SERGE E PRZEDBORSKI

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint Molecular targets for neuroprotection
    Serge Przedborski
    Departments of Neurology and Pathology, and the Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:14-8. 2004
  2. ncbi request reprint The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety
    S Przedborski
    Department of Neurology, Columbia University, New York, USA
    J Neurochem 76:1265-74. 2001
  3. pmc Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
    S Przedborski
    Department of Neurology, Columbia University, New York 10032, USA
    Proc Natl Acad Sci U S A 93:4565-71. 1996
  4. ncbi request reprint Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance
    Serge Przedborski
    Department of Neurology, Center of Neurobiology and Behavior, Columbia University, New York, NY, USA
    Neurologist 10:1-7. 2004
  5. ncbi request reprint The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease
    Serge Przedborski
    Neuroscience Research Laboratories of the Movement Disorder Division, Department of Neurology, Columbia University, New York, New York 10032, USA
    Ann N Y Acad Sci 991:189-98. 2003
  6. ncbi request reprint MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    Serge Przedborski
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Bioenerg Biomembr 36:375-9. 2004
  7. ncbi request reprint Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease
    Serge Przedborski
    Department of Neurology, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Antioxid Redox Signal 7:685-93. 2005
  8. pmc Neurodegeneration: what is it and where are we?
    Serge Przedborski
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Clin Invest 111:3-10. 2003
  9. ncbi request reprint Recent advances in amyotrophic lateral sclerosis research
    Serge Przedborski
    Department of Neurology, Columbia University College of Physicians and Surgeons, 650 West 168th Street, BB 307, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 3:70-7. 2003
  10. ncbi request reprint Pathogenesis of nigral cell death in Parkinson's disease
    Serge Przedborski
    Departmentsof Neurology, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Parkinsonism Relat Disord 11:S3-7. 2005

Research Grants

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Molecular targets for neuroprotection
    Serge Przedborski
    Departments of Neurology and Pathology, and the Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:14-8. 2004
    ..Information generated by these pre-clinical studies holds the promise to provide sound scientific basis for the development of effective neuroprotective therapies for ALS...
  2. ncbi request reprint The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety
    S Przedborski
    Department of Neurology, Columbia University, New York, USA
    J Neurochem 76:1265-74. 2001
  3. pmc Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity
    S Przedborski
    Department of Neurology, Columbia University, New York 10032, USA
    Proc Natl Acad Sci U S A 93:4565-71. 1996
    ..These results indicate that neuronally derived NO mediates, in part, MPTP-induced neurotoxicity. The similarity between the MPTP model and PD raises the possibility that NO may play a significant role in the etiology of PD...
  4. ncbi request reprint Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance
    Serge Przedborski
    Department of Neurology, Center of Neurobiology and Behavior, Columbia University, New York, NY, USA
    Neurologist 10:1-7. 2004
    ..PCD, rather than being passive, is an active mechanism of cell death tightly regulated by multiple molecular pathways...
  5. ncbi request reprint The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease
    Serge Przedborski
    Neuroscience Research Laboratories of the Movement Disorder Division, Department of Neurology, Columbia University, New York, New York 10032, USA
    Ann N Y Acad Sci 991:189-98. 2003
    ..How to target these factors to devise effective neuroprotective therapies for PD is also discussed...
  6. ncbi request reprint MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    Serge Przedborski
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Bioenerg Biomembr 36:375-9. 2004
    ..How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review...
  7. ncbi request reprint Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease
    Serge Przedborski
    Department of Neurology, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Antioxid Redox Signal 7:685-93. 2005
    ..This approach also enabled us to describe how our understanding of the mechanism of actions of certain toxins has evolved over time, which is particularly striking in the case of the quatrogenarian neurotoxin, 6-hydroxydopamine...
  8. pmc Neurodegeneration: what is it and where are we?
    Serge Przedborski
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Clin Invest 111:3-10. 2003
  9. ncbi request reprint Recent advances in amyotrophic lateral sclerosis research
    Serge Przedborski
    Department of Neurology, Columbia University College of Physicians and Surgeons, 650 West 168th Street, BB 307, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 3:70-7. 2003
    ....
  10. ncbi request reprint Pathogenesis of nigral cell death in Parkinson's disease
    Serge Przedborski
    Departmentsof Neurology, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Parkinsonism Relat Disord 11:S3-7. 2005
    ....
