VINCENT RACANIELLO

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells
    Juliet M Morrison
    Department of Microbiology, Columbia University College of Physicians, New York, NY 10032, USA
    J Virol 83:4412-22. 2009
  2. ncbi One hundred years of poliovirus pathogenesis
    Vincent R Racaniello
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W 168th St, New York, NY 10032, USA
    Virology 344:9-16. 2006
  3. ncbi Age-dependent poliovirus replication in the mouse central nervous system is determined by internal ribosome entry site-mediated translation
    Steven Kauder
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W. 168th St, New York, New York 10032, USA
    J Virol 80:2589-95. 2006
  4. ncbi Emerging infectious diseases
    Vincent R Racaniello
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 113:796-8. 2004
  5. ncbi Poliovirus tropism and attenuation are determined after internal ribosome entry
    Steven E Kauder
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 113:1743-53. 2004
  6. ncbi MDA-5 is cleaved in poliovirus-infected cells
    Paola M Barral
    Department of Urology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, 701 W 168th St, New York, NY 10032, USA
    J Virol 81:3677-84. 2007
  7. ncbi Enterovirus 70 receptor utilization is controlled by capsid residues that also regulate host range and cytopathogenicity
    Melissa Stewart Kim
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    J Virol 81:8648-55. 2007
  8. ncbi Amino acid changes in proteins 2B and 3A mediate rhinovirus type 39 growth in mouse cells
    Julie R Harris
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W. 168th St, New York, NY 10032, USA
    J Virol 79:5363-73. 2005
  9. ncbi Transgenic mouse model for echovirus myocarditis and paralysis
    Scott A Hughes
    Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:15906-11. 2003
  10. ncbi Hepatitis C virus internal ribosome entry site-dependent translation in Saccharomyces cerevisiae is independent of polypyrimidine tract-binding protein, poly(rC)-binding protein 2, and La protein
    Amy B Rosenfeld
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W. 168th St, New York, New York 10032, USA
    J Virol 79:10126-37. 2005

Research Grants

  1. Enterovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2007
  2. Rhinovirus Pathogenesis and Host Range
    VINCENT RACANIELLO; Fiscal Year: 2007
  3. Rhinovirus Pathogenesis and Host Range
    VINCENT RACANIELLO; Fiscal Year: 2006
  4. Transgenic Mouse Model for Echovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2004
  5. POLIOVIRUS USING INFECTIOUS VIRAL CDNA CLONE
    VINCENT RACANIELLO; Fiscal Year: 2002
  6. Rhinovirus Pathogenesis and Host Range
    Vincent R Racaniello; Fiscal Year: 2010

Collaborators

  • Devanand Sarkar
  • BERT SEMLER
  • Julie R Harris
  • Juliet M Morrison
  • Steven E Kauder
  • Paola M Barral
  • Melissa Stewart Kim
  • Steven Kauder
  • Amy B Rosenfeld
  • David M Brown
  • Scott A Hughes
  • Béatrice Baury
  • Jennifer Drahos
  • Paul B Fisher
  • Pankaj Gupta
  • Sherry Kan
  • Christopher T Cornell
  • Gwendolyn M Jang
  • Hervé M Blottiere
  • Patrick Lustenberger
  • Christian L Laboisse
  • Anne Jarry
  • Harshwardhan M Thaker
  • Philippe Blanchardie
  • Marc G Denis
  • Brian M McDermott
  • Damien Masson

