H A Sackeim

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint The definition and meaning of treatment-resistant depression
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, NY 10032, USA
    J Clin Psychiatry 62:10-7. 2001
  2. ncbi request reprint Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Dr, New York, NY 10032, USA
    JAMA 285:1299-307. 2001
  3. ncbi request reprint The effects of vagus nerve stimulation on cognitive performance in patients with treatment-resistant depression
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Neuropsychiatry Neuropsychol Behav Neurol 14:53-62. 2001
  4. ncbi request reprint The cognitive effects of electroconvulsive therapy in community settings
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 32:244-54. 2007
  5. ncbi request reprint Durability of antidepressant response to vagus nerve stimulation (VNS)
    Harold A Sackeim
    Departments of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 10:817-26. 2007
  6. ncbi request reprint Determining the duration of antidepressant treatment: application of signal detection methodology and the need for duration adaptive designs (DAD)
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Biol Psychiatry 59:483-92. 2006
  7. ncbi request reprint A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, NY 10032, USA
    Arch Gen Psychiatry 57:425-34. 2000
  8. doi request reprint Effect of concomitant pharmacotherapy on electroconvulsive therapy outcomes: short-term efficacy and adverse effects
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, New York, USA
    Arch Gen Psychiatry 66:729-37. 2009
  9. ncbi request reprint Optimal length of antidepressant trials in late-life depression
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    J Clin Psychopharmacol 25:S34-7. 2005
  10. pmc Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Brain Stimul 1:71-83. 2008

Research Grants

  1. AFFECTIVE AND COGNITIVE CONSEQUENCES OF ECT
    Harold Sackeim; Fiscal Year: 2003
  2. OPTIMIZATION OF ELECTROCONVULSIVE THERAPY
    Harold Sackeim; Fiscal Year: 2005
  3. AFFECTIVE AND COGNITIVE CONSEQUENCES OF ECT
    Harold Sackeim; Fiscal Year: 1990
  4. AFFECTIVE AND COGNITIVE CONSEQUENCES OF ECT
    Harold Sackeim; Fiscal Year: 2006

Detail Information

Publications82

  1. ncbi request reprint The definition and meaning of treatment-resistant depression
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, NY 10032, USA
    J Clin Psychiatry 62:10-7. 2001
    ..The Antidepressant Treatment History Form is presented as one method to formalize the evaluation of treatment adequacy and treatment resistance...
  2. ncbi request reprint Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Dr, New York, NY 10032, USA
    JAMA 285:1299-307. 2001
    ..Electroconvulsive therapy (ECT) is highly effective for treatment of major depression, but naturalistic studies show a high rate of relapse after discontinuation of ECT...
  3. ncbi request reprint The effects of vagus nerve stimulation on cognitive performance in patients with treatment-resistant depression
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Neuropsychiatry Neuropsychol Behav Neurol 14:53-62. 2001
    ..However, limited information regarding the effects of VNS on neurocognitive performance exists...
  4. ncbi request reprint The cognitive effects of electroconvulsive therapy in community settings
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 32:244-54. 2007
    ..Cognitive outcomes varied across treatment facilities and differences in ECT technique largely accounted for these differences. Sine wave stimulation and BL electrode placement resulted in more severe and persistent deficits...
  5. ncbi request reprint Durability of antidepressant response to vagus nerve stimulation (VNS)
    Harold A Sackeim
    Departments of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 10:817-26. 2007
    ..Yet patients who showed substantial clinical benefit maintained the improvement at remarkably high rates. This durability of benefit was not attributable to alterations in other treatments...
  6. ncbi request reprint Determining the duration of antidepressant treatment: application of signal detection methodology and the need for duration adaptive designs (DAD)
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Biol Psychiatry 59:483-92. 2006
    ..With remission now the treatment goal, antidepressant trial duration has increased. However, most patients do not remit and are exposed to prolonged, ineffective treatment...
  7. ncbi request reprint A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, NY 10032, USA
    Arch Gen Psychiatry 57:425-34. 2000
    ..While RUL ECT results in less severe short-term and long-term cognitive effects, there is concern that it is less efficacious than BL ECT...
