Geoffrey S Pitt

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin
    Smita Ghosh
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circ Res 98:1048-54. 2006
  2. ncbi request reprint Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels
    G S Pitt
    Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, California 94305, USA
    J Biol Chem 276:30794-802. 2001
  3. ncbi request reprint Calmodulin and CaMKII as molecular switches for cardiac ion channels
    Geoffrey S Pitt
    Department of Medicine, Division of Cardiology, College of Physicians and Surgeons of Columbia University, 630 W 168th St, PH 7W 318, New York, NY 10032, USA
    Cardiovasc Res 73:641-7. 2007
  4. pmc Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin
    Chaojian Wang
    Division of Cardiology, Department of Medicine, Duke University Medical Center, 2 Genome Ct, Durham, NC 27710, USA
    Structure 20:1167-76. 2012
  5. pmc CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation
    Andy Hudmon
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 171:537-47. 2005
  6. pmc Solution structure of the NaV1.2 C-terminal EF-hand domain
    Vesselin Z Miloushev
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032 3702, USA
    J Biol Chem 284:6446-54. 2009
  7. pmc The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability
    Hong Gang Wang
    Division of Cardiology, Department of Medicine, Duke University, Medical Center, Durham, NC 27710, USA
    J Biol Chem 288:13258-68. 2013
  8. pmc Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents
    Hong Gang Wang
    Division of Cardiology, Department of Medicine, and the Ion Channel Research Unit, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25741. 2011
  9. ncbi request reprint Calmodulin mediates Ca2+ sensitivity of sodium channels
    James Kim
    Department of Pharmacology, Division of Cardiology, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:45004-12. 2004
  10. doi request reprint Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini
    Chaojian Wang
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 28:1865-70. 2008

