M A Rubin
Affiliation: Columbia University
- Cribriform carcinoma of the prostate and cribriform prostatic intraepithelial neoplasia: incidence and clinical implicationsM A Rubin
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Am J Surg Pathol 22:840-8. 1998..The close association between high tumor volume and HGCP supports the theory that the development of HGCP is a late event in tumor progression, more compatible with the intraductal spread of tumor than dysplasia...
- Morphological features of TMPRSS2-ERG gene fusion prostate cancerJ M Mosquera
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 6110, USA
J Pathol 212:91-101. 2007..These features may also be helpful in diagnosing TMPRSS2-ERG fusion prostate cancer, which may have both prognostic and therapeutic implications...
- TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survivalS Perner
Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY, USA
J Pathol 217:65-72. 2009..We conclude that TTF1 amplification is a mechanism of high-level TTF1 expression in a subset of NSCLCs. When expressed at high levels, this routinely used diagnostic marker is also an independent biomarker of favourable prognosis in AC...
- Is microvascular invasion on radical prostatectomy specimens a useful predictor of PSA recurrence for prostate cancer patients?A de la Taille
Department of Urology, Columbia Presbyterian Medical Center, Columbia University School of Public Health, New York, NY 10032, USA
Eur Urol 38:79-84. 2000..The goal of this study was to investigate the clinical utility of vascular invasion in prostate cancer patients treated by radical prostatectomy as a predictor of PSA recurrence...
- Postatrophic hyperplasia of the prostate gland: neoplastic precursor or innocent bystander?R Shah
Department of Pathology, Section of Urology, University of Michigan, Ann Arbor, Michigan, USA
Am J Pathol 158:1767-73. 2001..Gain of 8c is significantly greater in PAH than benign prostate, SA, and even HGPIN. These findings demonstrate a strong association between PAH and PCA, supporting its role as a neoplastic precursor...
- Prevalence and location of peripheral nerve found on prostate needle biopsyM Zhou
Department of Pathology, University of Michigan, Ann Arbor, USA
Am J Clin Pathol 115:39-43. 2001..Careful examination of routine H&E-stained specimens is sufficient to detect all important PNI...
- Molecular markers for renal cell carcinoma: impact on diagnosis and treatmentM Zhou
Department of Pathology, University of Michigan Medical School, Ann Arbor, USA
Semin Urol Oncol 19:80-7. 2001..High-throughput DNA and tissue microarray techniques promise to revolutionize the discovery and validation of novel molecular markers...
- Relational database structure to manage high-density tissue microarray data and images for pathology studies focusing on clinical outcome: the prostate specialized program of research excellence modelS Manley
Department of Pathology, University of Michigan Comprehensive Cancer and Geriatrics Center, Ann Arbor, Michigan 48109-0946, USA
Am J Pathol 159:837-43. 2001..Because the review is performed over the Internet, this system is ideal for collaborative multi-institutional studies...
- Web-based tissue microarray image data analysis: initial validation testing through prostate cancer Gleason gradingG S Bova
Department of Pathology, Johns Hopkins University, Baltimore, MD 21287-6417, USA
Hum Pathol 32:417-27. 2001..hum pathol 32:417-427...
- Rapid ("warm") autopsy study for procurement of metastatic prostate cancerM A Rubin
Department of Pathology, University of Michigan, Ann Arbor 48109, USA
Clin Cancer Res 6:1038-45. 2000..The development and expansion of this program represent a valuable resource for molecular and clinical researchers...
- Lack of association of prostate carcinoma nuclear grading with prostate specific antigen recurrence after radical prostatectomyM Zhou
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
J Urol 166:2193-7. 2001..Nuclear morphology is subject to tissue fixation and processing artifact. Any nuclear morphometric study must consider this artifact...
- TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohortF Demichelis
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115 6110, USA
Oncogene 26:4596-9. 2007..005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression...
- [Cytogenetic alterations in renal tumors. Applications for comparative genomic hybridization and fluorescence in situ hybridization]K D Mertz
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Urologe A 45:316-8, 320-2. 2006..2;q21.2) translocation. Although not required for most clinical diagnoses, CGH and FISH complement the standard histologic diagnosis of RCC and may provide a definitive diagnosis in a small number of challenging cases...
- Use of laser capture microdissection, cDNA microarrays, and tissue microarrays in advancing our understanding of prostate cancerM A Rubin
Department of Pathology, Urology, and the Comprehensive Cancer and Geriatrics Center of the University of Michigan, Ann Arbor, MI 48109, USA
J Pathol 195:80-6. 2001..This review will concentrate on the application of laser capture microdissection, cDNA microarrays, and tissue microarrays in the area of prostate cancer research...
- Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesisM A Ficazzola
Department of Urology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Carcinogenesis 22:1271-9. 2001..Furthermore, these findings suggest that a significant component of the p53 G(1) arrest pathway might be inactivated in prostate cancer even in the absence of genetic mutations in p53...
- Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesisM A Rubin
Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
Am J Pathol 159:1211-8. 2001....
- Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cancer in Jewish menK L Nastiuk
Department of Pathology and Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
Prostate 40:172-7. 1999..We aimed to determine whether the common germline mutations of BRCA1 or BRCA2 in Ashkenazi Jewish men predisposed them to prostate cancer...
- Delineation of prognostic biomarkers in prostate cancerS M Dhanasekaran
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nature 412:822-6. 2001..Thus, the integration of cDNA microarray, high-density tissue microarray, and linked clinical and pathology data is a powerful approach to molecular profiling of human cancer...