA
    Anticancer Res 30:2489-96. 2010
    ..This study was carried out to determine whether aberrant methylation in WBC DNA can be used as a surrogate biomarker for breast cancer risk...
  40. pmc Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules
    Yu Chen
    Departments of Environmental Medicine and Medicine, and New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Environ Health Perspect 115:1415-20. 2007
    ..Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority...
  41. pmc Multiple genetic variants in telomere pathway genes and breast cancer risk
    Jing Shen
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th Street, P and S 19 418, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 19:219-28. 2010
    ..To explore the etiologic role of genetic variants in telomere pathway genes and breast cancer risk...
  42. doi request reprint Effect of selenium and vitamin e supplementation on plasma protein carbonyl levels in patients with arsenic-related skin lesions
    Julie Mahata
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Nutr Cancer 60:55-60. 2008
    ....
  43. pmc Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk
    Yu Chen
    Department of Environmental Medicine, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
    Cancer Res 68:9729-34. 2008
    ..90; 95% CI, 0.53-1.51; P for interaction=0.04). The findings suggest that placental CGB5 genotype may be predictive of maternal post-pregnancy breast cancer risk among women who give birth early in life...
  44. doi request reprint Genomic DNA methylation among women in a multiethnic New York City birth cohort
    Mary Beth Terry
    Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 17:2306-10. 2008
    ..Larger studies and studies that measure within-individual changes in DNA methylation over time are a necessary next step...
  45. pmc Silencing of Hint1, a novel tumor suppressor gene, by promoter hypermethylation in hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 W 168th St, New York, NY 10032, USA
    Cancer Lett 275:277-84. 2009
    ..These results suggest that promoter hypermethylation of Hint1 may play a role in hepatocarcinogenesis...
  46. pmc Association between plasma 25-hydroxyvitamin D and breast cancer risk
    Katherine D Crew
    Department of Medicine, Division of Hematology Oncology, Columbia University, New York, New York 10032, USA
    Cancer Prev Res (Phila) 2:598-604. 2009
    ..Well-designed clinical trials are urgently needed to determine whether vitamin D supplementation is effective for breast cancer chemoprevention...
  47. pmc Expression of activated checkpoint kinase 2 and histone 2AX in exfoliative oral cells after exposure to ionizing radiation
    Angela J Yoon
    Columbia University College of Dental Medicine, Columbia University Medical Center, 630 West 168th Street, PH15W 1562, New York, NY 10032, USA
    Radiat Res 171:771-5. 2009
    ..Both biomarkers showed statistically significant increases in levels of expression after the radiation exposure (P < 0.001). This suggests that pChk2 and gamma-H2AX may serve as sensitive indicators of low-dose radiation exposure...
  48. pmc Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk
    Jing Shen
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th Street, P and S 19 418, New York, NY 10032, USA
    Eur J Cancer 44:710-7. 2008
    ..69). These data suggest that XPCs have neither independent effects nor interactions with cigarette smoking and PAH-DNA adducts for breast cancer risk. Further studies with multiple genetic polymorphisms in NER pathway are warranted...
  49. ncbi request reprint Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk
    Katherine D Crew
    Department of Medicine and the Herbert Irving Comprehensive Cancer Center, Columbia University, 161 Fort Washington Avenue, 10 1072, New York, NY 10032, USA
    Carcinogenesis 28:2548-51. 2007
    ..Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in the FAS gene and detectable PAH-DNA adducts...
  50. ncbi request reprint Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk
    Katherine D Crew
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 161 Fort Washington Avenue, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 16:2033-41. 2007
    ..Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in NER pathway genes and detectable PAH-DNA adducts...
  51. ncbi request reprint Polymorphisms in cyclin D1 gene and hepatocellular carcinoma
    Yu Jing Zhang
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, New York 10032, USA
    Mol Carcinog 33:125-9. 2002
    ..The A870G polymorphism in CCND1 may influence differentiation and prognosis in HCC patients but requires further study...
  52. ncbi request reprint Organochlorine pesticide exposure in essential tremor: a case-control study using biological and occupational exposure assessments
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurotoxicology 27:579-86. 2006
    ..Our data suggest that these tremor-producing chemicals are not of major etiological importance in our patients with ET...
  53. ncbi request reprint Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients
    Yu Jing Zhang
    Department of Environmental Health Science, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Int J Cancer 119:985-91. 2006
    ..These data suggest that genetic, epigenetic and environmental exposure biomarkers in plasma may help in estimating the risk for the development of HCC...
  54. ncbi request reprint ADH3 genotype, alcohol intake and breast cancer risk
    Mary Beth Terry
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA, and Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Carcinogenesis 27:840-7. 2006
    ..9, 95 % CI=1.2-7.1; postmenopausal women OR=1.8, 95% CI=0.9-3.8). These population-based data support the hypothesis that fast metabolizers of alcohol have a higher risk of breast cancer risk, from alcohol intake than slow metabolizers...
  55. ncbi request reprint MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk
    Jing Shen
    Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
    Carcinogenesis 26:2131-7. 2005
    ....
