F P Perera

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. pmc The economic impact of early life environmental tobacco smoke exposure: early intervention for developmental delay
    Thaddeus Miller
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1585-8. 2006
  2. pmc International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth
    Hyunok Choi
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1744-50. 2006
  3. pmc Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland
    Susan Claire Edwards
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 118:1326-31. 2010
  4. pmc Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction
    Hyunok Choi
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 116:658-65. 2008
  5. pmc Prenatal exposure to air pollution, maternal psychological distress, and child behavior
    Frederica P Perera
    DRPH, Mailman School of Public Health, Columbia University, 722 W 168th St, 12th Floor, New York, NY 10032
    Pediatrics 132:e1284-94. 2013
  6. pmc Prohypertensive effect of gestational personal exposure to fine particulate matter. Prospective cohort study in non-smoking and non-obese pregnant women
    Wieslaw A Jedrychowski
    Epidemiology and Preventive Medicine, Jagiellonian University Medical College, 7, Kopernika Street, Krakow, Poland
    Cardiovasc Toxicol 12:216-25. 2012
  7. pmc Prenatal bisphenol a exposure and child behavior in an inner-city cohort
    Frederica Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 120:1190-4. 2012
  8. pmc Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years
    Frederica P Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 120:921-6. 2012
  9. pmc Reproducibility and intraindividual variation over days in buccal cell DNA methylation of two asthma genes, interferon γ (IFNγ) and inducible nitric oxide synthase (iNOS)
    Dz Torrone
    Division of Pulmonary, Allergy and Critical Care of Medicine, PH8E, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Clin Epigenetics 4:3. 2012
  10. doi request reprint Effects of prenatal polycyclic aromatic hydrocarbon exposure and environmental tobacco smoke on child IQ in a Chinese cohort
    F Perera
    Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
    Environ Res 114:40-6. 2012

Detail Information

Publications92

  1. pmc The economic impact of early life environmental tobacco smoke exposure: early intervention for developmental delay
    Thaddeus Miller
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1585-8. 2006
    ..The high cost of childhood asthma related to ETS exposure has been widely recognized; however, the economic impact of ETS-related developmental delay has been less well understood...
  2. pmc International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth
    Hyunok Choi
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1744-50. 2006
    ..To address this gap in knowledge, we examined the association between prenatal exposure to airborne PAHs and birth weight, birth length, and birth head circumference, respectively, in Krakow, Poland, and New York City (NYC)...
  3. pmc Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland
    Susan Claire Edwards
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 118:1326-31. 2010
    ..In this prospective cohort study of Caucasian mothers and children in Krakow, Poland, we evaluated the role of prenatal exposure to urban air pollutants in the pathogenesis of neurobehavioral disorders...
  4. pmc Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction
    Hyunok Choi
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 116:658-65. 2008
    ..Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous air pollutants generated by combustion of organic material, including fossil fuel...
  5. pmc Prenatal exposure to air pollution, maternal psychological distress, and child behavior
    Frederica P Perera
    DRPH, Mailman School of Public Health, Columbia University, 722 W 168th St, 12th Floor, New York, NY 10032
    Pediatrics 132:e1284-94. 2013
    ..The goal was to evaluate potential interactions between prenatal exposure to airborne PAHs and maternal psychological distress during pregnancy on subsequent behavioral problems in children...
  6. pmc Prohypertensive effect of gestational personal exposure to fine particulate matter. Prospective cohort study in non-smoking and non-obese pregnant women
    Wieslaw A Jedrychowski
    Epidemiology and Preventive Medicine, Jagiellonian University Medical College, 7, Kopernika Street, Krakow, Poland
    Cardiovasc Toxicol 12:216-25. 2012
    ..3; 95% CI, 0.3-4.4) but were inversely related to parity (coeff. = -2.7; 95% CI, -4.6 to -0.73). In the observed cohort, the exposure to fine particulate matter during pregnancy was associated with increased maternal blood pressure...
