L Saiman

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Risk factors for hospital-acquired infections in the neonatal intensive care unit
    Lisa Saiman
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Semin Perinatol 26:315-21. 2002
  2. pmc Epidemiology of nontuberculous mycobacteria in patients without HIV infection, New York City
    Ethan E Bodle
    Columbia University, New York, New York, USA
    Emerg Infect Dis 14:390-6. 2008
  3. pmc Antimicrobial resistance among isolates causing invasive pneumococcal disease before and after licensure of heptavalent conjugate pneumococcal vaccine
    Tom Theodore Karnezis
    Department of Pediatrics, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 4:e5965. 2009
  4. doi request reprint Infection control in cystic fibrosis: barriers to implementation and ideas for improvement
    Lisa Saiman
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Curr Opin Pulm Med 15:626-31. 2009
  5. ncbi request reprint Open-label, follow-on study of azithromycin in pediatric patients with CF uninfected with Pseudomonas aeruginosa
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Pediatr Pulmonol 47:641-8. 2012
  6. pmc Adherence with tobramycin inhaled solution and health care utilization
    Becky A Briesacher
    University of Massachusetts Medical School and Meyers Primary Care Institute, Worcester, MA, USA
    BMC Pulm Med 11:5. 2011
  7. ncbi request reprint Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial
    Lisa Saiman
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032 3784, USA
    JAMA 290:1749-56. 2003
  8. pmc Evaluation of MicroScan Autoscan for identification of Pseudomonas aeruginosa isolates from cystic fibrosis patients
    Lisa Saiman
    Department of Pediatrics, Division of Infectious Diseases, Columbia University, New York, New York 10032, USA
    J Clin Microbiol 41:492-4. 2003
  9. ncbi request reprint Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Clin Infect Dis 37:1313-9. 2003
  10. pmc Infection control in cystic fibrosis
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Clin Microbiol Rev 17:57-71. 2004

Detail Information

Publications96

  1. ncbi request reprint Risk factors for hospital-acquired infections in the neonatal intensive care unit
    Lisa Saiman
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Semin Perinatol 26:315-21. 2002
    ..An understanding of the risk factors that are associated with hospital-acquired infections is essential to design preventive strategies...
  2. pmc Epidemiology of nontuberculous mycobacteria in patients without HIV infection, New York City
    Ethan E Bodle
    Columbia University, New York, New York, USA
    Emerg Infect Dis 14:390-6. 2008
    ..avium complex (MAC) (27%, (p < 0.01). NTM disease in patients without HIV is increasing. Laboratory-based surveillance may be useful for detecting non-MAC and non-respiratory tract disease...
  3. pmc Antimicrobial resistance among isolates causing invasive pneumococcal disease before and after licensure of heptavalent conjugate pneumococcal vaccine
    Tom Theodore Karnezis
    Department of Pediatrics, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 4:e5965. 2009
    ..We assessed trends in IPD including trends for IPD caused by penicillin non-susceptible strains before and after licensure of PCV-7 and the impact of the 2008 susceptibility breakpoints for penicillin on the epidemiology of resistance...
  4. doi request reprint Infection control in cystic fibrosis: barriers to implementation and ideas for improvement
    Lisa Saiman
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Curr Opin Pulm Med 15:626-31. 2009
    ..In addition, controversies regarding optimal infection control will be discussed. Finally, suggestions to improve infection control in CF will be proposed...
  5. ncbi request reprint Open-label, follow-on study of azithromycin in pediatric patients with CF uninfected with Pseudomonas aeruginosa
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Pediatr Pulmonol 47:641-8. 2012
    ..We now report the results of the open-label, follow-on study to assess durability of response to azithromycin and continued safety and tolerability...
  6. pmc Adherence with tobramycin inhaled solution and health care utilization
    Becky A Briesacher
    University of Massachusetts Medical School and Meyers Primary Care Institute, Worcester, MA, USA
    BMC Pulm Med 11:5. 2011
    ..Adherence with tobramycin inhalation solution (TIS) during routine cystic fibrosis (CF) care may differ from recommended guidelines and affect health care utilization...
  7. ncbi request reprint Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial
    Lisa Saiman
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032 3784, USA
    JAMA 290:1749-56. 2003
    ..Treatment strategies for cystic fibrosis (CF) lung disease include antibiotics, mucolytics, and anti-inflammatory therapies. Increasing evidence suggests that macrolide antibiotics might be beneficial in patients with CF...
  8. pmc Evaluation of MicroScan Autoscan for identification of Pseudomonas aeruginosa isolates from cystic fibrosis patients
    Lisa Saiman
    Department of Pediatrics, Division of Infectious Diseases, Columbia University, New York, New York 10032, USA
    J Clin Microbiol 41:492-4. 2003
    ..Extending the incubation to 48 h improved identification, but 15% of isolates remained misidentified. The MicroScan Autoscan system cannot be recommended for the identification of P. aeruginosa isolates from CF patients...