  8. doi request reprint Effect of concomitant pharmacotherapy on electroconvulsive therapy outcomes: short-term efficacy and adverse effects
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, New York, USA
    Arch Gen Psychiatry 66:729-37. 2009
    ..There is also continuing controversy regarding the relative efficacy and adverse effects of right unilateral and bilateral ECT...
  9. ncbi request reprint Optimal length of antidepressant trials in late-life depression
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    J Clin Psychopharmacol 25:S34-7. 2005
    ....
  10. pmc Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy
    Harold A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Brain Stimul 1:71-83. 2008
    ..Reducing the width of the electrical pulse and using the right unilateral electrode placement may decrease adverse cognitive effects, while preserving efficacy...
  11. ncbi request reprint Inadequacy of antidepressant treatment for patients with major depression who are at risk for suicidal behavior
    M A Oquendo
    Mental Health Clinical Research Center for the Study of Suicidal Behavior, Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 156:190-4. 1999
    ..The authors' goal was to determine whether suicide attempters with major depression received more intensive antidepressant treatment than depressed patients who had not attempted suicide...
  12. ncbi request reprint Learning and memory in bipolar and unipolar major depression: effects of aging
    T Burt
    Department of Biological Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Neuropsychiatry Neuropsychol Behav Neurol 13:246-53. 2000
    ..The goal of this study was to examine the effects of aging on neuropsychological functions in bipolar and unipolar major depression...
  13. ncbi request reprint ECT in bipolar and unipolar depression: differences in speed of response
    J J Daly
    Department of Biological Psychiatry, New York State Psychiatric Institute, NY 10032, USA
    Bipolar Disord 3:95-104. 2001
    ..We contrasted a large sample of bipolar (BP) and unipolar (UP) depressed patients in likelihood and rapidity of clinical improvement with ECT...
  14. ncbi request reprint Vagus nerve stimulation (VNS) for treatment-resistant depression: efficacy, side effects, and predictors of outcome
    H A Sackeim
    Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Neuropsychopharmacology 25:713-28. 2001
    ..Evidence concerning VNS' long-term therapeutic benefits and tolerability will be critical in determining its role in treatment-resistant depression...
  15. ncbi request reprint The effects of electroconvulsive therapy on memory of autobiographical and public events
    S H Lisanby
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Arch Gen Psychiatry 57:581-90. 2000
    ..This study examined the short- and long-term effects of differing forms of ECT on memory of personal and impersonal (public) events...
  16. pmc Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, New York, NY 10032, USA
    Neuroimage 19:1215-27. 2003
    ..Brain regions where systematic relationships between CR and brain activation differ as a function of aging are loci where compensation for aging has occurred. They may mediate differential ability to cope with brain changes in aging...
  17. ncbi request reprint Focal prefrontal seizures induced by bilateral ECT
    L S Boylan
    Department of Neurology, New York University School of Medicine, New York, New York, USA
    J ECT 17:175-9. 2001
    ..These events were more likely to occur later in the course of treatment. DISCUSSION: We suggest that BL ECT may induce focal seizures in prefrontal areas and that these seizures are more likely to occur later in the treatment course...
  18. ncbi request reprint ECT in the treatment of status epilepticus
    S H Lisanby
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032 2695, USA
    J ECT 17:210-5. 2001
    ..Owing to its potent anticonvulsant actions, electroconvulsive therapy (ECT) has been proposed as an intervention for treatment-resistant seizure disorders...
  19. ncbi request reprint A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy
    B A Fallon
    Columbia University, 1051 Riverside Drive, Unit 69, New York, NY 10032, USA
    Neurology 70:992-1003. 2008
    ..Optimal treatment remains uncertain for patients with cognitive impairment that persists or returns after standard IV antibiotic therapy for Lyme disease...
  20. ncbi request reprint Repetitive transcranial magnetic stimulation to SMA worsens complex movements in Parkinson's disease
    L S Boylan
    Department of Neurology, New York University School of Medicine, NY, New York, USA
    Clin Neurophysiol 112:259-64. 2001
    ..Promising beneficial effects on movement during or after rTMS have been reported...