  7. pmc Prenatal bisphenol a exposure and child behavior in an inner-city cohort
    Frederica Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 120:1190-4. 2012
    ..However, there have been limited and inconclusive results with respect to sex-specific BPA effects on child behavior...
  8. pmc Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years
    Frederica P Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 120:921-6. 2012
    ....
  9. pmc Reproducibility and intraindividual variation over days in buccal cell DNA methylation of two asthma genes, interferon γ (IFNγ) and inducible nitric oxide synthase (iNOS)
    Dz Torrone
    Division of Pulmonary, Allergy and Critical Care of Medicine, PH8E, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Clin Epigenetics 4:3. 2012
    ..19 to 0.56, P = 0.06 to 0.30). Our data reveal DNA methylation as a dynamic epigenetic mechanism that can be accessed safely and reproducibly in an inner city pediatric cohort using non-invasive buccal swabs and pyrosequencing technology...
  10. doi request reprint Effects of prenatal polycyclic aromatic hydrocarbon exposure and environmental tobacco smoke on child IQ in a Chinese cohort
    F Perera
    Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
    Environ Res 114:40-6. 2012
    ..We tested the hypothesis that, after adjusting for potential confounders, prenatal exposure to these pollutants would be associated with lower IQ scores at 5 years of age...
  11. pmc Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma
    Carolyn Chang
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Clin Mol Allergy 8:11. 2010
    ..Our objective was to compare indoor allergen-induced CBMC with age 5 peripheral blood mononuclear cell (PBMC) proliferation and determine which may be associated with age 5 allergic immune responses and asthma in an inner city cohort...
  12. pmc Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice
    Lin Lin
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Allergy Asthma Clin Immunol 6:7. 2010
    ..fumigatus) allergen and diesel exhaust particles will be associated with altered IgE production, airway inflammation, airway hyperreactivity (AHR), and airway remodeling of adult offspring...
  13. pmc Benefits of reducing prenatal exposure to coal-burning pollutants to children's neurodevelopment in China
    Frederica Perera
    Department of Environmental Health Sciences, Columbia University, New York, New York, USA
    Environ Health Perspect 116:1396-400. 2008
    ..PAHs are reproductive and developmental toxicants, mutagens, and carcinogens...
  14. ncbi request reprint A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures
    F P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Neurotoxicology 26:573-87. 2005
    ..05). These results underscore the importance of policies that reduce exposure to ETS, air pollution, and pesticides with potentially adverse effects on fetal growth and child neurodevelopment...
  15. ncbi request reprint DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and China
    Frederica Perera
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, Columbia Center for Children s Environmental Health, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 14:709-14. 2005
    ..The data support preventive policies to limit PAH exposure to pregnant women and children...
  16. pmc Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1287-92. 2006
    ..The results require confirmation but suggest that environmental PAHs at levels recently encountered in New York City air may adversely affect children's cognitive development at 3 years of age, with implications for school performance...
  17. pmc Molecular evidence of an interaction between prenatal environmental exposures and birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Avenue B 109, New York, NY 10032, USA
    Environ Health Perspect 112:626-30. 2004
    ..This study provides evidence that combined exposure to environmental pollutants at levels currently encountered in New York City adversely affects fetal development...
  18. pmc Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center cohort
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:1497-502. 2007
    ....
  19. ncbi request reprint Children's environmental health research--highlights from the Columbia Center for Children's Environmental Health
    Frederica Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Ann N Y Acad Sci 1076:15-28. 2006
    ..This article summarizes the recent findings from the Center's projects in the context of current research in children's environmental health...
  20. pmc Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage
    Frederica P Perera
    Mailman School of Public Health of Columbia University, Department of Environmental Health Sciences, New York, New York 10032, USA
    Environ Health Perspect 112:1133-6. 2004
    ..The findings have implications for risk assessment, given the need to protect children as a sensitive subset of the population...
  21. pmc Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years
    Frederica P Perera
    Department of Environmental Health Sciences, Columbia Center for Children s Environmental Healt, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Pediatrics 124:e195-202. 2009
    ..This study evaluated the relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) and child intelligence...
