R L Sacco

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Levels of acute phase proteins remain stable after ischemic stroke
    Mitchell S V Elkind
    Gertrude H, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    BMC Neurol 6:37. 2006
  2. pmc Endothelial dysfunction is associated with carotid plaque: a cross-sectional study from the population based Northern Manhattan Study
    Tatjana Rundek
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, USA
    BMC Cardiovasc Disord 6:35. 2006
  3. ncbi request reprint High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study
    R L Sacco
    Neurological Institute, 710 W 168 St, New York, NY 10032, USA
    JAMA 285:2729-35. 2001
  4. ncbi request reprint Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial
    R L Sacco
    The Neurological Institute, Columbia University, 710 W 168th St, Room 547, New York, NY 10032, USA
    JAMA 285:1719-28. 2001
  5. ncbi request reprint Lifestyle factors and stroke risk: exercise, alcohol, diet, obesity, smoking, drug use, and stress
    B Boden-Albala
    Department of Neurology, Columbia University College of Physicians and Surgeons 710 West 168th Street, New York, NY, 10032, USA
    Curr Atheroscler Rep 2:160-6. 2000
  6. ncbi request reprint Update on antiplatelet therapy for stroke prevention
    R L Sacco
    Department of Neurology and Public Health Epidemiology, Sergievsky Center, Neurological Institute, College of Physicians and Surgeons of Columbia University, New York Presbyterian Hospital, New York 10032, USA
    Arch Intern Med 160:1579-82. 2000
  7. ncbi request reprint Reducing the risk of stroke in diabetes: what have we learned that is new?
    Ralph L Sacco
    Neurology and Public Health, Columbia University, College of Physicians and Surgeons, The New York Presbyterian Hospital, New York 10032, USA
    Diabetes Obes Metab 4:S27-34. 2002
  8. ncbi request reprint Comparison of warfarin versus aspirin for the prevention of recurrent stroke or death: subgroup analyses from the Warfarin-Aspirin Recurrent Stroke Study
    Ralph L Sacco
    Columbia University and Mailman School of Public Health, Neurological Institute of the New York Presbyterian Hospital, New York, NY, USA
    Cerebrovasc Dis 22:4-12. 2006
  9. ncbi request reprint The state of patient-oriented research in neurology
    Ralph L Sacco
    Neurological Institute, New York, NY 10032, USA
    Neurology 62:1051-5. 2004
  10. ncbi request reprint The protective effect of moderate alcohol consumption on ischemic stroke
    R L Sacco
    Department of Neurology, Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    JAMA 281:53-60. 1999

Detail Information

Publications147 found, 100 shown here

  1. pmc Levels of acute phase proteins remain stable after ischemic stroke
    Mitchell S V Elkind
    Gertrude H, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    BMC Neurol 6:37. 2006
    ..Inflammation and inflammatory biomarkers play an important role in atherosclerosis and cardiovascular disease. Little information is available, however, on time course of serum markers of inflammation after stroke...
  2. pmc Endothelial dysfunction is associated with carotid plaque: a cross-sectional study from the population based Northern Manhattan Study
    Tatjana Rundek
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, USA
    BMC Cardiovasc Disord 6:35. 2006
    ..The objective of this study was to determine whether endothelial dysfunction is independently associated with carotid plaque in a community of northern Manhattan...
  3. ncbi request reprint High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study
    R L Sacco
    Neurological Institute, 710 W 168 St, New York, NY 10032, USA
    JAMA 285:2729-35. 2001
    ..However, the association of specific lipoprotein classes and ischemic stroke has not been well defined, particularly in higher-risk minority populations...
  4. ncbi request reprint Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial
    R L Sacco
    The Neurological Institute, Columbia University, 710 W 168th St, Room 547, New York, NY 10032, USA
    JAMA 285:1719-28. 2001
    ..Elucidation of the ischemic cascade has helped stimulate development of neuroprotective drugs aimed at limiting brain injury in the hours following an ischemic stroke. To date, none of these drugs has shown clinical efficacy...
  5. ncbi request reprint Lifestyle factors and stroke risk: exercise, alcohol, diet, obesity, smoking, drug use, and stress
    B Boden-Albala
    Department of Neurology, Columbia University College of Physicians and Surgeons 710 West 168th Street, New York, NY, 10032, USA
    Curr Atheroscler Rep 2:160-6. 2000
    ..Despite the obstacles to the modification of lifestyle factors, health professionals should be encouraged to continue to identify such factors and help improve our ability to prevent stroke...
  6. ncbi request reprint Update on antiplatelet therapy for stroke prevention
    R L Sacco
    Department of Neurology and Public Health Epidemiology, Sergievsky Center, Neurological Institute, College of Physicians and Surgeons of Columbia University, New York Presbyterian Hospital, New York 10032, USA
    Arch Intern Med 160:1579-82. 2000
    ..This combination is currently recommended as one of the first-line treatments for stroke prevention after first transient ischemic attack or stroke...