  21. ncbi request reprint Neuropsychological dysfunction in depressed suicide attempters
    J G Keilp
    Department of Neuroscience, New York State Psychiatric Institute, USA
    Am J Psychiatry 158:735-41. 2001
    ..This more extensive neuropsychological impairment in the context of depression may be a risk factor for severe suicide attempts...
  22. ncbi request reprint Sham TMS: intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials
    S H Lisanby
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 49:460-3. 2001
    ..This sham was about half as potent in inducing MEPs over the motor cortex as active TMS. Some sham TMS conditions produce substantial cortical stimulation, making it critical to carefully select the sham manipulation for clinical trials...
  23. ncbi request reprint Serotonin, cerebral blood flow, and cerebral metabolic rate in geriatric major depression and normal aging
    M S Nobler
    Departments of Biological Psychiatry and Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 126, New York, NY, USA
    Brain Res Brain Res Rev 30:250-63. 1999
    ..If this is due to diminished responsivity of 5-HT systems, then the ability to identify antidepressant nonresponders via 5-HT challenge in combination with neuroimaging measures may have important clinical utility...
  24. ncbi request reprint Randomized controlled trial of the cognitive side-effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS)
    Tammy D Moscrip
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY, USA
    Int J Neuropsychopharmacol 9:1-11. 2006
    ..Time to task completion following MST did not differ from sham. These findings suggest that MST results in a more benign acute cognitive side-effect profile than ECS in this model, consistent with initial observations with human MST...
  25. ncbi request reprint Correlates of trait impulsiveness in performance measures and neuropsychological tests
    John G Keilp
    Department of Neuroscience, New York State Psychiatric Institute, Columbia University Medical College, Box 42, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatry Res 135:191-201. 2005
    ....
  26. ncbi request reprint A new approach to spatial covariance modeling of functional brain imaging data: ordinal trend analysis
    Christian Habeck
    Cognitive Neuroscience Division, Taub Institute, and Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neural Comput 17:1602-45. 2005
    ..In sum, OrT has potential applications to not only studies of young adults and their cognitive abilities, but also studies of normal aging and neurological and psychiatric disease...
  27. ncbi request reprint Randomized, double-blind, placebo-controlled trial of fluoxetine treatment for elderly patients with dysthymic disorder
    D P Devanand
    Late Life Depression Clinic, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 126, New York, NY 10032, USA
    Am J Geriatr Psychiatry 13:59-68. 2005
    ..The authors compared the efficacy and side effects of fluoxetine and placebo in elderly outpatients with dysthymic disorder...
  28. ncbi request reprint An open treatment trial of venlafaxine for elderly patients with dysthymic disorder
    D P Devanand
    Late Life Depression Clinic and the Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 126, New York, NY 10032, USA
    J Geriatr Psychiatry Neurol 17:219-24. 2004
    ..These results indicate that in elderly patients with DD, placebo-controlled trials of a dual reuptake inhibitor such as venlafaxine would be needed to assess its efficacy or to compare its efficacy to that of other antidepressants...
  29. ncbi request reprint Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial
    Steven P Roose
    New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 161:2050-9. 2004
    ..This study determined the efficacy of antidepressant medication for the treatment of depression in the "old-old."..
  30. ncbi request reprint WAIS-III and WMS-III performance in chronic Lyme disease
    John G Keilp
    Columbia University College of Physicians and Surgeons, Department of Psychiatry, New York, New York 10032, USA
    J Int Neuropsychol Soc 12:119-29. 2006
    ..Deficits in chronic Lyme disease are consistent with a subtle neuropathological process affecting multiple performance tasks, although further work is needed to definitively rule out nonspecific illness effects...
  31. doi request reprint Regional cerebral blood flow and metabolic rate in persistent Lyme encephalopathy
    Brian A Fallon
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Arch Gen Psychiatry 66:554-63. 2009
    ..There is controversy regarding whether objective neurobiological abnormalities exist after intensive antibiotic treatment for Lyme disease...