  22. pmc Children are likely to suffer most from our fossil fuel addiction
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 116:987-90. 2008
    ....
  23. pmc Molecular epidemiology and prevention of cancer
    F P Perera
    Columbia University, School of Public Health, New York, New York, USA
    Environ Health Perspect 103:233-6. 1995
    ..They should be useful in early identification of at risk individuals and in designing and monitoring interventions (smoking cessation, exposure reduction, and chemoprevention)...
  24. pmc Molecular epidemiology in environmental carcinogenesis
    F P Perera
    Columbia University School of Public Health, Division of Environmental Health Sciences, New York, New York 10032, USA
    Environ Health Perspect 104:441-3. 1996
    ..Results of these studies are encouraging; they suggest that biomarkers, once validated, can be useful in identifying populations and individuals at risk in time to intervene effectively...
  25. ncbi request reprint Environment and cancer: who are susceptible?
    F P Perera
    Division of Environmental Health Sciences, Columbia University School of Public Health, 60 Haven Avenue, B 1, New York, NY 10032, USA
    Science 278:1068-73. 1997
    ..This will necessitate revision of current risk assessment methodologies to explicitly account for individual variation in susceptibility to environmental carcinogens...
  26. pmc Molecular epidemiologic research on the effects of environmental pollutants on the fetus
    F P Perera
    Joseph L Mailman School of Public Health at Columbia University, New York, NY 10032, USA
    Environ Health Perspect 107:451-60. 1999
    ....
  27. ncbi request reprint Molecular epidemiology: on the path to prevention?
    F P Perera
    Division of Environmental Health Sciences, Joseph L Mailman School of Public Health at Columbia University, New York, NY 10032, USA
    J Natl Cancer Inst 92:602-12. 2000
    ..4 billion in direct costs alone...
  28. pmc Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growth
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 113:1062-7. 2005
    ..04). The findings suggest that exposure to elevated levels of PAHs, indicated by PAH-DNA adducts in cord blood, may have contributed to reduced fetal growth in women exposed to the WTC event...
  29. pmc The challenge of preventing environmentally related disease in young children: community-based research in New York City
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Avenue, New York, NY 10032, USA
    Environ Health Perspect 110:197-204. 2002
    ..In turn, communities become better equipped to relay environmental health concerns to policy makers. In this paper we describe the center's research and its academic-community partnership and present some preliminary findings...
  30. pmc Molecular Epidemiology, prenatal exposure and prevention of cancer
    Frederica Perera
    Mailman School of Public Health, Columbia University, 100 Haven Avenue, Tower 3, 25F, New York, NY 10032, USA
    Environ Health 10:S5. 2011
    ..Thus, the early developmental period represents an important window for cancer prevention...
  31. pmc Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city children
    Frederica P Perera
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 119:1176-81. 2011
    ..Prenatal PAH exposure measured by personal monitoring has been linked to cognitive deficits in childhood in a prospective study conducted by the Columbia Center for Children's Environmental Health...
  32. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
    ..This study provides evidence that environmental pollutants at levels currently encountered in New York City adversely affect fetal development...
  33. pmc Prenatal environmental exposures, epigenetics, and disease
    Frederica Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY, United States
    Reprod Toxicol 31:363-73. 2011
    ..The findings discussed indicate that identification of environmental chemicals that dysregulate the prenatal epigenome should be a priority in health research and disease prevention...
  34. ncbi request reprint In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns
    Frederica Perera
    Columbia University School of Public Health, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 11:1134-7. 2002
    ..These results provide the first demonstration of a molecular link between somatic mutation in the newborn and transplacental exposure to common air pollutants, a finding that is relevant to cancer risk assessment...
  35. ncbi request reprint Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth
    R M Whyatt
    Columbia Center for Children s Environmental Health, Department of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, 60 Haven Ave, B 1, New York, NY 10032, USA
    Toxicol Appl Pharmacol 206:246-54. 2005
    ..No association was seen between birth weight and length and cord plasma chlorpyrifos or diazinon among newborns born after 1/1/01 (P > 0.8). Results support recent regulatory action to phase out residential uses of these insecticides...