  7. ncbi request reprint Reducing the risk of stroke in diabetes: what have we learned that is new?
    Ralph L Sacco
    Neurology and Public Health, Columbia University, College of Physicians and Surgeons, The New York Presbyterian Hospital, New York 10032, USA
    Diabetes Obes Metab 4:S27-34. 2002
    ..Wide-scale adherence to these guideline recommendations for the prevention of primary and secondary stroke would significantly benefit the public health...
  8. ncbi request reprint Comparison of warfarin versus aspirin for the prevention of recurrent stroke or death: subgroup analyses from the Warfarin-Aspirin Recurrent Stroke Study
    Ralph L Sacco
    Columbia University and Mailman School of Public Health, Neurological Institute of the New York Presbyterian Hospital, New York, NY, USA
    Cerebrovasc Dis 22:4-12. 2006
    ..Pending future clinical trial evidence to the contrary, antiplatelets are recommended for survivors of noncardioembolic stroke...
  9. ncbi request reprint The state of patient-oriented research in neurology
    Ralph L Sacco
    Neurological Institute, New York, NY 10032, USA
    Neurology 62:1051-5. 2004
  10. ncbi request reprint The protective effect of moderate alcohol consumption on ischemic stroke
    R L Sacco
    Department of Neurology, Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    JAMA 281:53-60. 1999
    ..Moderate alcohol consumption has been shown to be protective for coronary heart disease, but the relationship between moderate alcohol consumption and ischemic stroke is more controversial...
  11. ncbi request reprint Homocysteine and the risk of ischemic stroke in a triethnic cohort: the NOrthern MAnhattan Study
    Ralph L Sacco
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Stroke 35:2263-9. 2004
    ..We investigated the association between mild to moderate fasting tHcy level and the incidence of ischemic stroke, myocardial infarction, and vascular death in a multiethnic prospective study...
  12. ncbi request reprint Race-ethnicity and determinants of carotid atherosclerosis in a multiethnic population. The Northern Manhattan Stroke Study
    R L Sacco
    Department of Neurology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Stroke 28:929-35. 1997
    ..The aim of this study was to determine the importance of race-ethnicity and other factors associated with carotid atherosclerosis in a mixed population of Hispanics, blacks, and whites...
  13. ncbi request reprint Efficacy of aspirin plus extended-release dipyridamole in preventing recurrent stroke in high-risk populations
    Ralph L Sacco
    Department of Neurology, College of Physicians and Surgeons and the Mailman School of Public Health, Columbia University, Neurological Institute, New York, NY 10032, USA
    Arch Neurol 62:403-8. 2005
    ..To assess the efficacy of aspirin plus extended-release dipyridamole compared with aspirin alone for the prevention of recurrent stroke among high-risk groups...
  14. ncbi request reprint Leisure-time physical activity and ischemic stroke risk: the Northern Manhattan Stroke Study
    R L Sacco
    Department of Neurology, Sergievsky Center, Columbia University College of Physicians and Surgeons and School of Public Health, New York, NY, USA
    Stroke 29:380-7. 1998
    ..The objective of this study was to investigate the association between leisure-time physical activity and ischemic stroke in an urban, elderly, multiethnic population...
  15. ncbi request reprint Experimental treatments for acute ischaemic stroke
    Ralph L Sacco
    Department of Neurology, College of Physicians and Surgeons Columbia University, New York, NY, USA
    Lancet 369:331-41. 2007
    ..The findings of these randomised trials are anticipated to allow improved treatment of patients with acute stroke...
  16. ncbi request reprint Cigarette smoking as a determinant of high-grade carotid artery stenosis in Hispanic, black, and white patients with stroke or transient ischemic attack
    H Mast
    Stroke Unit, The Neurological Institute, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Stroke 29:908-12. 1998
    ..We sought to investigate the association of cigarette smoking with high-grade carotid artery stenosis in Hispanic, black, and white patients with cerebral ischemia in two independent samples...
  17. ncbi request reprint Race-ethnic disparities in the impact of stroke risk factors: the northern Manhattan stroke study
    R L Sacco
    Columbia University College of Physicians and Surgeons and School of Public Health, New York, NY, USA
    Stroke 32:1725-31. 2001
    ..CONCLUSIONS: The prevalence, OR, and EF for stroke risk factors vary by race-ethnicity. These differences are crucial to the etiology of stroke, as well as to the design and implementation of stroke prevention programs...
  18. ncbi request reprint Race-ethnic differences in patent foramen ovale, atrial septal aneurysm, and right atrial anatomy among ischemic stroke patients
    Carlos J Rodriguez
    Columbia University, College of Physicians and Surgeons, Department of Medicine, Division of Cardiology, 630 W 168th St, New York, NY 10032, USA
    Stroke 34:2097-102. 2003
    ..In particular, little is known about whether patent foramen ovale (PFO), atrial septal aneurysm (ASA), and other atrial anomalies associated with cryptogenic stroke differ among minority populations...