  9. ncbi request reprint Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Clin Infect Dis 37:1313-9. 2003
    ..We report that MW2, which was previously limited to the midwestern United States, has spread to the northeastern United States and has become a health care-associated pathogen...
  10. pmc Infection control in cystic fibrosis
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Clin Microbiol Rev 17:57-71. 2004
    ..It will be critical to measure the dissemination, implementation, and potential impact of these guidelines to monitor changes in practice and reduction in infections...
  11. ncbi request reprint The mycobacteriology of non-tuberculous mycobacteria
    Lisa Saiman
    Columbia University, New York, NY 10032, USA
    Paediatr Respir Rev 5:S221-3. 2004
    ..Pulsed- field gel electrophoresis is the method of choice to determine strain relatedness. At present, susceptibility testing for non-tuberculous mycobacteria is not fully standardised and has not been correlated with clinical outcomes...
  12. ncbi request reprint Microbiology of early CF lung disease
    Lisa Saiman
    Columbia University, New York 10032, USA
    Paediatr Respir Rev 5:S367-9. 2004
    ..aeruginosa from the lower airway was unlikely, but a positive culture did not predict lower airway infection. Similar findings were noted for H. influenzae and S. aureus...
  13. ncbi request reprint The use of macrolide antibiotics in patients with cystic fibrosis
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Curr Opin Pulm Med 10:515-23. 2004
    ..There has been much recent interest in the use of macrolide antibiotics as chronic suppressive therapy in patients with cystic fibrosis. Three recent randomized, placebo-controlled trials have been conducted...
  14. ncbi request reprint Heterogeneity of treatment response to azithromycin in patients with cystic fibrosis
    Lisa Saiman
    Department of Pediatics, Columbia University, NY 10032, USA
    Am J Respir Crit Care Med 172:1008-12. 2005
    ..2% improvement in the 168-d relative change in FEV1 among azithromycin participants compared with placebo participants...
  15. ncbi request reprint Strategies for prevention of nosocomial sepsis in the neonatal intensive care unit
    Lisa Saiman
    Columbia University, Department of Pediatrics, Division of Infectious Diseases, New York 10032, USA
    Curr Opin Pediatr 18:101-6. 2006
    ....
  16. ncbi request reprint Providing a safety net for children: investigating a multistate outbreak of Ralstonia mannitolilytica related to a contaminated reusable device
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York, USA
    Pediatrics 119:1207-9. 2007
  17. ncbi request reprint Clinical utility of synergy testing for multidrug-resistant Pseudomonas aeruginosa isolated from patients with cystic fibrosis: 'the motion for'
    Lisa Saiman
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Paediatr Respir Rev 8:249-55. 2007
    ..Synergy testing has also been advocated for isolates from patients failing to respond to therapy for treatment of a pulmonary exacerbation or from patients with substantial drug allergies for whom antibiotic choices are limited...
  18. doi request reprint Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa: a randomized controlled trial
    Lisa Saiman
    Columbia University, Department of Pediatrics, 650 W 168th St, PH 4 West, Room 420, New York, NY 10032, USA
    JAMA 303:1707-15. 2010
    ..Azithromycin is recommended as therapy for cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa infection, but there has not been sufficient evidence to support the benefit of azithromycin in other patients with CF...
  19. doi request reprint Infection prevention and control in cystic fibrosis
    Lisa Saiman
    Department of Pediatrics, Columbia University, and Morgan Stanley Children s Hospital of NewYork Presbyterian, New York, New York 10032, USA
    Curr Opin Infect Dis 24:390-5. 2011
    ....
  20. pmc Identification and antimicrobial susceptibility of Alcaligenes xylosoxidans isolated from patients with cystic fibrosis
    L Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Clin Microbiol 39:3942-5. 2001
    ..xylosoxidans from other CF pathogens. Standards for processing CF specimens should be developed, and the optimal method for antimicrobial susceptibility testing of A. xylosoxidans should be determined...
  21. pmc Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis
    L Saiman
    Department of Pediatrics, Columbia University, 650 West 168th St, New York, NY 10032, USA
    Antimicrob Agents Chemother 45:2838-44. 2001
    ..The tested cathelicidin-derived peptides represent a novel class of antimicrobial agents and warrant further development as prophylactic or therapeutic agents for CF lung disease...
  22. ncbi request reprint Prevalence of infectious diseases among internationally adopted children
    L Saiman
    Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Pediatrics 108:608-12. 2001
    ..Internationally adopted children are at increased risk of infections acquired in their country of origin. Ongoing surveillance of this unique population is needed to detect changing epidemiology and provide appropriate care...
