C Reitz

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc Alzheimer's disease and the amyloid cascade hypothesis: a critical review
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Int J Alzheimers Dis 2012:369808. 2012
  2. pmc Dyslipidemia and the risk of Alzheimer's disease
    Christiane Reitz
    The Gertrude H Sergievsky, The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Atheroscler Rep 15:307. 2013
  3. pmc Effect of genetic variation in LRRTM3 on risk of Alzheimer disease
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York, USA
    Arch Neurol 69:894-900. 2012
  4. pmc Dyslipidemia and dementia: current epidemiology, genetic evidence, and mechanisms behind the associations
    Christiane Reitz
    The Gertrude H Sergievsky Center, The Taub Institute for Research on Alzheimer s Disease and The Aging Brain New York, NY, USA
    J Alzheimers Dis 30:S127-45. 2012
  5. pmc A summary risk score for the prediction of Alzheimer disease in elderly persons
    Christiane Reitz
    The Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:835-41. 2010
  6. pmc Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:1491-7. 2010
  7. pmc Memory performance is related to amyloid and tau pathology in the hippocampus
    C Reitz
    Gertrude H Sergievsky Center Taub Institute for Research on the Aging Brain, 630 West 168 Street, Columbia University, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 80:715-21. 2009
  8. pmc Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    Arch Neurol 66:834-40. 2009
  9. pmc Linking hippocampal structure and function to memory performance in an aging population
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:1385-92. 2009
  10. pmc Relation between vascular risk factors and neuropsychological test performance among elderly persons with Alzheimer's disease
    Christiane Reitz
    The Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Neurol Sci 257:194-201. 2007