  19. ncbi request reprint Elevated white blood cell count and carotid plaque thickness : the northern manhattan stroke study
    M S Elkind
    Department of Neurology, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Stroke 32:842-9. 2001
    ..We sought to determine whether white blood cell count (WBC) is associated with carotid plaque thickness in a stroke-free, multiethnic cohort...
  20. ncbi request reprint Abdominal obesity and risk of ischemic stroke: the Northern Manhattan Stroke Study
    Seung Han Suk
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Stroke 34:1586-92. 2003
    ..The relationship between abdominal obesity and ischemic stroke remains less clear. Our aim was to evaluate abdominal obesity as an independent risk factor for ischemic stroke in a multiethnic community...
  21. ncbi request reprint Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on C
    Ralph L Sacco
    Stroke 37:577-617. 2006
    ....
  22. pmc Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study
    T Rundek
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Neurology 70:1200-7. 2008
    ..The risk associated with small, nonstenotic carotid plaques is less clear. The objective of this study was to examine the association between maximum carotid plaque thickness and risk of vascular events in an urban multiethnic cohort...
  23. ncbi request reprint Stroke in the young in the northern Manhattan stroke study
    Bradley S Jacobs
    Wayne State University Detroit Medical Center Comprehensive Stroke Program, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Stroke 33:2789-93. 2002
    ..The purpose of this study was to determine stroke incidence rates in these populations and to compare rates among various race-ethnic, sex, and age groups...
  24. pmc Left ventricular systolic dysfunction and the risk of ischemic stroke in a multiethnic population
    Allison G Hays
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Stroke 37:1715-9. 2006
    ..The stroke risk associated with LVD, especially of mild degree, in the general population is unclear. The purpose of this study was to evaluate the relationship between LVD and ischemic stroke in a multiethnic cohort...
  25. ncbi request reprint Mortality and causes of death after first ischemic stroke: the Northern Manhattan Stroke Study
    A Hartmann
    Stroke Center, Department of Neurology, Columbia University College of Physicians and Surgeons and School of Public Health, New York, NY, USA
    Neurology 57:2000-5. 2001
    ..To analyze the early and long-term causes of death after first ischemic stroke in the multiethnic northern Manhattan community...
  26. pmc Quality of life declines after first ischemic stroke. The Northern Manhattan Study
    M S Dhamoon
    Neurological Institute, Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 W 168th Street, New York, NY 10032, USA
    Neurology 75:328-34. 2010
    ..Quality of life (QOL) after stroke is poorly characterized. We sought to determine long-term natural history and predictors of QOL among first ischemic stroke survivors without stroke recurrence or myocardial infarction (MI)...
  27. ncbi request reprint Aortic atheroma morphology and the risk of ischemic stroke in a multiethnic population
    M R Di Tullio
    Departments of Medicine, Neurology, and Public Health Epidemiology, Sergievsky Center, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Am Heart J 139:329-36. 2000
    ..Moreover, data have been obtained in predominantly white populations, and little is known about the association between atheromas and stroke in minorities...
  28. ncbi request reprint Subarachnoid hemorrhage incidence among Whites, Blacks and Caribbean Hispanics: the Northern Manhattan Study
    D L Labovitz
    Department of Neurology, New York University School of Medicine, New York, NY, USA
    Neuroepidemiology 26:147-50. 2006
    ..9), and 1.6 (95% CI 0.8-2.8) for blacks (9 cases, incidence 12.8). The 30-day case fatality rate was 26%. Risk of death increased significantly with age and severity at onset but was not influenced by gender or race-ethnicity...
  29. ncbi request reprint Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study
    Halina White
    Department of Neurology, College of Physicians and Surgeons, USA
    Circulation 111:1327-31. 2005
    ..The aim of this population-based study was to determine ischemic stroke subtype incidence rates for whites, blacks, and Hispanics living in one community...
  30. pmc Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, USA
    N Engl J Med 359:1238-51. 2008
    ..Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel...
  31. ncbi request reprint A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke
    J P Mohr
    Neurological Institute, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    N Engl J Med 345:1444-51. 2001
    ....
  32. ncbi request reprint Valvular strands and cerebral ischemia. Effect of demographics and strand characteristics
    J K Roberts
    Department of Neurology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Stroke 28:2185-8. 1997
    ..Little is known about this association in different age, sex, and race-ethnic subgroups and the effect of various strand characteristics on this association...
  33. ncbi request reprint Association of increased body mass index and impaired endothelial function among Hispanic women
    Todd Pulerwitz
    Department of Medicine, Division of Cardiology, Columbia University, New York, New York, USA
    Am J Cardiol 97:68-70. 2006
    ..16 +/- 0.04, p <0.0001) but not in men (beta -0.02 +/- 0.06, p = 0.72). This is the first study to demonstrate a gender-specific difference in endothelial function associated with body mass index...