  23. ncbi request reprint Risk factors for latent tuberculosis infection among children in New York City
    L Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Pediatrics 107:999-1003. 2001
    ....
  24. pmc Synergistic activities of macrolide antibiotics against Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans isolated from patients with cystic fibrosis
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Antimicrob Agents Chemother 46:1105-7. 2002
    ....
  25. ncbi request reprint Risk factors for candidemia in Neonatal Intensive Care Unit patients. The National Epidemiology of Mycosis Survey study group
    L Saiman
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Pediatr Infect Dis J 19:319-24. 2000
    ..Candida species are important nosocomial pathogens in neonatal intensive care unit (NICU) patients...
  26. pmc Evaluation of reference dilution test methods for antimicrobial susceptibility testing of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis
    L Saiman
    Department of Pediatrics and Clinical Microbiology, Columbia University, New York, New York 10032, USA
    J Clin Microbiol 37:2987-91. 1999
    ..Thus, this broth microdilution assay can serve as a reference method and facilitate future studies to determine the optimal method for antibiotic susceptibility testing of CF strains...
  27. ncbi request reprint Molecular epidemiology of staphylococcal scalded skin syndrome in premature infants
    L Saiman
    Department of Pediatrics, Columbia University and Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Pediatr Infect Dis J 17:329-34. 1998
    ..We describe two cases of SSSS in very low birth weight infants in a neonatal intensive care unit (NICU) and the success of infection control strategies used to prevent an outbreak...
  28. ncbi request reprint Risk factors for Candida species colonization of neonatal intensive care unit patients
    L Saiman
    Department of Pediatrics, Columbia University, New York, NY, USA
    Pediatr Infect Dis J 20:1119-24. 2001
    ..particularly C. parapsilosis, from the hands of health care workers. H2 blockers, third generation cephalosporins and delayed enteral feedings alter gastrointestinal tract ecology, thereby facilitating colonization...
  29. pmc Comparison of agar diffusion methodologies for antimicrobial susceptibility testing of Pseudomonas aeruginosa isolates from cystic fibrosis patients
    J L Burns
    Department of Pediatrics, Division of Infectious Disease, University of Washington, Seattle, Washington, USA
    J Clin Microbiol 38:1818-22. 2000
    ..1 and 2.2% major errors (false resistance). Overall, both agar diffusion methods appear to be broadly acceptable for routine clinical use in susceptibility testing of CF isolates of P. aeruginosa...
  30. ncbi request reprint Comparison of two commercial systems (Vitek and MicroScan-WalkAway) for antimicrobial susceptibility testing of Pseudomonas aeruginosa isolates from cystic fibrosis patients
    J L Burns
    Department of Pediatrics, Division of Infectious Disease, Children s Hospital and Regional Medical Center, University of Washington, P O Box 5371 CH 32, Seattle, WA 98105 0371, USA
    Diagn Microbiol Infect Dis 39:257-60. 2001
    ....
  31. ncbi request reprint Nonsusceptible Streptococcus pneumoniae in children with chronic otitis media with effusion and recurrent otitis media undergoing ventilating tube placement
    J Haddad
    Division of Pediatric Otolaryngology Head and Neck Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Pediatr Infect Dis J 19:432-7. 2000
    ..If these children undergo ventilating tube placement, there is an opportunity to culture middle ear fluid and the nasopharynx to determine carriage of NSP...
  32. ncbi request reprint Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. The National Epidemiology of Mycosis Survey
    H M Blumberg
    Division of Infectious Diseases, Department of Medicine, Emory University School of Medicinel, Atlanta, GA 30303, USA
    Clin Infect Dis 33:177-86. 2001
    ..3). Prospective clinical studies are needed to identify which antifungal agents are most protective and which high-risk patients will benefit from antifungal prophylaxis...
  33. ncbi request reprint Predictors and outcomes for pregnant women with vaginal-rectal carriage of community-associated methicillin-resistant Staphylococcus aureus
    Katherine T Chen
    Department of Obstetrics and Gynecology, Columbia University, New York, New York 10032, USA
    Am J Perinatol 24:235-40. 2007
    ..Additional microbiologic studies and epidemiologic studies are needed to clarify the relationship between S. aureus and GBS, given that these two colonizing organisms have the potential to become pathogens...
  34. doi request reprint Respiratory microbiology of patients with cystic fibrosis in the United States, 1995 to 2005
    Samiya Razvi
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Chest 136:1554-60. 2009
    ..Numerous improvements in diagnostic and therapeutic strategies for patients with cystic fibrosis (CF) have occurred during the past 2 decades. We hypothesized that these changes could impact trends in respiratory microbiology...