  36. ncbi request reprint Biomarkers of polycyclic aromatic hydrocarbon-DNA damage and cigarette smoke exposures in paired maternal and newborn blood samples as a measure of differential susceptibility
    R M Whyatt
    Division of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 10:581-8. 2001
    ..The results have implications for risk assessment, which currently does not adequately account for sensitive subsets of the population...
  37. pmc Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns
    Shuang Wang
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 17:405-13. 2008
    ..However, with our limited sample size, the current findings are suggestive only, warranting further study...
  38. ncbi request reprint Risk of wheezing associated with house-dust mite allergens and indoor air quality among three-year-old children. Kraków inner city study
    Wiesław Jeedrychowski
    Chair of Epidemiology and Preventive Medicine College of Medicine, Jagiellonian University, Krakow, Poland
    Int J Occup Med Environ Health 20:117-26. 2007
    ....
  39. pmc An intervention to reduce residential insecticide exposure during pregnancy among an inner-city cohort
    Megan K Williams
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1684-9. 2006
    ....
  40. pmc Relation between prenatal lipid-soluble micronutrient status, environmental pollutant exposure, and birth outcomes
    Elizabeth T Masters
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Am J Clin Nutr 86:1139-45. 2007
    ..Significant effects of environmental pollutants on birth outcomes have been observed in our study population, and nutritional status may be an additional factor influencing fetal development and effects of environmental toxins...
  41. pmc Predictors of personal polycyclic aromatic hydrocarbon exposures among pregnant minority women in New York City
    Cathryn C Tonne
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 112:754-9. 2004
    ..This is the largest study to date characterizing personal exposures to PAHs, a ubiquitous class of carcinogenic air contaminants in urban environments, and is unique in its focus on pregnant minority women...
  42. pmc Residential pesticide use during pregnancy among a cohort of urban minority women
    Robin M Whyatt
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 110:507-14. 2002
    ..Diazinon exposures for some women may have exceeded health-based levels, and our findings support recent federal action to phase out residential use of this insecticide...
  43. ncbi request reprint Prenatal exposure, maternal sensitization, and sensitization in utero to indoor allergens in an inner-city cohort
    R L Miller
    Division of Pulmonary, Allergy, Critical Care, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Am J Respir Crit Care Med 164:995-1001. 2001
    ....
  44. pmc Prenatal exposures to phthalates among women in New York City and Krakow, Poland
    Jennifer J Adibi
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 111:1719-22. 2003
    ..01), and BBzP and monobenzyl phthalate (r = 0.65, p < 0.01). These results demonstrate considerable phthalate exposures during pregnancy among women in these two cohorts and indicate that inhalation is an important route of exposure...
  45. ncbi request reprint Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study
    D Tang
    Division of Environmental Health Sciences, Joseph L. Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Cancer Res 61:6708-12. 2001
    ..The findings are of interest because they suggest that individuals who become cases have greater biological susceptibility to tobacco carcinogens, a biological difference, which manifests most clearly while exposure is ongoing...
  46. pmc Developmental effects of exposure to environmental tobacco smoke and material hardship among inner-city children
    V A Rauh
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Avenue B 109, New York, NY 10032, USA
    Neurotoxicol Teratol 26:373-85. 2004
    ..The study concluded that prenatal exposure to ETS in the home has a negative impact on 2-year cognitive development, and this effect is exacerbated under conditions of material hardship in this urban minority sample...
  47. ncbi request reprint Biomarkers in styrene-exposed boatbuilders
    D D Brenner
    Division of Environmental Sciences, Columbia University School of Public Health, New York, NY 10032
    Mutat Res 261:225-36. 1991
    ..p.m.) can induce damage at the cellular/molecular level. Appropriately-selected panels of biomarkers can be useful in identifying potentially harmful exposures...