  34. pmc Relationship between periodontal disease, tooth loss, and carotid artery plaque: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Moise Desvarieux
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
    Stroke 34:2120-5. 2003
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. The present study investigates the relationship of periodontal disease and tooth loss with subclinical atherosclerosis...
  35. ncbi request reprint The incidence of deep and lobar intracerebral hemorrhage in whites, blacks, and Hispanics
    D L Labovitz
    St Luke s Roosevelt Hospital Center, New York, USA
    Neurology 65:518-22. 2005
    ..The authors conducted a population-based incidence study to directly compare the incidence of deep vs lobar ICH in all three race-ethnic groups...
  36. ncbi request reprint Recurrent stroke and cardiac risks after first ischemic stroke: the Northern Manhattan Study
    M S Dhamoon
    Mount Sinai School of Medicine, New York, NY, USA
    Neurology 66:641-6. 2006
    ..Few population-based studies with long-term follow-up have compared risk of recurrent stroke and cardiac events after first ischemic stroke. The relative risk of these two outcomes may inform treatment decisions...
  37. ncbi request reprint Impact of valvular thickness on stroke recurrence in medically treated patients with stroke
    K Okajima
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cerebrovasc Dis 24:375-80. 2007
    ..It remains controversial whether left-sided valvular thickening (VaT) is a risk factor for ischemic stroke. Little is known about the relationship between VaT and the recurrent adverse event rate in medically treated patients with stroke...
  38. ncbi request reprint Lacunar infarct or deep intracerebral hemorrhage: who gets which? The Northern Manhattan Study
    Daniel L Labovitz
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Neurology 68:606-8. 2007
    ..We compared LAC to DICH cases derived from a population-based incidence study. In multivariate analysis, LAC cases were significantly older, more likely to have diabetes, and had higher cholesterol than DICH cases...
  39. pmc Physical activity and risk of ischemic stroke in the Northern Manhattan Study
    J Z Willey
    Department of Neurology, Columbia University, New York, USA
    Neurology 73:1774-9. 2009
    ..We sought to examine whether physical activity, as measured by intensity of exercise and energy expended, is protective against ischemic stroke...
  40. ncbi request reprint Social isolation and outcomes post stroke
    B Boden-Albala
    Department of Neurology, Columbia University College of Physicians and Surgeons, The Mailman School of Public Health, New York, NY, USA
    Neurology 64:1888-92. 2005
    ..To assess the relationship between social isolation and stroke outcomes in a multiethnic cohort...
  41. pmc Lower prevalence of silent brain infarcts in the physically active: the Northern Manhattan Study
    J Z Willey
    Departments of Neurology, Columbia University, New York, NY 10032, USA
    Neurology 76:2112-8. 2011
    ..To examine the independent association between physical activity and subclinical cerebrovascular disease as measured by silent brain infarcts (SBI) and white matter hyperintensity volume (WMHV)...
  42. ncbi request reprint Predictors of resource use after acute hospitalization: the Northern Manhattan Stroke Study
    T Rundek
    Department of Neurology, Columbia University College of Physicians and Surgeons and School of Public Health, New York, USA
    Neurology 55:1180-7. 2000
    ..To determine demographic and clinical predictors of discharge destinations following acute care hospitalization for stroke in the community of northern Manhattan...
  43. ncbi request reprint Microemboli in patients with vertebrobasilar ischemia: association with vertebrobasilar and cardiac lesions
    H C Koennecke
    Neurological Institute, Department of Neurology, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Stroke 28:593-6. 1997
    ....
  44. ncbi request reprint Chlamydia pneumoniae and the risk of first ischemic stroke : The Northern Manhattan Stroke Study
    M S Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, and the Columbia Presbyterian Medical Center of New York Presbyterian Hospital, New York, NY, USA
    Stroke 31:1521-5. 2000
    ..The data on its association with ischemic stroke are limited. We sought to determine whether chronic C pneumoniae infection is associated with ischemic stroke in a multi-ethnic population...
  45. ncbi request reprint Association between large aortic arch atheromas and high-intensity transient signals in elderly stroke patients
    T Rundek
    Neurological Institute, New York Presbyterian Hospital, NY 10032, USA
    Stroke 30:2683-6. 1999
    ..The aim of this study was to determine whether large AAs are associated with an increased frequency of high-intensity transient signals (HITS) in elderly patients with IS...
  46. pmc Drug Insight: statins and stroke
    Ralph L Sacco
    Neurological Institute, Columbia University College of Physicians and Surgeons, Mailman School of Public Health, New York, NY, USA
    Nat Clin Pract Cardiovasc Med 2:576-84. 2005
    ....