Collaborators

Detail Information

Publications22

  1. ncbi request reprint KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin
    Smita Ghosh
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Circ Res 98:1048-54. 2006
    ..These findings offer a new mechanism for LQTS defects and provide a basis for understanding novel ways that intracellular Ca2+ and CaM regulate ion channels...
  2. ncbi request reprint Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels
    G S Pitt
    Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, California 94305, USA
    J Biol Chem 276:30794-802. 2001
    ..When the C-terminal lobe of CaM binds to the nearby CaM effector sequence (IQ motif), the braking effect is relieved, and CDI is accelerated...
  3. ncbi request reprint Calmodulin and CaMKII as molecular switches for cardiac ion channels
    Geoffrey S Pitt
    Department of Medicine, Division of Cardiology, College of Physicians and Surgeons of Columbia University, 630 W 168th St, PH 7W 318, New York, NY 10032, USA
    Cardiovasc Res 73:641-7. 2007
    ..This review highlights various mechanisms by which CaM and CaMKII regulate cardiovascular ion channel activity and presents a novel model for CaMKII regulation of Ca(V)1.2 Ca(2+) channel function...
  4. pmc Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin
    Chaojian Wang
    Division of Cardiology, Department of Medicine, Duke University Medical Center, 2 Genome Ct, Durham, NC 27710, USA
    Structure 20:1167-76. 2012
    ..Furthermore, we identify a critical interaction that contributes to the specificity of individual Na(V) CTD isoforms for distinctive FHFs...
  5. pmc CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation
    Andy Hudmon
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 171:537-47. 2005
    ..These findings clarify the molecular basis of CDF and demonstrate a novel enzymatic mechanism by which ion channel gating can be modulated by activity...
  6. pmc Solution structure of the NaV1.2 C-terminal EF-hand domain
    Vesselin Z Miloushev
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032 3702, USA
    J Biol Chem 284:6446-54. 2009
    ..Clinically significant mutations identified in the C-terminal region of NaV1 sodium channels cluster in the helix I-IV interface and the helix II-III interhelical segment or in helices III and IV of the NaV1.2 (1777-1882) structure...
  7. pmc The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability
    Hong Gang Wang
    Division of Cardiology, Department of Medicine, Duke University, Medical Center, Durham, NC 27710, USA
    J Biol Chem 288:13258-68. 2013
    ..The necessity for, or redundancy of, distinctive KChIP proteins is not known...
  8. pmc Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents
    Hong Gang Wang
    Division of Cardiology, Department of Medicine, and the Ion Channel Research Unit, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25741. 2011
    ..In addition, our results reveal a surprising lack of contribution of VGCCs to synaptogenesis during early development in cultured hippocampal neurons...
  9. ncbi request reprint Calmodulin mediates Ca2+ sensitivity of sodium channels
    James Kim
    Department of Pharmacology, Division of Cardiology, Columbia University, New York, New York 10032, USA
    J Biol Chem 279:45004-12. 2004
    ..Together, these data offer new biochemical evidence for Ca2+/CaM modulation of Na+ channel function...
  10. doi request reprint Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini
    Chaojian Wang
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 28:1865-70. 2008
    ..We propose a new model for CDI in which the noncanonical Ca2+/CaM-dependent dimerization of the two NR1 subunits inactivates the channel by propagating a conformational change from the short NR1 CT to the nearby channel pore...
  11. pmc Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels
    Chaojian Wang
    Ion Channel Research Unit, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:24253-63. 2011
    ..Together, these results give new insights into details of the interactions between FHFs and Na(V)1.x CTs, and the consequent regulation of Na(+) channels...
  12. pmc Accessory subunit KChIP2 modulates the cardiac L-type calcium current
    Morten B Thomsen
    Department of Medicine, Duke University Medical Center, Box 103030 Medical Center, Durham, NC 27710, USA
    Circ Res 104:1382-9. 2009
    ..2, resulting in increased I(Ca,L). In the context of recent reports that KChIP2 modulates multiple K(V) and Na(V) currents, these results suggest that KChIP2 is a multimodal regulator of cardiac ionic currents...
  13. ncbi request reprint Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons
    Hong Gang Wang
    Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Neurosci 27:9086-93. 2007
    ..Furthermore, this Ca2+/CaM-accelerated trafficking was activity dependent. Thus, CaM imparts Ca2+-dependent regulation not only to mature Ca(V)1.2 channels at the cell surface but also to steps during channel biosynthesis...
  14. pmc Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases
    Lillian Seu
    Department of Pharmacology, Division of Cardiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Gen Physiol 128:605-13. 2006
    ..Together, these results offer new insights into the molecular mechanism of RGK-mediated Ca(2+) channel current modulation...
  15. ncbi request reprint Essential Ca(V)beta modulatory properties are AID-independent
    Janet M Maltez
    Department of Pharmacology, Columbia University, New York, New York 10032, USA
    Nat Struct Mol Biol 12:372-7. 2005
    ....
  16. ncbi request reprint Remodeled cardiac calcium channels
    Geoffrey S Pitt
    Department of Medicine, Columbia University, New York, NY, USA
    J Mol Cell Cardiol 41:373-88. 2006
    ..In addition, it will review the recent advances made in our understanding of the function of the various molecular building blocks that contribute to the proper functioning of the cardiac calcium channel...
  17. pmc The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction
    Albert Y Sun
    Division of Cardiovascular Diseases, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Circ Cardiovasc Genet 4:163-8. 2011
    ..We hypothesized that the S1103Y cardiac sodium channel SCN5A variant influences the propensity for ventricular arrhythmias in black patients with heart failure and reduced ejection fraction...
  18. ncbi request reprint Identification of the components controlling inactivation of voltage-gated Ca2+ channels
    James Kim
    Department of Pharmacology, College of Physicians and Surgeons, of Columbia University, 630 West 168th Street, PH 7W 318, New York, NY 10032 USA
    Neuron 41:745-54. 2004
    ....
  19. pmc The real estate of cardiac signaling: location, location, location
    Meena S George
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:7535-6. 2006
  20. ncbi request reprint Genetics of cardiac repolarization
    Svati H Shah
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    Nat Genet 41:388-9. 2009
    ..Two genome-wide association studies (GWAS) of variation in the QT interval in population-based cohorts now report association with variants in a subset of ion channel genes and other new associations...
  21. pmc FGF14 regulates presynaptic Ca2+ channels and synaptic transmission
    Haidun Yan
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Cell Rep 4:66-75. 2013
    ..Thus, FHFs are multimodal, regulating several discrete neuronal signaling events. SCA27 most likely results at least in part from dysregulation of Ca2+ channel function...
  22. ncbi request reprint Aldosterone, ion channels, and sudden death: another piece of the circle?
    Geoffrey S Pitt
    Am J Physiol Heart Circ Physiol 290:H2176-7. 2006