  11. ncbi request reprint Experimental developments in movement disorders: update on proposed free radical mechanisms
    S Przedborski
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Curr Opin Neurol 11:335-9. 1998
    ..Finally, the degree to which toxin-induced and genetically engineered experimental models have been useful in delineating parts of the mechanisms involved in the cascade of events that lead to neuronal death is emphasized...
  12. ncbi request reprint Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
    S Przedborski
    Department of Neurology, Columbia University, New York, NY 10032, USA
    J Neurochem 76:637-40. 2001
    ....
  13. doi request reprint Inflammation and Parkinson's disease pathogenesis
    Serge Przedborski
    Department of Neurology, Pathology and Cell Biology, Columbia University, New York, New York, USA
    Mov Disord 25:S55-7. 2010
    ..Therapeutic strategies geared toward reducing inflammation and inhibiting the production of these glial-derived toxic molecules may be a promising neuroprotective strategy for the treatment of Parkinson's disease and related conditions...
  14. pmc D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, New York, USA
    J Clin Invest 112:892-901. 2003
    ..Because of the safety record of ketone bodies in the treatment of epilepsy and their ability to penetrate the blood-brain barrier, DbetaHB may be a novel neuroprotective therapy for PD...
  15. ncbi request reprint Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice
    Dong Kug Choi
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 25:6594-600. 2005
    ..This study demonstrates that MPO participates in the MPTP neurotoxic process and suggests that inhibitors of MPO may provide a protective benefit in PD...
  16. ncbi request reprint L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ann Neurol 56:51-60. 2004
    ..This study demonstrates that HADH II/ABAD modulates MPTP neurotoxicity and suggests that HADH II/ABAD mimetics may provide protective benefit in the treatment of PD...
  17. ncbi request reprint Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
    ..This study demonstrates that microglial-related inflammatory events play a significant role in the MPTP neurotoxic process and suggests that minocycline may be a valuable neuroprotective agent for the treatment of PD...
  18. pmc Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
    Makiko Nagai
    Department of Neurology, Columbia University, 710 West 168th Street, New York, New York 10032, USA
    Nat Neurosci 10:615-22. 2007
    ..Identification of the astrocyte-derived soluble factor(s) may have far-reaching implications for ALS from both a pathogenic and therapeutic standpoint...
  19. pmc Programmed cell death in amyotrophic lateral sclerosis
    Christelle Guegan
    Department of Neurology, Columbia University, New York, New York, USA
    J Clin Invest 111:153-61. 2003
  20. pmc Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
    Yanping Li
    Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA
    Nat Neurosci 12:826-8. 2009
    ..These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics...
  21. pmc Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage
    Celine Perier
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:19126-31. 2005
    ..This molecular scenario may have far-reaching implications for the development of effective neuroprotective therapies for these incurable illnesses...
  22. pmc NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Du Chu Wu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:6145-50. 2003
    ..This study supports a critical role for NADPH-oxidase in the pathogenesis of PD and suggests that targeting this enzyme or enhancing extracellular antioxidants may provide novel therapies for PD...
  23. ncbi request reprint Proteasome inhibition and Parkinson's disease modeling
    Jordi Bove
    Department of Neurology, Columbia University, New York, NY, USA
    Ann Neurol 60:260-4. 2006
    ..Although theoretically appealing, this specific model of Parkinson's disease appears to exhibit poor reproducibility...
  24. ncbi request reprint Genetic clues to the pathogenesis of Parkinson's disease
    Miquel Vila
    Department of Neurology, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Nat Med 10:S58-62. 2004
    ..These breakthroughs have not provided a direct explanation for the disease process. Nevertheless, they have helped transform Parkinson's disease research by providing tangible clues to the neurobiology of the disorder...
  25. pmc The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice
    Du Chu Wu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:12132-7. 2006
    ..These findings suggest a non-cell-autonomous mechanism through which inflammation could hasten motor neuron death and contribute to the selective motor neuronal degeneration in ALS...
  26. ncbi request reprint Pathogenic role of glial cells in Parkinson's disease
    Peter Teismann
    Neuroscience Research, Movement Disorder Division, Department of Neurology, Columbia University, New York, New York 10032, USA
    Mov Disord 18:121-9. 2003
    ..We discuss the potential protective and deleterious effects of glial cells in the SNpc of PD and examine how those factors may contribute to the pathogenesis of this disease...
  27. pmc Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease
    Cristina Malagelada
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 30:1166-75. 2010
    ....
  28. pmc Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP
    William Dauer
    Department of Neurology, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 99:14524-9. 2002
    ....