  47. ncbi request reprint Usefulness of fasting blood glucose to predict vascular outcomes among individuals without diabetes mellitus (from the Northern Manhattan Study)
    Kazuo Eguchi
    Center for Behavioral Cardiovascular Health, Division of General Medicine, Columbia University Medical Center, New York, NY, USA
    Am J Cardiol 100:1404-9. 2007
    ..The effects were more apparent for MI than for ischemic stroke; however, FBG was a strong predictor of ischemic stroke among African-American subjects...
  48. ncbi request reprint Epidemiology of stroke in young adults: race/ethnic differences
    Ji Y Chong
    Columbia University Neurological Institute, 710 W 168th St, NY 10032 2603, USA
    J Thromb Thrombolysis 20:77-83. 2005
    ..Furthermore, analysis of race/ethnic differences in stroke subtypes may help clarify mechanisms of stroke in young adults and potential race-ethnic differences in early stroke risk factors...
  49. ncbi request reprint Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke
    Steven R Levine
    Department of Neurology, Mt Sinai School of Medicine, New York, NY 10029 6574, USA
    JAMA 291:576-84. 2004
    ..The presence of antiphospholipid antibodies (aPL) has been associated with vascular occlusive events. However, the role of aPL in predicting ischemic events, particularly recurrent ischemic stroke, is controversial...
  50. ncbi request reprint Impact of aortic stiffness on ischemic stroke in elderly patients
    Kenichi Sugioka
    Department of Medicine, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Stroke 33:2077-81. 2002
    ..The atherosclerotic process also affects aortic distensibility, which can also be assessed by TEE. The purpose of this study was to evaluate the possible association of aortic stiffness by TEE with ischemic stroke in elderly patients...
  51. pmc Impact of mitral annular calcification on cardiovascular events in a multiethnic community: the Northern Manhattan Study
    Shun Kohsaka
    Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    JACC Cardiovasc Imaging 1:617-23. 2008
    ..We sought to determine the magnitude of the association between mitral annular calcification (MAC) and vascular events in a multiethnic cohort...
  52. pmc Electrocardiographic left atrial abnormalities and risk of ischemic stroke
    Shun Kohsaka
    Department of Cardiology, Texas Heart Institute, Baylor College of Medicine, Houston, Texas, USA
    Stroke 36:2481-3. 2005
    ..We evaluated the association between electrocardiographic left atrial abnormality (ECG-LAA) and ischemic stroke, especially whether ECG-LAA provides additional prognostic information to that provided by echocardiography...
  53. ncbi request reprint Epidemiology and natural history of arteriovenous malformations
    C Stapf
    Columbia Arteriovenous Malformation Study Project, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neurosurg Focus 11:e1. 2001
    ..Together, these data should help inform therapeutic decisionmaking...
  54. pmc Total homocysteine and cognition in a tri-ethnic cohort: the Northern Manhattan Study
    C B Wright
    Division of Stroke and Critical Care, Department of Neurology, College of Physicians and Surgeons of Columbia University, NI Room 640, 710 W168th Street, New York, NY 10032, USA
    Neurology 63:254-60. 2004
    ..The authors examined homocysteine and cognition in a tri-ethnic community sample 40 years and older...
  55. ncbi request reprint Surgical closure of patent foramen ovale in cryptogenic stroke patients
    S Homma
    Department of Medicine, Columbia University, New York, NY, USA
    Stroke 28:2376-81. 1997
    ..This report reviews our experience with cryptogenic stroke patients with PFO who underwent surgical PFO closure and were followed for recurrence of neurological events...
  56. pmc Impaired flow-mediated vasodilatation is associated with increased left ventricular mass in a multiethnic population. The Northern Manhattan Study
    Takuya Hasegawa
    Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Hypertens 23:413-9. 2010
    ..We tested the hypothesis that impaired flow-mediated vasodilatation (FMD) is associated with increased LV mass in a population-based multiethnic cohort...
  57. pmc Snoring and insomnia are not associated with subclinical atherosclerosis in the Northern Manhattan Study
    Alberto Ramos-Sepulveda
    Department of Neurology, Miller School of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Int J Stroke 5:264-8. 2010
    ..We investigated the relationship between markers of subclinical atherosclerosis, insomnia, snoring, and carotid intima-media thickness, in the Northern Manhattan Study...
  58. pmc Soluble tumor necrosis factor receptor 1 level is associated with left ventricular hypertrophy: the northern Manhattan study
    Yasuyoshi Takei
    Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Am J Hypertens 22:763-9. 2009
    ..We sought to evaluate whether inflammatory markers were independently associated with LVH in a multiethnic population in northern Manhattan...
  59. pmc Heritability and linkage analysis for carotid intima-media thickness: the family study of stroke risk and carotid atherosclerosis
    Ralph L Sacco
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Stroke 40:2307-12. 2009
    ..The aim of this study was to identify quantitative trait loci (QTL) for carotid intima-media thickness (CIMT) a risk factor for stroke and cardiovascular disease...