  35. ncbi request reprint Gram-negative bacilli associated with catheter-associated and non-catheter-associated bloodstream infections and hand carriage by healthcare workers in neonatal intensive care units
    Elaine L Larson
    Department of Pediatrics, School of Nursing, Columbia University, New York, NY, USA
    Pediatr Crit Care Med 6:457-61. 2005
    ....
  36. ncbi request reprint The epidemiology of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit, 2000-2007
    A J Carey
    Department of Pediatrics, Division of Neonatology, Columbia University, New York, NY 10032, USA
    J Perinatol 30:135-9. 2010
    ..To assess the epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) infections in a neonatal intensive care unit (NICU)...
  37. ncbi request reprint An outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit
    Lisa Saiman
    Department of Pediatrics Columbia University and New York Presbyterian Medical Center, Children s Hospital of New York, New York, New York 10032, USA
    Infect Control Hosp Epidemiol 24:317-21. 2003
    ..To describe the epidemiologic and molecular investigations that successfully contained an outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a neonatal intensive care unit (NICU)...
  38. ncbi request reprint Safety and tolerability of linezolid in children
    Lisa Saiman
    Columbia University, New York, NY, USA
    Pediatr Infect Dis J 22:S193-200. 2003
    ..Because of the increasing use of linezolid, it is important to review the common adverse events (AEs) associated with its use in children with the use of data from clinical trials...
  39. ncbi request reprint Outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails
    Archana Gupta
    Department of Pediatrics, Columbia University, New York Presbyterian Hospital, New York, New York 10032, USA
    Infect Control Hosp Epidemiol 25:210-5. 2004
    ..From April to June 2001, an outbreak of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae infections was investigated in our neonatal intensive care unit...
  40. ncbi request reprint Epidemiology of enterococci in a neonatal intensive care unit
    Jennifer Duchon
    College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Infect Control Hosp Epidemiol 29:374-6. 2008
    ..Surveillance triggered by even a single clinical culture positive for VRE may be justified in the neonatal intensive care unit, because a single culture result may represent a large hidden reservoir of VRE-colonized infants...
  41. pmc Antimicrobial resistance patterns of colonizing flora on nurses' hands in the neonatal intensive care unit
    Heather A Cook
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Infect Control 35:231-6. 2007
    ..The purpose of this study was to examine effects of hand hygiene product and skin condition on the antimicrobial resistance patterns of colonizing hand flora among nurses...
  42. ncbi request reprint Epidemiology of methicillin-susceptible Staphylococcus aureus in the neonatal intensive care unit
    Philip L Graham
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Infect Control Hosp Epidemiol 23:677-82. 2002
    ....
  43. pmc Concordance of Gastrointestinal Tract Colonization and Subsequent Bloodstream Infections With Gram-negative Bacilli in Very Low Birth Weight Infants in the Neonatal Intensive Care Unit
    Ann Smith
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Pediatr Infect Dis J 29:831-5. 2010
    ....
  44. pmc Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection
    J P Clancy
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Thorax 68:818-25. 2013
    ..Arikace is a liposomal amikacin preparation for aerosol delivery with potent Pseudomonas aeruginosa killing and prolonged lung deposition...
  45. ncbi request reprint Nosocomial rotavirus in a pediatric hospital
    A J Ratner
    Department of Pediatrics, Babies and Children's Hospital of New York, New York-Presbyterian Medical Center, Columbia University, College of Physicians and Surgeons, New York City, USA
    Infect Control Hosp Epidemiol 22:299-301. 2001
    ..Improved compliance with infection control and case-finding among patients and healthcare workers halted the outbreak...
  46. ncbi request reprint Update on the epidemiology and management of Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, in patients with cystic fibrosis
    Anne Stone
    Department of Pediatrics, Division of Pediatric Pulmonary Medicine, Morgan Stanley Children s Hospital of New York Presbyterian Hospital, New York, New York 10032, USA
    Curr Opin Pulm Med 13:515-21. 2007
    ..aureus...
  47. doi request reprint Hospital-acquired infections in the NICU: epidemiology for the new millennium
    Alison J Carey
    Division of Neonatology, Columbia University Medical Center, New York Presbyterian Hospital, 3959 Broadway, CHC 115, New York, NY 10032, USA
    Clin Perinatol 35:223-49, x. 2008
    ..This review focuses on two major pathogens that cause nosocomial infection, Candida and methicillin-resistant Staphylococcus aureus. The difficult diagnosis of meningitis in the neonate also is discussed...
  48. ncbi request reprint Evaluation and treatment of neonates with suspected late-onset sepsis: a survey of neonatologists' practices
    Lorry G Rubin
    Department of Pediatrics, Schneider Children s Hospital of the North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
    Pediatrics 110:e42. 2002
    ..To ascertain current diagnostic and treatment practices for suspected late-onset sepsis in infants in neonatal intensive care units (NICUs) and identify areas that may benefit from clinical practice guidelines...