  29. ncbi request reprint Protocol for the MPTP mouse model of Parkinson's disease
    Vernice Jackson-Lewis
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Nat Protoc 2:141-51. 2007
    ..This protocol calls for implementation of safety measures and for the acquisition of several pieces of equipment, which are a one-time investment worth making if one elects to use this model on a regular basis...
  30. pmc CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism
    Robert M Silva
    Department of Neurology, The College of Physicians and Surgeons, Columbia University, New York 10032, USA
    J Neurochem 95:974-86. 2005
    ..We conclude that the role of CHOP depends on the nature of the toxic stimulus. For 6OHDA, an oxidative metabolite of dopamine, it is a mediator of apoptotic death...
  31. ncbi request reprint Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS
    Christelle Guegan
    Department of Neurology, Columbia University, New York, New York 10032, USA
    Mol Cell Neurosci 20:553-62. 2002
    ....
  32. ncbi request reprint Free radical and nitric oxide toxicity in Parkinson's disease
    Serge Przedborski
    Departments of Neurology and Pathology, Columbia University, New York, New York, USA
    Adv Neurol 91:83-94. 2003
  33. ncbi request reprint Targeting programmed cell death in neurodegenerative diseases
    Miquel Vila
    Department of Neurology, Columbia University, 650 West 168th Street, BB 307, New York, New York 10032, USA
    Nat Rev Neurosci 4:365-75. 2003
  34. pmc What can pluripotent stem cells teach us about neurodegenerative diseases?
    Hynek Wichterle
    Department of Neurology, Columbia University, New York, New York, USA
    Nat Neurosci 13:800-4. 2010
    ..Progress in these four areas will substantially accelerate effective application of pluripotent stem cells...
  35. ncbi request reprint Is prostaglandin E(2) a pathogenic factor in amyotrophic lateral sclerosis?
    Gabriele Almer
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ann Neurol 59:980-3. 2006
    ..To elucidate the role of cyclooxygenase-1 (Cox1) and prostaglandin E(2) in ALS neurodegeneration...
  36. doi request reprint Is there a pathogenic role for mitochondria in Parkinson's disease?
    Cristofol Vives-Bauza
    Department of Neurology, Columbia University, New York, New York 10032, USA
    Parkinsonism Relat Disord 15:S241-4. 2009
    ....
  37. pmc Inflammation in ALS and SMA: sorting out the good from the evil
    Dimitra Papadimitriou
    Department of Neurology, New York, NY, USA
    Neurobiol Dis 37:493-502. 2010
    ..Herein, we will review neuroinflammation in both ALS and SMA not only from the angle of neuropathology but also from the angle of its potential role in the pathogenesis and treatment of these two dreadful paralytic disorders...
  38. ncbi request reprint Transgenic superoxide dismutase overproducer: murine
    Serge Przedborski
    Departments of Neurology and Pathology, Columbia University, New York, New York 10032, USA
    Methods Enzymol 349:180-90. 2002
  39. pmc Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
    Peter Teismann
    Neuroscience Research Laboratories of the Movement Disorder Division, Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:5473-8. 2003
    ..Because of the safety record of the COX-2 inhibitors, and their ability to penetrate the blood-brain barrier, these drugs may be therapies for PD...
  40. pmc Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
    Marta Martinez-Vicente
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, New York, New York 10461, USA
    J Clin Invest 118:777-88. 2008
    ..As blockage of CMA increases cellular vulnerability to stressors, we propose that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons...
  41. ncbi request reprint Parkinson's disease: mechanisms and models
    William Dauer
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Neuron 39:889-909. 2003
    ..PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process...
  42. doi request reprint Control of mitochondrial integrity in Parkinson's disease
    Cristofol Vives-Bauza
    Department of Neurology, Motor Neuron Biology and Disease, Columbia University, New York, NY, USA
    Prog Brain Res 183:99-113. 2010
    ....
  43. ncbi request reprint Nitric oxide and reactive oxygen species in Parkinson's disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    IUBMB Life 55:329-35. 2003
    ..Similar contribution of reactive nitrogen and oxygen species may well underlie the neurodegenerative processes in Parkinson's disease...
  44. ncbi request reprint Alpha-synuclein overexpression increases cytosolic catecholamine concentration
    Eugene V Mosharov
    Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA
    J Neurosci 26:9304-11. 2006
    ....
  45. pmc Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model
    Hitoshi Kikuchi
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:6025-30. 2006
    ..Our results suggest a toxic mechanism for mutant SOD1 by which this ubiquitously expressed pathogenic protein could affect motor neuron survival and contribute to the selective motor neuronal degeneration in ALS...