  60. doi request reprint Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Gregory W Albers
    Stanford University Medical Center, Stanford Stroke Center, 701 Welch Road, Palo Alto, CA 94304 1705, USA
    Chest 133:630S-669S. 2008
    ..5; range, 2.0 to 3.0) [Grade 1A]. In patients with venous sinus thrombosis, we recommend unfractionated heparin (Grade 1B) or low-molecular-weight heparin (Grade 1B) over no anticoagulant therapy during the acute phase...
  61. ncbi request reprint Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    Gregory W Albers
    Stanford University Medical Center, Stanford Stroke Center, 701 Welch Rd, Building B, Suite 325, Palo Alto, CA 94304 1705, USA
    Chest 126:483S-512S. 2004
    ..5; range, 2.0 to 3.0) [Grade 1A]. In patients with venous sinus thrombosis, we recommend unfractionated heparin (Grade 1B) or low molecular weight heparin (Grade 1B) over no anticoagulant therapy during the acute phase...
  62. doi request reprint Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack
    Robert J Adams
    Stroke 39:1647-52. 2008
  63. ncbi request reprint Left atrial size and the risk of ischemic stroke in an ethnically mixed population
    M R Di Tullio
    Department of Medicine, Columbia Presbyterian Medical Center, New York, NY, USA
    Stroke 30:2019-24. 1999
    ..Data are available almost exclusively for white patients. The purpose of this study was to evaluate the association between left atrial size and ischemic stroke in a multiethnic population...
  64. ncbi request reprint Relative elevation in baseline leukocyte count predicts first cerebral infarction
    M S V Elkind
    Department of Neurology, Columbia University College of Physicians and Surgeons, Joseph Mailman School of Public Health, New York, NY, USA
    Neurology 64:2121-5. 2005
    ..Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease...
  65. ncbi request reprint Gender differences in self-report of recovery after stroke: the Northern Manhattan Study
    J Y Chong
    Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 67:1282-4. 2006
    ..Self-reported responses in stroke outcome assessments require further validation by gender and may need to consider the confounding effects of depression...
  66. pmc Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family Study
    H F Lin
    Genome Center, Columbia University, 1150 Saint Nicholas Avenue, New York, NY 10032, USA
    Diabetologia 48:2006-12. 2005
    ..However, studies of genetic contributions to the syndrome are sparse. Against this background, we sought to estimate the heritability of the metabolic syndrome and its component traits...
  67. pmc Endothelial function in individuals with coronary artery disease with and without type 2 diabetes mellitus
    Gissette Reyes-Soffer
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Metabolism 59:1365-71. 2010
    ..This finding may be relevant to the greater early and late morbidity and mortality observed in patients with both CAD and T2DM...
  68. ncbi request reprint Physical activity attenuates the effect of increased left ventricular mass on the risk of ischemic stroke: The Northern Manhattan Stroke Study
    Carlos J Rodriguez
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Am Coll Cardiol 39:1482-8. 2002
    ..The goal of this study was to determine whether the risk of ischemic stroke associated with increased left ventricular mass (LVM) is modified by physical activity (PA)...
  69. ncbi request reprint Ultrasound assessment of subclinical cardiovascular disease in a community-based multiethnic population and comparison to the Framingham score
    Yukio Abe
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Am J Cardiol 98:1374-8. 2006
    ..In the intermediate FRS category, FRS appears to underestimate the coronary risk more in women than in men and more in whites and especially in blacks than in Hispanics...
  70. pmc Relation of Apo(a) size to carotid atherosclerosis in an elderly multiethnic population
    Furcy Paultre
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 22:141-6. 2002
    ..03). This association was significant for all men (P=0.03) and for white women (P=0.007). The results suggest that molecular properties of apo(a) are important in determining the atherogenicity of Lp(a)...
  71. ncbi request reprint Additional impact of electrocardiographic over echocardiographic diagnosis of left ventricular hypertrophy for predicting the risk of ischemic stroke
    Shun Kohsaka
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am Heart J 149:181-6. 2005
    ..The purpose of this study is to determine if electrocardiographically derived criteria for LVH provide additional prognostic value over echocardiography for predicting ischemic stroke in a multiethnic population...
  72. pmc Association between carotid intima-media thickness and aortic arch plaques
    Elena Tessitore
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Am Soc Echocardiogr 23:772-7. 2010
    ..The aim of this study was to investigate this association in an elderly asymptomatic cohort and to assess the possibility of using CIMT to predict the presence or absence of large aortic arch plaques...
  73. pmc Carotid artery plaque thickness is associated with increased serum calcium levels: the Northern Manhattan study
    Mishaela R Rubin
    Department of Medicine, Columbia University College of Physicians and Surgeons, PH8W 864, 630 W 168th St, New York, NY 10032, USA
    Atherosclerosis 194:426-32. 2007
    ..We investigated the association between serum calcium and carotid plaque thickness, a powerful early predictor of clinical coronary and cerebrovascular events...