  56. ncbi request reprint Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk
    Jing Shen
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 14:336-42. 2005
    ..Further understanding of the biological function of XRCC1 variants and their interactions with PAH-DNA adducts, antioxidants, and other genes in the pathway are needed...
  57. pmc Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Breast Cancer Res 7:R71-81. 2005
    ....
  58. ncbi request reprint Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, and breast cancer risk
    Mary Beth Terry
    Department of Epidemiology, Mailman School of Public Health, Columbia University, PH 18 102, 600 West 168th Street, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 13:2053-8. 2004
    ..Overall, this study suggests that those individuals with this polymorphism in the XPD gene may face an increased risk of breast cancer from PAH-DNA adducts and cigarette smoking...
  59. ncbi request reprint A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 85:121-31. 2004
    ....
  60. ncbi request reprint Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columfbia University, Room 720G, 722 West 168th Street, New York, NY 10032, USA
    Cancer Lett 201:57-65. 2003
    ..Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions...
  61. ncbi request reprint IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer risk
    Jing Shen
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Breast Cancer Res Treat 99:1-7. 2006
    ..Additional studies focused on the biological function of the variant-G allele and interactions with other genetic polymorphisms are necessary to confirm our findings...
  62. ncbi request reprint Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry
    Mary Beth Terry
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 724, New York, NY 10032, USA
    Breast Cancer Res Treat 106:281-8. 2007
    ..However, only 19% and 42% of sisters were discordant by ADH1B and ADH1C, respectively, and even fewer were discordant by both genotype and alcohol intake, making it difficult to detect differences if they existed...
  63. ncbi request reprint Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer
    Heather Greenlee
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, 7th Floor, New York, NY 10032, USA
    Breast Cancer Res Treat 102:111-7. 2007
    ....
  64. ncbi request reprint Relationship between urinary 15-F2t-isoprostane and 8-oxodeoxyguanosine levels and breast cancer risk
    Pavel Rossner
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 15:639-44. 2006
    ..In summary, our results suggest that urinary markers of lipid peroxidation and oxidative DNA damage may be associated with breast cancer risk...
  65. pmc Polycyclic aromatic hydrocarbon- and aflatoxin-albumin adducts, hepatitis B virus infection and hepatocellular carcinoma in Taiwan
    Hui Chen Wu
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, USA
    Cancer Lett 252:104-14. 2007
    ..Environmental PAH exposure seems to enhance the hepatocarcinogenicity of chronic HBV infection...
  66. ncbi request reprint Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer
    Jing Shen
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 701 West 168th Street, Room 505, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 15:1614-9. 2006
    ..These findings suggest that those polymorphisms we have investigated to date in nucleotide excision repair pathway genes explain only a small amount of the variability in DRC...
  67. ncbi request reprint DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis
    Habibul Ahsan
    Department of Epidemiology, Mailman School of Public Health, Columbia University, Room 18 129, 622 West 168th Street, New York, NY 10032, USA
    Toxicol Lett 143:123-31. 2003
    ..Future larger studies are needed to confirm this novel finding and investigate how combinations of different candidate genes and/or other host and environmental factors may influence the risk of arsenic induced skin and other cancers...
  68. ncbi request reprint Arsenic induces oxidative DNA damage in mammalian cells
    Maris Kessel
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, NY 10032, USA
    Mol Cell Biochem 234:301-8. 2002
    ..Taken together, our data provide clear evidence that reactive oxygen species play an important causal role in the genotoxicity of arsenic in mammalian cells...
  69. ncbi request reprint Is correction for protein concentration appropriate for protein adduct dosimetry? Hypothesis and clues from an aflatoxin B1-exposed population
    Tao Peng
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China
    Cancer Sci 98:140-6. 2007
    ..The present data suggest that interindividual variation in plasma protein concentration may influence the dosimetry and relevant interpretation of protein biomarkers...
  70. ncbi request reprint Cooked meat and risk of breast cancer--lifetime versus recent dietary intake
    Susan E Steck
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Epidemiology 18:373-82. 2007
    ..Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs) are carcinogens formed in or on the surface of well-done meat, cooked at high temperature...
  71. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysis
    Marilie D Gammon
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    Arch Environ Health 59:640-9. 2004
    ..These data provide only modest support for an association between PAH-DNA adducts and breast cancer development...
  72. ncbi request reprint Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer
    Shu Yuan Chen
    Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taipei, Taiwan
    Int J Cancer 108:606-12. 2004
    ..Our study suggests the importance of gene-environment interaction on the development of incomplete IM...
  73. ncbi request reprint Active and passive cigarette smoke and breast cancer survival
    Sharon K Sagiv
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Ann Epidemiol 17:385-93. 2007
    ..The association between active and passive cigarette smoking before breast cancer diagnosis and survival was investigated among a cohort of invasive breast cancer cases (n = 1273) participating in a population-based case-control study...
  74. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh
    M Hafizur Rahman
    Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University BSMMU, Dhaka, Bangladesh
    Int Arch Occup Environ Health 76:533-8. 2003
    ..In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds...
