Christine A Richardson
Affiliation: Columbia University
- Rad51 overexpression promotes alternative double-strand break repair pathways and genome instabilityChristine Richardson
Department of Pathology, Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, 1150 St Nicholas Avenue, New York, NY 10032, USA
Oncogene 23:546-53. 2004..Increased Rad51 also promoted aneuploidy and multiple chromosomal rearrangements. These data provide a link between elevated Rad51 protein levels, genome instability, and tumor progression...
- RAD51, genomic stability, and tumorigenesisChristine Richardson
Department of Pathology, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
Cancer Lett 218:127-39. 2005..Insights into the connection between disregulated Rad51 and malignant phenotype indicate that Rad51 is a potential target for new anti-cancer regimens including those that use siRNA technology...
- Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cellsDavid M Weinstock
Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
DNA Repair (Amst) 5:1065-74. 2006..Although SSA can efficiently mediate translocations between identical repeats, its contribution to translocation formation is likely very limited because of sequence divergence between repetitive elements in the genome...
- Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammationKenneth R Hallows
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
J Biol Chem 281:4231-41. 2006..We propose that therapies to activate AMPK in the CF airway may be beneficial in reducing excessive airway inflammation, a major cause of CF morbidity...