  74. ncbi request reprint Presence of calcified carotid plaque predicts vascular events: the Northern Manhattan Study
    Shyam Prabhakaran
    Rush University Medical Center, Department of Neurological Sciences, 1725 W Harrison Street, Suite 1121, Chicago, IL 60612, USA shyam
    Atherosclerosis 195:e197-201. 2007
    ..The prognostic implications of carotid plaque calcification (CPC) relative to subsequent vascular events are unclear. Our aim was to determine the association between CPC and risk of vascular events in a prospective multi-ethnic cohort...
  75. pmc High-sensitivity C-reactive protein predicts mortality but not stroke: the Northern Manhattan Study
    M S V Elkind
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 73:1300-7. 2009
    ..To determine whether high-sensitivity C-reactive protein (hsCRP) and serum amyloid A (SAA) predict stroke, vascular events, and mortality in a prospective cohort study...
  76. ncbi request reprint Free protein S deficiency: a possible association with cerebrovascular occlusion
    R L Sacco
    Neurological Institute, New York, NY 10032
    Stroke 20:1657-61. 1989
    ..The frequency of free protein S deficiency in this group of stroke patients was far higher than the expected prevalence in the general population...
  77. pmc Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
    Hannah Gardener
    Department of Neurology, Miller School of Medicine, University of Miami, FL, USA
    BMC Cardiovasc Disord 9:55. 2009
    ..The objective of this cross-sectional analysis was to investigate the relation between blood lipids and carotid plaque...
  78. pmc Metabolic syndrome increases carotid artery stiffness: the Northern Manhattan Study
    David Della-Morte
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Int J Stroke 5:138-44. 2010
    ..The metabolic syndrome and its components are established cardiovascular disease risk factors and may also increase arterial stiffness; however, data regarding this are limited...
  79. pmc Atherosclerotic disease of the proximal aorta and the risk of vascular events in a population-based cohort: the Aortic Plaques and Risk of Ischemic Stroke (APRIS) study
    Cesare Russo
    Departments of Medicine, Columbia University, New York, NY 10032, USA
    Stroke 40:2313-8. 2009
    ..However, this association in the general population is unclear. We sought to assess whether proximal aortic plaques are associated with vascular events in a community-based cohort...
  80. pmc Race/ethnic disparities in left ventricular diastolic function in a triethnic community cohort
    Cesare Russo
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Am Heart J 160:152-8. 2010
    ..We sought to assess whether race-ethnic differences in diastolic function exist. Such differences may contribute to the observed disparities in cardiovascular outcomes...
  81. ncbi request reprint Factors associated with in-hospital mortality after administration of thrombolysis in acute ischemic stroke patients: an analysis of the nationwide inpatient sample 1999 to 2002
    Brian T Bateman
    Columbia Presbyterian Medical College for Physicians and Surgeons, Columbia University, New York, NY, USA
    Stroke 37:440-6. 2006
    ..We therefore examined outcomes in acute stroke patients treated with thrombolysis using the largest discharge database available in the United States for the years 1999 to 2002...
  82. pmc Association between diabetes mellitus and left ventricular hypertrophy in a multiethnic population
    Kazuo Eguchi
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
    Am J Cardiol 101:1787-91. 2008
    ..Presence of T2DM increased the risk of LV hypertrophy by about 1.5-fold, and it possibly interacted with central obesity...
  83. pmc Ethnic differences in the relationship of carotid atherosclerosis to coronary calcification: the Multi-Ethnic Study of Atherosclerosis
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 2154, USA
    Atherosclerosis 197:132-8. 2008
    ..These differences should be pursued for relationships to coronary events to determine whether coronary calcium carries the same risk information in other ethnic groups as it does in Whites...
  84. pmc The association between kidney disease and cardiovascular risk in a multiethnic cohort: findings from the Northern Manhattan Study (NOMAS)
    Thomas L Nickolas
    Stroke 39:2876-9. 2008
    ..The objective of this study was to determine the relationship between chronic kidney disease (CKD), race-ethnicity, and vascular outcomes...
  85. pmc Effect of parathyroidectomy on subclinical cardiovascular disease in mild primary hyperparathyroidism
    M D Walker
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Eur J Endocrinol 167:277-85. 2012
    ..It is unclear whether parathyroidectomy (PTX) improves these abnormalities. The purpose of this study was to determine whether cardiovascular abnormalities in PHPT improve with PTX...
  86. ncbi request reprint Prevalence and predictors of early seizure and status epilepticus after first stroke
    D L Labovitz
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Neurology 57:200-6. 2001
    ..Acute stroke has been reported to cause 22% of all cases of status epilepticus in adults. The determinants of ES and status epilepticus (SE) after stroke, however, are not well understood...