  32. ncbi request reprint Design makes a difference: a meta-analysis of antidepressant response rates in placebo-controlled versus comparator trials in late-life depression
    Joel R Sneed
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Geriatr Psychiatry 16:65-73. 2008
    ..No quantitative review has been conducted to test this hypothesis...
  33. ncbi request reprint Vascular depression: A distinct diagnostic subtype?
    Joel R Sneed
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Biol Psychiatry 60:1295-8. 2006
    ..g., expert consensus), and vascular depression might serve as a prototype for future psychiatric classification...
  34. ncbi request reprint Deep brain stimulation in movement and psychiatric disorders
    David E Hardesty
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, New York 10032, USA
    Biol Psychiatry 61:831-5. 2007
    ..Deep brain stimulation may prove to be a reasonable option for severely ill and treatment-resistant patients who otherwise have limited therapeutic options and a poor prognosis...
  35. doi request reprint Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial
    Sarah H Lisanby
    Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 34:522-34. 2009
    ..Shorter duration of current illness and lack of anxiety comorbidity may also confer an increased likelihood of good antidepressant response to TMS...
  36. ncbi request reprint Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates
    Tarique D Perera
    Department of Biological Psychiatry, New York State Psychiatric Institute New York, New York 10032, USA
    J Neurosci 27:4894-901. 2007
    ..This study demonstrates that ECS is capable of inducing neurogenesis in the nonhuman primate hippocampus and supports the possibility that antidepressant interventions produce similar alterations in the human brain...
  37. ncbi request reprint The WAIS-III and major depression: absence of VIQ/PIQ differences
    Marianne Gorlyn
    Department of Neuroscience, New York State Psychiatric Institute, NY 10032, USA
    J Clin Exp Neuropsychol 28:1145-57. 2006
    ..Results suggest general intellectual performance in depression is best characterized by deficits in processing speed, rather than global nonverbal abilities, and that this deficit is consistent across depression subtypes...
  38. ncbi request reprint Response inhibition predicts poor antidepressant treatment response in very old depressed patients
    Joel R Sneed
    Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Geriatr Psychiatry 15:553-63. 2007
    ..There have been mixed findings regarding the prognostic significance of age of onset, executive dysfunction, and hyperintensity burden on treatment outcome in late-life depression...
  39. pmc Randomized double-blind placebo-controlled donepezil augmentation in antidepressant-treated elderly patients with depression and cognitive impairment: a pilot study
    Gregory H Pelton
    Late Life Depression Clinic, The Memory Disorders Center, and The Division of Geriatric Psychiatry, New York State Psychiatric Institute, NY, USA
    Int J Geriatr Psychiatry 23:670-6. 2008
    ..To assess combined antidepressant and cognitive enhancer treatment in elderly patients presenting with depression plus cognitive impairment...
  40. ncbi request reprint Dorsolateral prefrontal cortical pathology in generalized anxiety disorder: a proton magnetic resonance spectroscopic imaging study
    Sanjay J Mathew
    Department of Biological Psychiatry, New York State Psychiatric Institute, Columbia Unversity, New York, NY 10032, USA
    Am J Psychiatry 161:1119-21. 2004
    ..The present study used proton magnetic resonance spectroscopy to assess concentrations of N-acetylaspartate, often considered a marker of neuronal viability, in generalized anxiety disorder patients...
  41. ncbi request reprint Adequacy of antidepressant treatment after discharge and the occurrence of suicidal acts in major depression: a prospective study
    Maria A Oquendo
    New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 159:1746-51. 2002
    ..The authors prospectively studied the adequacy of antidepressant treatment and its impact on suicidal acts in the 2 years after hospitalization for major depression...
  42. ncbi request reprint A computer algorithm for calculating the adequacy of antidepressant treatment in unipolar and bipolar depression
    Maria A Oquendo
    Silvio O Conte Centers for the Neuroscience of Mental Disorders for the Study of the Neurobiology of Suicidal Behavior, New York, USA
    J Clin Psychiatry 64:825-33. 2003
    ..The updated ATHF presented here includes newer medications and a computer algorithm to automate the evaluation of the adequacy of pharmacotherapy or electroconvulsive therapy for depression...