  48. ncbi request reprint Molecular epidemiology: recent advances and future directions
    F P Perera
    Division of Environmental Health Science, Joseph L Mailman School of Public Health at Columbia University, and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Carcinogenesis 21:517-24. 2000
    ..Its success in fully reaching this potential will depend on the application of validated biomarkers, with adherence to sound epidemiologic and ethical principles...
  49. doi request reprint Length at birth and effect of prenatal and postnatal factors on early wheezing phenotypes. Kraków epidemiologic cohort study
    Wiesław Jedrychowski
    Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Krakow, Poland
    Int J Occup Med Environ Health 21:111-9. 2008
    ....
  50. pmc Endotoxin in inner-city homes: associations with wheeze and eczema in early childhood
    Matthew S Perzanowski
    Columbia s Center for Children s Environmental Health, Columbia University, New York, NY 10032, USA
    J Allergy Clin Immunol 117:1082-9. 2006
    ..The relevance of this aspect of the hygiene hypothesis to US inner-city communities that have disproportionately high asthma prevalence has not been determined...
  51. ncbi request reprint Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers
    L A Mooney
    Department of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 10:641-8. 2001
    ..g., estrogens) and may explain a heightened risk of smoking-induced lung cancer in women compared with men...
  52. ncbi request reprint Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons
    Kirsti A Bocskay
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, B 109, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 14:506-11. 2005
    ..If confirmed, this finding may open new avenues for prevention...
  53. pmc Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland
    Wieslaw Jedrychowski
    Epidemiology and Preventive Medicine, Medical College, Jagiellonian University, 7A Kopernika Street, Krakow, Poland
    Environ Health Perspect 112:1398-402. 2004
    ..These results indicate the need to reduce ambient fine particulate concentrations. However, further research should establish possible biologic mechanisms explaining the observed relationship...
  54. ncbi request reprint Variability of total exposure to PM2.5 related to indoor and outdoor pollution sources Krakow study in pregnant women
    Wieslaw A Jedrychowski
    Chair of Epidemiology and Preventive Medicine, Medical College, Jagiellonian University, 7A, Kopernika St, 31 034 Krakow, Poland
    Sci Total Environ 366:47-54. 2006
    ....
  55. pmc Children's health and the environment: a new agenda for prevention research
    P J Landrigan
    Department of Community Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Environ Health Perspect 106:787-94. 1998
    ..To anchor the agenda, CEHN calls for long-term, stable investment and for creation of a national network of pediatric environmental health research and prevention centers...
  56. ncbi request reprint Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adducts in breast tissue sections
    G Motykiewicz
    Division of Environmental Health Sciences, Joseph L. Mailman School of Public Health, Columbia University, Gliwice, Poland
    Cancer Detect Prev 25:328-35. 2001
    ....
  57. pmc Ambient metals, elemental carbon, and wheeze and cough in New York City children through 24 months of age
    Molini M Patel
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Am J Respir Crit Care Med 180:1107-13. 2009
    ..The effects of exposure to specific components of ambient fine particulate matter (PM(2.5)), including metals and elemental carbon (EC), have not been fully characterized in young children...
  58. pmc Lack of association between physical activity in smokers and plasma glutathione peroxidase levels
    Andrew Rundle
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 17:1004-6. 2008
  59. pmc Prenatal exposure to PBDEs and neurodevelopment
    Julie B Herbstman
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, Columbia Center for Children s Environmental Health, New York, New York 10032, USA
    Environ Health Perspect 118:712-9. 2010
    ..Animal studies suggest that prenatal PBDE exposure may result in adverse neurodevelopmental effects...
  60. pmc Effects of prenatal exposure to coal-burning pollutants on children's development in China
    Deliang Tang
    Mailman School of Public Health, Columbia University, Department of Environmental Health Sciences, Columbia University, New York, NY 10032 USA
    Environ Health Perspect 116:674-9. 2008
    ..Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs), lead, and mercury are released by combustion of coal and other fossil fuels...