Detail Information

Publications32

  1. pmc Alzheimer's disease and the amyloid cascade hypothesis: a critical review
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Int J Alzheimers Dis 2012:369808. 2012
    ..This paper provides a critical overview of the evidence for and against the amyloid cascade hypothesis in AD and provides suggestions for future directions...
  2. pmc Dyslipidemia and the risk of Alzheimer's disease
    Christiane Reitz
    The Gertrude H Sergievsky, The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Atheroscler Rep 15:307. 2013
    ..The aim of this article is to provide a comprehensive review of the findings of epidemiological, genetic, and cell biology studies aiming to elucidate the role of cholesterol in the pathogenesis of AD...
  3. pmc Effect of genetic variation in LRRTM3 on risk of Alzheimer disease
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York, USA
    Arch Neurol 69:894-900. 2012
    ..To explore the role of leucine-rich repeat transmembrane 3 (LRRTM3) in late-onset Alzheimer disease (AD) by independent genetic epidemiologic and functional studies...
  4. pmc Dyslipidemia and dementia: current epidemiology, genetic evidence, and mechanisms behind the associations
    Christiane Reitz
    The Gertrude H Sergievsky Center, The Taub Institute for Research on Alzheimer s Disease and The Aging Brain New York, NY, USA
    J Alzheimers Dis 30:S127-45. 2012
    ..The aim of this review is to summarize the findings of epidemiological and cell biological studies to elucidate the role of cholesterol in AD etiology...
  5. pmc A summary risk score for the prediction of Alzheimer disease in elderly persons
    Christiane Reitz
    The Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:835-41. 2010
    ..To develop a simple summary risk score for the prediction of Alzheimer disease in elderly persons based on their vascular risk profiles...
  6. pmc Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Arch Neurol 67:1491-7. 2010
    ..To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models...
  7. pmc Memory performance is related to amyloid and tau pathology in the hippocampus
    C Reitz
    Gertrude H Sergievsky Center Taub Institute for Research on the Aging Brain, 630 West 168 Street, Columbia University, New York, NY 10032, USA
    J Neurol Neurosurg Psychiatry 80:715-21. 2009
    ..To determine the relation of amyloid and tau pathology in the hippocampal formation to decline in memory and other cognitive functions in Alzheimer's disease (AD)...
  8. pmc Validity of self-reported stroke in elderly African Americans, Caribbean Hispanics, and Whites
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    Arch Neurol 66:834-40. 2009
    ..The validity of a self-reported stroke remains inconclusive...
  9. pmc Linking hippocampal structure and function to memory performance in an aging population
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:1385-92. 2009
    ..Magnetic resonance imaging is used to assess structure and function in the hippocampal formation...
  10. pmc Relation between vascular risk factors and neuropsychological test performance among elderly persons with Alzheimer's disease
    Christiane Reitz
    The Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Neurol Sci 257:194-201. 2007
    ..Vascular risk factors increase the risk of Alzheimer's disease (AD). The mechanisms for these associations are unclear, and may be due to misdiagnosis of a vascular dementia syndrome as AD...
  11. pmc Impact of plasma lipids and time on memory performance in healthy elderly without dementia
    C Reitz
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neurology 64:1378-83. 2005
    ..To examine the association of plasma lipid levels to changes in cognitive function in elderly subjects without dementia...
  12. pmc Effect of smoking and time on cognitive function in the elderly without dementia
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurology 65:870-5. 2005
    ..To examine the association between smoking and changes in cognitive function over time in elderly persons without dementia...
  13. pmc Hypertension and the risk of mild cognitive impairment
    Christiane Reitz
    The Gertrude H Sergievsky Center, Columbia University Medical Center, Columbia University, New York, NY 10706, USA
    Arch Neurol 64:1734-40. 2007
    ..To explore whether hypertension is associated with the risk of mild cognitive impairment (MCI), an intermediate stage of dementia, because there are conflicting data relating hypertension to the risk of Alzheimer disease...
  14. pmc Subclinical cerebrovascular disease in mild cognitive impairment
    J A Luchsinger
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Neurology 73:450-6. 2009
    ..Cerebrovascular disease (CVD) may contribute to mild cognitive impairment (MCI). We sought to determine the relation of white matter hyperintensity (WMH) volume and infarcts in brain MRI to MCI in a community-based sample...
  15. pmc Stroke and memory performance in elderly persons without dementia
    Christiane Reitz
    Gertrude H Sergievsky Center, The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Arch Neurol 63:571-6. 2006
    ..However, it remains unclear if cerebrovascular disease is directly related to cognitive decline in the absence of cognitive impairment or dementia...
  16. pmc Plasma homocysteine and risk of mild cognitive impairment
    Christiane Reitz
    The Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N Y, USA
    Dement Geriatr Cogn Disord 27:11-7. 2009
    ..We sought to explore whether fasting plasma homocysteine is associated with the risk of mild cognitive impairment (MCI), an intermediate stage to dementia...
  17. pmc Aggregation of vascular risk factors and risk of incident Alzheimer disease
    J A Luchsinger
    Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Neurology 65:545-51. 2005
    ..The prevalence of Alzheimer disease (AD) is increasing in the elderly, and vascular risk factors may increase its risk...
  18. pmc Endophenotypes in normal brain morphology and Alzheimer's disease: a review
    C Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neuroscience 164:174-90. 2009
    ..Given that the pathways from genotypes to end-stage phenotypes are circuitous at best, identifying endophenotypes more proximal to the effects of genetic variation may expedite the attempts to link genetic variants to disorders...
  19. pmc Frequency of subclinical heart disease in elderly persons with dementia
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Am J Geriatr Cardiol 16:183-8. 2007
    ..With the increasing prevalence of Alzheimer's disease and vascular dementia, clinicians have to be more attentive to the presence of structural heart disease and its complications in persons with these conditions...
  20. pmc Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1
    Richard Mayeux
    Gertrude H Sergievsky Center, Columbia University, New York, NY, USA
    Alzheimers Dement 7:15-34. 2011
    ..Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in "mixed dementia"...
  21. pmc The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease
    Joseph H Lee
    Sergievsky Center, 630 W 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 8:384-91. 2008
    ..However, putative variants have not yet been identified. Further research is necessary to determine its utility as a diagnostic marker of AD or as a target for new therapeutic approaches...
  22. pmc Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals
    Joseph H Lee
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 68:320-8. 2011
    ....
  23. ncbi request reprint Relation of diabetes to mild cognitive impairment
    Jose A Luchsinger
    Department of Medicine, Taub Institute for Research of Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Arch Neurol 64:570-5. 2007
    ..Type 2 diabetes mellitus is an important risk factor for Alzheimer disease and is more prevalent in elderly minority persons compared with non-Hispanic white persons...
  24. pmc Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Arch Neurol 67:564-9. 2010
    ..Elevated blood pressure (BP) and fluctuation in BP may lead to cerebrovascular disease through ischemic changes and compromised cerebral autoregulation...
  25. pmc Plasma lipid levels in the elderly are not associated with the risk of mild cognitive impairment
    Christiane Reitz
    Gertrude H Sergievsky Center, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, N Y, USA
    Dement Geriatr Cogn Disord 25:232-7. 2008
    ..Baseline data were collected from 1992 to 1994, follow-up data were collected at 18-month intervals...
  26. pmc Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan
    Adam M Brickman
    Departmentof Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Arch Neurol 65:1053-61. 2008
    ..Aging is accompanied by a decrease in brain volume and by an increase in cerebrovascular disease...
  27. pmc Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)
    C Reitz
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Transl Psychiatry 3:e256. 2013
    ..More importantly, the results indicate that variants within these genes have epistatic effects on AD risk...
  28. pmc Comparison of clinical manifestations in Alzheimer disease and dementia with Lewy bodies
    Angela Nervi
    Gertrude H Sergievsky Center, Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Columbia University, New York, NY 10032, USA
    Arch Neurol 65:1634-9. 2008
    ..The clinical delineation of dementia with Lewy bodies (DLB) from Alzheimer disease (AD) remains unclear...
  29. pmc Relation of plasma lipids to Alzheimer disease and vascular dementia
    Christiane Reitz
    Gertrude H Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Arch Neurol 61:705-14. 2004
    ..The relation between plasma lipid levels and Alzheimer disease (AD) and vascular dementia (VaD), and the impact of drugs to lower lipid levels remains unclear...
  30. pmc Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Alzheimers Dis 19:229-51. 2010
    ..In addition, we discuss the potentials and difficulties researchers face in designing appropriate studies for gene discovery...
  31. pmc Use of genetic variation as biomarkers for Alzheimer's disease
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Ann N Y Acad Sci 1180:75-96. 2009
    ..Here, we review the usefulness of genetic variation as diagnostic tools and biomarkers in LOAD and discuss the potentials and difficulties researchers face in designing appropriate studies for gene discovery...