  43. ncbi request reprint New developments in electroconvulsive therapy and magnetic seizure therapy
    Sarah H Lisanby
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York City, USA
    CNS Spectr 8:529-36. 2003
    ..This article reviews the experience to date with MST, and places this work in the broader context of other means of optimizing convulsive therapy in the treatment of depression...
  44. pmc Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Arch Neurol 60:359-65. 2003
    ..This has been interpreted as suggesting that cognitive reserve allows these patients to cope better with the pathologic changes in AD...
  45. ncbi request reprint Sertraline treatment of elderly patients with depression and cognitive impairment
    D P Devanand
    Late Life Depression Clinic, Memory Disorders Center, Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 26, New York, NY 10032, USA
    Int J Geriatr Psychiatry 18:123-30. 2003
    ....
  46. ncbi request reprint Clinical trials in late-life depression: revisited
    Steven P Roose
    Department of Clinical Psychopharmacology, NY State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Geriatr Psychiatry 10:503-5. 2002
  47. ncbi request reprint Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis
    Tal Burt
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 5:73-103. 2002
    ..We also review the application of TMS in the study of the pathophysiology of psychiatric disorders and summarize studies of the safety of TMS in human subjects...
  48. ncbi request reprint Neurophysiological characterization of magnetic seizure therapy (MST) in non-human primates
    Sarah H Lisanby
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 126, New York, NY 10032, USA
    Suppl Clin Neurophysiol 56:81-99. 2003
  49. pmc Cognitive reserve-mediated modulation of positron emission tomographic activations during memory tasks in Alzheimer disease
    Nikolaos Scarmeas
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Arch Neurol 61:73-8. 2004
    ..Epidemiological data and evidence from positron emission tomography suggest that it may be mediated through education or IQ...
  50. ncbi request reprint Seizure expression during electroconvulsive therapy: relationships with clinical outcome and cognitive side effects
    Tarique D Perera
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 29:813-25. 2004
    ....
  51. ncbi request reprint Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapy
    Sarah H Lisanby
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 28:1852-65. 2003
    ..Magnetic seizure induction in patients with depression is feasible, and appears to have a superior acute side effect profile than ECT. Future research will be needed to establish whether MST has antidepressant efficacy...
  52. ncbi request reprint Absence of histological lesions in primate models of ECT and magnetic seizure therapy
    Andrew J Dwork
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 161:576-8. 2004
    ..The authors present preliminary findings from the first nonhuman primate neuropathological study of ECT to use perfusion fixation and adequate controls and the first to compare ECT with magnetic seizure therapy, to their knowledge...
  53. ncbi request reprint Effects of medications on cerebral blood flow in late-life depression
    Mitchell S Nobler
    Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 126, New York, NY 10032, USA
    Curr Psychiatry Rep 4:51-8. 2002
    ..Studies of the effects of medications on rCBF in LLD have implications for understanding the neurobiology of treatment resistance in the elderly as well as the mechanisms of action of antidepressant treatments...
  54. ncbi request reprint A primate model of anterograde and retrograde amnesia produced by convulsive treatment
    Tammy D Moscrip
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, New York, USA
    J ECT 20:26-36. 2004
    ..This study developed and validated a cognitive battery to assess amnesia in nonhuman primates, providing new experimental paradigms for evaluating the cognitive effects of convulsive treatment...
  55. ncbi request reprint Electro-convulsive therapy practices in the community
    J Prudic
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York 10032, USA
    Psychol Med 31:929-34. 2001
    ..CONCLUSION: There is marked variability in the nature of ECT practices in community settings. The extent to which this variability impacts on the benefits and risks of ECT needs to be examined...