  61. pmc PAH-DNA adducts in cord blood and fetal and child development in a Chinese cohort
    Deliang Tang
    Department of Environmental Health Sciences, and Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA, and Chongqing Children Hospital, China
    Environ Health Perspect 114:1297-300. 2006
    ..001), and 30 months of age (p<0.001). The findings suggest that exposure to elevated levels of PAHs, with the Tongliang power plant being a significant source, is associated with reduced fetal and child growth in this population...
  62. pmc Traditional physical activity indexes derived from the Harvard alumni activity survey have low construct validity in a lower income, urban population
    Andrew Rundle
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Urban Health 84:722-32. 2007
    ..99 BMI units, 2.97 mmHg of diastolic blood pressure, and 3.96 mmHg of systolic blood pressure. This work suggests that the TWA scale has greater construct validity than the traditional PAI scale in this population...
  63. pmc Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma
    Frederica Perera
    The Columbia Center for Children s Environmental Health, Columbia University Mailman School of Public Health, New York, New York, United States of America
    PLoS ONE 4:e4488. 2009
    ..The results support the emerging theory of early origins of later life disease development...
  64. doi request reprint Air pollution threatens the health of children in China
    Alexander Millman
    Columbia University, 100 Haven Ave, 25F, Tower 3, New York, NY 10032, USA
    Pediatrics 122:620-8. 2008
    ..DATA SOURCES/DATA EXTRACTION: To fill this gap, we reviewed relevant published environmental studies, biomedical and molecular/epidemiologic research, and economic and policy analyses...
  65. ncbi request reprint Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study
    Frederica P Perera
    Division of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York City, NY 10032, USA
    Carcinogenesis 23:1641-6. 2002
    ..The findings underscore the complex and important role of biological susceptibility as a determinant of risk from carcinogens found in tobacco smoke and other environmental compounds...
  66. pmc Relation between cord blood mercury levels and early child development in a World Trade Center cohort
    Sally Ann Lederman
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 116:1085-91. 2008
    ..This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development...
  67. ncbi request reprint Risk for asthma in 1-year-old infants residing in New York City high-risk neighborhoods
    Ilan H Meyer
    Mailman School of Public Health, Columbia University, Columbia Center for Children s Environmental Health, New York, New York 10032, USA
    J Asthma 40:545-50. 2003
  68. pmc Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns
    Robin M Whyatt
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 111:749-56. 2003
    ..Findings indicate that pesticide exposures are frequent but decreasing and that the pesticides are readily transferred to the developing fetus during pregnancy...
  69. ncbi request reprint Personal exposure to fine particles and benzo[a]pyrene. Relation with indoor and outdoor concentrations of these pollutants in Kraków
    Wiesław Jedrychowski
    Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Kopernika 7A, 31 034 Krakow, Poland
    Int J Occup Med Environ Health 20:339-48. 2007
    ..This study assessed personal exposure of pregnant women to fine particles (PM(25)) and benzo[a]pyrene (B[a]P) and the relationship between pollutant concentrations in ambient and indoor air...
  70. pmc Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children
    Virginia A Rauh
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Ave, B 109, New York, NY 10032, USA
    Pediatrics 118:e1845-59. 2006
    ..The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children...
  71. pmc Fluorescence in situ hybridization is necessary to detect an association between chromosome aberrations and polycyclic aromatic hydrocarbon exposure in utero and reveals nonrandom chromosome involvement
    Kirsti A Bocskay
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Mol Mutagen 48:114-23. 2007
    ..Together, these results suggest that PAHs may be targeting specific chromosomes and highlight the importance of using the more sensitive detection methods to assess risk in populations with low levels of exposure...
  72. pmc Within- and between-home variability in indoor-air insecticide levels during pregnancy among an inner-city cohort from New York City
    Robin M Whyatt
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:383-9. 2007
    ..Residential insecticide use is widespread in the United States, but few data are available on the persistence and variability in levels in the indoor environment...
  73. pmc Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort
    Rachel L Miller
    Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, PH8C, 630 168th Street, New York, NY 10032, USA
    Chest 126:1071-8. 2004
    ....