  49. pmc Risk factors for candidemia in critically ill infants: a matched case-control study
    Kristina N Feja
    Department of Pediatrics, Columbia University Medical Center, New York, New York 10032, USA
    J Pediatr 147:156-61. 2005
    ..To determine risk factors for late-onset candidemia among infants in the neonatal intensive care unit (NICU)...
  50. ncbi request reprint Nosocomial transmission of methicillin-resistant Staphylococcus aureus from a mother to her preterm quadruplet infants
    Anne Sophie Morel
    Department of Pediatrics, Division of Infectious Diseases and New York Presbyterian Hospital, Columbia University, New York, NY 10032, USA
    Am J Infect Control 30:170-3. 2002
    ..We report the first documented outbreak of probable transmission of MRSA from a mother to 3 of her preterm quadruplet infants postnatally...
  51. pmc Epidemiology and diagnosis of hospital-acquired conjunctivitis among neonatal intensive care unit patients
    Janet Haas
    Columbia University School of Nursing, New York, NY, USA
    Pediatr Infect Dis J 24:586-9. 2005
    ..Reporting may be inaccurate in this population given that the National Nosocomial Infection Surveillance System (NNIS) definition is largely dependent on a positive culture, whereas clinical practice often consists of empiric treatment...
  52. ncbi request reprint Attributable costs and length of stay of an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae outbreak in a neonatal intensive care unit
    Patricia W Stone
    School of Nursing, Columbia University, New York, New York, 10032, USA
    Infect Control Hosp Epidemiol 24:601-6. 2003
    ....
  53. ncbi request reprint Infection control recommendations for patients with cystic fibrosis: microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York, USA
    Infect Control Hosp Epidemiol 24:S6-52. 2003
  54. pmc Antimicrobial susceptibility and synergy studies of Stenotrophomonas maltophilia isolates from patients with cystic fibrosis
    Pablo San Gabriel
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Antimicrob Agents Chemother 48:168-71. 2004
    ..To determine appropriate treatment for patients with CF, it is important to monitor the prevalence, antimicrobial susceptibility, and clinical impact of S. maltophilia in this patient population...
  55. pmc Risk factors for late-onset health care-associated bloodstream infections in patients in neonatal intensive care units
    Sharon E Perlman
    Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Infect Control 35:177-82. 2007
    ....
  56. ncbi request reprint Molecular epidemiology of gram-negative bacilli from infected neonates and health care workers' hands in neonatal intensive care units
    Valerie Waters
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Clin Infect Dis 38:1682-7. 2004
    ..In contrast, only 9% of strains that caused infections were cultured from nurses' hands. These data suggest that practices in addition to hand hygiene are needed to prevent horizontal transmission of GNB in the NICU...
  57. pmc Colistin susceptibility testing: evaluation of reliability for cystic fibrosis isolates of Pseudomonas aeruginosa and Stenotrophomonas maltophilia
    Samuel M Moskowitz
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA
    J Antimicrob Chemother 65:1416-23. 2010
    ..To assess the reliability of four standard testing methods, this pilot study used a challenge set that included polymyxin-resistant isolates of Pseudomonas aeruginosa and Stenotrophomonas maltophilia...
  58. ncbi request reprint Development of a statewide collaborative to decrease NICU central line-associated bloodstream infections
    J Schulman
    Department of Pediatrics Newborn Medicine, Weill Cornell Medical College, Weill Cornell Medical Center, New York, NY, USA
    J Perinatol 29:591-9. 2009
    ....
  59. ncbi request reprint Persistence of immunity to varicella-zoster virus after vaccination of healthcare workers
    L Saiman
    Department of Pediatrics, Columbia University, College of Phyicians and Surgeons, New York City, New York 10032, USA
    Infect Control Hosp Epidemiol 22:279-83. 2001
    ..CONCLUSIONS: The VZV vaccine effectively protected HCWs from varicella, particularly from serious disease. Currently available serological tests are not optimal, and improved assays are needed...
  60. ncbi request reprint The gastrointestinal tract serves as the reservoir for Gram-negative pathogens in very low birth weight infants
    Philip L Graham
    Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA
    Pediatr Infect Dis J 26:1153-6. 2007
    ..Ninety-five percent (18 of 19) of paired bloodstream infection or antecedent rectal cultures were genotypically concordant. The gastrointestinal tract is the reservoir for most cases of Gram-negative sepsis in this population...