  56. ncbi request reprint A unilateral, prolonged, nonconvulsive seizure in a patient treated with bilateral ECT
    V Parker
    Department of Biological Psychiatry, New York State Psychiatric Institute, New York, USA
    J ECT 17:141-5. 2001
    ..This case also highlights the importance of two-channel EEG recording during ECT. Without two recording channels we doubt that this event would have been detected, perhaps resulting in nonconvulsive status epilepticus...
  57. ncbi request reprint Magnetoelectric brain stimulation in the assessment of brain physiology and pathophysiology
    L S Boylan
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Clin Neurophysiol 111:504-12. 2000
    ..To review findings from transcranial magnetic stimulation (TMS)-induced motor evoked potentials in normal subjects, in various neurological diseases and with pharmacologic manipulation...
  58. ncbi request reprint Effectiveness of electroconvulsive therapy in community settings
    Joan Prudic
    Department of Biological Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 126, New York, NY 10032, USA
    Biol Psychiatry 55:301-12. 2004
    ..Clinical trials indicate that electroconvulsive therapy (ECT) is the most effective treatment for major depression, but its effectiveness in community settings has not been examined...
  59. ncbi request reprint Open-label trial of riluzole in generalized anxiety disorder
    Sanjay J Mathew
    Department of Biological Psychiatry, New York State Psychiatric Institute, USA
    Am J Psychiatry 162:2379-81. 2005
    ..There is a need to identify novel pharmacotherapies for anxiety disorders. The authors examined the safety and efficacy of riluzole, an antiglutamatergic agent, in adult outpatients with generalized anxiety disorder...
  60. ncbi request reprint Adverse life events in elderly patients with major depression or dysthymic disorder and in healthy-control subjects
    D P Devanand
    Late Life Depression Clinic and the Department of Biological Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York 10032, USA
    Am J Geriatr Psychiatry 10:265-74. 2002
    ..The subjective impact of adverse life events may play an important role in the expression of depressive illness in elderly patients, particularly in major depression, and it needs to be considered in clinical management...
  61. ncbi request reprint Different brain networks mediate task performance in normal aging and AD: defining compensation
    Y Stern
    Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Neurology 55:1291-7. 2000
    ..To determine whether the pathologic mechanisms of AD alter the brain networks subserving performance of a verbal recognition task...
  62. pmc Parietal cortex and representation of the mental Self
    Hans C Lou
    Magnetic Brain Stimulation Laboratory, Department of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:6827-32. 2004
    ..This network is strikingly similar to the network of the resting conscious state, suggesting that self-monitoring is a core function in resting consciousness...
  63. ncbi request reprint Age-related characteristics of depression: a preliminary STAR*D report
    Mustafa M Husain
    Dept of Psychiatry, Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75390 8898, USA
    Am J Geriatr Psychiatry 13:852-60. 2005
    ..The authors explore the relationships between current age and depression severity, course of illness, presenting symptom features, and comorbid symptoms...
  64. ncbi request reprint Predictors of remission after electroconvulsive therapy in unipolar major depression
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Clin Psychiatry 66:1043-9. 2005
    ..Electroconvulsive therapy (ECT) is the most effective biological treatment for major depression. However, there is little agreement about clinically useful predictors of acute ECT outcomes...
  65. ncbi request reprint Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial
    H Brent Solvason
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19014, USA
    Biol Psychiatry 62:1208-16. 2007
    ..We tested whether transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (DLPFC) is effective and safe in the acute treatment of major depression...
  66. ncbi request reprint Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, One Baylor Plaza, BCM 350, Houston, TX 77030, USA
    Biol Psychiatry 51:280-7. 2002
    ..This open, naturalistic follow-up study was conducted to determine whether the initial promising effects were sustained, and whether changes in function would be observed...
  67. ncbi request reprint Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Control Clin Trials 25:119-42. 2004
    ..Participants with an adequate symptomatic response may enter the 12-month naturalistic follow-up phase with brief monthly and more complete quarterly assessments...
  68. doi request reprint Neurobiological correlates of the cognitive side effects of electroconvulsive therapy
    Mitchell S Nobler
    Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY 10595, USA
    J ECT 24:40-5. 2008
    ..Interestingly, such data also appear to indicate a dissociation of the neural systems critical to the efficacy and adverse cognitive effects of ECT...