  74. pmc Prenatal insecticide exposures and birth weight and length among an urban minority cohort
    Robin M Whyatt
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 112:1125-32. 2004
    ..Findings support recent regulatory action to phase out residential uses of the insecticides...
  75. pmc The effects of the World Trade Center event on birth outcomes among term deliveries at three lower Manhattan hospitals
    Sally Ann Lederman
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 112:1772-8. 2004
    ..The observed adverse effects suggest an impact of pollutants and/or stress related to the WTC disaster and have implications for the health and development of exposed children...
  76. ncbi request reprint Prevalence of allergy symptoms and total IgE in a New York City cohort and their association with birth order
    Inge F Goldstein
    Columbia s Children s Center for Environmental Health CCCEH, Columbia University, New York, NY, USA
    Int Arch Allergy Immunol 137:249-57. 2005
    ..As part of an ongoing prospective birth cohort study, the prevalence of early phenotypes of asthma and/or allergy was compared with those reported in other studies, and the association with birth order was evaluated...
  77. pmc Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort
    Matthew S Perzanowski
    Columbia Center for Children s Environmental Health, Columbia University, New York, NY 10032, USA
    J Allergy Clin Immunol 121:1047-52. 2008
    ..Cat ownership is inversely associated with atopy and asthma in some areas of the world, but the relevance of cat ownership to allergic disease in the inner city is less known...
  78. doi request reprint Modeling exposure to air pollution from the WTC disaster based on reports of perceived air pollution
    Sally Ann Lederman
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 100 Haven Avenue, 25F, New York, NY 10032, USA
    Risk Anal 28:287-301. 2008
    ..MAP developed from reports of PAP may be useful to identify high-risk areas and predict health outcomes when there are multiple sources of pollution and a "distance from source" analysis is impossible...
  79. ncbi request reprint Molecular epidemiologic studies of polycyclic aromatic hydrocarbon-DNA adducts and breast cancer
    Andrew Rundle
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Mol Mutagen 39:201-7. 2002
    ..14%). We hypothesize that the higher prevalence results from a referral bias and discuss how this may influence our results...
  80. pmc Health and environmental consequences of the world trade center disaster
    Philip J Landrigan
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 112:731-9. 2004
    ..Continuing follow-up of all exposed populations is required to document the long-term consequences of the disaster...
  81. pmc Effects of winter birth season and prenatal cockroach and mouse allergen exposure on indoor allergen-specific cord blood mononuclear cell proliferation and cytokine production
    Cynthia Lendor
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Ann Allergy Asthma Immunol 101:193-9. 2008
    ..Relationships among a particular birth season, maternal allergen exposure during the birth season, and childhood development of allergies to allergens in higher concentration during the birth season may be important...
  82. ncbi request reprint Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers
    Laverne A Mooney
    Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 14:237-42. 2005
    ..We assessed the chemopreventive effects of antioxidant supplementation using B(a)P-DNA adducts in leukocytes as an intermediate cancer risk marker...
  83. pmc Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, California, USA
    Environ Health Perspect 113:1419-29. 2005
    ..These centers present barriers encountered, solutions found, and considerations for future research, with the hope that the lessons learned can help inform the planning and conduct of the National Children's Study...
  84. pmc Emerging technology in molecular epidemiology: what epidemiologists need to know
    Frederica P Perera
    Department of Environmental Health Sciences, Columbia Center for Children s Environmental Health, Columbia Mailman School of Public Health, New York, NY, USA
    Epidemiology 19:350-2. 2008
    ..These examples show how interdisciplinary training in molecular epidemiology programs can help ensure that new technologies are used effectively to understand the mechanisms driving exposure-disease relationships...
  85. ncbi request reprint Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control study
    Deliang Tang
    Department of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York City, NY 10032, USA
    Breast Cancer Res Treat 78:217-22. 2003
    ..Contrary to our hypothesis PAH-DNA adduct levels in breast tissue were not associated with SULT1A1 genotype. Our findings are consistent with a prior report that the Arg/His polymorphism in SULT1A1 is associated with breast cancer risk...