  87. pmc Long-term functional recovery after first ischemic stroke: the Northern Manhattan Study
    Mandip S Dhamoon
    Neurological Institute, 710 W 168th Street, Box 206, New York, NY 10032
    Stroke 40:2805-11. 2009
    ..We hypothesized that patients with ischemic stroke experience functional decline over 5 years independent of recurrent stroke and other risk factors...
  88. pmc Dietary total fat intake and ischemic stroke risk: the Northern Manhattan Study
    Bernadette Boden-Albala
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, N Y, USA
    Neuroepidemiology 32:296-301. 2009
    ..We hypothesized that total dietary fat as part of a Western diet is associated with increased risk of ischemic stroke...
  89. pmc Design of a family study among high-risk Caribbean Hispanics: the Northern Manhattan Family Study
    Ralph L Sacco
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ethn Dis 17:351-7. 2007
    ..Understanding the gene environment interaction is the critical next step toward the development of new and unique approaches to disease prevention and interventions...
  90. pmc Lipoprotein-associated phospholipase A2 activity and risk of recurrent stroke
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, and Columbia Presbyterian Medical Center, New York Presbyterian Hospital, New York, NY, USA
    Cerebrovasc Dis 27:42-50. 2009
    ..Lp-PLA(2) mass correlates only moderately with levels of Lp-PLA(2) activity. The relationship of Lp-PLA(2) activity to risk of stroke recurrence is unknown. We hypothesized that Lp-PLA(2) activity levels would predict risk of recurrence...
  91. pmc High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART)
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, New York, N Y, USA
    Cerebrovasc Dis 28:266-75. 2009
    ..We sought to determine whether lovastatin at doses above those currently approved can be administered safely within 24 h after an acute ischemic stroke...
  92. doi request reprint The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Int J Stroke 3:210-8. 2008
    ..The presently described trial represents a new approach for treatment of acute ischemic stroke, as well as a novel way of conducting a phase I trial, evaluating safety and determining an optimal dose of a potential neuroprotectant drug...
  93. doi request reprint Diabetes, fasting glucose levels, and risk of ischemic stroke and vascular events: findings from the Northern Manhattan Study (NOMAS)
    Bernadette Boden-Albala
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Diabetes Care 31:1132-7. 2008
    ..We explored the relationship between FBG among diabetic subjects and risk of ischemic stroke in a multiethnic prospective cohort...
  94. pmc Patent foramen ovale, cardiac valve thickening, and antiphospholipid antibodies as risk factors for subsequent vascular events: the PICSS-APASS study
    Kumar Rajamani
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Stroke 40:2337-42. 2009
    ..PFO is associated with cryptogenic ischemic stroke. Also, the presence of aPL is associated with ischemic cerebrovascular disease...
  95. ncbi request reprint Effect of aspirin and warfarin therapy in stroke patients with valvular strands
    Shunichi Homma
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Stroke 35:1436-42. 2004
    ..The recurrent rate of adverse events in stroke patients with valvular strands has not been defined and, importantly, there are no randomized studies to evaluate efficacy of antithrombotic therapies in these patients...
  96. ncbi request reprint Moderate alcohol consumption reduces risk of ischemic stroke: the Northern Manhattan Study
    Mitchell S V Elkind
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 37:13-9. 2006
    ..Moderate alcohol consumption is protective against coronary disease, but its relationship to ischemic stroke (IS) is controversial...
  97. ncbi request reprint Interleukin-2 levels are associated with carotid artery intima-media thickness
    Mitchell S V Elkind
    Department of Neurology, Neurology Stroke Division, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, Rm 641, New York, NY 10032, USA
    Atherosclerosis 180:181-7. 2005
    ..To show that serum interleukin levels are associated with carotid intima-media thickness (IMT)...
  98. pmc Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study
    Suh Hang Hank Juo
    Columbia University Genome Center, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Stroke 35:2243-7. 2004
    ..The genetic basis of IMT and obesity has not been well-characterized in Caribbean Hispanics. The purpose of this study was to examine the genetic and environmental contributions to IMT and obesity in this population...
  99. ncbi request reprint Secondary stroke prevention
    Fred Rincon
    Department of Neurology, The Neurological Institute of New York, Columbia University Medical Center, New York, NY 10034, USA
    J Cardiovasc Nurs 23:34-41; quiz 42-3. 2008
    ..The purpose of this review is to highlight the recently published American Stroke Association/American Heart Association guidelines for the secondary prevention of stroke...
  100. ncbi request reprint Lipid-lowering agent use at ischemic stroke onset is associated with decreased mortality
    Mitchell S V Elkind
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurology 65:253-8. 2005
    ..The authors hypothesized that patients with ischemic stroke taking LLAs would have better outcomes than patients not taking LLAs...
  101. ncbi request reprint Prognostic implications of left ventricular mass among Hispanics: the Northern Manhattan Study
    Carlos J Rodriguez
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Hypertension 48:87-92. 2006
    ..Our findings identify the Hispanic population with increased LVM as a high-risk subgroup...