  46. pmc Toxin-induced models of Parkinson's disease
    Jordi Bove
    Department of Neurology, Columbia University, New York, New York 10032, USA
    NeuroRx 2:484-94. 2005
    ..However, we also try to provide the reader with an idea about the various strengths and the weaknesses of these neurotoxic models...
  47. ncbi request reprint Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia
    Xiaohong Li
    Department of Neurology, Pritzker School of Medicine and Center for Comprehensive Care and Research on Memory Disorders, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Ann Neurol 58:858-64. 2005
    ..However, the strong association between heterozygosity and PPA raises new questions about its cause and the role of PrP in other neurodegenerative diseases...
  48. ncbi request reprint Glial cell response: A pathogenic factor in Parkinson's disease
    Du Chu Wu
    Neuroscience Research, Movement Disorder Division, Department of Neurology, Columbia University, New York, New York, USA
    J Neurovirol 8:551-8. 2002
    ..In this review, the authors discuss the potential protective and deleterious effects of glial cells in the SNpc of PD and examine how these factors may contribute to the pathogenesis of this disease...
  49. pmc PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    Cristofol Vives-Bauza
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:378-83. 2010
    ..Thus by impairing this process, mutations in either Parkin or PINK1 may alter mitochondrial turnover which, in turn, may cause the accumulation of defective mitochondria and, ultimately, neurodegeneration in Parkinson's disease...
  50. pmc Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance
    Chun Zhou
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ann N Y Acad Sci 1147:93-104. 2008
    ..If correct, this may be a reason why neuroprotective trials using a single agent, such as an antioxidant, have thus far generated disappointing results...
  51. pmc The kinase domain of mitochondrial PINK1 faces the cytoplasm
    Chun Zhou
    Department of Neurology, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:12022-7. 2008
    ..These results are critical in rectifying the location and orientation of PINK1 in mitochondria, and they should help decipher its normal physiological function and potential pathogenic role in PD...
  52. doi request reprint A sequel to the tale of p25/Cdk5 in neurodegeneration
    Burcin Ikiz
    Department of Neurology, Pathology, and Cell Biology and Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA
    Neuron 60:731-2. 2008
    ..This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions...
  53. pmc Intrabody and Parkinson's disease
    Chun Zhou
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Biochim Biophys Acta 1792:634-42. 2009
    ..Furthermore, we propose possible intrabody applications against leucine-rich repeat kinase 2 (LRRK2), whose mutations are the most frequent known cause of familial and sporadic PD...

Research Grants17

  1. Proinflammatory enzymes in amytrophic lateral sclerosis
    Serge Przedborski; Fiscal Year: 2009
    ..Herein, we propose to; search for this toxic factor; to demonstrate by which mechanism it kills cells; and to demonstrate whether a similar situation occurs in an animal model of ALS. ..
  2. Mechanisms of Bax-mediated cell death in the MPTP model
    Serge Przedborski; Fiscal Year: 2007
    ..Collectively, the proposed studies should shed light on the molecular mechanisms of neurodegeneration in PD and help to identify new molecular targets for therapeutic intervention. ..
  3. Effect of enriched environment on ALS neurodegeneration
    Serge Przedborski; Fiscal Year: 2005
    ..This development/exploratory project offers an high-risk/high-yield set of studies which may demonstrate, in an original way, how environment may impact on the occurrence and the progression of ALS. ..
  4. Proinflammatory enzymes in amyotrophic lateral sclerosis
    Serge Przedborski; Fiscal Year: 2004
    ..It should also shed light onto the mechanisms of neurodegeneration in ALS. ..
  5. SYNUCLEIN AND NIGRAL DOPAMINERGIC NEURON DEGENERATION
    Serge Przedborski; Fiscal Year: 2003
    ....
  6. NITRIC OXIDE AND PROTEIN NITROTYROSINE IN THE MPTP MODEL
    Serge Przedborski; Fiscal Year: 2002
    ..This proposal contains a comprehensive set of experiments, which should provide important insights into the role of NO in MPTP toxicity. It should also shed light on the mechanism(s) of neurodegeneration in PD. ..
  7. Proinflammatory enzymes in amytrophic lateral sclerosis
    SERGE E PRZEDBORSKI; Fiscal Year: 2010
    ..Herein, we propose to;search for this toxic factor;to demonstrate by which mechanism it kills cells;and to demonstrate whether a similar situation occurs in an animal model of ALS. ..