  69. ncbi request reprint Clinical outcome of ECT in patients with major depression and comorbid borderline personality disorder
    Ulrike Feske
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:2073-80. 2004
    ..The authors compared the acute outcome of ECT in depressed patients with borderline personality disorder, with personality disorders other than borderline personality disorder, and with no personality disorder...
  70. ncbi request reprint Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial
    Rena Cooper-Kazaz
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel
    Arch Gen Psychiatry 64:679-88. 2007
    ..Antidepressant treatments that achieve a higher remission rate than those currently available are urgently needed. The thyroid hormone triiodothyronine may potentiate antidepressant effects...
  71. ncbi request reprint Length of the ECT course in bipolar and unipolar depression
    Harold A Sackeim
    J ECT 21:195-7. 2005
  72. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005
    ..We examined the effects of adjunctive VNS over 24 months in this cohort...
  73. ncbi request reprint Factors associated with health-related quality of life among outpatients with major depressive disorder: a STAR*D report
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas UT Southwestern Medical Center, Dallas 75390 9119, and the Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:185-95. 2006
    ..The aim of this study was to examine sociodemographic and clinical correlates of HRQOL in a large cohort of outpatients with MDD...
  74. ncbi request reprint Report by the ACNP Task Force on response and remission in major depressive disorder
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Neuropsychopharmacology 31:1841-53. 2006
    ..Research to evaluate these recommendations empirically is needed...
  75. ncbi request reprint A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, 67 President Street 502 N, Charleston, SC 29425, USA
    Biol Psychiatry 58:364-73. 2005
    ..To better understand these effects on long-term outcome, we compared 12-month VNS+TAU outcomes with those of a comparable TRD group...
  76. ncbi request reprint Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychiatr Clin North Am 26:457-94, x. 2003
    ..This article provides the overall rationale for STAR*D and details the rationale for key design, measurement, and analytic features of the study...
  77. ncbi request reprint Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:355-63. 2005
    ..The need for effective, long-term treatment for recurrent or chronic, treatment-resistant depression is well established...
  78. ncbi request reprint Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    Am J Psychiatry 163:1905-17. 2006
    ..This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  79. ncbi request reprint Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:347-54. 2005
    ..Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy...
  80. ncbi request reprint Relapse during continuation pharmacotherapy after acute response to ECT: a comparison of usual care versus protocolized treatment
    James D Tew
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA USA
    Ann Clin Psychiatry 19:1-4. 2007
    ..quot; This study compares the effectiveness of usual care versus protocolized pharmacotherapy in preventing relapse following ECT...
  81. ncbi request reprint Acceptability of second-step treatments to depressed outpatients: a STAR*D report
    Stephen R Wisniewski
    Department of Psychiatry, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, and Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 164:753-60. 2007
    ..This study sought to identify factors that affect patients' willingness to accept different second-step treatment approaches...
  82. ncbi request reprint Response to Drs Abrams and Kellner: the cognitive effects of ECT in community settings
    Harold A Sackeim
    J ECT 23:65-7. 2007

Research Grants21

  1. AFFECTIVE AND COGNITIVE CONSEQUENCES OF ECT
    Harold Sackeim; Fiscal Year: 2003
    ..Such findings should have fundamental impact on our understanding of mechanisms and on the practice of ECT. ..
  2. OPTIMIZATION OF ELECTROCONVULSIVE THERAPY
    Harold Sackeim; Fiscal Year: 2005
    ....
  3. AFFECTIVE AND COGNITIVE CONSEQUENCES OF ECT
    Harold Sackeim; Fiscal Year: 1990
    ..This research is designed to address the questions of where in the dosing range unilateral ECT is optimized and, when optimized, how does this treatment compare to bilateral ECT...
  4. AFFECTIVE AND COGNITIVE CONSEQUENCES OF ECT
    Harold Sackeim; Fiscal Year: 2006
    ..Confirming this benefit and demonstrating that spatial targeting further reduces cognitive burden should have fundamental impact on ECT practice. ..