  61. ncbi request reprint Molecular epidemiology of Serratia marcescens outbreaks in two neonatal intensive care units
    Vladana Milisavljevic
    Department of Pediatrics, School of Nursing, Columbia University, New York, New York, USA
    Infect Control Hosp Epidemiol 25:719-21. 2004
    ..We report the utility of genetic fingerprinting to identify, investigate, and control two distinct outbreaks of S. marcescens...
  62. ncbi request reprint Validation of a multicenter computer-based surveillance system for hospital-acquired bloodstream infections in neonatal intensive care departments
    Philip L Graham
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Am J Infect Control 32:232-4. 2004
    ..The sensitivity (84%), specificity (99%), and positive (84%) and negative (99%) predictive values of NYARP were excellent when coagulase-negative staphylococcal bloodstream infections were removed...
  63. ncbi request reprint Epidemiology of candidemia at a Children's hospital, 2002 to 2006
    Natalie Neu
    Departments of Pediatrics, Columbia University Medical Center, New York, New York, USA
    Pediatr Infect Dis J 28:806-9. 2009
    ..There are few recent studies evaluating trends in the epidemiology of candidemia including changes in species or utilization of antifungal agents in children...
  64. ncbi request reprint Pulmonary infections in patients with cystic fibrosis
    Sujatha Rajan
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Columbia University, New York, NY 10032, USA
    Semin Respir Infect 17:47-56. 2002
    ..Novel strategies to disrupt biofilm formation, stimulate chloride conductance, and replace abnormal CFTR are currently being studied...
  65. ncbi request reprint Antibiotic use in neonatal intensive care units and adherence with Centers for Disease Control and Prevention 12 Step Campaign to Prevent Antimicrobial Resistance
    Sameer J Patel
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, New York, NY, USA
    Pediatr Infect Dis J 28:1047-51. 2009
    ....
  66. ncbi request reprint Staphylococcus aureus nasal colonization among pediatric cystic fibrosis patients and their household contacts
    Anne Stone
    Division of Pediatric Pulmonology, Department of Pediatrics, Columbia University, New York, NY, USA
    Pediatr Infect Dis J 28:895-9. 2009
    ..Little is known about the prevalence of Staphylococcus aureus nasal colonization and the epidemiology of methicillin-susceptible and methicillin-resistant S. aureus (MRSA) among cystic fibrosis (CF) patients and their household members...
  67. doi request reprint Changes in the molecular epidemiological characteristics of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit
    Alison J Carey
    Department of Pediatrics, Division of Neonatology, Drexel University College of Medicine, St Christopher s Hospital For Children, Philadelphia, Pennsylvania 19134, USA
    Infect Control Hosp Epidemiol 31:613-9. 2010
    ..To determine whether the molecular epidemiological characteristics of methicillin-resistant Staphylococcus aureus (MRSA) had changed in a level III neonatal intensive care unit (NICU)...
  68. pmc Completeness of pediatric TB reporting in New York City
    Pablo San Gabriel
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Public Health Rep 118:144-53. 2003
    ..Hospital-based sources were used to develop alternative surveillance to assess completeness of reporting for pediatric TB in northern Manhattan and Harlem from 1993 through 1995...
  69. ncbi request reprint Linezolid treatment of vancomycin-resistant Enterococcus faecium ventriculitis
    Philip L Graham
    Departments of Pediatrics and Epidemiology, Columbia, University, New York, NY 10032, USA
    Pediatr Infect Dis J 21:798-800. 2002
    ..The patient tolerated the therapy without adverse effects...
  70. ncbi request reprint A review of antimicrobial control strategies in hospitalized and ambulatory pediatric populations
    Sameer J Patel
    Department of Pediatrics, Division of Pediatric Infectious Diseases, New York Presbyterian Hospital, New York, NY 10032, USA
    Pediatr Infect Dis J 26:531-7. 2007
    ..Thus, it is difficult to determine the most effective interventions. Future studies should be designed to overcome the biases encountered in current publications...
  71. ncbi request reprint Genetic relatedness of Staphylococcus epidermidis from infected infants and staff in the neonatal intensive care unit
    Vladana Milisavljevic
    Department of Pediatrics, Columbia University, New York, NY, USA
    Am J Infect Control 33:341-7. 2005
    ..The genetic relatedness of Staphylococcus epidermidis associated with infections in infants and cultured from the hands of nurses was assessed...
  72. ncbi request reprint Risk factors for late onset gram-negative sepsis in low birth weight infants hospitalized in the neonatal intensive care unit
    Philip L Graham
    Department of Pediatrics, Columbia University, New York Presbyterian Hospital, New York, NY, USA
    Pediatr Infect Dis J 25:113-7. 2006
    ..We investigated risk factors for late onset Gram-negative sepsis in very low birth weight (<1500 g) NICU patients...