  86. ncbi request reprint The interaction between alcohol consumption and GSTM1 genotype on polycyclic aromatic hydrocarbon-DNA adduct levels in breast tissue
    Andrew Rundle
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Cancer Epidemiol Biomarkers Prev 12:911-4. 2003
    ..This apparent difference in PAH metabolism in response to alcohol may be an important clue as to how alcohol influences breast cancer risk...
  87. pmc Estimating individual-level exposure to airborne polycyclic aromatic hydrocarbons throughout the gestational period based on personal, indoor, and outdoor monitoring
    Hyunok Choi
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 116:1509-18. 2008
    ....
  88. ncbi request reprint Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer
    Deliang Tang
    Department of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 75:159-66. 2002
    ..68 OD v.s. 0.40 OD, p = 0.01). The trend of increasing PAH-DNA adduct levels with either the Asn/Asn or Gln/Gln genotype was greater in tumor tissue than the trend in BBD control tissue...
  89. pmc Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study
    Frederica P Perera
    Department of Environmental Health Sciences, Columbia Center for Children s Environmental Health, Mailman School of Public Health of Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 15:1417-9. 2006
  90. ncbi request reprint The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes
    Sarah M Mense
    Department of Environmental Health Sciences, Columbia University, Mailman School of Public Health, New York, New York 10032, USA
    Toxicol Sci 93:125-35. 2006
    ..These results suggest that inflammatory activation of astrocytes might be an important mechanism underlying neurotoxicity of both chlorpyrifos and cyfluthrin...
  91. ncbi request reprint The National Children's Study: a 21-year prospective study of 100,000 American children
    Philip J Landrigan
    Center for Children s Health and the Environment, Department of Community and Preventive Medicine, New York, New York, USA
    Pediatrics 118:2173-86. 2006
    ..Data from the National Children's Study will guide development of a comprehensive blueprint for disease prevention in children...
  92. ncbi request reprint A bibliometric analysis of scientific production in cancer molecular epidemiology
    Donatella Ugolini
    Dipartimento di Oncologia, Biologia e Genetica, University of Genoa, Genoa 16132, Italy
    Carcinogenesis 28:1774-9. 2007
    ..The main purpose of this research was to compare the scientific production in the field of cancer molecular epidemiology among countries and to evaluate the publication trend between 1995 and 2004...

Research Grants40

  1. Environmental Health in Minority Women /Infants
    Frederica Perera; Fiscal Year: 2006
    ..abstract_text> ..
  2. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  3. Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children
    Frederica Perera; Fiscal Year: 2009
    ....
  4. Molecular Epidemiology and Lung Cancer: A Nested Case-Control Study
    Frederica Perera; Fiscal Year: 2009
    ....
  5. Developmental effects of early-life exposure to airborne PAHs.
    Frederica Perera; Fiscal Year: 2009
    ..The exposures we are studying are not unique to Poland but are ubiquitous worldwide; our results will thus be generalizable to other geographic and ethnic populations. ..
  6. Molecular Epidemiology and Lung Cancer: A Nested Case-Control Study
    Frederica P Perera; Fiscal Year: 2010
    ..abstract_text> ..
  7. Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children
    Frederica P Perera; Fiscal Year: 2010
    ....
  8. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
  9. HEALTH EFFECTS OF PAH & ETS IN MINORITY WOMEN & NEWBORNS
    Frederica Perera; Fiscal Year: 2001
    ....
  10. Molecular Epidemiology and Lung Cancer: A Nested Case-Control Study
    Frederica Perera; Fiscal Year: 2009
    ....
  11. Developmental effects of early-life exposure to airborne PAHs.
    Frederica P Perera; Fiscal Year: 2010
    ..The exposures we are studying are not unique to Poland but are ubiquitous worldwide;our results will thus be generalizable to other geographic and ethnic populations. ..