  75. ncbi request reprint Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts
    Marilie D Gammon
    Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 11:677-85. 2002
    ..These data indicate that PAH-DNA adduct formation may influence breast cancer development, although the association does not appear to be dose dependent and may have a threshold effect...
  76. ncbi request reprint Associated factors in modulating aflatoxin B1-albumin adduct level in three Chinese populations
    Peng Tao
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China
    Dig Dis Sci 50:525-32. 2005
    ..The relationship between AAA level and liver biochemistry indicates injury induced by aflatoxin to both hepatic parenchyma and biliary tract. But the associations vary with age and HV infection status...
  77. ncbi request reprint Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York
    Mia M Gaudet
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res Treat 108:93-9. 2008
    ..p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function...
  78. pmc No effect of cigarette smoking dose on oxidized plasma proteins
    Chih Ching Yeh
    Department of Health Risk Management, China Medical University College of Public Health, Taichung, Taiwan
    Environ Res 106:219-25. 2008
    ..Our results indicate that the measurement of plasma carbonyls by this ELISA technique is still an easy and suitable method for studies of diseases related to oxidative stress...
  79. ncbi request reprint Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 27:1876-82. 2006
    ..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers...
  80. ncbi request reprint Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York
    Mia M Gaudet
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hil, NC 27516, USA
    Breast Cancer Res Treat 99:235-40. 2006
    ....
  81. pmc Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma
    Zhi Ming Liu
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi Province, China
    Cancer Lett 263:212-22. 2008
    ..Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region...
  82. ncbi request reprint Evaluation of oxidative stress in a group of adolescents exposed to a high level of aflatoxin B1--a multi-center and multi-biomarker study
    Tao Peng
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Province, China
    Carcinogenesis 28:2347-54. 2007
    ..These findings suggest significant contribution from AFB1 exposure to oxidative stress and subsequent repair among adolescents that may impose substantial risk for hepatocarcinogenesis in adulthood in this region...
  83. doi request reprint PAH, genetic susceptibility and breast cancer risk: an update from the Long Island Breast Cancer Study Project
    Marilie D Gammon
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Eur J Cancer 44:636-40. 2008
  84. ncbi request reprint IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study Project
    Rebecca J Cleveland
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Carcinogenesis 27:758-65. 2006
    ..Our results demonstrate a role for alleles with fewer than (CA)19 repeats as a risk factor for breast cancer and also suggest that several traditional breast cancer risk factors modify the association of the IGF1 (CA)19 repeat genotype...
  85. ncbi request reprint MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York
    Mia M Gaudet
    Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
    Cancer Causes Control 16:1225-34. 2005
    ..This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk...
  86. ncbi request reprint Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement use
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Epidemiol 162:943-52. 2005
    ..CC genotypes were prevalent in approximately 64% of controls; thus, the preventive potential for fruit consumption has widespread implications...
  87. ncbi request reprint GSTM1 [corrected] deletion modifies the levels of polycyclic aromatic hydrocarbon-DNA adducts in human sperm
    Valentina Paracchini
    Molecular and Genetic Epidemiology Unit, Palazzina Bertarelli, Fondazione Policlinico IRCCS, Via Pace 9, 20122 Milano, Italy
    Mutat Res 586:97-101. 2005
    ..This study presents for the first time the effect of a common polymorphism in a gene that metabolizes PAHs on DNA-adduct levels in sperm...
  88. ncbi request reprint Oxidative and nitrosative stress markers in bus drivers
    Pavel Rossner
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, Videnska 1083, 142 20 Prague, Czech Republic
    Mutat Res 617:23-32. 2007
    ..32, p<0.001). Both oxidative and nitrosative stress markers positively correlated with PM2.5 and PM10 exposure. In conclusion, our study indicates that exposure to PM2.5 and PM10 results in increased oxidative and nitrosative stress...

Research Grants16

  1. Biological Markers of Aflatoxin Exposure and Methylation
    Regina M Santella; Fiscal Year: 2010
    ..The development of screening methods for the early detection of disease in high risk populations will lead to better treatment and survival. ..
  2. BIOLOGICAL MARKERS OF AFLATOXIN EXPOSURE
    Regina Santella; Fiscal Year: 2007
    ..Our collaborative study with Dr. Chen has provided much useful data on environmental and genetic risk factors for cancer development. ..
  3. Center for Environmental Health in Northern Manhattan
    Regina Santella; Fiscal Year: 2007
    ..Strong institutional commitment further strengthens the Center. ..
  4. BIOLOGICAL MARKERS OF AFLATOXIN EXPOSURE
    Regina Santella; Fiscal Year: 2004
    ..These pilot studies will allow us to determine whether tumor DNA can be found at a high enough frequency to be useful in diagnosis and studies of etiology, when in the cancer process they are detectable. ..
  5. BIOLOGICAL MARKERS OF AFLATOXIN EXPOSURE
    Regina Santella; Fiscal Year: 2000
    ..Preliminary to an intervention study, current serum levels of several micronutrients in a high risk region will be determined to assess whether subjects living in this area are deficient. ..