  73. ncbi request reprint Nontuberculous mycobacterial infections in pediatric hematopoietic stem cell transplant recipients: case report and review of the literature
    Ouzama Nicholson
    Department of Pediatrics, Columbia University, New York, NY, USA
    Pediatr Infect Dis J 25:263-7. 2006
    ..We reviewed NTM infections among pediatric HSCT patients at our institution from 2000-2004 and identified 2 additional cases. Fourteen published case reports of NTM disease in children are reviewed...
  74. ncbi request reprint Prevalence of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in pregnant women
    Katherine T Chen
    Department of Obstetrics and Gynecology and Epidemiology, Columbia University, New York, New York 10032, USA
    Obstet Gynecol 108:482-7. 2006
    ..To estimate the extent of Staphylococcus aureus vaginal-rectal colonization among pregnant women as severe S aureus infections have emerged in pregnant and postpartum women and infants...
  75. ncbi request reprint Effectiveness of barrier precautions and surveillance cultures to control transmission of multidrug-resistant organisms: a systematic review of the literature
    Sally W Aboelela
    Center for Interdisciplinary Research on Antimicrobial Resistance, Columbia University School of Nursing, New York, NY 10032, USA
    Am J Infect Control 34:484-94. 2006
    ..We focused on control measures that have a great potential to affect patient care, patient services, and hospital cost/resources: barrier precautions/patient isolation and surveillance cultures...
  76. ncbi request reprint Effect of antiseptic handwashing vs alcohol sanitizer on health care-associated infections in neonatal intensive care units
    Elaine L Larson
    School of Nursing, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, 630 W 168th Street, New York, NY 10032, USA
    Arch Pediatr Adolesc Med 159:377-83. 2005
    ....
  77. pmc In vitro activity of doripenem (S-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis
    Yunhua Chen
    Department of Pediatrics, Columbia University, 622 West 168th St, PH4W 470, New York, NY 10032, USA
    Antimicrob Agents Chemother 49:2510-1. 2005
    ..Doripenem had somewhat better activity than established antimicrobial agents...
  78. ncbi request reprint Plesiomonas shigelloides sepsis and splenic abscess in an adolescent with sickle-cell disease
    K Ampofo
    Division of Pediatric Infectious Diseases, The Children's Hospital of New York, New York-Presbyterian Medical Center, New York, NY, USA
    Pediatr Infect Dis J 20:1178-9. 2001
    ..Despite the high mortality rate reported in extraintestinal P. shigelloides infection, the patient survived after drainage of the abscess and treatment with antibiotics...
  79. doi request reprint Survey of infection control policies for patients with cystic fibrosis in the United States
    Juyan Zhou
    Department of Pediatrics, Columbia University, New York, NY 10032, USA
    Am J Infect Control 36:220-2. 2008
    ..Although routine mask use by patients remains an unresolved issue, many policies advocated this practice. Future studies should address barriers to implementation of these evidence-based guidelines and continue to monitor implementation...
  80. ncbi request reprint Effects of azithromycin on clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients
    Thor Wagner
    Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY, USA
    Chest 128:912-9. 2005
    ..This effect is less predictable against CIs than the prototypic strain PAO1...
  81. pmc Compliance of clinical microbiology laboratories in the United States with current recommendations for processing respiratory tract specimens from patients with cystic fibrosis
    Juyan Zhou
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, College of Physicians and Surgeons, 650 West 168th St, PH 4 West Room 470, New York, NY 10032, USA
    J Clin Microbiol 44:1547-9. 2006
    ..Standardizing laboratory practices will improve treatment, infection control, and our understanding of the changing epidemiology of CF microbiology...
  82. doi request reprint Novel influenza A(H1N1) in a pediatric health care facility in New York City during the first wave of the 2009 pandemic
    Yolanda Miroballi
    Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Pediatr Adolesc Med 164:24-30. 2010
    ..To describe the burden of care experienced by our pediatric health care facility in New York, New York, from May 3, 2009, to July 31, 2009, during the novel influenza A(H1N1) pandemic that began in spring 2009...
  83. ncbi request reprint A survey of latent tuberculosis infection among laboratory healthcare workers in New York City
    Elizabeth Garber
    TB study group, Division of Infectious Diseases, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Infect Control Hosp Epidemiol 24:801-6. 2003
    ..To determine the prevalence of positive tuberculin skin tests (TSTs), incidence of TST conversion, risk factors for positive TSTs, and history of active TB among HCWs in microbiology laboratories in New York City...
  84. pmc Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosis
    Juyan Zhou
    Division of Infectious Diseases, Department of Pediatrics, Columbia University, College of Physicians and Surgeons, 650 West 168th Street, PH 4 West Room 470, New York, NY 10032, USA
    Antimicrob Agents Chemother 51:1085-8. 2007
    ..Minocycline, meropenem, and ceftazidime were the most active, inhibiting 38%, 26%, and 23% of strains, respectively. Synergy was rarely noted (range, 1% to 15% of strains per antibiotic combination)...