Detail Information

Publications13

  1. ncbi Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells
    Juliet M Morrison
    Department of Microbiology, Columbia University College of Physicians, New York, NY 10032, USA
    J Virol 83:4412-22. 2009
    ..These results support an inhibitory role for 2A(pro) in the most downstream event in interferon signaling, the antiviral activities of ISGs...
  2. ncbi One hundred years of poliovirus pathogenesis
    Vincent R Racaniello
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W 168th St, New York, NY 10032, USA
    Virology 344:9-16. 2006
    ..The dilemma is not how to answer the remaining questions, but whether there will be sufficient time to do so before global eradication of poliomyelitis leads to cessation of research on the disease...
  3. ncbi Age-dependent poliovirus replication in the mouse central nervous system is determined by internal ribosome entry site-mediated translation
    Steven Kauder
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W. 168th St, New York, New York 10032, USA
    J Virol 80:2589-95. 2006
    ..These findings show that HRV2 IRES-mediated translation is a determinant of virus replication in the murine brain and spinal cord and suggest that the IRES determines the species specificity of HRV2 infection...
  4. ncbi Emerging infectious diseases
    Vincent R Racaniello
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 113:796-8. 2004
    ..The selective forces that drive the emergence of new infectious diseases, and the implications for our survival, are just beginning to be understood...
  5. ncbi Poliovirus tropism and attenuation are determined after internal ribosome entry
    Steven E Kauder
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 113:1743-53. 2004
    ..Tropism of wild-type and vaccine strains of poliovirus is therefore determined after internal ribosome entry...
  6. ncbi MDA-5 is cleaved in poliovirus-infected cells
    Paola M Barral
    Department of Urology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, 701 W 168th St, New York, NY 10032, USA
    J Virol 81:3677-84. 2007
    ..Poliovirus-induced cleavage of MDA-5 may be a mechanism to antagonize production of type I interferon in response to viral infection...
  7. ncbi Enterovirus 70 receptor utilization is controlled by capsid residues that also regulate host range and cytopathogenicity
    Melissa Stewart Kim
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    J Virol 81:8648-55. 2007
    ..The five EV70 residues define a region of the capsid that controls viral host range, DAF utilization, and cytopathogenicity...
  8. ncbi Amino acid changes in proteins 2B and 3A mediate rhinovirus type 39 growth in mouse cells
    Julie R Harris
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W. 168th St, New York, NY 10032, USA
    J Virol 79:5363-73. 2005
    ..The observation that changes in HRV39 2B and 3A proteins lead to viral growth in mouse cells suggests that one or both of these proteins interact with host cell proteins to promote viral replication...
  9. ncbi Transgenic mouse model for echovirus myocarditis and paralysis
    Scott A Hughes
    Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:15906-11. 2003
    ..These findings establish human very late antigen 2 transgenic mice as a model for echovirus pathogenesis...
  10. ncbi Hepatitis C virus internal ribosome entry site-dependent translation in Saccharomyces cerevisiae is independent of polypyrimidine tract-binding protein, poly(rC)-binding protein 2, and La protein
    Amy B Rosenfeld
    Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 W. 168th St, New York, New York 10032, USA
    J Virol 79:10126-37. 2005
    ..These findings demonstrate that the genome of S. cerevisiae encodes all proteins necessary for internal initiation of translation mediated by the HCV IRES...
  11. ncbi Changes in rhinovirus protein 2C allow efficient replication in mouse cells
    Julie R Harris
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Virol 77:4773-80. 2003
    ..The characterization of a rhinovirus host range mutant will facilitate the investigation of cellular proteins required for efficient viral growth and the development of a murine model for rhinovirus infection...
  12. ncbi Cell-dependent role for the poliovirus 3' noncoding region in positive-strand RNA synthesis
    David M Brown
    Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, California 92697, USA
    J Virol 78:1344-51. 2004
    ..These data suggest that, together with a cellular factor(s) that is limiting in neuronal cells, the poliovirus 3' noncoding region is involved in positive-strand synthesis during genome replication...
  13. ncbi Identification of secreted CD155 isoforms
    Béatrice Baury
    Institut National de la Santé et de la Recherche Médicale U539, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes, France
    Biochem Biophys Res Commun 309:175-82. 2003
    ..The high level of CD155 synthesis in many tissues and the presence of sCD155 in biological fluids suggest the existence of an important role for the protein in cellular function...

Research Grants16

  1. Enterovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2007
    ..The biological role of poliovirus-induced cleavage of RIG-I and MDA-5 will be determined. Because poliovirus is a model pathogen, the results will contribute to the control of other medically relevant viruses. ..
  2. Rhinovirus Pathogenesis and Host Range
    VINCENT RACANIELLO; Fiscal Year: 2007
    ..The identification of cell proteins that play a role in rhinovirus replication may reveal new targets for therapeutic intervention of the common cold. ..
  3. Rhinovirus Pathogenesis and Host Range
    VINCENT RACANIELLO; Fiscal Year: 2006
    ....
  4. Transgenic Mouse Model for Echovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2004
    ..Establishment of a small animal model may yield information about echovirus pathogenesis that could stimulate development of echovirus vaccines or antiviral drugs. ..
  5. POLIOVIRUS USING INFECTIOUS VIRAL CDNA CLONE
    VINCENT RACANIELLO; Fiscal Year: 2002
    ..The results of these experiments will contribute to the long term goal of this research, which is to provide a complete description of the replication and pathogenesis of a human viral pathogen. ..
  6. Rhinovirus Pathogenesis and Host Range
    Vincent R Racaniello; Fiscal Year: 2010
    ..The identification of cell proteins that play a role in rhinovirus replication may reveal new targets for therapeutic intervention of the common cold. ..