  85. ncbi request reprint Nosocomial transmission of Mycobacterium tuberculosis in a children's hospital
    E H Lee
    Department of Pediatrics, Children s Hospital of New York Presbyterian, New York, USA
    Int J Tuberc Lung Dis 9:689-92. 2005
    ..adult facilities, including the importance of screening the adult visitors of children admitted with suspected TB...
  86. pmc Developing Clinical Decision Support within a Commercial Electronic Health Record System to Improve Antimicrobial Prescribing in the Neonatal ICU
    R S Hum
    Department of Pediatrics, Columbia University, NY, NY
    Appl Clin Inform 5:368-87. 2014
    ..To develop and implement a clinical decision support (CDS) tool to improve antibiotic prescribing in neonatal intensive care units (NICUs) and to evaluate user acceptance of the CDS tool...
  87. pmc Prevalence and clinical relevance of Staphylococcus warneri in the neonatal intensive care unit
    Jeannie P Cimiotti
    Center for Health Outcomes and Policy Research, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 28:326-30. 2007
    ..To describe the prevalence of Staphylococcus warneri on the hands of nurses and the clinical relevance of this organism among neonates in the neonatal intensive care unit (NICU)...
  88. ncbi request reprint Hospital-acquired infections in the neonatal intensive care unit. Introduction
    Lisa Saiman
    Semin Perinatol 26:313-4. 2002
  89. ncbi request reprint Bloodstream infections in patients given treatment with intravenous prostanoids
    Alexander J Kallen
    Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Infect Control Hosp Epidemiol 29:342-9. 2008
    ..An investigation was conducted to determine rates of prostanoid-associated BSI in this patient population and possible risk factors for infection...
  90. ncbi request reprint The efficacy and safety of meropenem and tobramycin vs ceftazidime and tobramycin in the treatment of acute pulmonary exacerbations in patients with cystic fibrosis
    Jeffrey L Blumer
    Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Chest 128:2336-46. 2005
    ....
  91. ncbi request reprint Clinical response to azithromycin in cystic fibrosis correlates with in vitro effects on Pseudomonas aeruginosa phenotypes
    Dao Nguyen
    Children s Hospital and Regional Medical Center, Seattle, Washington, USA
    Pediatr Pulmonol 42:533-41. 2007
    ..The in vitro effect of AZM on PLC correlates with FEV(1) response to AZM. This suggests that AZM anti-virulence effects may be predictive of clinical response and play a role in the mechanism of action of AZM in CF patients...
  92. ncbi request reprint A low incidence of nontuberculous mycobacterial infections in pediatric hematopoietic stem cell transplantation recipients
    Elif Unal
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Biol Blood Marrow Transplant 12:1188-97. 2006
    ..Multicenter studies are needed to identify the risk factors, early diagnostic criteria, and optimal therapy...
  93. pmc Factors associated with hand hygiene practices in two neonatal intensive care units
    Bevin Cohen
    Oceanside High School, Oceanside, NY, USA
    Pediatr Infect Dis J 22:494-9. 2003
    ....
  94. pmc Impact of staffing on bloodstream infections in the neonatal intensive care unit
    Jeannie P Cimiotti
    Center for Health Outcomes and Policy Research, School of Nursing, University of Pennsylvania, Philadelphia, 19104 6096, USA
    Arch Pediatr Adolesc Med 160:832-6. 2006
    ..To examine the association between registered nurse staffing and healthcare-associated bloodstream infections in infants in the neonatal intensive care unit (NICU)...
  95. ncbi request reprint Infection control recommendations for patients with cystic fibrosis: Microbiology, important pathogens, and infection control practices to prevent patient-to-patient transmission
    Lisa Saiman
    Am J Infect Control 31:S1-62. 2003
  96. ncbi request reprint Perspectives on antimicrobial resistance: establishing an interdisciplinary research approach
    Elaine L Larson
    School of Nursing and Mailman School of Public Health, USA
    Am J Infect Control 33:410-8. 2005

Research Grants6

  1. Applied Research in Antimicrobial Resistance: Studies of Susceptibility Testing
    Lisa Saiman; Fiscal Year: 2007
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
  2. Improving Antimicrobial Prescribing Practices in the Neonatal Intensive Care Unit
    Lisa Saiman; Fiscal Year: 2009
    ..abstract_text> ..
  3. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
  4. Improving Antimicrobial Prescribing Practices in the Neonatal Intensive Care Unit
    Lisa Saiman; Fiscal Year: 2010
    ..abstract_text> ..